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  1. Article ; Online: Ventricular structure-function relations in health and disease: part II. Clinical considerations.

    Buckberg, Gerald D / Hoffman, Julien I E / Coghlan, H Cecil / Nanda, Navin C

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2015  Volume 47, Issue 5, Page(s) 778–787

    Abstract: Normal cardiac function of the left and right ventricles, together with the septum, is related to form/function interactions within the helical ventricular myocardial band. This knowledge is a prerequisite to understanding form/function interactions in ... ...

    Abstract Normal cardiac function of the left and right ventricles, together with the septum, is related to form/function interactions within the helical ventricular myocardial band. This knowledge is a prerequisite to understanding form/function interactions in diseases and for planning new treatments. Topics discussed include congestive heart failure in dilated hearts of ischaemic, valvar or nonischaemic origin as well as diastolic dysfunction. Similar thinking underlies novel treatments for dyssynchrony in pacing, together with focusing upon varying global left or right ventricular anatomy to correct mitral and tricuspid insufficiency caused by tethering of the leaflets. The septum is the lion of the right ventricle and insight is provided into offsetting septal damage during cardiac surgery, rebuilding its anatomical structure in post-tetralogy pulmonary insufficiency, as well as rectifying its dysfunction by decompression in patients with a left ventricular assist device.
    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Ventricles/anatomy & histology ; Humans ; Stroke Volume ; Ventricular Function/physiology
    Language English
    Publishing date 2015-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezu279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ventricular structure-function relations in health and disease: Part I. The normal heart.

    Buckberg, Gerald D / Hoffman, Julien I E / Coghlan, H Cecil / Nanda, Navin C

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2015  Volume 47, Issue 4, Page(s) 587–601

    Abstract: The heart's structure-function relationships explain normal cardiac dynamics and clarify how they are disrupted by disease. For 500 years, anatomists described circumferential and helical cardiac fibres, yet disagreed about their relationships. One ... ...

    Abstract The heart's structure-function relationships explain normal cardiac dynamics and clarify how they are disrupted by disease. For 500 years, anatomists described circumferential and helical cardiac fibres, yet disagreed about their relationships. One current model is attributed to Torrent Guasp who described functional pathways, the helical ventricular myocardial band (HVMB) with two interconnected loops: an outer basal loop with transverse fibres surrounds an inner apical helical loop that is composed of oblique descending and ascending segments that create a conical apical vortex. This review addresses the potential role of the HVMB in explaining the mechanics of isovolumic contraction, ejection, post-ejection isovolumic interval, rapid filling, torsion and recoiling. During the post-ejection isovolumic interval, a ∼ 90-ms hiatus exists between the end of contraction of the descending and the ascending segments. Compromise of this hiatus by disease disturbs the interdependence between torsion and 'untwisting' and impairs cardiac function. The validity of conventional expressions such as isovolumic relaxation, hyperechogenic septal line, untwisting and mitral valve opening will be revisited.
    MeSH term(s) Heart Ventricles/anatomy & histology ; Humans ; Models, Cardiovascular ; Myocardial Contraction/physiology ; Ventricular Function/physiology
    Language English
    Publishing date 2015-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezu278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: 'The electrical spiral of the heart': its role in the helical continuum. The hypothesis of the anisotropic conducting matrix.

    Coghlan, H Cecil / Coghlan, Anthony R / Buckberg, Gerald D / Cox, James L

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2006  Volume 29 Suppl 1, Page(s) S178–87

    Abstract: The study of the dissemination of the electrical impulse throughout the ventricular myocardium, which gave rise to the current theories, was carried out without taking into consideration the complex architecture of the cardiac muscle elucidated by more ... ...

    Abstract The study of the dissemination of the electrical impulse throughout the ventricular myocardium, which gave rise to the current theories, was carried out without taking into consideration the complex architecture of the cardiac muscle elucidated by more recent researchers. We propose a novel hypothesis based on the special macroscopic structure of the heart, the anisotropic electrical and mechanical behavior of the myocardium, the characteristics of the intercellular matrix and its very special collagen scaffolding, chemical composition, and biochemistry. The unique properties of the intercellular matrix would make it especially suited to function, in conjunction with the specialized conducting system (His-Purkinje system) as an efficient anisotropic conductor for the spread of electrical activation in the heart in order to allow an optimal sequence of excitation-contraction coupling that results in the coordination of effective myocardial contraction in birds and mammals of the most varied known heart rates. An analysis of certain clinical conditions that raise questions regarding current hypothesis and a review of novel techniques for recording transmembrane and extracellular potentials, which will provide a much firmer basis for the study of cardiac activation and the influence of myofiber architecture and which will allow in depth testing of hypotheses are presented.
    MeSH term(s) Animals ; Anisotropy ; Endocardium/physiology ; Heart Conduction System/physiology ; Humans ; Muscle Fibers, Skeletal/physiology ; Myocardial Contraction/physiology ; Purkinje Fibers/physiology
    Language English
    Publishing date 2006-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1016/j.ejcts.2006.02.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ruptured giant right coronary artery aneurysm percutaneously plugged.

    Hillegass, William B / Gupta, Himanshu / Katragadda, Raghunath / Knoblauch, Johnnie / Coghlan, Cecil / Misra, Vijay K

    The Journal of invasive cardiology

    2007  Volume 19, Issue 3, Page(s) 139–141

    Abstract: The endovascular management of a patient with a ruptured giant coronary aneurysm presenting with chest pain followed by anterior chest wall ecchymosis and shock is described. The inflow to a large, acutely leaking right coronary aneurysm was successfully ...

    Abstract The endovascular management of a patient with a ruptured giant coronary aneurysm presenting with chest pain followed by anterior chest wall ecchymosis and shock is described. The inflow to a large, acutely leaking right coronary aneurysm was successfully sealed with the Amplatzer Vascular Plug device. The patient was estimated to be at very high risk for surgical intervention. The use of this device to seal an acutely leaking coronary aneurysm has not been previously described.
    MeSH term(s) Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/therapy ; Chest Pain/etiology ; Coronary Aneurysm/complications ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/therapy ; Ecchymosis/etiology ; Embolization, Therapeutic ; Humans ; Male ; Middle Aged ; Prostheses and Implants ; Shock/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 31: Show issues

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  5. Article ; Online ; Conference proceedings: Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease.

    Buckberg, Gerald D / Weisfeldt, Myron L / Ballester, Manel / Beyar, Raphael / Burkhoff, Daniel / Coghlan, H Cecil / Doyle, Mark / Epstein, Neal D / Gharib, Morteza / Ideker, Ray E / Ingels, Neil B / LeWinter, Martin M / McCulloch, Andrew D / Pohost, Gerald M / Reinlib, Leslie J / Sahn, David J / Sopko, George / Spinale, Francis G / Spotnitz, Henry M /
    Torrent-Guasp, Francisco / Shapiro, Edward P

    Circulation

    2004  Volume 110, Issue 14, Page(s) e333–6

    MeSH term(s) Aging/physiology ; Animals ; Cardiac Surgical Procedures ; Cell Size ; Diagnostic Imaging/methods ; Diastole ; Disease Models, Animal ; Forecasting ; Heart Failure/etiology ; Heart Ventricles/pathology ; Humans ; Models, Cardiovascular ; Myocardial Contraction ; Myocytes, Cardiac/ultrastructure ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2004-10-05
    Publishing country United States
    Document type Congresses ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.CIR.0000143625.56882.5C
    Database MEDical Literature Analysis and Retrieval System OnLINE

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