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  1. Article ; Online: Comment on 'Utilising 3D printing in assessment of anticipated difficult airways': a response.

    Iliff, H A / Ahmad, I / Woodford, C

    Anaesthesia reports

    2023  Volume 11, Issue 2, Page(s) e12257

    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: #JanuAIRWAY: providing airway education through social media.

    Iliff, H A / Lawson, T / Ahmad, I

    Anaesthesia reports

    2022  Volume 10, Issue 2, Page(s) e12174

    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12174
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  3. Article ; Online: Airway topicalization in pediatric anesthesia: An international cross-sectional study.

    Iliff, H A / Baxter, A / Chakladar, A / Endlich, Y / McGuire, B / Peyton, J

    Paediatric anaesthesia

    2023  Volume 34, Issue 2, Page(s) 145–152

    Abstract: Background: There is no national or international consensus or guideline on recommended dosing of lidocaine for airway topicalization in children. Doses quoted in the literature vary substantially.: Aims: The primary aim of the study was to ascertain ...

    Abstract Background: There is no national or international consensus or guideline on recommended dosing of lidocaine for airway topicalization in children. Doses quoted in the literature vary substantially.
    Aims: The primary aim of the study was to ascertain current international dosing practices (mg.kg
    Methods: This cross-sectional study consisted of 11-20 questions across three domains-population demographics, clinical practice, and local anesthetic systemic toxicity. It adhered to the consensus-based checklist for reporting of survey studies. Responses were collected over 14 weeks using a combination of probability (cluster and simple random) and nonprobability (purposive, convenience and snowball) sampling. Data were analyzed based on the response rate per question with proportions expressed as percentages and nonparametric data expressed as median (interquartile range [range]) in an effort to minimize nonresponse error. No weighting of items or propensity scoring was applied.
    Results: After initial exclusions, 1501 participants from 69 countries, across six continents, were included. Consultant anesthetists or those with an equivalent level of experience accounted for 1262/1501 (84.1%) of responses. Results showed heterogeneity in dosing and timing regimens and evidence that dosing may contribute to adverse outcomes. The maximum dose reported by participants who use lidocaine for airway topicalization as part of their normal practice was 5 mg.kg
    Conclusion: The results support the need for further research and consensus in this area, in order to provide safe provision of lidocaine airway topicalization in children. It is hoped the results of this study can support future collaborative work in this area.
    MeSH term(s) Humans ; Child ; Anesthetics, Local ; Cross-Sectional Studies ; Pediatric Anesthesia ; Lidocaine ; Anesthesia, Local/methods
    Chemical Substances Anesthetics, Local ; Lidocaine (98PI200987)
    Language English
    Publishing date 2023-10-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14783
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    Zs.A 3306: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Utilising 3D printing in assessment of anticipated difficult airways.

    Iliff, H A / Ahmad, I / Evans, S / Ingham, J / Rees, G / Woodford, C

    Anaesthesia reports

    2023  Volume 11, Issue 1, Page(s) e12232

    Language English
    Publishing date 2023-05-28
    Publishing country England
    Document type Journal Article
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12232
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  5. Article ; Online: General anaesthesia and euthanasia: difficulties defining the difference in end-of-life care.

    Iliff, H A / El-Boghdadly, K / Finlay, I

    Anaesthesia

    2021  Volume 77, Issue 2, Page(s) 232–233

    MeSH term(s) Anesthesia, General ; Euthanasia ; Humans ; Terminal Care
    Language English
    Publishing date 2021-10-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15605
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    Zs.A 388: Show issues Location:
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  6. Article ; Online: Using virtual reality for difficult airway management planning.

    Iliff, H A / Ahmad, I / Evans, S / Ingham, J / Rees, G / Woodford, C

    Anaesthesia reports

    2022  Volume 10, Issue 2, Page(s) e12175

    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12175
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  7. Article ; Online: Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system.

    Licastro, Ester / Pignataro, Giuseppe / Iliff, Jeffrey J / Xiang, Yanxiao / Lo, Eng H / Hayakawa, Kazuhide / Esposito, Elga

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 229

    Abstract: Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc. Accumulating evidence suggest that signals for central-systemic ... ...

    Abstract Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc. Accumulating evidence suggest that signals for central-systemic crosstalk may utilize glymphatic and lymphatic pathways. The glymphatic system is functionally connected to the meningeal lymphatic system, and together these pathways may be involved in the distribution of soluble proteins and clearance of metabolites and waste products from the CNS. Lymphatic vessels in the dura and meninges transport cerebrospinal fluid, in part collected from the glymphatic system, to the cervical lymph nodes, where solutes coming from the brain (i.e., VEGFC, oligomeric α-syn, β-amyloid) might activate a systemic inflammatory response. There is also an element of time since the immune system is strongly regulated by circadian rhythms, and both glymphatic and lymphatic dynamics have been shown to change during the day and night. Understanding the mechanisms regulating the brain-cervical lymph node (CLN) signaling and how it might be affected by diurnal or circadian rhythms is fundamental to find specific targets and timing for therapeutic interventions.
    MeSH term(s) Central Nervous System ; Lymphatic Vessels/physiology ; Brain/metabolism ; Lymphatic System ; Meninges
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-05911-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 'Shielded' anaesthetists and intensivists during the COVID-19 pandemic.

    Iliff, H A / Simpson, K A / Tomlinson, C R / Webb, C M

    Anaesthesia

    2020  Volume 75, Issue 11, Page(s) 1541–1542

    MeSH term(s) Anesthetists ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Intensive Care Units ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Practice Guidelines as Topic ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15153
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    Zs.A 388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Unexpected difficult tracheal intubation secondary to subglottic stenosis leading to emergency front-of-neck airway.

    Ellis, H / Iliff, H A / Lahloub, F M F / Smith, D R K / Rees, G J

    Anaesthesia reports

    2021  Volume 9, Issue 1, Page(s) 90–94

    Abstract: A 26-year-old woman presenting for an elective day case procedure under general anaesthesia had undiagnosed subglottic stenosis leading to a life threatening airway emergency requiring emergency front-of-neck airway. We outline the case and discuss key ... ...

    Abstract A 26-year-old woman presenting for an elective day case procedure under general anaesthesia had undiagnosed subglottic stenosis leading to a life threatening airway emergency requiring emergency front-of-neck airway. We outline the case and discuss key anaesthetic considerations in subglottic stenosis, including concerning features of a medical/anaesthetic history and the potential for rapid deterioration of a stenotic airway following manipulation. We also consider the effect of anaesthesia on the calibre of subglottic stenosis and the effects of positive pressure ventilation. Subglottic stenosis is a rare condition with congenital, acquired and idiopathic origins; however, iatrogenic trauma is the most common cause. We are aware of a small number of published case reports of previously undiagnosed subglottic stenosis in adults discovered after induction of anaesthesia; situational deterioration to 'cannot intubate, cannot oxygenate' scenarios appear even rarer.
    Language English
    Publishing date 2021-05-09
    Publishing country England
    Document type Case Reports
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12115
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  10. Article ; Online: CSF β-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury.

    Li, Ge / Iliff, Jeffrey / Shofer, Jane / Mayer, Cynthia L / Meabon, James / Cook, David / Pagulayan, Kathleen F / Raskind, Murray A / Zetterberg, Henrik / Blennow, Kaj / Peskind, Elaine R

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209197

    Abstract: Background and objectives: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. This study ... ...

    Abstract Background and objectives: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. This study investigated early AD changes using CSF biomarkers in veterans with blast mTBI.
    Methods: This was a cross-sectional case-control study of veterans with mTBI and non-mTBI veterans and civilians from 2 study sources. Blast-mTBI veterans had at least 1 war zone blast or combined blast/impact mTBI meeting Veterans Affairs (VA) and Department of Defense (DoD) criteria for mTBI. Non-mTBI participants had no lifetime history of TBI. All participants underwent standardized clinical and neuropsychological assessments and lumbar puncture for collection of the CSF. CSF biomarkers were measured using MesoScale Discovery assays for Aβ40 and Aβ42 and INNOTEST ELISAs for phosphorylated tau181 (p-tau181) and total tau (t-tau).
    Results: Our sample comprised 51 participants with mTBI and 85 non-mTBI participants with mean (SD) ages 34.0 (10.1) and 33.5 years (8.9), respectively. All participants but 1 (99%) were male. Differences in CSF AD biomarkers between mTBI and non-mTBI groups were age dependent and most pronounced at older ages (omnibus test
    Discussion: CSF Aβ levels decreased in middle-aged veterans with blast-related mTBI. These data suggest that chronic neuropathologic processes associated with blast mTBI share properties in common with pathogenic processes known to portend AD onset, thus raising concern that veterans with blast-related mTBI may develop a dementing disorder later in life.
    MeSH term(s) Middle Aged ; Humans ; Male ; Aged ; Female ; Brain Concussion/complications ; Case-Control Studies ; Veterans ; Cross-Sectional Studies ; Amyloid beta-Peptides ; Alzheimer Disease/pathology ; tau Proteins ; Brain Injuries, Traumatic/complications ; Biomarkers ; Memory Disorders/complications
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Biomarkers
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209197
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