Article: Tunable C-H functionalization and dearomatization enabled by an organic photocatalyst.
2024 Volume 15, Issue 11, Page(s) 4114–4120
Abstract: C-H functionalization and dearomatization constitute fundamental transformations ... we report a photocatalytic strategy to modulate the reaction pathways that can be directed toward either C-H ...
| Abstract | C-H functionalization and dearomatization constitute fundamental transformations of aromatic compounds, which find wide applications in various research areas. However, achieving both transformations from the same substrates with a single catalyst by operating a distinct mechanism remains challenging. Here, we report a photocatalytic strategy to modulate the reaction pathways that can be directed toward either C-H functionalization or dearomatization under redox-neutral or net-reductive conditions, respectively. Two sets of indoles and indolines bearing tertiary alcohols are divergently furnished with good yields and high selectivity. The key to success is the introduction of isoazatruxene ITN-2 as a novel photocatalyst (PC), which outperforms the commonly used PCs. The ready synthesis and high modulability of isoazatruxene type PCs indicate their great application potential. |
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| Language | English |
| Publishing date | 2024-02-06 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2559110-1 |
| ISSN | 2041-6539 ; 2041-6520 |
| ISSN (online) | 2041-6539 |
| ISSN | 2041-6520 |
| DOI | 10.1039/d4sc00120f |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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