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Article ; Online: Electrosynthesis of >20 g/L H

Li, Huihui / Quispe-Cardenas, Estefanny / Yang, Shasha / Yin, Lifeng / Yang, Yang

ACS ES&T engineering

2021 Volume 2, Issue 2, Page(s) 242–250

Abstract: ... concentration H ...

Abstract	Hydrogen peroxide (HP) production via electrochemical oxygen reduction reaction (ORR-HP) is a critical reaction for energy storage and environmental remediation. The onsite production of high-concentration H
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article
ISSN	2690-0645
ISSN (online)	2690-0645
DOI	10.1021/acsestengg.1c00366
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Article ; Online: L-theanine attenuates H

Li, Zhongqing / Huang, Zhiqing / Jia, Gang / Zhao, Hua / Liu, Guangmang / Chen, Xiaoling

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 186, Page(s) 114561

Abstract: This study investigated the protective effects of L-theanine on hydrogen peroxide (H ...

Abstract	This study investigated the protective effects of L-theanine on hydrogen peroxide (H
MeSH term(s)	Humans ; Hydrogen Peroxide/toxicity ; NF-kappa B/metabolism ; MAP Kinase Signaling System ; Intestinal Diseases ; Apoptosis ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; Inflammation ; Epithelial Cells/metabolism ; Glutamates
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; NF-kappa B ; theanine (8021PR16QO) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Glutamates
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114561
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Article ; Online: Theoretical study on L-H

Feng, Wanwan / Li, Dan / Cheng, Longjiu

The Journal of chemical physics

2022 Volume 157, Issue 9, Page(s) 94302

Abstract: ... as the representative of SSHBs, [F-H-F] ...

Abstract	Short strong hydrogen bonds (SSHBs) play a crucial role in many chemical processes. Recently, as the representative of SSHBs, [F-H-F]
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0103228
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Article ; Online: Prediction and validation of cross-protective candidate antigen of Hyalomma asiaticum cathepsin L between H. asiaticum and H. anatolicum.

Song, Ruiqi / Zhai, Xuejie / Fan, Xinli / Li, Yongchang / Huercha / Ge, Ting / Li, Caishan / Li, Min / He, Wenwen / Zheng, Huizhen / Gan, Lu / Zhang, Yang / Chahan, Bayin

Experimental & applied acarology

2022 Volume 86, Issue 2, Page(s) 283–298

Abstract: Hyalomma asiaticum and H. anatolicum are tick species in Eurasia and Africa with major medical and ... veterinary significance. Beside their direct pathogenic effects, H. asiaticum and H. anatolicum are vectors ... as a sustainable alternative approach. Cathepsin L-like cysteine protease (CPL) is a potent hemoglobinase, and ...

Abstract	Hyalomma asiaticum and H. anatolicum are tick species in Eurasia and Africa with major medical and veterinary significance. Beside their direct pathogenic effects, H. asiaticum and H. anatolicum are vectors of important diseases of livestock and in some instances of zoonoses. In search of ways to address the increasing incidence of global acaricide resistance, tick control through vaccination is regarded as a sustainable alternative approach. Cathepsin L-like cysteine protease (CPL) is a potent hemoglobinase, and plays important roles in the digestion of blood acquired from a host. CPL from H. anatolicum (HanCPL) with high similarity (> 90%) for H. asiaticum CPL (HasCPL) were aligned by in silico analysis. After further in vitro validation, the anti-HasCPL sera have cross-reactivity between the different total native protein of life stages and tissues for H. asiaticum and H. anatolicum. Furthermore, we further confirmed that recombinant HasCPL (rHasCPL) immunized rabbits were partially cross-protected (54.8%) by H. anatolicum infestation.
MeSH term(s)	Acaricides ; Animals ; Antigens ; Cathepsin L ; Ixodidae ; Rabbits ; Tick Infestations/veterinary ; Ticks
Chemical Substances	Acaricides ; Antigens ; Cathepsin L (EC 3.4.22.15)
Language	English
Publishing date	2022-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	11320-7
ISSN	1572-9702 ; 0168-8162
ISSN (online)	1572-9702
ISSN	0168-8162
DOI	10.1007/s10493-022-00689-9
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Article ; Online: An M cell-targeting recombinant L. lactis vaccine against four H. pylori adhesins.

Zhang, Furui / Shi, Tianyi / Zhang, Zhen / Wang, Shue / Liu, Jing / Li, Yonghong / Wang, Xuequan / Liu, Kunmei / Guo, Le

Applied microbiology and biotechnology

2024 Volume 108, Issue 1, Page(s) 231

Abstract: ... In the present study, an M cell-targeting L. lactis surface display system (plSAM) was built to favor ... and humoral immune responses against four key H. pylori adhesins (Urease, CagL, HpaA, and Lpp20 ... in the gastrointestinal tract, thus enabling effective prevention of H. pylori infection and to some extent eliminating H ...

Abstract	The acidic environment and enzyme degradation lead to oral vaccines often having little immune effect. Therefore, it is an attractive strategy to study an effective and safe oral vaccine delivery system that can promote gastrointestinal mucosal immune responses and inhibit antigen degradation. Moreover, the antigens uptake by microfold cells (M cells) is the determining step in initiating efficient immune responses. Therefore, M cell-targeting is one promising approach for enhancing oral vaccine potency. In the present study, an M cell-targeting L. lactis surface display system (plSAM) was built to favor the multivalent epitope vaccine antigen (FAdE) to achieve effective gastrointestinal mucosal immunity against Helicobacter pylori. Therefore, a recombinant Lactococcus lactic acid vaccine (LL-plSAM-FAdE) was successfully prepared, and its immunological properties and protective efficacy were analyzed. The results showed that LL-plSAM-FAdE can secretively express the recombinant proteins SAM-FAdE and display the SAM-FAdE on the bacterial cell surface. More importantly, LL-plSAM-FAdE effectively promoted the phagocytosis and transport of vaccine antigen by M cells in the gastrointestinal tract of mice, and simulated high levels of cellular and humoral immune responses against four key H. pylori adhesins (Urease, CagL, HpaA, and Lpp20) in the gastrointestinal tract, thus enabling effective prevention of H. pylori infection and to some extent eliminating H. pylori already present in the gastrointestinal tract. KEY POINTS: • M-cell-targeting L. lactis surface display system LL- plSAM was designed • This system displays H. pylori vaccine-promoted phagocytosis and transport of M cell • A promising vaccine candidate for controlling H. pylori infection was verified.
MeSH term(s)	Animals ; Mice ; Helicobacter pylori/genetics ; M Cells ; Antigens, Bacterial ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Vaccines, Synthetic ; Bacterial Vaccines ; Helicobacter Infections/prevention & control ; Mice, Inbred BALB C ; Antibodies, Bacterial ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism
Chemical Substances	Antigens, Bacterial ; Adhesins, Bacterial ; Vaccines, Synthetic ; Bacterial Vaccines ; Antibodies, Bacterial
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-024-13070-0
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Article: L-Cysteine-Derived H

Zhou, Xin / Chu, Xili / Xin, Danqing / Li, Tingting / Bai, Xuemei / Qiu, Jie / Yuan, Hongtao / Liu, Dexiang / Wang, Dachuan / Wang, Zhen

Frontiers in molecular neuroscience

2019 Volume 12, Page(s) 58

Abstract: We have reported previously that L-cysteine-derived hydrogen sulfide (H ...

Abstract	We have reported previously that L-cysteine-derived hydrogen sulfide (H
Language	English
Publishing date	2019-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2019.00058
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Article ; Online: Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H

Li, Xinle / Hua, Yanan / Yang, Caixia / Liu, Sijing / Tan, Li / Guo, Jinlin / Li, Yang

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 112

Abstract: ... induced by H: Results: The results showed that a total mulberry polysaccharides (TMP) has ... mannose (18.2%). TMP reduced the accumulation of ROS in HepG2 cells after H: Conclusions: This study ... demonstrates that TMP can reduce ROS accumulation in H ...

Abstract	Background: Mori Fructus is an economical and readily available traditional Chinese medicine and food. Polysaccharides in Mori Fructus have clear antioxidant activity and have been found to alleviate oxidative stress (OS)-induced liver damage in experimental studies. The mechanism of regulation of cellular antioxidant activity by mulberry polysaccharides has been suggested to be Nrf2, but it is not clear whether the Nrf2 pathway is mediated by activation of other targets, and the exact process of effects in hepatocytes has yet to be elucidated. Methods: In this study, the basic characterization of total polysaccharides extracted from mulberry fruits (Morus nigra Linn.) was analyzed. A model of oxidative damage induced by H Results: The results showed that a total mulberry polysaccharides (TMP) has a molecular weight of 57.5 kDa with a pyranose ring mainly composed of glucose (48.81%), galactose (22.79%) and mannose (18.2%). TMP reduced the accumulation of ROS in HepG2 cells after H Conclusions: This study demonstrates that TMP can reduce ROS accumulation in H
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Morus ; Hydrogen Peroxide/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Hep G2 Cells ; Reactive Oxygen Species/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Fruit ; NF-E2-Related Factor 2/metabolism ; Chemical and Drug Induced Liver Injury, Chronic ; Superoxide Dismutase/metabolism ; Polysaccharides/pharmacology
Chemical Substances	Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Reactive Oxygen Species ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; NF-E2-Related Factor 2 ; Superoxide Dismutase (EC 1.15.1.1) ; Polysaccharides
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03925-w
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Article ; Online: Enzymatic acylation improves the stability and bioactivity of lutein: Protective effects of acylated lutein derivatives on L-O2 cells upon H

Tan, Xinjia / Li, Haimei / Huang, Wenjing / Ma, Wenwen / Lu, Yuyun / Yan, Rian

Food chemistry

2023 Volume 410, Page(s) 135393

Abstract: The instability of lutein has limited its wide application especially in the food industry. In this study, enzymatic acylation of lutein with divinyl adipate was investigated. Three new acylated lutein derivatives, lutein-3-O-adipate (compound 1), lutein- ...

Abstract	The instability of lutein has limited its wide application especially in the food industry. In this study, enzymatic acylation of lutein with divinyl adipate was investigated. Three new acylated lutein derivatives, lutein-3-O-adipate (compound 1), lutein-3'-O-adipate (compound 2) and lutein-di-adipate (compound 3), were identified and their stabilities and bioactivates were evaluated. Notably, compounds 1-3 showed better thermal, light stability and stronger scavenging capacity to ABTS radical cation (ABTS
MeSH term(s)	Hydrogen Peroxide/toxicity ; Lutein/pharmacology ; Oxidative Stress ; Antioxidants/pharmacology ; Acylation
Chemical Substances	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Hydrogen Peroxide (BBX060AN9V) ; Lutein (X72A60C9MT) ; Antioxidants
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.135393
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Article ; Online: Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on H

Tian, Yaqin / Zhang, Xiuling / Du, Meiling / Li, Fengfeng / Xiao, Manyu / Zhang, Wentao

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 9996040

Abstract: Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized ... antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong ... scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid ...

Abstract	Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and H
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; HEK293 Cells ; Humans ; Hydrogen Peroxide/chemistry ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/pharmacology ; Oleanolic Acid/therapeutic use ; Oxidative Stress/drug effects ; Saponins/pharmacology ; Saponins/therapeutic use
Chemical Substances	Antioxidants ; Drugs, Chinese Herbal ; Saponins ; Oleanolic Acid (6SMK8R7TGJ) ; araloside A (7518-22-1) ; Hydrogen Peroxide (BBX060AN9V) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/9996040
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Article ; Online: Bistrochelides H-L: Biscembranoids from the south China sea soft coral Sarcophyton serenei.

Yan, Xia / Liu, Jing / Huang, Jian / Wang, Yiji / Leng, Xue / Li, Te / Ouyang, Han / Yan, Xiaojun / He, Shan

Phytochemistry

2022 Volume 204, Page(s) 113438

Abstract: Five undescribed biscembranoids, bistrochelides H-L, along with four known biscembranoids ...

Abstract	Five undescribed biscembranoids, bistrochelides H-L, along with four known biscembranoids, glaucumolides A-B and bistrochelides A-B, were isolated from the soft coral Sarcophyton serenei collected off the Xisha Island in the South China Sea. The structures of these compounds were elucidated by HRESIMS (high-resolution electrospray ionization mass spectroscopy) spectrometry, NMR (nuclear magnetic resonance) spectroscopy, X-ray diffraction analysis, electronic circular dichroism (ECD), and the comparison of their spectroscopic data with those reported in the literature. In bioassay, some compounds showed a strong inhibitory effect on osteoclast precursor cells at the concentration of 10 μM. Additionally, all compounds exhibited weakly antimicrobial activity against Vibrio harveyi.
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113438
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