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  1. Article ; Online: [Vaccination immunology in SARS-CoV-2].

    Helweg-Larsen, Jannik / Benfield, Thomas

    Ugeskrift for laeger

    2021  Volume 183, Issue 11

    Abstract: The duration of immunity after SARS-CoV-2 infection or vaccination is uncertain, but major advances have been made in the understanding of SARS-CoV-2 B- and T-cell protection. In this review, key data from studies of re-infection as well as B- and T-cell ...

    Abstract The duration of immunity after SARS-CoV-2 infection or vaccination is uncertain, but major advances have been made in the understanding of SARS-CoV-2 B- and T-cell protection. In this review, key data from studies of re-infection as well as B- and T-cell immunity after infection and vaccination are presented.
    MeSH term(s) B-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Humans ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language Danish
    Publishing date 2021-03-01
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Pneumocystis jiroveci

    Helweg-Larsen, Jannik

    applied molecular biology, epidemiology and diagnosis

    2004  

    Author's details Jannik Helweg-Larsen
    Language English ; Danish
    Size 27 S. : Ill. graph. Darst.
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kopenhagen, Univ., Diss., 2004
    Note Zsfassung in dän. Sprache
    HBZ-ID HT014305042
    ISBN 87-7891-094-3 ; 978-87-7891-094-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 E 123 order for loan Magazin

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  3. Article: Fatal chronic meningitis caused by

    Gheshlaghi, Mariam / Helweg-Larsen, Jannik

    Medical mycology case reports

    2019  Volume 27, Page(s) 22–24

    Abstract: We report a case of fatal ... ...

    Abstract We report a case of fatal chronic
    Language English
    Publishing date 2019-12-17
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2019.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [SARS-CoV-2 vaccines].

    Benfield, Thomas Lars / Helweg-Larsen, Jannik

    Ugeskrift for laeger

    2021  Volume 183, Issue 10

    Abstract: Control of the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will require one or more vaccines. Currently, numerous SARS-CoV-2 vaccines are in either pre-clinical or clinical ... ...

    Abstract Control of the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will require one or more vaccines. Currently, numerous SARS-CoV-2 vaccines are in either pre-clinical or clinical development. Twenty are in fase III development. In this review we summarise available safety and efficacy data of two RNA based vaccines, two non-replication competent vector-based vaccine, one inactivated whole-virus vaccine, and one subunit. All being either approved or nearing approval.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language Danish
    Publishing date 2021-03-01
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  5. Article ; Online: Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation

    Mariam Gheshlaghi / Jannik Helweg-Larsen

    Medical Mycology Case Reports, Vol 27, Iss , Pp 22-

    2020  Volume 24

    Abstract: We report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed. Keywords: Candida dubliniensis meningitis, Chronic meningitis, Liver ... ...

    Abstract We report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed. Keywords: Candida dubliniensis meningitis, Chronic meningitis, Liver transplantation, Invasive candidiasis
    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Group A Streptococcus Meningitis in Adults, Denmark.

    Nielsen, Henrik / Storgaard, Merete / Helweg-Larsen, Jannik / Larsen, Lykke / Jepsen, Micha P G / Hansen, Birgitte R / Wiese, Lothar / Bodilsen, Jacob

    Emerging infectious diseases

    2023  Volume 29, Issue 9, Page(s) 1937–1939

    Abstract: We report a 21-fold increase in group A Streptococcus meningitis in adults in Denmark during October 13, 2022-April 12, 2023, concurrent with an outbreak of invasive streptococcal disease. We describe clinical characteristics of the outbreak cases and ... ...

    Abstract We report a 21-fold increase in group A Streptococcus meningitis in adults in Denmark during October 13, 2022-April 12, 2023, concurrent with an outbreak of invasive streptococcal disease. We describe clinical characteristics of the outbreak cases and prognosis for patients in comparison to those for previous sporadic cases.
    MeSH term(s) Humans ; Adult ; Meningitis, Bacterial/epidemiology ; Streptococcal Infections/epidemiology ; Streptococcus pyogenes ; Disease Outbreaks ; Denmark/epidemiology
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2909.230627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation

    Gheshlaghi, Mariam / Helweg-Larsen, Jannik

    Medical mycology case reports. 2020 Mar., v. 27

    2020  

    Abstract: We report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed. ...

    Abstract We report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed.
    Keywords Candida ; case studies ; hydrocephalus ; liver transplant ; meningitis
    Language English
    Dates of publication 2020-03
    Size p. 22-24.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2019.12.009
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Invasive Aspergillosis among Lung Transplant Recipients during Time Periods with Universal and Targeted Antifungal Prophylaxis-A Nationwide Cohort Study.

    Crone, Cornelia Geisler / Wulff, Signe Marie / Ledergerber, Bruno / Helweg-Larsen, Jannik / Bredahl, Pia / Arendrup, Maiken Cavling / Perch, Michael / Helleberg, Marie

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 11

    Abstract: The optimal prevention strategy for invasive aspergillosis (IA) in lung transplant recipients (LTXr) is unknown. In 2016, the Danish guidelines were changed from universal to targeted IA prophylaxis. Previously, we found higher rates of adverse events in ...

    Abstract The optimal prevention strategy for invasive aspergillosis (IA) in lung transplant recipients (LTXr) is unknown. In 2016, the Danish guidelines were changed from universal to targeted IA prophylaxis. Previously, we found higher rates of adverse events in the universal prophylaxis period. In a Danish nationwide study including LTXr, for 2010-2019, we compared IA rates in time periods with universal vs. targeted prophylaxis and during person-time with vs. person-time without antifungal prophylaxis. IA hazard rates were analyzed in multivariable Cox models with adjustment for time after LTX. Among 295 LTXr, antifungal prophylaxis was initiated in 183/193 and 6/102 during the universal and targeted period, respectively. During the universal period, 62% discontinued prophylaxis prematurely. The median time on prophylaxis was 37 days (IQR 11-84). IA was diagnosed in 27/193 (14%) vs. 15/102 (15%) LTXr in the universal vs. targeted period, with an adjusted hazard ratio (aHR) of 0.94 (95% CI 0.49-1.82). The aHR of IA during person-time with vs. person-time without antifungal prophylaxis was 0.36 (95% CI 0.12-1.02). No difference in IA was found during periods with universal vs. targeted prophylaxis. Prophylaxis was protective of IA when taken. Targeted prophylaxis may be preferred over universal due to comparable IA rates and lower rates of adverse events.
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9111079
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  9. Article ; Online: Associations between invasive aspergillosis and cytomegalovirus in lung transplant recipients: a nationwide cohort study.

    Wulff, Signe Marie / Perch, Michael / Helweg-Larsen, Jannik / Bredahl, Pia / Arendrup, Maiken Cavling / Lundgren, Jens / Helleberg, Marie / Crone, Cornelia Geisler

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2023  Volume 131, Issue 11, Page(s) 574–583

    Abstract: Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one ... ...

    Abstract Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one infection is warranted after detecting the other. All Danish LTXr, 2010-2019, were followed for IA and CMV for 2 years after transplantation. IA was defined using ISHLT criteria. Adjusted incidence rate ratios (aIRR) were estimated by Poisson regression adjusted for time after transplantation. We included 295 LTXr, among whom CMV and IA were diagnosed in 128 (43%) and 48 (16%). The risk of CMV was high the first 3 months after IA, IR 98/100 person-years of follow-up (95% CI 47-206). The risk of IA was significantly increased in the first 3 months after CMV, aIRR 2.91 (95% CI 1.32-6.44). Numbers needed to screen to diagnose one case of CMV after IA, and one case of IA after CMV was approximately seven and eight, respectively. Systematic screening for CMV following diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
    MeSH term(s) Humans ; Cytomegalovirus ; Cohort Studies ; Transplant Recipients ; Risk Factors ; Aspergillosis/epidemiology ; Aspergillosis/etiology ; Lung ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/complications ; Invasive Fungal Infections ; Antiviral Agents ; Retrospective Studies
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-04-24
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Empiric treatment of healthcare-associated central nervous system infections in Denmark: do we need carbapenems?

    Kraef, Christian / Hertz, Frederik Boetius / Riis Olesen, Birthe / Sigurdsson, Sigurdur Thor / Bergdal, Ove Ketil / Gitz Holler, Jon / Mens, Helene / Helweg-Larsen, Jannik / Andersen, Åse Bengaard / Møller, Kirsten / Knudsen, Jenny Dahl

    Infectious diseases (London, England)

    2024  Volume 56, Issue 5, Page(s) 402–409

    Abstract: Background: Carbapenems are widely used for empiric treatment of healthcare-associated central nervous system (CNS) infections. We investigated the feasibility of a carbapenem-sparing strategy, utilising a third-generation cephalosporin (ceftriaxone or ... ...

    Abstract Background: Carbapenems are widely used for empiric treatment of healthcare-associated central nervous system (CNS) infections. We investigated the feasibility of a carbapenem-sparing strategy, utilising a third-generation cephalosporin (ceftriaxone or cefotaxime) (combined with vancomycin) for the empirical treatment of healthcare-associated CNS infections in Eastern Denmark.
    Methods: The departments of neurosurgery and neuro-intensive care at Copenhagen University Hospital Rigshospitalet. First, we analysed local microbiological data (1st January 2020-31st August 2022) to identify microorganisms non-susceptible to third-generation cephalosporin. Subsequently, we assessed all carbapenem prescriptions over a three-month period for their indication and justification.
    Results: In total, 25,247 bacterial cultures were identified, of which 2,563 CNS-related, were included in the analysis. The positivity rate was 10.5% (
    Conclusion: An empiric treatment strategy relying on a third-generation cephalosporin appears suitable for healthcare-associated CNS infections at our tertiary hospital, serving a population of 2.6 million. However, in patients with prolonged hospitalization (≥10 days), immunosuppression, prior broad-spectrum antibiotic use, or history of resistant Gram-negative bacteria, empirical prescription of carbapenem may be needed.
    MeSH term(s) Humans ; Carbapenems/therapeutic use ; Ceftriaxone ; Anti-Bacterial Agents/therapeutic use ; Cross Infection/drug therapy ; Delivery of Health Care ; Central Nervous System ; Central Nervous System Infections/drug therapy ; Denmark
    Chemical Substances Carbapenems ; Ceftriaxone (75J73V1629) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2024.2315478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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