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  1. Article: Restricted diffusion characteristics in oscillating gradient spin echo with mesoscopic phantom.

    Oshiro, Hinako / Hata, Junichi / Nakashima, Daisuke / Oshiro, Rintaro / Hayashi, Naoya / Haga, Yawara / Hagiya, Kei / Yoshimaru, Daisuke / Okano, Hideyuki

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26391

    Abstract: In diffusion magnetic resonance imaging, oscillating gradient spin echo (OGSE) has an extremely short diffusion time if motion probing gradient (MPG) is applied to the waveform. Further, it can detect microstructural specificity. OGSE changes sensitivity ...

    Abstract In diffusion magnetic resonance imaging, oscillating gradient spin echo (OGSE) has an extremely short diffusion time if motion probing gradient (MPG) is applied to the waveform. Further, it can detect microstructural specificity. OGSE changes sensitivity to spin displacement velocity based on the MPG phase. The current study aimed to investigate the restricted diffusion characteristics of each OGSE waveform using the capillary phantom with various b-values, frequencies, and MPG phases. We performed OGSE (b-value = 300, 500, 800, 1200, 1600, and 2000 s/mm
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26391
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  2. Article ; Online: The Authors' Reply.

    Mori, Daisuke / Kobayashi, Midori / Wada, Masafumi / Tokuchi, Maho / Misegawa, Soichiro / Saito, Rina / Nomi, Hiroki / Haga, Ryota / Nagatoya, Katsuyuki / Yamauchi, Atsushi

    Internal medicine (Tokyo, Japan)

    2024  

    Language English
    Publishing date 2024-01-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3074-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
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  3. Article: Maxillary Protrusion with Severe Overjet Treated by Maxillary Anterior Alveolar Osteotomy.

    Tomita, Daisuke / Haga, Shugo / Tanzawa, Fumi / Miyazawa, Taira / Nakano, Haruhisa / Maki, Koutaro

    Case reports in dentistry

    2024  Volume 2024, Page(s) 3850765

    Abstract: In addition to affecting oral functions such as temporomandibular joint function, mastication, and speech, malocclusion caused by skeletal maxillary prognathism also entails sociopsychological implications. Surgical orthodontic treatment to improve ... ...

    Abstract In addition to affecting oral functions such as temporomandibular joint function, mastication, and speech, malocclusion caused by skeletal maxillary prognathism also entails sociopsychological implications. Surgical orthodontic treatment to improve occlusion and oral function and to correct esthetic disharmony is important to improve patients' quality of life. We report the case of a 32-year-old woman who visited our hospital with a chief complaint of proclined upper front teeth. Clinical examination revealed maxillary overgrowth and severe labial inclination of the maxillary incisors with palatal gingival recession. The incisal protrusion was corrected with a maxillary anterior alveolar osteotomy-a surgical orthodontic method that could improve the overbite without causing excessive lingual inclination, while also minimizing orthodontic movement of the maxillary anterior teeth. This treatment is generally indicated in cases of maxillary prognathism with a relatively stable occlusal relationship in the molar region. As a result of the treatment, the patient's chief complaint improved and a long-term functional occlusion was achieved. This paper outlines the pre- and posttreatment skeletal and occlusal changes.
    Language English
    Publishing date 2024-03-09
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627632-X
    ISSN 2090-6455 ; 2090-6447
    ISSN (online) 2090-6455
    ISSN 2090-6447
    DOI 10.1155/2024/3850765
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  4. Article ; Online: Influence of Diffusion Time and Temperature on Restricted Diffusion Signal: A Phantom Study.

    Oshiro, Hinako / Hata, Junichi / Nakashima, Daisuke / Hayashi, Naoya / Haga, Yawara / Hagiya, Kei / Yoshimaru, Daisuke / Okano, Hideyuki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2023  Volume 23, Issue 2, Page(s) 136–145

    Abstract: Purpose: Diffusion MRI is a physical measurement method that quantitatively indicates the displacement of water molecules diffusing in voxels. However, there are insufficient data to characterize the diffusion process physically in a uniform structure ... ...

    Abstract Purpose: Diffusion MRI is a physical measurement method that quantitatively indicates the displacement of water molecules diffusing in voxels. However, there are insufficient data to characterize the diffusion process physically in a uniform structure such as a phantom. This study investigated the transitional relationship between structure scale, temperature, and diffusion time for simple restricted diffusion using a capillary phantom.
    Methods: We performed diffusion-weighted pulsed-gradient stimulated-echo acquisition mode (STEAM) MRI with a 9.4 Tesla MRI system (Bruker BioSpin, Ettlingen, Germany) and a quadrature coil with an inner diameter of 86 mm (Bruker BioSpin). We measured the diffusion coefficients (radial diffusivity [RD]) of capillary plates (pore sizes 6, 12, 25, 50, and 100 μm) with uniformly restricted structures at various temperatures (10ºC, 20ºC, 30ºC, and 40ºC) and multiple diffusion times (12-800 ms). We evaluated the characteristics of scale, temperature, and diffusion time for restricted diffusion.
    Results: The RD decayed and became constant depending on the structural scale. Diffusion coefficient fluctuations with temperature occurred mostly under conditions of a large structural scale and short diffusion time. We obtained data suggesting that temperature-dependent changes in the diffusion coefficients follow physical laws.
    Conclusion: No water molecules were observed outside the glass tubes in the capillary plates, and the capillary plates only reflected a restricted diffusion process within the structure.We experimentally evaluated the characteristics of simple restricted diffusion to reveal the transitional relationship of the diffusion coefficient with diffusion time, structure scale, and temperature through composite measurement.
    MeSH term(s) Temperature ; Magnetic Resonance Imaging ; Diffusion Magnetic Resonance Imaging/methods ; Diffusion ; Biological Transport ; Phantoms, Imaging ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-02-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1880-2206
    ISSN (online) 1880-2206
    ISSN 1880-2206
    DOI 10.2463/mrms.mp.2022-0103
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  5. Article ; Online: Effectiveness of the 'hoisting method' for shunt placement.

    Miki, Kenji / Inoue, Daisuke / Kawashima, Masatou / Haga, Sei

    British journal of neurosurgery

    2021  , Page(s) 1–2

    Abstract: Purpose: The abdominal procedure of ventriculoperitoneal or lumboperitoneal shunt is difficult because of a deep and narrow operative view, especially for obese patients. We have developed the 'Hoisting method,' which enables us to make abdominal ... ...

    Abstract Purpose: The abdominal procedure of ventriculoperitoneal or lumboperitoneal shunt is difficult because of a deep and narrow operative view, especially for obese patients. We have developed the 'Hoisting method,' which enables us to make abdominal procedures easy and safe.
    Material and methods: We report our experience with five cases between April 2020 and March 2021.
    Results: The placement of the shunt was easy and safe in all patients without any complications.
    Conclusion: The shunt method is very effective and easy without requiring additional devices.
    Language English
    Publishing date 2021-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2021.1937519
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2210: Show issues Location:
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  6. Article ; Online: Identification of the reporter gene combination that shows high contrast for cellular level MRI.

    Hayashi, Naoya / Hata, Junichi / Yoshida, Tetsu / Yoshimaru, Daisuke / Haga, Yawara / Oshiro, Hinako / Oku, Ayano / Kishi, Noriyuki / Shirakawa, Takako / Okano, Hideyuki

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297273

    Abstract: Currently, we can label the certain cells by transducing specific genes, called reporter genes, and distinguish them from other cells. For example, fluorescent protein such as green fluorescence protein (GFP) is commonly used for cell labeling. However, ... ...

    Abstract Currently, we can label the certain cells by transducing specific genes, called reporter genes, and distinguish them from other cells. For example, fluorescent protein such as green fluorescence protein (GFP) is commonly used for cell labeling. However, fluorescent protein is difficult to observe in living animals. We can observe the reporter signals of the luciferin-luciferase system from the outside of living animals using in vivo imaging systems, although the resolution of this system is low. Therefore, in this study, we examined the reporter genes, which allowed the MRI-mediated observation of labeled cells in living animals. As a preliminary stage of animal study, we transduced some groups of plasmids that coded the protein that could take and store metal ions to the cell culture, added metal ions solutions, and measured their T1 or T2 relaxation values. Finally, we specified the best reporter gene combination for MRI, which was the combination of transferrin receptor, DMT1, and Ferritin-M6A for T1WI, and Ferritin-M6A for T2WI.
    MeSH term(s) Animals ; Genes, Reporter ; Ferritins/genetics ; Cell Line, Tumor ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Magnetic Resonance Imaging/methods ; Ions/metabolism
    Chemical Substances Ferritins (9007-73-2) ; Green Fluorescent Proteins (147336-22-9) ; Ions
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297273
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  7. Article ; Online: A Case of Huge Scrotal Hematoma during Mechanical Thrombectomy.

    Tsurusaki, Yuichiro / Sakai, Shota / Morita, Takao / Miki, Kenji / Inoue, Daisuke / Haga, Sei / Arihiro, Shoji

    Journal of neuroendovascular therapy

    2022  Volume 16, Issue 11, Page(s) 565–569

    Abstract: Objective: We report a case of huge scrotal hematoma during emergency mechanical thrombectomy.: Case presentation: An 85-year-old man presented with sudden aphasia and right-sided hemiplegia. He was diagnosed with cerebral infarction due to left M1 ... ...

    Abstract Objective: We report a case of huge scrotal hematoma during emergency mechanical thrombectomy.
    Case presentation: An 85-year-old man presented with sudden aphasia and right-sided hemiplegia. He was diagnosed with cerebral infarction due to left M1 occlusion and underwent an emergency mechanical thrombectomy. The treatment was completed with full recanalization, but when replacing the long sheath in the right femoral artery with a short sheath, the patient flexed his leg. The sheath could not be replaced, resulting in a massive scrotal hematoma. Shortly after, the patient went into cardiopulmonary arrest but recovered spontaneous circulation after cardiopulmonary resuscitation. The puncture site was treated hemostatically with manual compression, and the scrotal hematoma was not enlarged. He was transferred to another hospital with a modified Rankin Scale score of 5.
    Conclusion: Scrotal hematoma is a rare but potentially fatal puncture site complication that should be considered during neuro-endovascular treatment.
    Language English
    Publishing date 2022-08-20
    Publishing country Japan
    Document type Case Reports
    ISSN 2186-2494
    ISSN (online) 2186-2494
    DOI 10.5797/jnet.cr.2022-0049
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  8. Article: Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos.

    Sakai, Daisuke / Murakami, Yuki / Shigeta, Daichi / Tomosugi, Mitsuhiro / Sakata-Haga, Hiromi / Hatta, Toshihisa / Shoji, Hiroki

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1212375

    Abstract: Physiological hypoxia is critical for placental mammalian development. However, the underlying mechanisms by which hypoxia regulates embryonic development remain unclear. We discovered that the expression of glycolytic genes partially depends on hypoxia ... ...

    Abstract Physiological hypoxia is critical for placental mammalian development. However, the underlying mechanisms by which hypoxia regulates embryonic development remain unclear. We discovered that the expression of glycolytic genes partially depends on hypoxia in neuroepithelial cells of E8.25 mouse embryos. Consistent with this finding, inhibiting glycolysis during the early phase of neural tube closure (E8.0-8.5) resulted in a neural tube closure defect. In contrast, inhibiting the electron transport chain did not affect neural tube formation. Furthermore, inhibiting glycolysis affected cell proliferation, but not differentiation and survival. Inhibiting glycolysis repressed the phosphorylation of myosin light chain 2, and consequent neural plate folding. Our findings revealed that anaerobic glycolysis regulates neuroepithelial cell proliferation and apical constriction during the early phase of neural tube closure.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1212375
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  9. Article ; Online: Effect of Dapagliflozin on Serum Uric Acid Levels in Patients with Advanced Chronic Kidney Disease.

    Mori, Daisuke / Kobayashi, Midori / Wada, Masafumi / Tokuchi, Maho / Misegawa, Soichiro / Saito, Rina / Nomi, Hiroki / Haga, Ryota / Nagatoya, Katsuyuki / Yamauchi, Atsushi

    Internal medicine (Tokyo, Japan)

    2023  Volume 63, Issue 3, Page(s) 353–357

    Abstract: Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are hypoglycemic agents, have been shown to be cardioprotective through a variety of mechanisms, and the effect of lowering uric acid (UA) levels may be one of the mechanisms. In the ... ...

    Abstract Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are hypoglycemic agents, have been shown to be cardioprotective through a variety of mechanisms, and the effect of lowering uric acid (UA) levels may be one of the mechanisms. In the present retrospective study, we investigated the changes in serum UA levels in patients with chronic kidney disease (CKD) treated with SGLT2 inhibitors. Methods We included 31 patients with CKD who were newly started on dapagliflozin for renal protection and evaluated trends in various parameters, including serum UA levels and UA excretion from urine. Results The patients' median age was 71 years old, 20 patients were men, 7 patients had diabetes, and the median estimated glomerular filtration rate was 33.9 mL/min/1.73 m
    MeSH term(s) Male ; Humans ; Aged ; Female ; Uric Acid ; Retrospective Studies ; Renal Insufficiency, Chronic ; Kidney ; Glomerular Filtration Rate ; Benzhydryl Compounds ; Glucosides
    Chemical Substances Uric Acid (268B43MJ25) ; dapagliflozin (1ULL0QJ8UC) ; Benzhydryl Compounds ; Glucosides
    Language English
    Publishing date 2023-06-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1828-23
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  10. Article ; Online: Commonality and variance of resting-state networks in common marmoset brains.

    Muta, Kanako / Haga, Yawara / Hata, Junichi / Kaneko, Takaaki / Hagiya, Kei / Komaki, Yuji / Seki, Fumiko / Yoshimaru, Daisuke / Nakae, Ken / Woodward, Alexander / Gong, Rui / Kishi, Noriyuki / Okano, Hideyuki

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8316

    Abstract: Animal models of brain function are critical for the study of human diseases and development of effective interventions. Resting-state network (RSN) analysis is a powerful tool for evaluating brain function and performing comparisons across animal ... ...

    Abstract Animal models of brain function are critical for the study of human diseases and development of effective interventions. Resting-state network (RSN) analysis is a powerful tool for evaluating brain function and performing comparisons across animal species. Several studies have reported RSNs in the common marmoset (Callithrix jacchus; marmoset), a non-human primate. However, it is necessary to identify RSNs and evaluate commonality and inter-individual variance through analyses using a larger amount of data. In this study, we present marmoset RSNs detected using > 100,000 time-course image volumes of resting-state functional magnetic resonance imaging data with careful preprocessing. In addition, we extracted brain regions involved in the composition of these RSNs to understand the differences between humans and marmosets. We detected 16 RSNs in major marmosets, three of which were novel networks that have not been previously reported in marmosets. Since these RSNs possess the potential for use in the functional evaluation of neurodegenerative diseases, the data in this study will significantly contribute to the understanding of the functional effects of neurodegenerative diseases.
    MeSH term(s) Animals ; Humans ; Callithrix ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain Mapping/methods ; Neurodegenerative Diseases
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58799-w
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