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  1. Thesis ; Audio / Video: The life and professional contributions of Matthew Mann II to competitive swimming in the United States

    Saunders, Robert Charles

    1980  

    Author's details Robert Charles Saunders
    Size 6149 Seiten
    Edition [Mikroform-Ausg.]
    Document type Thesis ; Audio / Video
    Thesis / German Habilitation thesis Thesis, Ohio State University, 1980
    HBZ-ID HT016398737
    Database Central Library of Sport Science of the German Sport University Cologne

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  2. Article ; Online: The impact of substrate dampness on the transfer of glass fragments to upper garments when breaking windows.

    Saunders, Matthew / Gupta, Anjali / Roux, Claude / Spindler, Xanthe

    Forensic science international

    2023  Volume 350, Page(s) 111791

    Abstract: Glass fragments are often recovered from garments worn by the authors of certain types of crimes and are useful as they present strong connections to the scene at both the source and activity level. It is known that the transfer of glass fragments is ... ...

    Abstract Glass fragments are often recovered from garments worn by the authors of certain types of crimes and are useful as they present strong connections to the scene at both the source and activity level. It is known that the transfer of glass fragments is impacted when recipient garments are dampened, such as by rain, however, the details of the effect are not clear. This research aimed to determine the impact of substrate dampness on glass retention. Across the three test garments, a cotton t-shirt was found to increase in retentiveness with increasing dampness, while a wool/polyester blend jumper and a cotton hoodie were both found to increase only to a point, before decreasing again when the garment was saturated. This is attributed to the construction of the fabrics, as it does not appear to be related to the identity of the textile itself. It was also found that the size distribution of fragments changed with dampness. All the garments retained a smaller proportion of fragments less than 0.5 mm in size when saturated or dampened than when dry, along with an increase in the proportion of fragments in the 1-1.5 mm and greater than 1.5 mm size categories. These results indicate that is important to consider the impact of substrate dampening when relevant, and that this consideration must be done holistically as different substrates respond to dampening in different ways. It also indicates that consideration of the size distribution in fragment populations may reveal additional information in complex scenarios.
    Language English
    Publishing date 2023-07-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2023.111791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1104: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: COVID-19, tuberculosis and poverty: preventing a perfect storm.

    Saunders, Matthew J / Evans, Carlton A

    The European respiratory journal

    2020  Volume 56, Issue 1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Poverty ; SARS-CoV-2 ; Tuberculosis
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01348-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  4. Article ; Online: The Influence of Sex Hormones in Liver Function and Disease.

    Kasarinaite, Alvile / Sinton, Matthew / Saunders, Philippa T K / Hay, David C

    Cells

    2023  Volume 12, Issue 12

    Abstract: The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian liver physiology and the development of new model systems to improve ... ...

    Abstract The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian liver physiology and the development of new model systems to improve our understanding of liver biology in health and disease. A major risk factor for the development of liver disease is hepatic fibrosis. Key drivers of this process are metabolic dysfunction and pathologic activation of the immune system. Although non-alcoholic fatty liver disease (NAFLD) is largely regarded as benign, it does progress to non-alcoholic steatohepatitis in a subset of patients, increasing their risk of developing cirrhosis and hepatocellular carcinoma. NAFLD susceptibility varies across the population, with obesity and insulin resistance playing a strong role in the disease development. Additionally, sex and age have been identified as important risk factors. In addition to the regulation of liver biochemistry, sex hormones also regulate the immune system, with sexual dimorphism described for both innate and adaptive immune responses. Therefore, sex differences in liver metabolism, immunity and their interplay are important factors to consider when designing, studying and developing therapeutic strategies to treat human liver disease. The purpose of this review is to provide the reader with a general overview of sex steroid biology and their regulation of mammalian liver physiology.
    MeSH term(s) Animals ; Humans ; Female ; Male ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver Cirrhosis/pathology ; Gonadal Steroid Hormones ; Liver Neoplasms ; Steroids ; Mammals
    Chemical Substances Gonadal Steroid Hormones ; Steroids
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12121604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Remote hearing-aid delivery and support: perspectives of patients and their hearing care providers.

    Blyth, Matthew / Saunders, Gabrielle H

    International journal of audiology

    2024  , Page(s) 1–9

    Abstract: Objective: To explore the perspectives of patients and hearing care providers (HCPs) about an adult remote hearing-aid delivery service implemented during the COVID-19 pandemic.: Design: Service evaluation via surveys. The patient survey measured ... ...

    Abstract Objective: To explore the perspectives of patients and hearing care providers (HCPs) about an adult remote hearing-aid delivery service implemented during the COVID-19 pandemic.
    Design: Service evaluation via surveys. The patient survey measured satisfaction with the service, perceived hearing-aid handling skills, and preferences for future services. The HCP survey explored the impact of teleaudiology on outcomes compared to in-person care and factors important for successful teleaudiology.
    Study sample: 378 patients and 14 HCPs.
    Results: Patients were highly satisfied with the service and self-reported good hearing-aid handling skills. However, 2 in 3 patients said they would prefer a future hearing-aid fitting to be in-person rather than remote. HCPs thought teleaudiology had positive impacts on convenience, accessibility, and flexibility, but negative impacts on communication, rapport, and the quality of care. HCPs considered computer literacy and individual preferences to be important for successful remote care; the age of the patient was considered less important.
    Conclusions: Patients were generally highly satisfied with the service and for 1 in 3 it was their preferred mode of future hearing-aid fitting. Future services should be aware that a one-size-fits-all approach will not satisfy all patients and that teleaudiology should be offered on the basis of individual preference.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073098-6
    ISSN 1708-8186 ; 1499-2027
    ISSN (online) 1708-8186
    ISSN 1499-2027
    DOI 10.1080/14992027.2024.2304585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ending Tuberculosis through Prevention.

    Saunders, Matthew J / Evans, Carlton A

    The New England journal of medicine

    2019  Volume 380, Issue 11, Page(s) 1073–1074

    MeSH term(s) HIV ; Humans ; Isoniazid ; Rifampin/analogs & derivatives ; Tuberculosis/prevention & control
    Chemical Substances Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR) ; rifapentine (XJM390A33U)
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1901656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Ancestral sequence reconstruction for protein engineers.

    Spence, Matthew A / Kaczmarski, Joe A / Saunders, Jake W / Jackson, Colin J

    Current opinion in structural biology

    2021  Volume 69, Page(s) 131–141

    Abstract: In addition to its value in the study of molecular evolution, ancestral sequence reconstruction (ASR) has emerged as a useful methodology for engineering proteins with enhanced properties. Proteins generated by ASR often exhibit unique or improved ... ...

    Abstract In addition to its value in the study of molecular evolution, ancestral sequence reconstruction (ASR) has emerged as a useful methodology for engineering proteins with enhanced properties. Proteins generated by ASR often exhibit unique or improved activity, stability, and/or promiscuity, all of which are properties that are valued by protein engineers. Comparison between extant proteins and evolutionary intermediates generated by ASR also allows protein engineers to identify substitutions that have contributed to functional innovation or diversification within protein families. As ASR becomes more widely adopted as a protein engineering approach, it is important to understand the applications, limitations, and recent developments of this technique. This review highlights recent exemplifications of ASR, as well as technical aspects of the reconstruction process that are relevant to protein engineering.
    MeSH term(s) Biological Evolution ; Evolution, Molecular ; Humans ; Phylogeny ; Protein Engineering ; Proteins/genetics
    Chemical Substances Proteins
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2021.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: High-Dimensional Parameter Search Method to Determine Force Field Mixing Terms in Molecular Simulations.

    Saunders, Matthew / Wineman-Fisher, Vered / Jakobsson, Eric / Varma, Sameer / Pandit, Sagar A

    Langmuir : the ACS journal of surfaces and colloids

    2022  Volume 38, Issue 9, Page(s) 2840–2851

    Abstract: Molecular dynamics (MD) force fields for lipids and ions are typically developed independently of one another. In simulations consisting of both lipids and ions, lipid-ion interaction energies are estimated using a predefined set of mixing rules for ... ...

    Abstract Molecular dynamics (MD) force fields for lipids and ions are typically developed independently of one another. In simulations consisting of both lipids and ions, lipid-ion interaction energies are estimated using a predefined set of mixing rules for Lennard-Jones (LJ) interactions. This, however, does not guarantee their reliability. In fact, compared to the quantum mechanical reference data, Lorentz-Berthelot mixing rules substantially underestimate the binding energies of Na
    MeSH term(s) Ions/chemistry ; Lipid Bilayers/chemistry ; Molecular Dynamics Simulation ; Reproducibility of Results ; Thermodynamics
    Chemical Substances Ions ; Lipid Bilayers
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c03105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantifying peatland land use and CO

    Habib, Wahaj / Ingle, Ruchita / Saunders, Matthew / Connolly, John

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1171

    Abstract: Ireland has > 50% of the EU's ocean-raised bogs; however, degradation through land-use activities has transformed them from carbon (C) sinks to sources. Given their significant role in climate mitigation, it is essential to quantify the emissions ... ...

    Abstract Ireland has > 50% of the EU's ocean-raised bogs; however, degradation through land-use activities has transformed them from carbon (C) sinks to sources. Given their significant role in climate mitigation, it is essential to quantify the emissions resulting from land use degradation of these ecosystems. A seven-class land-use classification system for Irish peatlands (LUCIP) was developed and mapped using Sentinel-2 imagery, random forest machine learning and Google Earth Engine. The results revealed that agricultural grassland comprised 43% of the land use on raised bogs, followed by, forestry (21%), cutover (11%), cutaway (10%) remnant peatlands (13%), waterbodies and built-up ~ 1% each. The overall accuracy of the map was 89%. The map was used to estimate CO
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51660-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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