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  1. Article ; Online: A response to the commentary by Jianquan Yang, Wen Guo, Rong Huang, Chunyang Zhou, and Man Lu.

    Zheng, Zhen-Yuan / Xu, Li-Yan

    Cancer letters

    2022  Volume 533, Page(s) 215596

    Language English
    Publishing date 2022-02-15
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.215596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Detection of Cistanches Herba (Rou Cong Rong) Medicinal Products Using Species-Specific Nucleotide Signatures

    Xiao-yue Wang / Rong Xu / Jun Chen / Jing-yuan Song / Steven-G Newmaster / Jian-ping Han / Zheng Zhang / Shi-lin Chen

    Frontiers in Plant Science, Vol

    2018  Volume 9

    Abstract: Cistanches Herba is a medicinal plant that has tonification properties and is commonly used in Asia. Owing to the imbalance between supply and demand, adulterants are frequently added for profit. However, there is no regulatory oversight because quality ... ...

    Abstract Cistanches Herba is a medicinal plant that has tonification properties and is commonly used in Asia. Owing to the imbalance between supply and demand, adulterants are frequently added for profit. However, there is no regulatory oversight because quality control tools are not sufficient for identifying heavily processed products. Thus, a novel molecular tool based on nucleotide signatures and species-specific primers was developed. The ITS2 regions from 251 Cistanches Herba and adulterant samples were sequenced. On the basis of SNP sites, four nucleotide signatures within 30~37 bp and six species-specific primers were developed, and they were validated by artificial experimental mixtures consisting of six different species and different ratios. This method was also applied to detect 66 Cistanches Herba products on the market, including extracts and Chinese patent medicines. The results demonstrated the utility of nucleotide signatures in identifying adulterants in mixtures. The market study revealed 36.4% adulteration: 19.7% involved adulteration with Cynomorium songaricum or Cistanche sinensis, and 16.7% involved substitution with Cy. songaricum, Ci. sinensis, or Boschniakia rossica. The results also revealed that Cy. songaricum was the most common adulterant in the market. Thus, we recommend the use of species-specific nucleotide signatures for regulating adulteration and verifying the quality assurance of medicinal product supply chains, especially for processed products whose DNA is degraded.
    Keywords Cistanches Herba ; Chinese patent medicine ; nucleotide signature ; degraded DNA ; medicine quality control ; Plant culture ; SB1-1110
    Subject code 590
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Thesis: Study of the role and mechanism of PDCD10 in an acquired resistance model of temozolomide in glioblastoma cell lines

    Zhong, Rongde / Zhu, Yuan

    2023  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Rongde Zhong ; 1. Gutachter: Frau Prof. Dr. rer. nat. Y. Zhu, 2. Gutachter: Herr Univ.-Prof. Dr. med. B. Scheffler
    Language English
    Size 62 Blätter, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2023
    HBZ-ID HT030025034
    Database Catalogue ZB MED Medicine, Health

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    2023 E 1050 order for loan Magazin

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  4. Article ; Online: Ropivacaine inhibits the proliferation and metastasis of gastric cancer cells via the SNX10/SRC/STAT3 pathway.

    Deng, Rong-Rong / Yuan, You-Ping

    Chemical biology & drug design

    2023  Volume 103, Issue 1, Page(s) e14405

    Abstract: Gastric cancer currently has no effective treatment due to its high metastasis and heterogeneity. It has been reported that ropivacaine (Rop) can inhibit the growth, migration, and invasion of gastric cancer. However, the therapeutic mechanism of Rop ... ...

    Abstract Gastric cancer currently has no effective treatment due to its high metastasis and heterogeneity. It has been reported that ropivacaine (Rop) can inhibit the growth, migration, and invasion of gastric cancer. However, the therapeutic mechanism of Rop still needs to be further explored to provide insights for its clinical application. This study aimed to explore the effects of Rop on the growth, migration, and invasion of gastric cancer cells and the underlying mechanisms. The expression levels of SNX10 were assessed in gastric cancer tissues and cell line AGS by qRT-PCR. Cell Counting Kit-8 (CCK8) assay, wound-healing assay, and transwell assay were then used to examine the effects of Rop on the AGS cell viability, migration, invasion, and proliferation, respectively. Additionally, colony formation assay was used to measure cell proliferation ability, and flow cytometry was used to detect apoptosis level. Protein levels of SNX10, SRC, and STAT3 were detected by western blot. According to the experimental results, the decreased SNX10 mRNA expression was observed in gastric cancer tissue and cell line AGS. Rop inhibited the proliferation, migration, and invasion of AGS cells, but promoted apoptosis and upregulated SNX10 expression. Moreover, Rop inhibited the expression of MMP-2 and MMP-9, phosphorylation of SRC and STAT3. SNX10 knockdown could reverse Rop-induced anticancer effects. Collectively, Rop showed a potential role in preventing proliferation and metastasis of gastric cancer. The action mechanism of Rop may be related to the upregulation of SNX10 expression and further inhibition of SRC/STAT3 signaling pathway. Our findings provide new insights into the anticancer properties of Rop.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Ropivacaine/pharmacology ; Ropivacaine/therapeutic use ; Cell Movement ; Signal Transduction ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis ; Gene Expression Regulation, Neoplastic ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Sorting Nexins/genetics ; Sorting Nexins/metabolism
    Chemical Substances Ropivacaine (7IO5LYA57N) ; STAT3 protein, human ; STAT3 Transcription Factor ; SNX10 protein, human ; Sorting Nexins
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.14405
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  5. Article: Editorial: Woody oil crops: key trait formation and regulation.

    Cao, Heping / Gong, Wenfang / Rong, Jun / Yuan, Deyi

    Frontiers in plant science

    2023  Volume 14, Page(s) 1328990

    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1328990
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  6. Article ; Online: Decision Support System for Prioritization of Offshore Wind Farm Site by Utilizing Picture Fuzzy Combined Compromise Solution Group Decision Method.

    Rong, Yuan / Yu, Liying

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 7

    Abstract: The selection of offshore wind farm site (OWFS) has important strategic significance for vigorously developing offshore new energy and is deemed as a complicated uncertain multicriteria decision-making (MCDM) process. To further promote offshore wind ... ...

    Abstract The selection of offshore wind farm site (OWFS) has important strategic significance for vigorously developing offshore new energy and is deemed as a complicated uncertain multicriteria decision-making (MCDM) process. To further promote offshore wind power energy planning and provide decision support, this paper proposes a hybrid picture fuzzy (PF) combined compromise solution (CoCoSo) technique for prioritization of OWFSs. To begin with, a fresh PF similarity measure is proffered to estimate the importance of experts. Next, the novel operational rules for PF numbers based upon the generalized Dombi norms are defined, and four novel generalized Dombi operators are propounded. Afterward, the PF preference selection index (PSI) method and PF stepwise weights assessment ratio analysis (SWARA) model are propounded to identify the objective and subjective weight of criteria, separately. In addition, the enhanced CoCoSo method is proffered via the similarity measure and new operators for ranking OWFSs with PF information. Lastly, the applicability and feasibility of the propounded PF-PSI-SWARA-CoCoSo method are adopted to ascertain the optimal OWFS. The comparison and sensibility investigations are also carried out to validate the robustness and superiority of our methodology. Results manifest that the developed methodology can offer powerful decision support for departments and managers to evaluate and choose the satisfying OWFSs.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25071081
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  7. Article ; Online: Identification of novel biomarkers of ferroptosis involved in keloid based on bioinformatics analysis.

    Yuan, Tian / Meijia, Li / Rong, Cheng / Jian, Yuan / Lijun, Hao

    International wound journal

    2024  Volume 21, Issue 1, Page(s) e14606

    Abstract: Keloid is a fibroproliferative disease of unknown aetiology, which has a significant impact the quality of life of patients. Ferroptosis plays an important role in the occurrence and development of fibrosis, but there is still a lack of research related ... ...

    Abstract Keloid is a fibroproliferative disease of unknown aetiology, which has a significant impact the quality of life of patients. Ferroptosis plays an important role in the occurrence and development of fibrosis, but there is still a lack of research related to keloids. The objective of this work was to identify the hub genes related to ferroptosis in keloid to better understand the keloid process. The microarray data (GSE7890 GSE145725, and GSE44270) (23 keloid and 22 normal fibroblast) were analysed via the gene expression comprehensive database (GEO). Only GSE7890 met the FerrDB database. Cell cycle and pathway analysis were performed with gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to differentially expressed genes (DEG). The differential genes were confirmed in other GEO datasets (GSE145725 and GSE44270), and multi-fibrosis-gene correlation analysed. To validate these hub genes, quantitative real-time PCR (qRT-PCR) was conducted. A total of 581 DEGs were screened, with 417 genes down-regulated and 164 genes up-regulated, with 11 ferroptosis genes significantly up-regulated in both keloid and normal tissue, and 6 genes are consistent with our findings and are associated with multiple fibrosis genes. The qRT-PCR results and tissues of normal skin and keloid agreed with our predictions. Our findings provide new evidence for the ferroptosis-related molecular pathways and biomarker of keloid.
    MeSH term(s) Humans ; Ferroptosis/genetics ; Keloid/genetics ; Quality of Life ; Biomarkers ; Computational Biology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6006: Show issues Location:
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  8. Article: [A study on factors associated with age of Alzheimer's disease onset].

    Rong, M / Yuan, M Q / Fang, Y

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2023  Volume 44, Issue 7, Page(s) 1068–1072

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Cognition ; Cognition Disorders ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/genetics
    Chemical Substances Apolipoprotein E4
    Language Chinese
    Publishing date 2023-07-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    DOI 10.3760/cma.j.cn112338-20221007-00861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3276: Show issues Location:
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  9. Article ; Online: Conjugated [5]Cumulene Polymers Enabled by Condensation Polymerization of Propargylic Electrophiles.

    Wang, Zi-Yuan / Zhu, Rong

    Journal of the American Chemical Society

    2023  Volume 145, Issue 43, Page(s) 23755–23763

    Abstract: Cumulenes, ...

    Abstract Cumulenes,
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c08290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trajectories of cognitive decline in different domains prior to AD onset in persons with mild cognitive impairment.

    Yuan, Manqiong / Rong, Meng / Long, Xianxian / Lian, Shuli / Fang, Ya

    Archives of gerontology and geriatrics

    2024  Volume 122, Page(s) 105375

    Abstract: Objectives: To explore the trajectories and the change-points of global and five domain-specific cognitive functions before the onset of Alzheimer's disease (AD).: Methods: Data was retrieved from the Alzheimer's Disease Neuroimaging Initiative with ... ...

    Abstract Objectives: To explore the trajectories and the change-points of global and five domain-specific cognitive functions before the onset of Alzheimer's disease (AD).
    Methods: Data was retrieved from the Alzheimer's Disease Neuroimaging Initiative with follow-up from 2005 to 2022. Participants with mild cognitive impairment (MCI) at baseline and those who progressed to AD during follow-up were included. The time of AD onset was defined as the visit time when participant was first diagnosed as AD during follow-up. Global and five domain-specific cognitive functions (immediate memory, visuospatial ability, language, processing speed and executive function) were assessed by Mini-Mental State Examination, Immediate recalling trials of Rey Auditory Verbal Learning Test, Clock Drawing Test, Animal Fluency Test, Part A and B of Trail Making Test, respectively. Their trajectories and change-points before AD onset were explored by generalized additive mixed models and piecewise linear regression models, respectively.
    Results: 349 participants were diagnosed as MCI at baseline and converted to AD during follow-up, who were included in this study. They had been visited on an average of 4.6 times (SD = 2.1, range = 2.0-13.0), with a total of 1593 visits. Their mean baseline age and AD onset age were 74.4 (SD = 6.4, range = 60.0-88.4) and 77.0 (SD = 6.8, range = 60.5-94.7) years, respectively. Baseline age and educational year were significantly associated with global cognitive, immediate memory, language and executive function. Men presented better global cognitive function (β = 0.54, p < 0.05) but poorer immediate memory (β = -1.72, p < 0.05) than women. Immediate memory and visuospatial ability showed the earliest change-points at 4 years before the onset of AD (Note as T-4years), followed by language (T-3.5years), executive function (T-2.5 years), processing speed (T-2.0 years), and finally the global cognitive function (T-1.5years).
    Conclusions: The trajectories of the six neuropsychological scores were non-linear and showed deterioration in functions over time. Immediate memory and visuospatial ability showed the earliest change-points prior to AD onset.
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2024.105375
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    Zs.A 1729: Show issues Location:
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