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Article ; Online: Pulmonary epithelioid hemangioendothelioma: A case of computed-tomography diagnostic analysis and follow-up.

Chen, Fu-Xing / Li, Jun-Qiang / Xie, Ping-Kun

2022 Volume 46, Issue 6, Page(s) 2329–2331

MeSH term(s)	Humans ; Female ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Hemangioendothelioma, Epithelioid/diagnostic imaging ; Hemangioendothelioma, Epithelioid/surgery ; Follow-Up Studies ; Tomography, X-Ray Computed ; Bone Neoplasms ; Breast Neoplasms
Language	English
Publishing date	2022-12-12
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.006
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Zs.B 2831: Show issues

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Article ; Online: Radiation-induced non-targeted effect of immunity provoked by mitochondrial DNA damage triggered cGAS/ AIM2 pathways

Wen Zhang / Shi Chen / Hua Guan / Ping-Kun Zhou

Radiation Medicine and Protection, Vol 3, Iss 2, Pp 47-

2022 Volume 55

Abstract: Non-targeted effect is an important complement to the classical target theory of radiation biology which takes nuclear genomic DNA as the core target. The principle of radiation target theory is to assume that an organism or cell has one or more ... ...

Abstract	Non-targeted effect is an important complement to the classical target theory of radiation biology which takes nuclear genomic DNA as the core target. The principle of radiation target theory is to assume that an organism or cell has one or more sensitive points or targets, hit and inactivation of which directly by radiation leads to considerable damage and the death event. Recent findings indicate that not only cell nucleus but also other cellular parts can be considered as possible targets. Mitochondrion is considered as a critical organelle where the non-targeted effect is initiated. A series of recent studies have provided substantial evidence and solid data which profoundly facilitate the understanding of radiation-induced non-targeted effects emitted from mitochondrion in the irradiated cells, such the major apparent performances, signaling pathways and biological significance. Mitochondrial genome is more sensitive to genotoxic than nuclear genome. Ionizing radiation can induce mtDNAs double-strand breaks directly or indirectly via increased mitochondrial ROS. Under stress conditions, mitochondrial DNA (mtDNA) fragments are released into the cytoplasm. The cytosol mtDNAs are sensed by cGAS and AIM2 proteins and they activate the corresponding signaling pathways, generating relevant inflammatory and immune responses. These newly developed mitochondrial DNA-initiating pathways may boost the development of targeted therapies for preventing normal tissue toxicity as well as radio-immunotherapy, an emerging trend for cancer therapies. Here we focus and discuss the mechanisms and biological significance of mtDNA-triggering cGAS/AIM2 signaling pathways of immune response from the aspect of non-targeted effect of radiation.
Keywords	Non-targeted effect ; Mitochondrial DNA ; cGAS ; Ionizing radiation ; Immune response ; Radiotherapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	570
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Medication Overuse and Medication Overuse Headache: Risk Factors, Comorbidities, Associated Burdens and Nonpharmacologic and Pharmacologic Treatment Approaches.

Chen, Ping-Kun / Wang, Shuu-Jiun

Current pain and headache reports

2019 Volume 23, Issue 8, Page(s) 60

Abstract: Purpose of review: With a worldwide high disease burden, medication overuse headache (MOH) is an endemic and disabling neurological disorder. Because of the limitations of previous study designs, there are still debates and questions regarding the ... ...

Abstract	Purpose of review: With a worldwide high disease burden, medication overuse headache (MOH) is an endemic and disabling neurological disorder. Because of the limitations of previous study designs, there are still debates and questions regarding the disease's nature and treatment strategy. This review will discuss the following concepts; (1) recent progress in association between medication overuse (MO) and MOH; (2) the burden, risk factors and comorbidities of MOH; (3) evidence of treatment in patients with MOH. Recent findings: The causal relationship between MO and MOH has not been identified. Currently, the treatment policy is still mainly based on small clinical observations, some with highly specified patients. In addition to withdrawal and preventive treatment, some studies have provided evidence for nonpharmacological treatments. Well-designed studies for specific treatment strategies with enough statistical power are warranted to make more relevant, better clinical decisions.
MeSH term(s)	Comorbidity ; Cost of Illness ; Headache Disorders, Secondary/epidemiology ; Humans ; Prescription Drug Overuse/adverse effects ; Risk Factors
Language	English
Publishing date	2019-07-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055062-5
ISSN	1534-3081 ; 1531-3433
ISSN (online)	1534-3081
ISSN	1531-3433
DOI	10.1007/s11916-019-0796-7
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Zs.A 5477: Show issues

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Article ; Online: Wogonin induces apoptosis in macrophages by exhibiting cytotoxic and genotoxic effects.

Tsai, Ping-Kun / Chiang, Chen-Yu / Wang, Tzu-Ching / Yeh, Kun-Lin / Chen, Wen-Ying / Chen, Chun-Jung / Tseng, Ching-Chi / Deng, Lie-Hua / Tzen, Jason Tze Cheng / Lu, Yin-Che / Kuan, Yu-Hsiang

Environmental toxicology

2024 Volume 39, Issue 5, Page(s) 2927–2936

Abstract: Macrophages play an important role in defending the body against invading pathogens. In the face of pathogens, macrophages become activated and release toxic materials that disrupt the pathogens. Macrophage overactivation can lead to severe illness and ... ...

Abstract	Macrophages play an important role in defending the body against invading pathogens. In the face of pathogens, macrophages become activated and release toxic materials that disrupt the pathogens. Macrophage overactivation can lead to severe illness and inflammation. Wogonin has several therapeutic effects, including anti-inflammatory, anticancer, antioxidant, and neuroprotective effects. No studies have investigated the cytotoxic effects of wogonin at concentrations of more than 0.1 mM in RAW264.7 cells. In this study, RAW 264.7 cells were treated with wogonin, which, at concentrations of more than 0.1 mM, had cytotoxic and genotoxic effects in the RAW264.7 cells, leading to apoptosis and necrosis. Further, wogonin at concentrations of more than 0.1 mM induced caspase-3, caspase-8, and caspase-9 activation and mitochondrial dysfunction and death receptor expression. These results suggest that wogonin induces apoptosis through upstream intrinsic and extrinsic pathways by exhibiting cytotoxic and genotoxic effects.
MeSH term(s)	Apoptosis ; Flavanones/pharmacology ; Macrophages ; DNA Damage
Chemical Substances	wogonin (POK93PO28W) ; Flavanones
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24150
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Zs.A 2676: Show issues

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Article: Non-headache symptoms in migraine patients.

Chen, Ping-Kun / Wang, Shuu-Jiun

F1000Research

2018 Volume 7, Page(s) 188

Abstract: Migraine is one of the most common neurological disorders. In addition to severe headaches, non-headache symptoms associated with migraine attacks as well as co-morbid disorders frequently aggravate the disabling of migraine patients. Some of these ... ...

Abstract	Migraine is one of the most common neurological disorders. In addition to severe headaches, non-headache symptoms associated with migraine attacks as well as co-morbid disorders frequently aggravate the disabling of migraine patients. Some of these symptoms are related to poor outcomes. In this review, we update the advances of studies on certain non-headache symptoms, including visual disturbance, gastrointestinal symptoms, allodynia, vestibular symptoms, and symptoms of co-morbid restless legs syndrome and psychiatric disorders.
Language	English
Publishing date	2018
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699932-8
ISSN	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.12447.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.

Lin, Chieh-Hsin / Chen, Ping-Kun / Wang, Shi-Heng / Lane, Hsien-Yuan

JAMA network open

2021 Volume 4, Issue 4, Page(s) e216156

Abstract: Importance: Female gender is a major risk factor for dementia; however, gender has not yet been adequately addressed by clinical trials. A recent study demonstrated that sodium benzoate, a D-amino acid oxidase inhibitor, improved cognitive function in ... ...

Abstract	Importance: Female gender is a major risk factor for dementia; however, gender has not yet been adequately addressed by clinical trials. A recent study demonstrated that sodium benzoate, a D-amino acid oxidase inhibitor, improved cognitive function in early-phase Alzheimer disease. Objective: To examine the potential gender difference in the effects of benzoate treatment on the behavioral and psychological symptoms of dementia (BPSD). Design, setting, and participants: This post hoc secondary analysis used data from a randomized, double-masked, placebo-controlled trial conducted in 3 major medical centers in Taiwan and enrolled 97 patients with BPSD. Data were analyzed between February 2014 and November 2017. Interventions: Six weeks of treatment of 250 to 1500 mg/d of sodium benzoate or placebo. Main outcomes and measures: The primary outcome measures were Alzheimer disease assessment scale-cognitive subscale (ADAS-cog) and Behavioral Pathology in Alzheimer Disease Rating Scale (BEHAVE-AD) scores. Results: Among 97 total participants (62 [64%] women; mean [SD] age, 75.4 [7.7] years), 49 patients (30 women and 19 men) were randomized to sodium benzoate, and 48 (32 women and 16 men) were randomized to placebo. Among 62 women, 6-week benzoate treatment significantly surpassed placebo in the effects on ADAS-cog performance (mean [SD] difference in score between baseline and end point, -3.1 [6.4] points vs 0 [4.5] points; Cohen d = 0.56; P = .04) but not BEHAVE-AD performance. In contrast, among 35 men, the 2 treatment groups did not differ significantly in both ADAS-cog and BEHAVE-AD scores. Compared with placebo, benzoate treatment also increased estradiol to follicle-stimulating hormone ratios among women (mean [SD] difference between baseline and end point, 0 [0.2] vs -0.1 [0.3]; P = .03). Conclusions and relevance: These findings suggest that benzoate treatment may improve cognitive function in women with later-phase dementia. In the future, longer dose-finding trials are warranted to further clarify the efficacy of benzoate for later-phase dementia and investigate the role of sex hormones and other factors in the pathogenesis of dementia. Trial registration: ClinicalTrials.gov Identifier: NCT02103673.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/drug therapy ; Cognition/drug effects ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Male ; Sex Factors ; Sodium Benzoate/administration & dosage
Chemical Substances	Sodium Benzoate (OJ245FE5EU)
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2021.6156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity.

Chen, Shi / Xie, Da-Fei / Li, Saiyu / Luo, Jinhua / Han, Yang / Guo, Hejiang / Gao, Shuaining / Huang, Xin / Guan, Hua / Huang, Ruixue / Zhou, Ping-Kun

Cell death & disease

2024 Volume 15, Issue 3, Page(s) 209

Abstract: Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How radiation changes the glycolysis status of ... ...

Abstract	Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How radiation changes the glycolysis status of cancer cells is still unclear. Here we revealed the role of TAB182 in regulating glycolysis and lactate production in cellular response to ionizing radiation. Irradiation can significantly stimulate the production of TAB182 protein, and inhibiting TAB182 increases cellular radiosensitivity. Proteomic analysis indicated that TAB182 influences several vital biological processes, including multiple metabolic pathways. Knockdown of TAB182 results in decreased lactate production and increased pyruvate and ATP levels in cancer cells. Moreover, knocking down TAB182 reverses radiation-induced metabolic changes, such as radioresistant-related lactate production. TAB182 is necessary for activating LDHA transcription by affecting transcription factors SP1 and c-MYC; its knockdown attenuates the upregulation of LDHA by radiation, subsequently suppressing lactate production. Targeted suppression of TAB182 significantly enhances the sensitivity of murine xenograft tumors to radiotherapy. These findings advance our understanding of glycolytic metabolism regulation in response to ionizing radiation, which may offer significant implications for developing new strategies to overcome tumor radioresistance.
MeSH term(s)	Humans ; Animals ; Mice ; L-Lactate Dehydrogenase/metabolism ; Lactate Dehydrogenase 5/metabolism ; Proteomics ; Cell Line, Tumor ; Glycolysis ; Lactates ; Radiation Tolerance/genetics
Chemical Substances	L-Lactate Dehydrogenase (EC 1.1.1.27) ; Lactate Dehydrogenase 5 (EC 1.1.1.27.-) ; Lactates
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06588-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exposure to polystyrene nanoplastics induces abnormal activation of innate immunity via the cGAS-STING pathway.

Xuan, Lihui / Wang, Yin / Qu, Can / Yi, Wensen / Yang, Jingjing / Pan, Huiji / Zhang, Jing / Chen, Cuimei / Bai, Chenjun / Zhou, Ping-Kun / Huang, Ruixue

Ecotoxicology and environmental safety

2024 Volume 275, Page(s) 116255

Abstract: Endogenous immune defenses provide an intrinsic barrier against external entity invasion. Microplastics in the environment, especially those at the nanoscale (nanoplastics or NPs), may pose latent health risks through direct exposure. While links between ...

Abstract	Endogenous immune defenses provide an intrinsic barrier against external entity invasion. Microplastics in the environment, especially those at the nanoscale (nanoplastics or NPs), may pose latent health risks through direct exposure. While links between nanoplastics and inflammatory processes have been established, detailed insights into how they may perturb the innate immune mechanisms remain uncharted. Employing murine and macrophage (RAW264.7) cellular models subjected to polystyrene nanoplastics (PS-NPs), our investigative approach encompassed an array of techniques: Cell Counting Kit-8 assays, flow cytometric analysis, acridine orange/ethidium bromide (AO/EB) fluorescence staining, cell transfection, cell cycle scrutiny, genetic manipulation, messenger RNA expression profiling via quantitative real-time PCR, and protein expression evaluation through western blotting. The results showed that PS-NPs caused RAW264.7 cell apoptosis, leading to cell cycle arrest, and activated the cGAS-STING pathway. This resulted in NF-κB signaling activation and increased pro-inflammatory mediator expression. Importantly, PS-NPs-induced activation of NF-κB and its downstream inflammatory cascade were markedly diminished after the silencing of the STING gene. Our findings highlight the critical role of the cGAS-STING pathway in the immunotoxic effects induced by PS-NPs. We outline a new mechanism whereby nanoplastics may trigger dysregulated innate immune and inflammatory responses via the cGAS/STING pathway.
MeSH term(s)	Animals ; Mice ; Microplastics/toxicity ; NF-kappa B ; Plastics ; Polystyrenes/toxicity ; Immunity, Innate ; Nucleotidyltransferases
Chemical Substances	Microplastics ; NF-kappa B ; Plastics ; Polystyrenes ; Nucleotidyltransferases (EC 2.7.7.-)
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116255
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Zs.A 1418: Show issues

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Article ; Online: Non-headache symptoms in migraine patients [version 1; referees

Ping-Kun Chen / Shuu-Jiun Wang

F1000Research, Vol

2 approved]

2018 Volume 7

Abstract	Migraine is one of the most common neurological disorders. In addition to severe headaches, non-headache symptoms associated with migraine attacks as well as co-morbid disorders frequently aggravate the disabling of migraine patients. Some of these symptoms are related to poor outcomes. In this review, we update the advances of studies on certain non-headache symptoms, including visual disturbance, gastrointestinal symptoms, allodynia, vestibular symptoms, and symptoms of co-morbid restless legs syndrome and psychiatric disorders.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to "The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut microbiota" [Free Radic. Biol. Med. 145 (2019) 223-236/ PMID: 31580946; DOI: 10.1016/j.freeradbiomed.2019.09.035].

Li, Ming / Gu, Meng-Meng / Lang, Yue / Shi, Jianming / Chen, Benjamin P C / Guan, Hua / Yu, Lan / Zhou, Ping-Kun / Shang, Zeng-Fu

Free radical biology & medicine

2023 Volume 204, Page(s) 83

Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Published Erratum
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2023.04.016
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Zs.A 2109: Show issues

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