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Article ; Online: Sperm DNA fragmentation index affect pregnancy outcomes and offspring safety in assisted reproductive technology

Fei Li / Xiaoyan Duan / Mingming Li / Xing Ma

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 8

Abstract: Abstract The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of DFI on pregnancy outcomes and the safety of ... ...

Abstract	Abstract The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of DFI on pregnancy outcomes and the safety of offspring in the context of Assisted Reproductive Technology (ART). In this study, we conducted an analysis of clinical data obtained from 6330 patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at the reproductive medical center of The First People's Hospital of Shangqiu and The Affiliated Hospital of Zhengzhou University. The patients was stratified into two distinct groups: IVF group and ICSI group, Within each group, patients were further classified into three subgroups. IVF: group A (< 15%) included 3123 patients, group B (15–30%) included 561 patients, and group C (≥ 30%) included 46 patients. ICSI: group A (< 15%) included 1967 patients, group B (15–30%) included 462 patients, and group C (≥ 30%) included 171 patients. Data were collected and subjected to statistical analysis. There were no significant differences in the basic characteristics among the three groups, and the sperm DFI did not significantly affect the fertilization rates, pregnancy rates, stillbirth rates and the number of birth defects. However, the incidences of miscarriage rates in IVF/ICSI groups with DFI > 30% and DFI 15–30% were significantly higher than those in IVF/ICSI groups with DFI < 15%, and the miscarriage rates in ICSI group with DFI > 30% were significantly higher than DFI 15–30% group, the smooth fitting curve shows that there is a positive correlation between miscarriage rates and sperm DFI (OR 1.095; 95% CI 1.068–1.123; P < 0.001). The birth weight of infants in the IVF/ICSI groups with DFI > 30% and DFI 15–30% exhibited a statistically significant decrease compared to those in the IVF/ICSI groups with DFI < 15%. Furthermore, the birth weight of infants in the ICSI group with DFI > 30% was lower than ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction: Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization.

Wang, Fei / Jiang, Mei / Chi, Yongbin / Huang, Gang / Jin, Mingming

Molecular and cellular biochemistry

2024 Volume 479, Issue 2, Page(s) 447

Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-023-04877-y
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Article ; Online: Sperm DNA fragmentation index affect pregnancy outcomes and offspring safety in assisted reproductive technology.

Li, Fei / Duan, Xiaoyan / Li, Mingming / Ma, Xing

Scientific reports

2024 Volume 14, Issue 1, Page(s) 356

Abstract: The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of DFI on pregnancy outcomes and the safety of offspring ... ...

Abstract	The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of DFI on pregnancy outcomes and the safety of offspring in the context of Assisted Reproductive Technology (ART). In this study, we conducted an analysis of clinical data obtained from 6330 patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at the reproductive medical center of The First People's Hospital of Shangqiu and The Affiliated Hospital of Zhengzhou University. The patients was stratified into two distinct groups: IVF group and ICSI group, Within each group, patients were further classified into three subgroups. IVF: group A (< 15%) included 3123 patients, group B (15-30%) included 561 patients, and group C (≥ 30%) included 46 patients. ICSI: group A (< 15%) included 1967 patients, group B (15-30%) included 462 patients, and group C (≥ 30%) included 171 patients. Data were collected and subjected to statistical analysis. There were no significant differences in the basic characteristics among the three groups, and the sperm DFI did not significantly affect the fertilization rates, pregnancy rates, stillbirth rates and the number of birth defects. However, the incidences of miscarriage rates in IVF/ICSI groups with DFI > 30% and DFI 15-30% were significantly higher than those in IVF/ICSI groups with DFI < 15%, and the miscarriage rates in ICSI group with DFI > 30% were significantly higher than DFI 15-30% group, the smooth fitting curve shows that there is a positive correlation between miscarriage rates and sperm DFI (OR 1.095; 95% CI 1.068-1.123; P < 0.001). The birth weight of infants in the IVF/ICSI groups with DFI > 30% and DFI 15-30% exhibited a statistically significant decrease compared to those in the IVF/ICSI groups with DFI < 15%. Furthermore, the birth weight of infants in the ICSI group with DFI > 30% was lower than that of the DFI 15-30% group. The smooth fitting curve analysis demonstrates a negative association between birth weight and sperm DFI (OR 0.913; 95% CI 0.890-0.937; P < 0.001). Sperm DFI has an impact on both miscarriage rates and birth weight in assisted reproductive technology. The smooth fitting curve analysis reveals a positive correlation between miscarriage rates and DFI, while a negative correlation is observed between birth weight and DFI.
MeSH term(s)	Pregnancy ; Female ; Humans ; Male ; Pregnancy Outcome ; Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/etiology ; Birth Weight ; DNA Fragmentation ; Semen ; Fertilization in Vitro/adverse effects ; Spermatozoa ; Pregnancy Rate ; Retrospective Studies
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45091-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: First-principles predictions of enhanced thermoelectric properties for Cs

Fei, Jiajia / Zhang, Xiaojiao / Li, Jialin / Li, Mingming / Long, Mengqiu

Journal of physics. Condensed matter : an Institute of Physics journal

2023 Volume 35, Issue 43

Abstract: Inspired by the exceptional charge transport properties and ultra-low thermal conductivity of halide perovskite, we investigate the electronic nature, thermal transport, and thermoelectric properties for Ruddlesden-Popper all-inorganic perovskite, ... ...

Abstract	Inspired by the exceptional charge transport properties and ultra-low thermal conductivity of halide perovskite, we investigate the electronic nature, thermal transport, and thermoelectric properties for Ruddlesden-Popper all-inorganic perovskite, Cs
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ace8e1
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Article ; Online: Multi-Graph Attention Networks with Bilinear Convolution for Diagnosis of Schizophrenia.

Yu, Renping / Pan, Cong / Fei, Xuan / Chen, Mingming / Shen, Dinggang

IEEE journal of biomedical and health informatics

2023 Volume PP

Abstract: The explorations of brain functional connectivity (FC) network using resting-state functional magnetic resonance imaging (rs-fMRI) can provide crucial insights into discriminative analysis of neuropsychiatric disorders such as schizophrenia (SZ). Graph ... ...

Abstract	The explorations of brain functional connectivity (FC) network using resting-state functional magnetic resonance imaging (rs-fMRI) can provide crucial insights into discriminative analysis of neuropsychiatric disorders such as schizophrenia (SZ). Graph attention network (GAT), which could capture the local stationary on the network topology and aggregate the features of neighboring nodes, has advantages in learning the feature representation of brain regions. However, GAT only can obtain the node-level features that reflect local information, ignoring the spatial information within the connectivity-based features that proved to be important for SZ diagnosis. In addition, existing graph learning techniques usually rely on a single graph topology to represent neighborhood information, and only consider a single correlation measure for connectivity features. Comprehensive analysis of multiple graph topologies and multiple measures of FC can leverage their complementary information that may contribute to identifying patients. In this paper, we propose a multi-graph attention network (MGAT) with bilinear convolution (BC) neural network framework for SZ diagnosis and functional connectivity analysis. Besides multiple correlation measures to construct connectivity networks from different perspectives, we further propose two different graph construction methods to capture both the low- and high-level graph topologies, respectively. Especially, the MGAT module is developed to learn multiple node interaction features on each graph topology, and the BC module is utilized to learn the spatial connectivity features of the brain network for disease prediction. Importantly, the rationality and advantages of our proposed method can be validated by the experiments on SZ identification. Therefore, we speculate that this framework may also be potentially used as a diagnostic tool for other neuropsychiatric disorders.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3229465
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Zs.A 5483: Show issues

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Article ; Online: Study on the optimization for emergency evacuation scheme under fire in university building complex

Shan Gao / Chen Chang / Qiang Liu / Mingming Zhang / Fei Yu

Heliyon, Vol 9, Iss 3, Pp e14277- (2023)

2023

Abstract: The evacuation in the university building complex involving a variety of campus buildings and a high density of occupants is barely simulated, especially by considering the safety awareness of evacuees and the impact of measured stair evacuation speed. ... ...

Abstract	The evacuation in the university building complex involving a variety of campus buildings and a high density of occupants is barely simulated, especially by considering the safety awareness of evacuees and the impact of measured stair evacuation speed. This paper simulates and optimizes the fire emergency evacuation scheme of a university building complex in Northwest China by using BIM technology and Pathfinder simulation evacuation software. The proposed evacuation optimization scheme of university building complex reduces the evacuation time by 15–20% compared with the original evacuation scheme of the university. Through the simulation, it is found that the evacuation time required for sleeping at night is the shortest, while the longest evacuation time is required during lunch, due to the dispersion of students. Therefore, in addition to considering the safety awareness of the evacuees and the measured evacuation speed of stairs, the corresponding campus evacuation plan should be formulated according to the distribution of buildings in the campus complex and the actual utilization in different periods, so as to avoid the safety exit congestion and being far away from the refuge, due to the dense population in a specific period of time. This study also provides a method for solving the problem of regional evacuation path planning.
Keywords	Building information model ; Fire accident ; Emergency evacuation ; University building ; Area evacuation ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	690
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LncRNA FGD5-AS1 potentiates autophagy-associated doxorubicin resistance by regulating the miR-154-5p/WNT5A axis in osteosarcoma.

Fei, Dan / Yuan, Hongping / Zhao, Mingming / Zhao, Dongxu

Cell biology international

2022 Volume 46, Issue 11, Page(s) 1937–1946

Abstract: Osteosarcoma is prevalent in children and adolescent. The oncogenic function of long-chain noncoding RNA (lncRNA) FGD5 antisense RNA 1 (FGD5-AS1) has been reported. However, the function of FGD5-AS1 in doxorubicin-resistance in osteosarcoma remains to be ...

Abstract	Osteosarcoma is prevalent in children and adolescent. The oncogenic function of long-chain noncoding RNA (lncRNA) FGD5 antisense RNA 1 (FGD5-AS1) has been reported. However, the function of FGD5-AS1 in doxorubicin-resistance in osteosarcoma remains to be illucidated. Quantitative real-time PCR (qRT-PCR) and western blot analysis (WB) were used to measure the expression of FGD5-AS1, miR-154-5p, WNT5A and autophagy proteins. MTT assay was used to assess cell viability and transwell assay was performed to evaluate migration. A nude mouse xenograft model was developed to verify the function of FGD5-AS1 in vivo. FGD5-AS1 was upregulated in doxorubicin-resistant (DXR) osteosarcoma cells. Knockdown of FGD5-AS1 suppressed osteosarcoma cell proliferation, migration, and autophagy. FGD5-AS1 upregulated WNT5A expression via sponging miR-154-5p. Furthermore, FGD5-AS1 enhanced osteosarcoma cell chemotherapy resistance through upregulation of WNT5A by inhibiting miR-154-5p. Suppression of FGD5-AS1 significantly suppressed tumor growth in nude mice. FGD5-AS1 may promote chemoresistance through WNT5A-induced autophagy by sponging miR-154-5p in osteosarcoma cells.
MeSH term(s)	Animals ; Autophagy/genetics ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Gene Expression Regulation, Neoplastic ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Wnt-5a Protein/genetics ; Wnt-5a Protein/metabolism
Chemical Substances	FGD5 protein, human ; Guanine Nucleotide Exchange Factors ; MIRN154 microRNA, human ; MicroRNAs ; RNA, Long Noncoding ; WNT5A protein, human ; Wnt-5a Protein ; Doxorubicin (80168379AG)
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.11889
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Article ; Online: LncRNA PWRN1 inhibits the progression of hepatocellular carcinoma by activating PKM2 activity.

Fei, Mingming / Li, Xianying / Liang, Shuhang / Zhou, Shuo / Wu, Huihui / Sun, Linmao / Liu, Yao / Hu, Qingsong / Liu, Lianxin / Wang, Jiabei

Cancer letters

2024 Volume 584, Page(s) 216620

Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent and leading causes of cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to play vital roles in cancer development and progression. The lncRNA PWRN1 (PWRN1) ...

Abstract	Hepatocellular carcinoma (HCC) is one of the most prevalent and leading causes of cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to play vital roles in cancer development and progression. The lncRNA PWRN1 (PWRN1), acts as a tumor suppressor factor, which is low expressed in some cancers. However, the molecular mechanisms underlying the effects of PWRN1, especially the regulatory relationship with RNA binding protein in HCC remain largely unknown. In the present study, we demonstrated that PWRN1 was significantly down-regulated in HCC and correlated with better prognosis; furthermore, gain-of-function experiments showed that PWRN1 inhibited the proliferation of HCC cells. We further found that PWRN1 up-regulated pyruvate kinase activity and thus hinders the proliferation of HCC in vitro and in vivo. Mechanistically, pyruvate kinase M2 (PKM2) was bound to it and maintained the high activity state of PKM2, thereby hindering PKM2 from entering the nucleus in the form of low-activity dimers, reducing the expression of c-Myc downstream gene LDHA, leading to a decrease in lactate levels, and inhibiting the growth of tumor cells. In addition, PWRN1 was found to inhibit aerobic glycolysis. Finally, TEPP-46, a pyruvate kinase activator, appeared to inhibit HCC proliferation by maintaining tetramer stability and increasing pyruvate kinase activity. Taken together, our results provide new insights into the biology hindering HCC proliferation and indicate that PWRN1 in combination with PKM2 activators might represent a novel therapeutic target for HCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glycolysis ; Liver Neoplasms/pathology ; Pyruvate Kinase/genetics ; Pyruvate Kinase/metabolism ; RNA, Long Noncoding/metabolism
Chemical Substances	Pyruvate Kinase (EC 2.7.1.40) ; RNA, Long Noncoding ; PKM2 protein, human (EC 2.7.1.40)
Language	English
Publishing date	2024-01-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2024.216620
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Article ; Online: LncRNA

Li, Xianying / Liang, Shuhang / Fei, Mingming / Ma, Kun / Sun, Linmao / Liu, Yao / Liu, Lianxin / Wang, Jiabei

International journal of biological sciences

2024 Volume 20, Issue 2, Page(s) 718–732

Abstract: As a crucial protumorigenic long noncoding RNA, colorectal tumor differential expression (CRNDE) has been confirmed to facilitate the progression of various cancers. However, its role in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) ... ...

Abstract	As a crucial protumorigenic long noncoding RNA, colorectal tumor differential expression (CRNDE) has been confirmed to facilitate the progression of various cancers. However, its role in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) is still unclear. Here we determined that CRNDE was upregulated in HCC samples and that CRNDE-positive cells were predominantly enriched in malignant tumor cells. In vivo functional assays revealed that CRNDE-induced tumor cells supported HCC progression, recruited abundant granulocyte myeloid-derived suppressor cells (G-MDSCs) and restricted the infiltration of T cells. In terms of mechanisms, CRNDE bound with Toll-like receptor 3 (TLR3) and activated NF-κB signaling to increase the secretion of c-x-c motif chemokine ligand 3 (CXCL3). CRNDE knockdown could significantly suppress the accumulation of G-MDSCs and enhance the infiltration of T cells in the TME of HCC in vivo. Taken together, our study reveals the CRNDE-NF-κB-CXCL3 axis plays a crucial role in driving the immunosuppressive niche to facilitate HCC progression by recruiting G-MDSCs.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; NF-kappa B/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Tumor Microenvironment/genetics
Chemical Substances	RNA, Long Noncoding ; NF-kappa B
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.85471
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Study on the optimization for emergency evacuation scheme under fire in university building complex.

Gao, Shan / Chang, Chen / Liu, Qiang / Zhang, Mingming / Yu, Fei

Heliyon

2023 Volume 9, Issue 3, Page(s) e14277

Abstract	The evacuation in the university building complex involving a variety of campus buildings and a high density of occupants is barely simulated, especially by considering the safety awareness of evacuees and the impact of measured stair evacuation speed. This paper simulates and optimizes the fire emergency evacuation scheme of a university building complex in Northwest China by using BIM technology and Pathfinder simulation evacuation software. The proposed evacuation optimization scheme of university building complex reduces the evacuation time by 15-20% compared with the original evacuation scheme of the university. Through the simulation, it is found that the evacuation time required for sleeping at night is the shortest, while the longest evacuation time is required during lunch, due to the dispersion of students. Therefore, in addition to considering the safety awareness of the evacuees and the measured evacuation speed of stairs, the corresponding campus evacuation plan should be formulated according to the distribution of buildings in the campus complex and the actual utilization in different periods, so as to avoid the safety exit congestion and being far away from the refuge, due to the dense population in a specific period of time. This study also provides a method for solving the problem of regional evacuation path planning.
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14277
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