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Article ; Online: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2.

Xu, Min / Hu, Tian-Yong / Li, Dong-Cai / Ma, Li / Zhang, Hua / Fan, Jun-Ting / Fan, Xiao-Mei / Zeng, Xian-Hai / Qiu, Shu-Qi / Liu, Zhi-Qiang / Cheng, Bao-Hui

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 280

Abstract: Background: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat ...

Abstract	Background: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. Methods: In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E Results: Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE Conclusions: YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65).
MeSH term(s)	Ammonia ; Animals ; China ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Female ; Molecular Structure ; NF-kappa B/drug effects ; NF-kappa B/metabolism ; Pharyngitis/drug therapy ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Ammonia (7664-41-7) ; Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-020-03077-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yan-Hou-Qing formula attenuates allergic airway inflammation via up-regulation of Treg and suppressing Th2 responses in Ovalbumin-induced asthmatic mice.

Cheng, Bao-Hui / Hu, Tian-Yong / Mo, Li-Hua / Ma, Li / Hu, Wen-Hui / Li, Yi-Sheng / Liu, Zhi-Qiang / Qiu, Shu-Qi

Journal of ethnopharmacology

2018 Volume 231, Page(s) 275–282

Abstract: Ethnopharmacological relevance: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen ...

Abstract	Ethnopharmacological relevance: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been designed for pharyngitis and cough treatment in Oriental medicine. In the present study, the anti-allergic effects and underlying mechanisms of YHQ in inhibition of airway hyper responsiveness (AHR) was explored in an ovalbumin (OVA)-induced allergic asthma mouse model. Materials and methods: BALB/c mice were sensitized by OVA and cholera toxin (CT) and challenged with OVA intranasally to induce allergic asthma mouse model. YHQ (200 mg/kg) was orally administered for 3 weeks from week-2 after OVA sensitization. The AHR and histological changes of lung tissues were evaluated by whole-body barometric plethysmography analysis and hematoxylin and eosin (H&E) staining, respectively. The serum concentration of OVA-specific IgE and T helper 2 (Th2) cytokines (IL-4 and IL-13) were determined by enzyme-linked immune sorbent assay (ELISA). Flow cytometry was performed to evaluate the percentage of CD4 Results: The elevated AHR responses, heavier inflammatory cell infiltration and Th2 cytokines in allergic asthma group indicated Ovalbumin-induced asthmatic mouse models were built successfully. Compared to allergic asthma group, OVA-induced AHR responses and eosinophil infiltration in lung were improved significantly, and the productions of OVA-specific IgE and Th2 cytokines, IL-4 and IL-13, in the serum were also reduced dramatically after the treatment of YHQ. Moreover, YHQ treatment significantly increased the percentage of CD4 Conclusions: YHQ improves the allergic asthma related symptoms via promotion of CD4
MeSH term(s)	Allergens ; Animals ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Asthma/blood ; Asthma/drug therapy ; Asthma/immunology ; Cholera Toxin ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Immunoglobulin E/blood ; Interleukin-13/blood ; Interleukin-4/blood ; Mice, Inbred BALB C ; Ovalbumin ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Th2 Cells/drug effects ; Th2 Cells/immunology
Chemical Substances	Allergens ; Anti-Asthmatic Agents ; Drugs, Chinese Herbal ; Interleukin-13 ; yan-hou-qing ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0) ; Ovalbumin (9006-59-1) ; Cholera Toxin (9012-63-9)
Language	English
Publishing date	2018-11-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.11.038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2

Min Xu / Tian-Yong Hu / Dong-Cai Li / Li Ma / Hua Zhang / Jun-Ting Fan / Xiao-Mei Fan / Xian-Hai Zeng / Shu-Qi Qiu / Zhi-Qiang Liu / Bao-Hui Cheng

BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-

2020 Volume 13

Abstract: Abstract Background Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore ...

Abstract	Abstract Background Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. Methods In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E2, leukotrienes (LT)-B4 and LT-D4 in pharyngeal tissue were measured via ELISA assay. Evans blue (EB) dye exudation test was performed parallelly to assess the integrity of pharyngeal tissue. Results Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE2 through down-regulation of COX-2. Conclusions YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65).
Keywords	Pharyngitis ; Inflammation ; Yan Hou Qing ; NF-κB ; COX-2 ; Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2

Xu, Min / Hu, Tian-Yong / Li, Dong-Cai / Ma, Li / Zhang, Hua / Fan, Jun-Ting / Fan, Xiao-Mei / Zeng, Xian-Hai / Qiu, Shu-Qi / Liu, Zhi-Qiang / Cheng, Bao-Hui

BMC Complement Med Ther. 2020 Dec., v. 20, no. 1 p.280-280

2020

Abstract: BACKGROUND: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat ...

Abstract	BACKGROUND: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. METHODS: In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E₂, leukotrienes (LT)-B₄ and LT-D₄ in pharyngeal tissue were measured via ELISA assay. Evans blue (EB) dye exudation test was performed parallelly to assess the integrity of pharyngeal tissue. RESULTS: Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE₂ through down-regulation of COX-2. CONCLUSIONS: YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65).
Keywords	Western blotting ; complement ; dexamethasone ; dyes ; exudation ; histopathology ; interleukin-6 ; leukotrienes ; pharyngitis ; pharynx ; phosphorylation ; prostaglandins ; rats
Language	English
Dates of publication	2020-12
Size	p. 280.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2662-7671
DOI	10.1186/s12906-020-03077-1
Database	NAL-Catalogue (AGRICOLA)

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Article: Yan-Hou-Qing formula attenuates allergic airway inflammation via up-regulation of Treg and suppressing Th2 responses in Ovalbumin-induced asthmatic mice

Cheng, Bao-Hui / Tian-Yong Hu / Li-Hua Mo / Li ma / Wen-Hui Hu / Yi-Sheng Li / Zhi-Qiang Liu / Shu-Qi Qiu

Journal of ethnopharmacology. 2019 Mar. 01, v. 231

2019

Abstract: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been ...

Abstract	Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been designed for pharyngitis and cough treatment in Oriental medicine. In the present study, the anti-allergic effects and underlying mechanisms of YHQ in inhibition of airway hyper responsiveness (AHR) was explored in an ovalbumin (OVA)-induced allergic asthma mouse model.BALB/c mice were sensitized by OVA and cholera toxin (CT) and challenged with OVA intranasally to induce allergic asthma mouse model. YHQ (200 mg/kg) was orally administered for 3 weeks from week-2 after OVA sensitization. The AHR and histological changes of lung tissues were evaluated by whole-body barometric plethysmography analysis and hematoxylin and eosin (H&E) staining, respectively. The serum concentration of OVA-specific IgE and T helper 2 (Th2) cytokines (IL-4 and IL-13) were determined by enzyme-linked immune sorbent assay (ELISA). Flow cytometry was performed to evaluate the percentage of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the spleen.The elevated AHR responses, heavier inflammatory cell infiltration and Th2 cytokines in allergic asthma group indicated Ovalbumin-induced asthmatic mouse models were built successfully. Compared to allergic asthma group, OVA-induced AHR responses and eosinophil infiltration in lung were improved significantly, and the productions of OVA-specific IgE and Th2 cytokines, IL-4 and IL-13, in the serum were also reduced dramatically after the treatment of YHQ. Moreover, YHQ treatment significantly increased the percentage of CD4+CD25+Foxp3+ Treg in OVA-induced allergic asthma mouse model.YHQ improves the allergic asthma related symptoms via promotion of CD4+CD25+Foxp3+ Treg and suppression of Th2 responses in mouse model, suggesting YHQ can be used as a potent agent to alleviate allergic asthma related symptoms.
Keywords	CD4-positive T-lymphocytes ; Oriental traditional medicine ; animal models ; anti-allergic agents ; asthma ; blood serum ; cholera toxin ; enzyme-linked immunosorbent assay ; eosin ; flow cytometry ; histology ; immunoglobulin E ; inflammation ; interleukin-13 ; interleukin-4 ; lungs ; mice ; oral administration ; ovalbumin ; sorbents ; staining
Language	English
Dates of publication	2019-0301
Size	p. 275-282.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.11.038
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

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Book: Yi huan guan xi xian zhuang yu fa zhan yan jiu

Bao, Yong

ji yu xin ren ji xiang guan zheng ce de si kao

2014

Author's details	Bao Yong zhu bian
MeSH term(s)	Physician-Patient Relations ; Health Policy
Keywords	China
Language	Chinese
Size	2, 2, 145 pages.
Edition	Di 1 ban.
Document type	Book
ISBN	9787313109019 ; 7313109016
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Yan fang xin bian

Bao, Xiang'ao

1994

Title translation	New compilation of tested remedies.
Author's details	Bao Xiang'ao bian ji ; jiao zhu zhe Li Shihua, Shi Hua, Sun Chengfeng
MeSH term(s)	Therapeutics ; Formularies as Topic ; Medicine, Chinese Traditional
Keywords	China
Language	Chinese
Size	52, 635 p. :, ill.
Edition	Di 1 ban.
Publisher	Zhongguo Zhong yi yao chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	9787800893469 ; 7800893464
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Re : He B, Yan L, Guo H, et al. The difference in superior adjacent segment pathology after lumbar posterolateral fusion by using 2 different pedicle screw insertion techniques in 9-year minimum follow-up. Spine (Phila Pa 1976) 2014;39:1093-8.

Gu, Su-xi / Ma, Yuanzheng / Chen, Xing / Cai, Xiao-jun / Cui, Xu / Bao, Da / Huang, Feng-shan / Luo, Zhan-peng / Li, Da-wei / Luo, Xiao-bo / Li, Li-tao

Spine

2014 Volume 39, Issue 24, Page(s) E1493

MeSH term(s)	Female ; Humans ; Lumbar Vertebrae/surgery ; Male ; Pedicle Screws ; Spinal Fusion/methods ; Spondylolisthesis/surgery
Language	English
Publishing date	2014-11-15
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000000618
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1305: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Book: Yan fang xin bian

Bao, Xiang'ao

(Zhong yi gu ji zheng li cong shu)

1990

Title translation	New compilation of proved recipes.
Author's details	Bao Xiang'ao bian ji
Series title	Zhong yi gu ji zheng li cong shu
MeSH term(s)	Drug Prescriptions ; Drugs, Chinese Herbal
Language	Chinese
Size	2 v.
Edition	Di 1 ban.
Publisher	Ren min wei sheng chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	9787117012607 ; 7117012609 ; 9787117012614 ; 7117012617
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Evaluation on regional suitability of household biogas in the Loess Plateau in North Shaanxi Province―A case study of Yan’an City

Bao Fengxia / Yang Gaihe / Feng Yongzhong

Journal of Northwest Sci-Tech University of Agriculture and Forestry

Nov.2008 , Issue (11)

Keywords	BIOGAS ; RURAL AREAS ; SHANXI ; BIOGAZ ; ZONE RURALE ; SHANXI ; BIOGAS ; ZONAS RURALES ; SHANXI ; http://www.fao.org/aos/agrovoc#c_9262 ; http://www.fao.org/aos/agrovoc#c_6699 ; http://www.fao.org/aos/agrovoc#c_7025
Language	zho
Document type	Article
ISSN	1671-9387
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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