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Article ; Online: [The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis].

Gaisenok, O V

2020 Volume 65, Issue 3, Page(s) 167–175

Abstract: This review article considers the possibilities of combined antiviral therapy in the treatment of patients with COVID-19, based on the analysis of the mechanism of action of known antiviral drugs in the framework of the medical hypothesis. The potential ... ...

Abstract	This review article considers the possibilities of combined antiviral therapy in the treatment of patients with COVID-19, based on the analysis of the mechanism of action of known antiviral drugs in the framework of the medical hypothesis. The potential effectiveness of the joint use of viral RNA polymerase inhibitors and a fusion inhibitor in this pathology is discussed. The review discusses the main representatives of these groups of drugs - ribavirin, riamilovir, umifenovir, favipiravir. The efficacy and safety profile of these drugs was analyzed, including the experience of their use in clinical trials conducted during the COVID-19 pandemic, as well as earlier work performed during the SARS and MERS epidemics.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Enzyme Inhibitors/therapeutic use ; Humans ; Pandemics ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/metabolism ; SARS-CoV-2/enzymology
Chemical Substances	Antiviral Agents ; Enzyme Inhibitors ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	Russian
Publishing date	2020-07-22
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	201241-8
ISSN	2411-2097 ; 0507-4088
ISSN (online)	2411-2097
ISSN	0507-4088
DOI	10.36233/0507-4088-2020-65-3-167-175
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Article: Сравнительный анализ вариабельности индекса гетерогенности эритроцитов в зависимости от принадлежности к определенной нозологической группе болезней по классификации МКБ-10.

Gaisenok, O V

Klinicheskaia laboratornaia diagnostika

2020 Volume 65, Issue 8, Page(s) 487–491

Abstract: The aim of this study was to investigate RDW variability and conduct a comparative analysis of the RDW level in patients depending on their belonging to a defined nosological group of diseases according to the ICD-10 classification. All patients who ... ...

Title translation	Comparative analysis of RDW variability depending on belonging to a defined nosological group of diseases according to ICD-10 classification.
Abstract	The aim of this study was to investigate RDW variability and conduct a comparative analysis of the RDW level in patients depending on their belonging to a defined nosological group of diseases according to the ICD-10 classification. All patients who complete blood count tests in our hospital from January to December 2016 were included in the study. The identification of the patient's belonging to a specific nosological group according to the ICD-10 classification was carried out on the basis of the disease analysis code indicated in the direction of the blood test. 8056 patient records were included in the final analysis. Deviations beyond the upper reference range for the RDW indicator (> 14.5%) in this study were identified for patients of the following nosological groups according to ICD-10: C - neoplasms; D - blood diseases; S - injuries; T - poisoning. Significant intergroup differences were obtained according to the Kruskal-Wallis rank analysis of variance (Kruskal-Wallis test: H (19, n= 7622) = 214.9672 p = 0.0000). According to the results of this study, we can conclude that RDW has specificity for certain diseases (neoplasms; blood diseases; injuries; poisoning). In case of cardiovascular and other diseases, deviations of this indicator beyond the limits of the upper reference values were not found in this study.
MeSH term(s)	Erythrocyte Indices ; Humans ; International Classification of Diseases ; Reference Values ; Retrospective Studies
Language	Russian
Publishing date	2020-08-06
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1155086-7
ISSN	0869-2084
ISSN	0869-2084
DOI	10.18821/0869-2084-2020-65-8-487-491
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Article ; Online: Forecasting risk analysis of detection for carotid artery stenosis based on serum levels grading of lipoprotein (a)

O.V. Gaisenok

Analiz Riska Zdorovʹû, Iss 3, Pp 133-

2022 Volume 142

Abstract: Aim of the study: to assess the relationship between Lp(a) serum levels grading and carotid artery stenosis (CAS). The Duplex Registry database was used for this study. CAS was verified by duplex scanning in the presence of an atherosclerotic plaque (AP), ...

Abstract	Aim of the study: to assess the relationship between Lp(a) serum levels grading and carotid artery stenosis (CAS). The Duplex Registry database was used for this study. CAS was verified by duplex scanning in the presence of an atherosclerotic plaque (AP), stenosing the lumen of the carotid artery (CA) by 20 % or more. Patients who underwent a blood test for Lp(a) and the results were entered into the registry database were selected for this study. The immunoturbidimetric method was used to determine the serum level of Lp(a) (mg/dl). Data from 51 patients (66.6 % men) were included in the final analysis: median age 49.0 [46.0; 59], total cholesterol (TC) 5.93 [5.13; 6.56], Lp(a) 26.5 [14.2; 76.0]. Spearman rank correlation analysis showed the presence of significant relationships (p < 0.05) between Lp(a) and age (r = 0.3), gender (r = 0.3), the presence of AP in the right ICA (r = 0.5), HDL (r = 0.3). OR and 95 % CI were calculated to determine the effect of Lp(a) grades on the probability of CAS detection: Lp(a) < 30 mg/dl OR 0.36 [0.11; 1.14] p = 0.04; Lp(a) > 30 mg/dl OR 1.42 [0.44; 4.58] p = 0.27. The prevalence of CAS in the group with Lp(a) level < 30 mg/dl was 33.3 %, 30–50 mg/dl – 50 %, 50–100 mg/dl – 40 %, > 100 mg/dl – 37.5 %. The model of multiple regression analysis for Lp(a) with TC in relation to the right ICA stenosis predicting showed R = 0.51, F = 8.4, p = 0.0007. The statistics of 3M model of the logistic regression function for CAS predicting based on the Lp(a) and TC data showed: -2 • log(likelihood) = 57.16, Chi-square = 8.17 (cc = 2), p = 0.016. The present study confirmed the relationship between the Lp(a) level and the CAS detection and the presence of an additive effect of total cholesterol on this. The reference role of Lp(a) gradation at the level of 30 mg/dl was determined as significant in relation to predicting CAS detection.
Keywords	lipoprotein(a) ; grading ; risk analysis ; carotid atherosclerosis ; stenosis ; duplex scanning ; prediction ; Medicine ; R
Subject code	630
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Drug Interactions and Side Effects of Co-Administration of Chloroquine/Hydroxychloroquine and Azithromycin

O. V. Gaisenok

Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 16, Iss 3, Pp 481-

on the Issue of Rational Pharmacotherapy of Patients with COVID-19 with Antimalarial Drugs

2020 Volume 486

Abstract: This review analyzes existing approaches to the treatment of COVID-19 patients with antimalarial drugs from the standpoint of rational pharmacotherapy. Particular attention is paid to drug interactions and side effects of co-administration of chloroquine/ ...

Abstract	This review analyzes existing approaches to the treatment of COVID-19 patients with antimalarial drugs from the standpoint of rational pharmacotherapy. Particular attention is paid to drug interactions and side effects of co-administration of chloroquine/hydroxychloroquine and azithromycin, considering the problem of cardiotoxicity and the high likelihood of cardiovascular disease in middle-aged and elderly people with COVID-19. The article discusses the prospects of using another representative from the group of antimalarial drugs - mefloquine in the treatment of COVID-19. Special attention is paid to the “proarrhythmogenic” side effects of azithromycin therapy, as well as to the problem of resistance of microorganisms to macrolides during antibiotic therapy of pneumonia, in particular to azithromycin. In conclusion, the article discusses the possibilities of alternative methods in the treatment of this disease.
Keywords	covid-19 ; chloroquine ; hydroxychloroquine ; azithromycin ; drug interactions ; side effects ; Therapeutics. Pharmacology ; RM1-950 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; covid19
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Stolichnaya Izdatelskaya Kompaniya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Determination of indications for coronary angiography in asymptomatic patients and patients with stable angina].

Gaĭsenok, O V / Martsevich, S Iu

Kardiologiia

2014 Volume 54, Issue 10, Page(s) 57–62

Abstract: A high percentage of patients undergoing coronary angiography which revealed no coronary lesions persists among patients with stable CHD. This problem persists in spite of the application of existing recommendations for the management of patients with ... ...

Abstract	A high percentage of patients undergoing coronary angiography which revealed no coronary lesions persists among patients with stable CHD. This problem persists in spite of the application of existing recommendations for the management of patients with stable CHD. Data of Russian and foreign authors analyzed in this article, which dedicated to this subject.
MeSH term(s)	Angina, Stable/diagnosis ; Asymptomatic Diseases ; Coronary Angiography/statistics & numerical data ; Disease Management ; Humans ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/physiopathology ; Patient Selection ; Practice Patterns, Physicians'/statistics & numerical data ; Risk Adjustment ; Unnecessary Procedures/adverse effects ; Unnecessary Procedures/statistics & numerical data
Language	Russian
Publishing date	2014-09-26
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
DOI	10.18565/cardio.2014.10.57-61
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Article ; Online: Red blood cell distribution width as a biomarker of chronic heart failure severity in elderly patients

O. V. Gaisenok / M. V. Leonova

Медицинский совет, Vol 0, Iss 14, Pp 134-

2021 Volume 140

Abstract: Introduction. Chronic heart failure (CHF) is recognized as one of the most severe cardiovascular diseases with a high mortality rate. Early identification of patients at risk of poor outcomes is critical to optimize treatment.Aim: to conduct comparative ... ...

Abstract	Introduction. Chronic heart failure (CHF) is recognized as one of the most severe cardiovascular diseases with a high mortality rate. Early identification of patients at risk of poor outcomes is critical to optimize treatment.Aim: to conduct comparative analysis of laboratory markers, including the erythrocyte heterogeneity index (RDW) in CHF patients of different functional classes (f.cl.) according to ICD-10 codes.Materials and methods. A retrospective cross-sectional study with an analysis of the electronic laboratory register (JanuaryDecember 2016). 8056 patients who underwent a clinical blood test and added CRP parameters were included. The determination of the patient’s belonging to CHF wascarried out according to the ICD-10 code indicated in the direction for analysis. Identification of CHF patients by f.cl. (NYHA) was carried out according to the ICD-10 codes: code I25.2 (Postponed myocardial infarction) – 1 f. cl.; code I11.0 (Hypertensive disease with predominant heart damage with heart failure) – 2–3 f.cl .; code I50.0 (Congestive heart failure) – 4 f.cl.Results. The proportion of patients with diseases of the circulatory system (code I) was 33.4% (n = 2686), of which 403 CHF patients were selected for the study. Distribution by f.cl. according to the code MKB-10: 1 ph.cl. – 0.83% (n = 67); 2–3 f.c. – 3.84% (n = 309); 4 ph.cl. – 0.33% (n = 27). Significant intergroup differences were obtained between ph.cl. (according to Kruskal–Wallis) for indicators: hemoglobin (H = 9.741111, p = 0.0077), erythrocytes (H = 7.176770, p = 0.0276), RDW indicator (H = 34.78287, p = 0.0000). There were no statistically significant differences in leukocytes, platelets, ESR, CRP.Conclusions. The presence of anemia in groups of patients with CHF of different f.cl., which often accompanies the disease, has not been confirmed. But statistically significant differences were revealed depending on the severity of f.cl. CHF according to the level of hemoglobin, the number of erythrocytes, and highly significant - according to the RDW indicator. The latter allows us to discuss the role of the RDW index as a possible new laboratory biomarker of CHF severity available for routine clinical practice.
Keywords	chronic heart failure ; nyha functional class ; laboratory markers ; red blood cell distribution width ; icd-10 classification ; Medicine ; R
Subject code	610
Language	Russian
Publishing date	2021-10-01T00:00:00Z
Publisher	Remedium Group LLC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Predictive significance of integral indices in the diagnosis of ischemic heart disease. Dependence on the possibility to perform exercise stress test].

Gaĭsenok, O V / Martsevich, S Iu

Kardiologiia

2013 Volume 53, Issue 8, Page(s) 24–27

Abstract: Integral indices are used for optimization of verification of coronary heart disease (CHD). When due to some reason it is not possible to carry out stress tests their pretest analogues gain special importance. The latter proposition has been confirmed in ...

Abstract	Integral indices are used for optimization of verification of coronary heart disease (CHD). When due to some reason it is not possible to carry out stress tests their pretest analogues gain special importance. The latter proposition has been confirmed in this study.
MeSH term(s)	Aged ; Cohort Studies ; Coronary Angiography ; Coronary Vessels/pathology ; Data Interpretation, Statistical ; Electrocardiography/methods ; Electrocardiography/standards ; Exercise Test/methods ; Exercise Test/standards ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/diagnosis ; Predictive Value of Tests ; Reproducibility of Results ; Russia ; Severity of Illness Index
Language	Russian
Publishing date	2013
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
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Article ; Online: THE ROLE OF MODERN ANTIPLATELET THERAPY IN PREVENTION OF ATHEROTHROMBOSIS

O. V. Gaisenok

Rational Pharmacotherapy in Cardiology, Vol 7, Iss 1, Pp 89-

THE IMPORTANCE OF CLOPIDOGREL AND ITS GENERIC DRUGS

2016 Volume 93

Abstract: Current issues of atherothrombosis prevention and treatment optimization with antiplatelet therapy in patients with cardioascular diseases are discussed. Role of clopidogrel in contemporary antiplatelet therapy is focused on, especially in the aspect of ... ...

Abstract	Current issues of atherothrombosis prevention and treatment optimization with antiplatelet therapy in patients with cardioascular diseases are discussed. Role of clopidogrel in contemporary antiplatelet therapy is focused on, especially in the aspect of the problem of aspirin resistance. Chronology of the clopidogrel generics appearance and prospects of their use is presented.
Keywords	atherothrombosis ; antiplatelet therapy ; clopidogrel ; generics ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Russian
Publishing date	2016-01-01T00:00:00Z
Publisher	Rational Pharmacotherapy in Cardiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: THE ROLE OF MODERN ANTIPLATELET THERAPY IN PREVENTION OF ATHEROTHROMBOSIS

O. V. Gaisenok

Rational Pharmacotherapy in Cardiology, Vol 7, Iss 1, Pp 89-

THE IMPORTANCE OF CLOPIDOGREL AND ITS GENERIC DRUGS

2016 Volume 93

Abstract	Current issues of atherothrombosis prevention and treatment optimization with antiplatelet therapy in patients with cardioascular diseases are discussed. Role of clopidogrel in contemporary antiplatelet therapy is focused on, especially in the aspect of the problem of aspirin resistance. Chronology of the clopidogrel generics appearance and prospects of their use is presented.
Keywords	атеротромбоз ; антитромбоцитарная терапия ; клопидогрел ; дженерические препараты ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Russian
Publishing date	2016-01-01T00:00:00Z
Publisher	Rational Pharmacotherapy in Cardiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SUDDEN CARDIAC DEATH

O. V. Gaisenok

Rational Pharmacotherapy in Cardiology, Vol 7, Iss 2, Pp 204-

ETIOLOGICY IN PATIENTS OF DIFFERENT AGES, RISK FACTORS AND PREVENTION

2016 Volume 211

Abstract: Sudden cardiac death etiologicy in different diseases is analyzed as well as its prevalence in different ages, risk factors and prevention. ...

Abstract	Sudden cardiac death etiologicy in different diseases is analyzed as well as its prevalence in different ages, risk factors and prevention.
Keywords	sudden cardiac death ; ventricular fibrillation ; ischemic heart disease ; cardiomyopathy ; congenital cardiac abnormalities ; risk factors ; prevention ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Russian
Publishing date	2016-01-01T00:00:00Z
Publisher	Rational Pharmacotherapy in Cardiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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