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Article ; Online: Low-dosage active vitamin D modifies the relationship between hypocalcemia and overhydration in patients with advanced chronic kidney disease.

Yamaguchi, Satoshi / Hamano, Takayuki / Yonemoto, Sayoko / Fujii, Naohiko / Isaka, Yoshitaka

2024 Volume 37, Issue 2, Page(s) 535–538

MeSH term(s)	Humans ; Hypocalcemia ; Renal Insufficiency, Chronic/complications ; Vitamin D/administration & dosage ; Vitamin D/blood ; Female ; Male ; Aged ; Middle Aged ; Water-Electrolyte Imbalance ; Calcium/blood
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2024-01-05
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01801-x
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Article ; Online: Burden of illness in Japanese patients with paroxysmal nocturnal hemoglobinuria receiving C5 inhibitors.

Obara, Naoshi / Usuki, Kensuke / Hayashi, Takeshi / Fujii, Masato / Ikezoe, Takayuki

International journal of hematology

2024 Volume 119, Issue 3, Page(s) 255–264

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening blood disorder characterized by hemolysis and resulting in anemia and fatigue. Current therapies for PNH in Japan rely on complement inhibitors targeting the C5 component of ... ...

Abstract	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening blood disorder characterized by hemolysis and resulting in anemia and fatigue. Current therapies for PNH in Japan rely on complement inhibitors targeting the C5 component of the complement. However, the disease burden of Japanese patients with PNH treated with C5 inhibitors (C5i) remains unclear. To investigate this topic, we conducted a cross-sectional survey study that included 59 Japanese patients with PNH treated with C5i. Although many participants received C5i for 1 year or longer, the mean hemoglobin (Hb) level was 10.2 g/dL. Fatigue and shortness of breath were the most common symptoms at the time of diagnosis and survey. In addition, patients with Hb levels ≥ 10.5 g/dL also reported fatigue, depression and reduced quality of life, albeit to a lesser extent. These results suggest that a substantial burden of illness remains in patients with C5i-treated PNH, likely resulting in low quality of life and effects of symptoms on daily life. This study contributes to understanding the unmet needs of the current therapies for PNH, highlighting the need for novel therapeutics.
MeSH term(s)	Humans ; Hemoglobinuria, Paroxysmal/drug therapy ; Japan ; Quality of Life ; Cross-Sectional Studies ; Antibodies, Monoclonal, Humanized ; Hemolysis ; Fatigue/etiology ; Cost of Illness
Chemical Substances	Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03698-5
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Article: 3D-OSEM versus FORE + OSEM: Optimal Reconstruction Algorithm for FDG PET with a Short Acquisition Time.

Tsuda, Keisuke / Suzuki, Takayuki / Toya, Kazuhito / Sato, Eisuke / Fujii, Hirofumi

World journal of nuclear medicine

2023 Volume 22, Issue 3, Page(s) 234–243

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2023-09-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0043-1774418
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Article ; Online: Load distribution structure of rear bumper beam to enhance vehicle body energy absorption in rear-end collisions.

Hasegawa, Atsushi / Fujii, Takayuki / Matsuura, Norikazu / Shimizu, Tomohiro

Traffic injury prevention

2023 Volume 24, Issue sup1, Page(s) S75–S79

Abstract: Objective: This research focused on FMVSS301, which is required for higher energy absorption as a regulation for rear-end collisions. Since they are offset collisions, the deformation of the non-collision side frame, which does not directly contact the ... ...

Abstract	Objective: This research focused on FMVSS301, which is required for higher energy absorption as a regulation for rear-end collisions. Since they are offset collisions, the deformation of the non-collision side frame, which does not directly contact the barrier, is less than on the collision side. The reason is that the rear bumper beam with curvature is deformed into a straight shape by the load from the barrier, resulting in an asymmetrical load distribution from the barrier that is biased toward the collision side. Therefore, the objective of this research was to construct a new bumper beam structure that reduces the difference in the load input to both frames and increases the energy absorption of the non-collision side frame. Method: The basic principle is to generate a counterforce against the lateral loads during transmitting the load from barrier to the frames. To achieve this, a bow-shaped rear bumper beam structure was devised. The rear bumper beam corresponds to the bow and the newly added connection plate to the string. The lateral load increase is suppressed and load distribution to the rear frame is maintained. Results: The designed rear bumper beam and rear components equipped with the rear bumper beam were both prepared and evaluated by drop test. With testing of the rear bumper beam, it was demonstrated that the load in the lateral direction, which conventionally generates over 80 kN, could be canceled. Tests of the rear component demonstrated that load distribution to the rear frame could be maintained, and the energy absorption of the non-collision side frame could be enhanced by 35 times. The total energy absorption of the barrier and the two frames was demonstrated to increase 2.9 times. Conclusion: The bow-shaped rear bumper beam was designed to distribute the load evenly to the collision and non-collision side frames, and to deform both frames, thereby achieving a higher energy absorption of the entire vehicle body. This is expected to be applicable to electric vehicles and FCVs, which require more energy absorption with increased vehicle weight.
MeSH term(s)	Humans ; Accidents, Traffic ; Equipment Design
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2023.2172573
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Article ; Online: Residual kidney function modifies the effect of cinacalcet on serum phosphorus levels among peritoneal dialysis patients.

Murashima, Miho / Fujii, Naohiko / Goto, Shunsuke / Hasegawa, Takeshi / Abe, Masanori / Hanafusa, Norio / Fukagawa, Masafumi / Hamano, Takayuki

Journal of nephrology

2024

Language	English
Publishing date	2024-01-27
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01863-x
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Article ; Online: Intra-/Extracorporeal Single-Incision Versus Conventional Laparoscopic Appendectomy in Children: A Systematic Review and Meta-Analysis.

Fujii, Takayuki / Tanaka, Aya / Katami, Hiroto / Shimono, Ryuichi

Journal of laparoendoscopic & advanced surgical techniques. Part A

2022 Volume 32, Issue 6, Page(s) 702–712

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Appendectomy/methods ; Appendicitis/surgery ; Child ; Humans ; Intraabdominal Infections ; Laparoscopy/methods ; Length of Stay ; Operative Time ; Surgical Wound ; Treatment Outcome
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0738
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Article ; Online: Urosepsis Risk in Neuromyelitis Optica Spectrum Disorder Patients Administered Satralizumab.

Fujita, Rina / Aratake, Yuriko / Nakata, Kyoko / Fujii, Chihiro / Kondo, Takayuki

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 22, Page(s) 3317–3320

Abstract: Objective The interleukin-6 (IL-6) inhibitor satralizumab is an established treatment for neuromyelitis optica spectrum disorder (NMOSD). Although IL-6 inhibitors are generally well-tolerated, serious infections, including sepsis, can occur. In this ... ...

Abstract	Objective The interleukin-6 (IL-6) inhibitor satralizumab is an established treatment for neuromyelitis optica spectrum disorder (NMOSD). Although IL-6 inhibitors are generally well-tolerated, serious infections, including sepsis, can occur. In this study, we compared the sepsis characteristics in NMOSD patients administered satralizumab (NMOSD-satralizumab) to those in rheumatoid arthritis patients administered tocilizumab (RA-tocilizumab), another IL-6 inhibitor. Methods We examined adverse event reports from the Japanese Pharmaceuticals and Medical Devices Agency regarding NMOSD-satralizumab from August 2020 to March 2022 and RA-tocilizumab from April 2008 to November 2019 (term 1) and to March 2022 (term 2). Results We identified 6 sepsis cases in NMOSD-satralizumab, of which 5 (83%) developed from urinary tract infections (UTIs). Although data were unavailable for two patients, three cases had urologic complications in addition to recognized risk factors for serious infections, such as an older age, corticosteroid use, obesity, diabetes mellitus and motor disability. Urosepsis was relatively infrequent in RA-tocilizumab (term 1: 24.2%, term 2: 20.1%). Conclusion Safe satralizumab use requires risk factor assessment to minimize the incidence of severe infections. Management of UTIs is also recommended.
MeSH term(s)	Humans ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/epidemiology ; Disabled Persons ; Motor Disorders ; Sepsis/epidemiology ; Aquaporin 4
Chemical Substances	satralizumab (YB18NF020M) ; Aquaporin 4
Language	English
Publishing date	2023-04-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1642-23
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Article ; Online: Impact of Concurrent Visual and Hearing Impairment on Incident Alzheimer's Disease: The LIFE Study.

Kim, Sung-A / Maeda, Megumi / Murata, Fumiko / Fujii, Takayuki / Ueda, Emi / Ono, Rei / Fukuda, Haruhisa

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 1, Page(s) 197–207

Abstract: Background: The prevalence of Alzheimer's disease (AD) is increasing in Japan due to population aging. The association between sensory impairment and incident AD remains unclear.: Objective: This study aimed to investigate the impact of sensory ... ...

Abstract	Background: The prevalence of Alzheimer's disease (AD) is increasing in Japan due to population aging. The association between sensory impairment and incident AD remains unclear. Objective: This study aimed to investigate the impact of sensory impairment on incident AD. Methods: We analyzed residents of five municipalities participating in the Longevity Improvement & Fair Evidence (LIFE) Study. The participants comprised individuals who had newly applied for long-term care needs certification between 2017 and 2022 and had no cognitive impairment upon application or AD diagnosis within the preceding six months. Participants were classified according to sensory impairment status: visual impairment (VI), hearing impairment (HI), neither sensory impairment (NSI), and dual sensory impairment (DSI). The month succeeding the certification application was set as the index month, and the interval from that month until AD onset was assessed. Multivariable Cox proportional hazards analysis was performed to calculate the risk of AD onset according to sensory impairment status while adjusting for sex, age, dependence level, self-reliance level, and comorbidities. Results: Among 14,186 participants, we identified 1,194 (8.4%) who developed AD over a median follow-up period of 22.6 months. VI and HI only were not associated with incident AD. However, DSI conferred a significantly higher risk (HR: 1.6, CI: 1.1-2.2, p = 0.008) of AD onset than NSI. Conclusions: Individuals with concurrent DSI have a higher risk of developing AD than those with single or NSI. Preventing and treating sensory impairment may not only improve functional outcomes, but could also help to reduce the future risk of AD.
MeSH term(s)	Humans ; Longevity ; Alzheimer Disease/epidemiology ; Alzheimer Disease/complications ; Vision Disorders/complications ; Hearing Loss/epidemiology ; Hearing Loss/complications ; Aging
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230806
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Article: Safety and efficacy of pipeline embolization device treatments for intradural internal carotid artery aneurysms in a single center in a Japanese population.

Kitamura, Takayuki / Fujii, Takashi / Yatomi, Kenji / Teranishi, Kohsuke / Mitome-Mishima, Yumiko / Oishi, Hidenori

Surgical neurology international

2023 Volume 14, Page(s) 92

Abstract: Background: The pipeline embolization device (PED) is the most common flow diverter device in the world. To date, there have been no reports of treatment outcomes specific to intradural internal carotid artery (ICA) aneurysms. The safety and efficacy of ...

Abstract	Background: The pipeline embolization device (PED) is the most common flow diverter device in the world. To date, there have been no reports of treatment outcomes specific to intradural internal carotid artery (ICA) aneurysms. The safety and efficacy of the PED treatments for intradural ICA aneurysms are reported. Methods: 131 patients with 133 aneurysms underwent PED treatments for intradural ICA aneurysms. The mean aneurysm dome size and neck length were 12.7 ± 4.3 mm and 6.1 ± 2.2 mm, respectively. We used adjunctive endosaccular coil embolization for 88 aneurysms (66.2%). A total of 113 aneurysms (85%) were angiographically followed up 6 months following the procedure, and 93 aneurysms (69.9%) were followed up for 1 year. Results: The angiographic outcome at 6 months showed that 94 (83.2%) aneurysms had O'Kelly-Marotta (OKM) grade D, 6 (5.3%) had C, 10 (8.8%) had B, and 3 (2.7%) had A. At 1 year, 82 (88.2%) aneurysms had OKM grade D, 6 (6.5%) had C, 3 (3.2%) had B, and 2 (2.2%) had A. Multivariate analysis showed that aneurysm neck size and adjunctive coiling were statistically significant in aneurysm occlusion status. Major morbidity modified Rankin Scale >2 and mortality rates related to procedures were 3.0% and 0%, respectively. Delayed aneurysm ruptures were not observed. Conclusion: These results reveal that PED treatment of intradural ICA aneurysms is safe and efficacious. The combined use of adjunctive coil embolization not only prevents delayed aneurysm ruptures but also contributes to an increase in the rate of complete occlusion.
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_1165_2022
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Article ; Online: Proposal for a Simple Equation for Limb Muscle Weight Calculation.

Kurokawa, Yasutaka / Kurokawa, Takayuki / Fujii, Misato / Tanifuji, Masatoshi / Nakajin, Takashi / Sato, Tsukasa / Machida, Ikuko

Medical science monitor : international medical journal of experimental and clinical research

2023 Volume 29, Page(s) e938606

Abstract: BACKGROUND Although body mass index (BMI) is currently being utilized frequently as an indicator of obesity, it provides little information concerning body composition; key components such as fat and muscle cannot be differentiated. It is especially non- ... ...

Abstract	BACKGROUND Although body mass index (BMI) is currently being utilized frequently as an indicator of obesity, it provides little information concerning body composition; key components such as fat and muscle cannot be differentiated. It is especially non-sensitive in identifying muscle mass, which can be challenging to examine without the use of radiologic methods. We sought to identify whether biometric values such as upper arm subcutaneous fat thickness/circumference could provide an adequate indicator of muscle mass. MATERIAL AND METHODS Patients admitted to our clinic for various causes were retrospectively studied in 95 consecutive cases. Physical parameters including upper arm subcutaneous fat thickness, upper arm circumference, weight, and height were measured. Then, values such as limb muscle weight (LMWDXA) and total fat weight (FWDXA) were obtained from dual-energy X-ray absorptiometry. Pearson's correlation coefficients were calculated and linear regression analysis was conducted. RESULTS Neither upper arm subcutaneous fat thickness nor upper arm circumference was correlated with LMWDXA. FWDXA also showed a correlation with BMI (r=0.823, P<0.001). LMWDXA also significantly correlated with measured body weight (BWm)-BMI (r=0.719, P<0.001). CONCLUSIONS From our analytic data we propose an equation for calculating muscle mass, designated the Simple Muscle Weight (SMW): SMW=289.2×(BWm-BMI)+3631. SMW calculation has potential for use as an easy and simple first-line diagnostic tool to identify diminished muscle mass.
MeSH term(s)	Humans ; Retrospective Studies ; Muscles ; Upper Extremity ; Body Mass Index ; Body Weight
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.938606
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