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  1. Article ; Online: ¿Infección por SARS-CoV-2 como desencadenante de un síndrome inflamatorio sistémico?

    Fernández-González, Sara M / Varela-Ferreiro, Nerea / Castro Aguiar, Susana / Pardo-Vázquez, Jerónimo José

    Enfermedades infecciosas y microbiologia clinica

    2020  Volume 39, Issue 5, Page(s) 262–264

    Title translation SARS-CoV-2 infection as trigger multisystem inflammatory syndrome?
    Language Spanish
    Publishing date 2020-09-09
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2020.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 infection as trigger multisystem inflammatory syndrome?

    Fernández-González, Sara M / Varela-Ferreiro, Nerea / Castro Aguiar, Susana / Pardo-Vázquez, Jerónimo José

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2020  Volume 39, Issue 5, Page(s) 262–264

    Title translation ¿Infección por SARS-CoV-2 como desencadenante de un síndrome inflamatorio sistémico?
    MeSH term(s) Aspirin/therapeutic use ; COVID-19/blood ; COVID-19/complications ; COVID-19/etiology ; COVID-19/immunology ; COVID-19/therapy ; COVID-19 Nucleic Acid Testing ; COVID-19 Serological Testing ; Child, Preschool ; False Negative Reactions ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Nasopharynx/virology ; Polymerase Chain Reaction ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Symptom Assessment ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/therapy
    Chemical Substances Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins, Intravenous ; Aspirin (R16CO5Y76E)
    Keywords covid19
    Language Spanish
    Publishing date 2020-09-09
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2020.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Incidence, Predictors and Outcomes of Noninvasive Ventilation Failure in Very Preterm Infants.

    Fernandez-Gonzalez, Sara M / Sucasas Alonso, Andrea / Ogando Martinez, Alicia / Avila-Alvarez, Alejandro

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 3

    Abstract: Non-invasive ventilation (NIV) is now considered the first-line treatment for respiratory distress syndrome in preterm infants. We aimed to evaluate the rates of non-invasive ventilation failure rate in very preterm infants, as well as to identify its ... ...

    Abstract Non-invasive ventilation (NIV) is now considered the first-line treatment for respiratory distress syndrome in preterm infants. We aimed to evaluate the rates of non-invasive ventilation failure rate in very preterm infants, as well as to identify its predictors and associated outcomes. We designed a single-center retrospective cohort study including infants ≤32 weeks gestational age and ≤1500 g. The NIV failure was defined as the need for intubation at <72 h of life. After applying inclusion and exclusion criteria, 154 patients were included in the study, with a mean GA of 29.7 ± two weeks. The NIV failure rate was 16.2% (n = 25) and it was associated with lower bronchopulmonary dysplasia (BPD)-free survival (OR 0.08; 95% CI 0.02−0.32) and higher incidence of intraventricular hemorrhage > II (OR 6.22; 95% CI 1.36−28.3). These infants were significantly smaller in GA and weight. Higher FiO2 during resuscitation (OR 1.14; 95% CI 1.06−1.22) and after surfactant administration (OR 1.17; 95% CI 1.05−1.31) represented independent risk factors for NIV failure. In conclusion, NIV failure is frequent and it could be predicted by a higher oxygen requirement during resuscitation and a modest response to surfactant therapy. Importantly, this NIV failure is associated with worse clinical outcomes.
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9030426
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  4. Article: Bull spermatozoa selected by thermotaxis exhibit high DNA integrity, specific head morphometry, and improve ICSI outcome.

    Ruiz-Díaz, Sara / Mazzarella, Rosane / Navarrete-López, Paula / Fernández-González, Raúl / de Frutos, Celia / Maroto, María / Cucala, Claudia / Beltrán-Breña, Paula / Lombó, Marta / Rizos, Dimitrios / Gutiérrez-Adán, Alfonso

    Journal of animal science and biotechnology

    2023  Volume 14, Issue 1, Page(s) 11

    Abstract: Background: Sperm migration by thermotaxis is a guidance mechanism that operates along the oviduct and it has proved to be a valid method for selecting spermatozoa with low DNA fragmentation (SDF) in mice, humans, and stallions. This study aimed to ... ...

    Abstract Background: Sperm migration by thermotaxis is a guidance mechanism that operates along the oviduct and it has proved to be a valid method for selecting spermatozoa with low DNA fragmentation (SDF) in mice, humans, and stallions. This study aimed to analyse if bull spermatozoa could be selected by thermotaxis and to assess their quality in terms of SDF as well as determine the presence of a specific sperm subpopulation based on sperm morphometry and assess their fertilizing capacity by ICSI.
    Methods: We used frozen-thawed sperm from 6 bulls and sperm selection by thermotaxis was performed with TALP medium supplemented with 25 mmol/L of HEPES and 5 mmol/L of caffeine. In these conditions, sperm selection was achieved, obtaining a net thermotaxis of 3.6%. Subsequently, we analysed the SDF of the migrated and not-migrated spermatozoa using the neutral COMET assay, and we evaluated the size of the sperm head using Hemacolor® staining with Motic Images Plus 3 software. Additionally, migrated and not-migrated spermatozoa by thermotaxis were used to fertilize bovine in vitro matured (IVM) oocytes by ICSI, a very inefficient procedure in cattle that is only successful when the oocyte is artificially activated.
    Results: The results showed lower SDF (χ², P < 0.001, 13.3% reduction, n = 8) and lower head size parameters (length and width, P < 0.01; and perimeter and area, P < 0.001; n = 4) in those spermatozoa migrated in comparison to those not-migrated. The distribution of sperm subpopulations structure varied between groups, highlighting cluster 2, characterized by spermatozoa with small head size, and high ellipticity and elongated heads, as the most abundant in the thermotaxis migrated group. When performed ICSI (without oocyte artificial activation) with the thermotactic sperm, the blastocyst rate was 32.2% ± 9.3% in the group microinjected with the thermotactic spermatozoa vs. 8.3% ± 7.8% in the group of not-migrated sperm (χ², P < 0.05).
    Conclusion: Our results showed that bull sperm selection by thermotaxis has a much higher DNA integrity, small and elongated head size parameters, and different sperm subpopulation structure than the not-selected spermatozoa. Additionally, we evidenced that thermotactic spermatozoa improve ICSI success rates.
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630162-3
    ISSN 2049-1891 ; 1674-9782
    ISSN (online) 2049-1891
    ISSN 1674-9782
    DOI 10.1186/s40104-022-00810-3
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  5. Article ; Online: ¿Infección por SARS-CoV-2 como desencadenante de un síndrome inflamatorio sistémico?

    Fernández-González, Sara M. / Varela-Ferreiro, Nerea / Castro Aguiar, Susana / Pardo-Vázquez, Jerónimo José

    Enfermedades Infecciosas y Microbiología Clínica ; ISSN 0213-005X

    2020  

    Keywords Microbiology (medical) ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.eimc.2020.07.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: ¿Infección por SARS-CoV-2 como desencadenante de un síndrome inflamatorio sistémico?/ ¿Infección por SARS-CoV-2 como desencadenante de un síndrome inflamatorio sistémico?/ SARS-CoV-2 infection as trigger multisystem inflammatory syndrome?

    Fernández-González, Sara M / Varela-Ferreiro, Nerea / Castro Aguiar, Susana / Pardo-Vázquez, Jerónimo José

    Enferm. infecc. microbiol. clin. (Ed. impr.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #753669
    Database COVID19

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  7. Article ; Online: Crosstalk between Melanin Concentrating Hormone and Endocrine Factors: Implications for Obesity.

    Prida, Eva / Fernández-González, Sara / Pena-León, Verónica / Pérez-Lois, Raquel / Fernø, Johan / Seoane, Luisa María / Quiñones, Mar / Al Massadi, Omar

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: Melanin-concentrating hormone (MCH) is a 19aa cyclic peptide exclusively expressed in the lateral hypothalamic area, which is an area of the brain involved in a large number of physiological functions and vital processes such as nutrient sensing, food ... ...

    Abstract Melanin-concentrating hormone (MCH) is a 19aa cyclic peptide exclusively expressed in the lateral hypothalamic area, which is an area of the brain involved in a large number of physiological functions and vital processes such as nutrient sensing, food intake, sleep-wake arousal, memory formation, and reproduction. However, the role of the lateral hypothalamic area in metabolic regulation stands out as the most relevant function. MCH regulates energy balance and glucose homeostasis by controlling food intake and peripheral lipid metabolism, energy expenditure, locomotor activity and brown adipose tissue thermogenesis. However, the MCH control of energy balance is a complex mechanism that involves the interaction of several neuroendocrine systems. The aim of the present work is to describe the current knowledge of the crosstalk of MCH with different endocrine factors. We also provide our view about the possible use of melanin-concentrating hormone receptor antagonists for the treatment of metabolic complications. In light of the data provided here and based on its actions and function, we believe that the MCH system emerges as an important target for the treatment of obesity and its comorbidities.
    MeSH term(s) Animals ; Energy Metabolism ; Humans ; Hypothalamic Area, Lateral/metabolism ; Hypothalamic Hormones/metabolism ; Lipid Metabolism ; Melanins/metabolism ; Neurosecretory Systems/metabolism ; Obesity/metabolism ; Pituitary Hormones/metabolism
    Chemical Substances Hypothalamic Hormones ; Melanins ; Pituitary Hormones ; melanin-concentrating hormone (67382-96-1)
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052436
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  8. Article ; Online: Egg-induced adult food protein-induced enterocolitis syndrome: Clinical phenotypes, natural history and immunological characteristics.

    Gonzalez-Delgado, Purificación / Anvari, Sara / Barrachina, Jordi / Portillo, Ana L Jimenez / Jimenez, Teodorikez / Marco de la Calle, Francisco M / Fernandez, Javier

    The journal of allergy and clinical immunology. In practice

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity.

    Martín-Escura, Cristina / Bonache, M Ángeles / Medina, Jessy A / Medina-Peris, Alicia / De Andrés-López, Jorge / González-Rodríguez, Sara / Kerselaers, Sara / Fernández-Ballester, Gregorio / Voets, Thomas / Ferrer-Montiel, Antonio / Fernández-Carvajal, Asia / González-Muñiz, Rosario

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium ( ... ...

    Abstract The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca
    MeSH term(s) Mice ; Animals ; TRPM Cation Channels/metabolism ; beta-Lactams ; Transient Receptor Potential Channels/metabolism ; Structure-Activity Relationship ; Antigens
    Chemical Substances TRPM Cation Channels ; beta-Lactams ; phenylalaninol (16088-07-6) ; Transient Receptor Potential Channels ; Antigens ; TRPM8 protein, mouse
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914894
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  10. Article: Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease.

    Robledo, Sara M / Pérez-Silanes, Silvia / Fernández-Rubio, Celia / Poveda, Ana / Monzote, Lianet / González, Víctor M / Alonso-Collado, Paloma / Carrión, Javier

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: In 2020, the WHO established the road map for neglected tropical diseases 2021-2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on ...

    Abstract In 2020, the WHO established the road map for neglected tropical diseases 2021-2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on Antimicrobial Resistance. In this context, the achievement of innovative strategies as an alternative to replace conventional therapies is a first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions, such as those caused by
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070939
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