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  1. Article ; Online: Predominance of visuoconstructive impairment after mild COVID-19?

    Díez-Cirarda, María / Yus, Miguel / Matías-Guiu, Jorge / Matias-Guiu, Jordi A

    Molecular psychiatry

    2022  Volume 28, Issue 2, Page(s) 536–537

    MeSH term(s) Humans ; COVID-19 ; Memory ; Neuropsychological Tests
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01797-z
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    Zs.A 4812: Show issues Location:
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  2. Article ; Online: The role of scientific journal editors during the COVID-19 pandemic.

    Matias-Guiu, J

    Neurologia

    2020  Volume 35, Issue 4, Page(s) 223–225

    Title translation El papel del editor de una revista científica durante la pandemia del Covid-19.
    MeSH term(s) COVID-19 ; Coronavirus Infections ; Editorial Policies ; Global Health ; Humans ; Information Dissemination ; Pandemics ; Periodicals as Topic/standards ; Pneumonia, Viral ; Publishing/standards ; Role ; Time Factors
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-02
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2654369-2
    ISSN 2173-5808 ; 2173-5808
    ISSN (online) 2173-5808
    ISSN 2173-5808
    DOI 10.1016/j.nrl.2020.05.005
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  3. Article ; Online: Death Rate Due to COVID-19 in Alzheimer's Disease and Frontotemporal Dementia.

    Matias-Guiu, Jordi A / Pytel, Vanesa / Matías-Guiu, Jorge

    Journal of Alzheimer's disease : JAD

    2020  Volume 78, Issue 2, Page(s) 537–541

    Abstract: We aimed to evaluate the frequency and mortality of COVID-19 in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD). We conducted an observational case series. We enrolled 204 patients, 15.2% of whom were diagnosed with COVID-19, and ...

    Abstract We aimed to evaluate the frequency and mortality of COVID-19 in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD). We conducted an observational case series. We enrolled 204 patients, 15.2% of whom were diagnosed with COVID-19, and 41.9% of patients with the infection died. Patients with AD were older than patients with FTD (80.36±8.77 versus 72.00±8.35 years old) and had a higher prevalence of arterial hypertension (55.8% versus 26.3%). COVID-19 occurred in 7.3% of patients living at home, but 72.0% of those living at care homes. Living in care facilities and diagnosis of AD were independently associated with a higher probability of death. We found that living in care homes is the most relevant factor for an increased risk of COVID-19 infection and death, with AD patients exhibiting a higher risk than those with FTD.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/mortality ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Female ; Frontotemporal Dementia/complications ; Frontotemporal Dementia/mortality ; Humans ; Hypertension/complications ; Independent Living ; Male ; Nursing Homes ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Prevalence ; Risk Factors
    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country Netherlands
    Document type Letter ; Observational Study
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-200940
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  4. Article ; Online: Murine experimental models of amyotrophic lateral sclerosis: an update.

    Moreno-Jiménez, L / Benito-Martín, M S / Sanclemente-Alamán, I / Matías-Guiu, J A / Sancho-Bielsa, F / Canales-Aguirre, A / Mateos-Díaz, J C / Matías-Guiu, J / Aguilar, J / Gómez-Pinedo, U

    Neurologia

    2023  Volume 39, Issue 3, Page(s) 282–291

    Abstract: Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose aetiology is unknown. It is characterised by upper and lower motor neuron degeneration. Approximately 90% of cases of ALS are sporadic, whereas the other ... ...

    Abstract Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose aetiology is unknown. It is characterised by upper and lower motor neuron degeneration. Approximately 90% of cases of ALS are sporadic, whereas the other 10% are familial. Regardless of whether the case is familial o sporadic, patients will develop progressive weakness, muscle atrophy with spasticity, and muscle contractures. Life expectancy of these patients is generally 2 to 5 years after diagnosis.
    Development: In vivo models have helped to clarify the aetiology and pathogenesis of ALS, as well as the mechanisms of the disease. However, as these mechanisms are not yet fully understood, experimental models are essential to the continued study of the pathogenesis of ALS, as well as in the search for possible therapeutic targets. Although 90% of cases are sporadic, most of the models used to study ALS pathogenesis are based on genetic mutations associated with the familial form of the disease; the pathogenesis of sporadic ALS remains unknown. Therefore, it would be critical to establish models based on the sporadic form.
    Conclusions: This article reviews the main genetic and sporadic experimental models used in the study of this disease, focusing on those that have been developed using rodents.
    MeSH term(s) Humans ; Animals ; Mice ; Amyotrophic Lateral Sclerosis/pathology ; Neurodegenerative Diseases ; DNA-Binding Proteins/genetics ; Mutation
    Chemical Substances DNA-Binding Proteins
    Language English
    Publishing date 2023-04-26
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2654369-2
    ISSN 2173-5808 ; 2173-5808
    ISSN (online) 2173-5808
    ISSN 2173-5808
    DOI 10.1016/j.nrleng.2021.07.004
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  5. Article ; Online: Underpinnings of verbal fluency in Multiple Sclerosis.

    Delgado-Álvarez, Alfonso / Delgado-Alonso, Cristina / Matías-Guiu, Jorge / Matias-Guiu, Jordi A

    Multiple sclerosis and related disorders

    2021  Volume 53, Page(s) 103056

    Abstract: The cognitive and language processes underlying verbal fluency remain unclear. While some cognitive processes related to memory and executive functioning have been more associated with category and letter verbal fluency, other less studied aspects of ... ...

    Abstract The cognitive and language processes underlying verbal fluency remain unclear. While some cognitive processes related to memory and executive functioning have been more associated with category and letter verbal fluency, other less studied aspects of language ability could be also related. We discuss the contribution of the recent study by Lebkuecher and colleagues (2021) about the role of language in verbal fluency, and the data from other studies evaluating the cognitive and neuroimaging correlates of verbal fluency in MS.
    MeSH term(s) Executive Function ; Humans ; Language ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnostic imaging ; Neuropsychological Tests
    Language English
    Publishing date 2021-05-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2021.103056
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  6. Article ; Online: In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies.

    Gómez-Pinedo, Ulises / Matías-Guiu, Jordi A / Ojeda-Hernandez, Denise / de la Fuente-Martin, Sarah / Kamal, Ola Mohamed-Fathy / Benito-Martin, Maria Soledad / Selma-Calvo, Belen / Montero-Escribano, Paloma / Matías-Guiu, Jorge

    Cells

    2023  Volume 12, Issue 11

    Abstract: The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or ... ...

    Abstract The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
    MeSH term(s) Humans ; Methylprednisolone/pharmacology ; Oligodendroglia ; Myelin Sheath ; Axons ; Cell Differentiation
    Chemical Substances Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12111515
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  7. Article ; Online: Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial.

    Matias-Guiu, Jordi A / González-Rosa, Javier / Hernández, Miguel Ángel / Martínez-Ginés, Maria Luisa / Portolés, Antonio / Pérez-Macías, Natalia / Benito-León, Julián / Padrón, Iván / Prieto, Julio / Matias-Guiu, Jorge

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e078661

    Abstract: Introduction: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), and effective treatments are lacking. Amantadine is one of the most used treatments, although its efficacy is under debate. Transcranial magnetic stimulation (TMS) ... ...

    Abstract Introduction: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), and effective treatments are lacking. Amantadine is one of the most used treatments, although its efficacy is under debate. Transcranial magnetic stimulation (TMS) is a promising intervention that has shown positive effects in some preliminary investigations. We aim to investigate the effect of 6 weeks of amantadine and/or TMS in fatigue due to MS.
    Methods and analysis: The study is a national, multicentre, phase 3, randomised, double-blind, cross-over, placebo-controlled and sham-controlled clinical trial. Adult patients with relapsing-remitting MS, Expanded Disability Status Scale score of 1.5-4.5 and Fatigue Severity Score>4 are eligible for the trial. Participants will be randomised to one of the sequences of the study. Each sequence consists of four periods of 6 weeks of treatment and three washout periods of 12-18 weeks. All patients will receive all the combinations of therapies. The primary outcome is the Modified Fatigue Impact Scale. The secondary outcomes are the Symbol Digit Modalities Test (cognition), Beck Depression Inventory-II (depressive symptoms) and Short-Survey 12 (quality of life). Safety and cost-effectiveness will also be evaluated. An exploratory substudy including MRI and blood biomarkers will be conducted.
    Ethics and dissemination: The study is approved by the Ethics Committee of the Hospital Clinico San Carlos and the Spanish Agency of Medications and Medical Devices. All study findings will be published in scientific peer-reviewed journals and presented at relevant scientific conferences.
    Trial registration number: EudraCT 2021-004868-95; NCT05809414.
    MeSH term(s) Adult ; Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy ; Transcranial Magnetic Stimulation ; Quality of Life ; Amantadine/therapeutic use ; Double-Blind Method ; Fatigue/therapy ; Fatigue/chemically induced ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic ; Clinical Trials, Phase III as Topic
    Chemical Substances Amantadine (BF4C9Z1J53)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-078661
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  9. Article ; Online: El papel del editor de una revista científica durante la pandemia del Covid-19

    Matias-Guiu, J.

    Neurología

    2020  Volume 35, Issue 4, Page(s) 223–225

    Keywords Clinical Neurology ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1056021-x
    ISSN 1578-1968 ; 0213-4853
    ISSN (online) 1578-1968
    ISSN 0213-4853
    DOI 10.1016/j.nrl.2020.05.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The role of scientific journal editors during the COVID-19 pandemic

    Matias-Guiu, J.

    Neurología (English Edition)

    2020  Volume 35, Issue 4, Page(s) 223–225

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2173-5808
    DOI 10.1016/j.nrleng.2020.05.011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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