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Article ; Online: Berardinelli-Seip Congenital Lipodystrophy - A Case Report and Review of Literature.

Munir, Atif / Haider, Miqdad / Chachar, Aijaz Zeeshan Khan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2022 Volume 32, Issue 6, Page(s) 817–819

Abstract: Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an ... ...

Abstract	Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Most of the cases reported are from Africa and North America. Only a handful of cases have been reported in the world. The aim of this case report is to highlight the significance of this rare metabolic disorder, which should be considered whilst managing young patients with severe insulin resistance. We present a case of a young Asian child with an increasing need for insulin for his diabetes. He was previously managed on the lines of type 1 diabetes mellitus and his insulin requirements kept on increasing. Diagnosis on the basis of genetic studies was not possible due to the non-availability of the test in Pakistan. BSCL is an infrequent condition leading to several cardiometabolic complications. Timely diagnosis can lead to better management and prevention of complications. Keywords: Insulin resistance, Lipodystrophy, Acanthosis nigricans, Hypertriglyceridemia, Genetic disease.
MeSH term(s)	Acanthosis Nigricans ; Child ; Humans ; Insulin/therapeutic use ; Insulin Resistance ; Lipodystrophy, Congenital Generalized/complications ; Lipodystrophy, Congenital Generalized/diagnosis ; Lipodystrophy, Congenital Generalized/genetics ; Male ; Rare Diseases
Chemical Substances	Insulin
Language	English
Publishing date	2022-01-04
Publishing country	Pakistan
Document type	Case Reports ; Review
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2022.06.817
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Article ; Online: Thyrotoxic Periodic Paralysis.

Haider, Miqdad / Khan Chachar, Aijaz Zeeshan / Munir, Atif

Journal of Ayub Medical College, Abbottabad : JAMC

2020 Volume 31, Issue 4, Page(s) 619–621

Abstract: Thyrotoxic periodic paralysis is an uncommon disorder characterized by hypokalaemia, thyrotoxicosis and paralysis, most commonly seen in South Asian males. Aim of our case series is to highlight the significance of this reversible cause of patients ... ...

Abstract	Thyrotoxic periodic paralysis is an uncommon disorder characterized by hypokalaemia, thyrotoxicosis and paralysis, most commonly seen in South Asian males. Aim of our case series is to highlight the significance of this reversible cause of patients presenting with neuromuscular paralysis. We present case series of 1 Asian and three Caucasian patients with thyrotoxic periodic paralysis who came with neuromuscular weakness secondary to thyrotoxicosis. All made a swift and uneventful recovery with no recurrence. Thyrotoxic periodic paralysis (TPP) is an infrequent condition having recurrent episodes of muscle weakness as main feature. Hypokalaemia is a common finding seen in these patients. Resolution of the attacks is achieved with correction of hypokalaemia and hyperthyroidism.
MeSH term(s)	Adult ; Aged, 80 and over ; Female ; Humans ; Hyperthyroidism/complications ; Hypokalemia/complications ; Male ; Muscle Weakness/etiology ; Paralysis/etiology ; Thyrotoxicosis/etiology ; Young Adult
Language	English
Publishing date	2020-01-13
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
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Book ; Online: Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients

Aijaz Zeeshan Khan Chachar, Khurshid Ahmad Khan, Mohsin Asif, Khushbakht Tanveer, Arous Khaqan, Rabia Basri

International Journal of Sciences

2020

Abstract: Background:The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Objectives: To assess ... ...

Abstract	Background:The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Objectives: To assess the efficacy of Ivermectin in mild cases of COVID-19 patients on the basis of predefined assessment criteria. Study Settings: Fatima Memorial Hospital, Lahore Study Design: Open label randomized control trial. Duration of Study: From 1st May, 2020 to 30th June, 2020.Patients & Methods: Sample size and technique: Sample size was 50 patients; 25 patients were kept in control group and 25 patients were kept in experimental group. Results: There were total 50 patients, divided into two groups case and control group.The mean age of the participants was 40.60 ± 17 and out of those 31 (62%) were male and 19 (38%) were females. Cough was observed more in case group (p= 0.049). Fever, myalgias and dyspnea were the commonest symptoms in both the groups (p= 1.000). Diarrhea and vomiting were more common in control group (p=0.0001, p= 0.042 respectively). On follow up at day 7, patients were stratified as asymptomatic and symptomatic. Amongst the case group, out of 25 patients, 16(64%) patients were asymptomatic and rest of the 9(36%) patients was asymptomatic. In control group, out of 25 patients, 15(60%) patients were asymptomatic and rest of the 10(40%) patients was asymptomatic. p-value (0.500). Statistically there was no significant difference between case group who were given ivermectin along with symptomatic treatment and control group who were only given symptomatic treatment without ivermectin, being asymptomatic on day 7 at follow up. p-value (0.500)
Keywords	Corona Virus ; Covid-19 ; SARS-COv-2 ; Antiviral ; Ivermectin ; Pandemic ; covid19
Language	English
Publisher	Alkhaer Publications
Publishing country	uk
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Clinical and Demographic Characteristics Including Comorbidities and Their Outcomes Among Patients Hospitalized With COVID-19 in Four Tertiary Care Hospitals Across Lahore.

Khan Chachar, Aijaz Zeeshan / Khan, Khurshid / Khan, Asma A / Muhammad Imran Hasan, Khan / Ashraf Zia, Muhammad / Siddique, Nasir / Bin Younis, Bilal / Khan, Zohaib Ahmad

Cureus

2021 Volume 13, Issue 1, Page(s) e12663

Abstract: Background The first case of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China, in 2019. By the first half of 2020, coronavirus disease 2019 (COVID-19) turned into a global pandemic. Objectives The ... ...

Abstract	Background The first case of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China, in 2019. By the first half of 2020, coronavirus disease 2019 (COVID-19) turned into a global pandemic. Objectives The aim of this study is to describe the clinical and demographic characteristics including comorbidities and their outcomes among patients hospitalized with COVID-19 in four tertiary care hospitals across Lahore
Language	English
Publishing date	2021-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12663
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Article: Clinical Characteristics, Comorbidities, and Outcome of Critically Sick Patients With COVID-19 Pneumonia Admitted in the Intensive Care Unit of a Tertiary Care Hospital in Lahore, Pakistan: A Retrospective Cohort Study.

Khan Chachar, Aijaz Zeeshan / Asif, Mohsin / Tanveer, Khushbakht / Rauf, Muhammad K / Iqbal, Javeid / Khan, Kinza / Khan, Zohaib / Bin Younis, Bilal / Khan, Khurshid

Cureus

2022 Volume 14, Issue 5, Page(s) e25286

Abstract: Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a multisystem disease that primarily involves the respiratory tract. The first case of COVID-19 was identified in late 2019 in the ... ...

Abstract	Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a multisystem disease that primarily involves the respiratory tract. The first case of COVID-19 was identified in late 2019 in the province of Wuhan, China, which was followed by the rapid spread of the disease globally, becoming a present-day pandemic. Objectives The aim of this study is to describe the clinical characteristics, comorbidities, and outcomes of critically sick patients with COVID-19 pneumonia admitted to the intensive care unit (ICU) of Fatima Memorial Hospital, Lahore, from March 2021 to August 2021. A total of 133 patients were chosen for this retrospective cohort study. Results There was a total of 133 patients, out of which 65 (48.9%) were male and 68 (51.1%) were female. Of these 133 patients, 70 (52.6%) were discharged home after recovery and 63 (47.4%) died; 96 (72.2%) patients had diabetes mellitus and of these, 53 (55.2%) patients died and 43 (44.8%) were discharged, 94 (70.7%) patients had hypertension, out of which 53 (56.4%) died and 41 (43.6%) were discharged home, 40 (30.1%) patients had ischemic heart disease (IHD), out of which 28 (70%) died and 12 (30%) were discharged. A total of 48 (36.1%) patients needed invasive positive pressure ventilation (IPPV) and 78 (58.6%) patients required noninvasive positive pressure ventilation (NIPPV). Conclusion Patients with one or more underlying co-morbidities had poor clinical outcomes compared to those with no co-morbidities, with the most vulnerable group being patients with Ischemic heart disease, chronic kidney disease, hypertension, and diabetes mellitus in descending order.
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: "Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience", a retrospective study-original article.

Chachar, Aijaz Zeeshan Khan / Khan, Khurshid Ahmed / Iqbal, Javeid / Shahid, Adnan Hussain / Asif, Mohsin / Fatima, Syeda Arzinda / Khan, Asma Afzal / Younis, Bilal Bin

Annals of medicine and surgery (2012)

2021 Volume 63, Page(s) 102165

Abstract: Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to ... ...

Abstract	Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to find that treatment of patients with COVID-19 pneumonia with Tocilizumab or steroids was associated with better outcomes. Study design: Quasi-experimental. Duration of study: From May 12, 2020 to June 12, 2020. Patients & methods sample size and technique: Sample size was 93; 33 patients were kept in the experimental group, given Tocilizumab, 8 mg/kg intravenously or 162 mg subcutaneously, and the rest of the 60 patients were given corticosteroids, methylprednisolone 80 mg/day. Consecutive sampling. Failure of therapy was labeled when patients were intubated or died, and the endpoints were failure-free survival which was the primary endpoint, and overall survival secondary at the time of discharge. Results: A total of 93 patients were enrolled, the Tocilizumab (TCZ) group (case) and Corticosteroid (CS) group (Control). The median age was 58 years (IQR-21), 37 (39.8%) patients with diabetes mellitus, 11 (11.8%) in the TCZ group, and 26 (28%) in the CS group. On the whole, the total median hospital stay in days was 7 with IQR (4), a total of 83 (89.2%) patients recovered successfully and discharged, 27 (29%) in the TCZ group and 56 (60.2%) in the CS group. Total 10 (10.8%) patients died, out of which 6 (6.5%) belonged to the TCZ group and 4 (4.3%) belonged to the CS group The median Oxygen requirement with IQR was 8 (9) in both the groups and in total as well, p-value (0.714). Conclusions: Tocilizumab is a quite effective treatment option for critically sick patients of Covid-19 by reducing their oxygen requirement drastically and so the ICU stay, median hospital stay and so the mortality as well. Clinicals trials registration: UIN # NCT04730323.
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.02.011
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Article: A Comparison of Disease Severity and Outcomes in COVID-19 Cases Taking Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Versus Other Antihypertensive Drugs.

Abdullah, Muhammad / Khan, Khurshid / Javed, Munaza / Iqbal, Javeid / Waheed, Khalid / Akhtar, Muhammad Naeem / Khan Chachar, Aijaz Zeeshan

Cureus

2021 Volume 13, Issue 1, Page(s) e12757

Abstract: Objective In this study, we aimed to compare the severity and outcomes in hypertensive patients presenting with coronavirus disease 2019 (COVID-19) who were taking angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) and ... ...

Abstract	Objective In this study, we aimed to compare the severity and outcomes in hypertensive patients presenting with coronavirus disease 2019 (COVID-19) who were taking angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) and those who were on other antihypertensive drugs. Methods This retrospective cohort study involved 182 hypertensive patients who presented with COVID-19 infection. The study population comprised 91 patients who were taking ACEIs/ARBs (group A) and 91 patients who were taking other antihypertensive drugs such as β-blockers (BBs), calcium channel blockers (CCBs), or thiazides (group B). All patients were provided the same type of treatment for the management of COVID-19. We recorded the data related to demographic and anthropometric variables as well as clinical symptoms during the treatment period. Disease severity and hospital mortality were the primary study endpoints. Results There was no significant difference in COVID-19-related outcomes between the groups except for the severity of lung infiltration on chest X-rays. There were 37 (41.1%) patients having >50% lung infiltration in group A and 53 (58.2%) in group B (p-value: 0.02). Severe disease was diagnosed in 37 (40.7%) patients in group A compared to 39 (42.7%) patients in group B (p-value: 0.76). In-hospital mortality was noted in 17 (18.7%) patients in group A and 22 (24.2%) patients in group B (p-value: 0.36). Conclusion Based on our results, we did not find any significant association between the use of ACEIs/ARBs and either the severity of COVID-19 infection necessitating admission to ICU or in-hospital mortality.
Language	English
Publishing date	2021-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12757
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Article ; Online: FREQUENCY OF VITAMIN D DEFICIENCY AMONG PATIENTS ATTENDING IN OUTPATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL IN LAHORE

Muhammad Nabeel Shafqat / Miqdad Haider / Aijaz Zeeshan Khan Chachar

Pakistan Armed Forces Medical Journal, Vol 69, Iss 3, Pp 681-

2019 Volume 684

Abstract: Objective: To determine the prevalence of Vitamin D deficiency among individuals attending in Fatima Memorial nHospital Lahore. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted at Medicine outpatient department ... ...

Abstract	Objective: To determine the prevalence of Vitamin D deficiency among individuals attending in Fatima Memorial nHospital Lahore. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted at Medicine outpatient department of Fatima Memorial Hospital Lahore, from May 2017 to Aug 2017. Material and Methods: A total of 460 individual participated in the study. All patients who attended the Medical Outpatient Department (OPD), above 20 years of age, well oriented and voluntarily agreeing to participate in the study were included. Patients who had any risk factor which could alter vitamin D levels were excluded from the study. Informed consent was taken before enrollment. All data were analyzed by using SPSS version 23.0 Results: A total of 460 people were included in the study out of which 101 (21.9%) were males and 359 (78.04%) were females. The mean age was 42.7 years with a range of 20 to 80 years of age. Median (range) of vitamin D in males was 23 (7.0-99) ng/ml while in females was 16 (1.3-107) ng/ml. Prevalence of vitamin D deficiency according to its severity was: mild deficiency: 22.6%, moderate deficiency: 24.8% and severe deficiency: 25.3%. Conclusion: Vitamin D deficiency is more prevalent among young age group and in women among all groups. Vitamin D deficiency is a common problem in our society. Proper and timely diagnosis and treatment can help in prevention of several diseases and can lead to better bone health.
Keywords	bone health ; vitamin d ; vitamin d deficiency ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Army Medical College Rawalpindi
Document type	Article ; Online
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Article: Pulmonary renal syndrome in a patient with vasculitis: Case report and review of literature.

Chachar, Aijaz Zeeshan Khan / Sabir, Omer / Haider, Irfan / Tanvir, Imrana / Rafique, Kashif / Tarif, Nauman

Pakistan journal of medical sciences

2016 Volume 31, Issue 6, Page(s) 1545–1548

Abstract: Granulomatosis with polyangiitis (GPA) previously known as Wegner's granulomatosis, is a small vessel vasculitis that preferentially involves capillaries, arterioles and venules, presenting as multisystemic disease classically with alveolar haemorrhage ... ...

Abstract	Granulomatosis with polyangiitis (GPA) previously known as Wegner's granulomatosis, is a small vessel vasculitis that preferentially involves capillaries, arterioles and venules, presenting as multisystemic disease classically with alveolar haemorrhage and renal insufficiency. We report a case of GPA diagnosed on history, clinical findings and supported by imaging and very high levels of C-ANCA. Renal biopsy confirmed the typical histopathological findings. We discuss herein the management of the case and review of literature.
Language	English
Publishing date	2016-02-11
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.316.8391
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