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  1. Book ; Online: Fast Facts : Asthma

    Douglass, Jo A.

    Improve patient self-management and drug use, achieve asthma control

    2021  

    Abstract: Asthma is the world’s most common chronic respiratory condition, affecting over 350 million people worldwide and inflicting a heavy individual, social and economic burden of disease. In this rapidly changing field, a plethora of new inhaled therapies and ...

    Title variant Fast Facts
    Author's details Jo A. Douglass, Timothy S.C. Hinks
    Abstract Asthma is the world’s most common chronic respiratory condition, affecting over 350 million people worldwide and inflicting a heavy individual, social and economic burden of disease. In this rapidly changing field, a plethora of new inhaled therapies and devices have emerged, as well as a better understanding of disease phenotyping and biology. This fully updated fifth edition of 'Fast Facts: Asthma' discusses recent trends in an easy-reference format, while highlighting imminent new developments, to provide a valuable resource for general practitioners, specialist asthma nurses and others with a keen interest in improving the outcomes of the very many people living with asthma. Table of Contents: • Pathophysiology • Epidemiology, etiology and natural history • Diagnosis and classification • Asthma medications • Management principles • Severe and refractory asthma • Acute asthma attacks • Preventing asthma attacks • Asthma in special circumstances • Developments
    Keywords Respiratory System
    Language English
    Size 1 online resource (140 pages) :, 32 figures, 32 in color, 24 tables
    Edition 5th edition.
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 1-910797-75-8 ; 1-912776-61-8 ; 978-1-910797-75-4 ; 978-1-912776-61-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Fast facts

    Holgate, Stephen T. / Douglass, Jo A.

    asthma

    (Fast facts)

    2013  

    Author's details Stephen T. Holgate, Jo A. Douglass
    Series title Fast facts
    Keywords Asthma
    Language English
    Size 1 online resource (128 p. : col. ill., col. maps.)
    Edition 4th ed.
    Publisher Health Press
    Publishing place Oxford
    Document type Book ; Online
    ISBN 1-908541-42-3 ; 1-908541-41-5 ; 1-908541-13-X ; 978-1-908541-42-0 ; 978-1-908541-41-3 ; 978-1-908541-13-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: How can air quality affect health?

    Douglass, Jo A

    Internal medicine journal

    2020  Volume 50, Issue 11, Page(s) 1403–1404

    Abstract: Over recent years, Australians have been subject to an unprecedented number of environmental events materially and visibly affecting air quality, including thunderstorm asthma and bushfire smoke. There is increasing evidence that poor air quality ... ...

    Abstract Over recent years, Australians have been subject to an unprecedented number of environmental events materially and visibly affecting air quality, including thunderstorm asthma and bushfire smoke. There is increasing evidence that poor air quality adversely affects health with consequences for mortality and morbidity with measured particulates (PM2.5) in January 2019 frequently exceeding World Health Organization standards. Biological factors can also impact air quality with thunderstorm asthma epidemics evidence of a prime example, the 2016 event being associated with severe impacts on health services. Given these events, consideration needs to be given to environmental health literacy which will support individuals with pre-existing illness to recognise and mitigate as far as possible the effects of adverse air quality. Recognising the impact of poor air quality should also urge physicians to advocate for clean air as a necessity for good health.
    MeSH term(s) Air Pollutants ; Air Pollution/adverse effects ; Asthma/epidemiology ; Australia/epidemiology ; Environmental Exposure ; Humans ; Morbidity
    Chemical Substances Air Pollutants
    Keywords covid19
    Language English
    Publishing date 2020-11-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 792: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 424: Show issues

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  4. Article ; Online: Overview of recent advancements in asthma management.

    Witt, Ashleigh / Douglass, Jo A / Harun, Nur-Shirin

    Internal medicine journal

    2022  Volume 52, Issue 9, Page(s) 1478–1487

    Abstract: Asthma is a common but complex heterogenous inflammatory airway disorder. Despite significant developments in our understanding of the pathophysiology and treatment of asthma, it remains a major cause of mortality and morbidity. Optimal management ... ...

    Abstract Asthma is a common but complex heterogenous inflammatory airway disorder. Despite significant developments in our understanding of the pathophysiology and treatment of asthma, it remains a major cause of mortality and morbidity. Optimal management involves addressing modifiable risk factors, titration of inhaled pharmacotherapy in a stepwise approach and, in severe disease, consideration of biologic agents. Appreciation of the clinical characteristics of asthma and recognition of the immune pathways involved has allowed the development of phenotypic and endotypic subtypes of asthma to be better defined. This has revolutionised asthma management, allowing risk stratification of patients, targeted use of biologic agents to modify cytokine responses that drive asthma and improved patient outcomes. Patient education and engagement are critical to the management of this disease in an era of personalised medicine and a rapidly changing global environment.
    MeSH term(s) Asthma/drug therapy ; Biological Factors/therapeutic use ; Cytokines ; Humans
    Chemical Substances Biological Factors ; Cytokines
    Language English
    Publishing date 2022-09-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Review of the Role of Pollen in COVID-19 Infection.

    Idrose, Nur Sabrina / Zhang, Jingwen / Lodge, Caroline J / Erbas, Bircan / Douglass, Jo A / Bui, Dinh S / Dharmage, Shyamali C

    International journal of environmental research and public health

    2023  Volume 20, Issue 10

    Abstract: There is current interest in the role of ambient pollen in the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 or COVID-19) infection risk. The aim of this review is to summarise studies published up until January 2023 investigating the ... ...

    Abstract There is current interest in the role of ambient pollen in the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 or COVID-19) infection risk. The aim of this review is to summarise studies published up until January 2023 investigating the relationship between airborne pollen and the risk of COVID-19 infection. We found conflicting evidence, with some studies showing that pollen may increase the risk of COVID-19 infection by acting as a carrier, while others showed that pollen may reduce the risk by acting as an inhibiting factor. A few studies reported no evidence of an association between pollen and the risk of infection. A major limiting factor of this research is not being able to determine whether pollen contributed to the susceptibility to infection or just the expression of symptoms. Hence, more research is needed to better understand this highly complex relationship. Future investigations should consider individual and sociodemographic factors as potential effect modifiers when investigating these associations. This knowledge will help to identify targeted interventions.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20105805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A single-center experience of COVID-19 infection in patients with primary immunodeficiency.

    Zhou, Jessie J / Jin, Celina / Leang, Zhi Xiang / Chatelier, Josh / Godsell, Jack / Tsang, Sylvia / Douglass, Jo A / Yong, Michelle K / Slavin, Monica / Bryant, Vanessa L / Slade, Charlotte A / Chan, Samantha

    The journal of allergy and clinical immunology. Global

    2024  Volume 3, Issue 2, Page(s) 100241

    Abstract: Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, ...

    Abstract Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, and local availability of vaccination and specific COVID-19 therapies. There are few reports on the experience of Australian patients with PID during the pandemic.
    Objectives: In this retrospective study, we describe the baseline characteristics and short-term outcomes of patients with PID who were infected by COVID-19 and known to the Royal Melbourne Hospital, a major tertiary center in Victoria, Australia.
    Methods: Between April 2021 and April 2022, a total of 31 of 138 patients with PID were affected by COVID-19. More than half of them had 3 vaccine doses at the time of infection (which at the time was considered being fully vaccinated) and received COVID-19-targeted treatment.
    Results: All of the infected patients had ambulatory disease, with no cases of morbidity or mortality. In line with the current literature, the PID subtypes described did not appear to independently predict worse outcomes.
    Conclusions: Some protective factors include this cohort's relatively younger average age and its high uptake of vaccination and COVID-19 therapies.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2024.100241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen.

    Idrose, Nur Sabrina / Lodge, Caroline J / Erbas, Bircan / Douglass, Jo A / Bui, Dinh S / Dharmage, Shyamali C

    International journal of environmental research and public health

    2022  Volume 19, Issue 12

    Abstract: Respiratory diseases such as asthma, allergic rhinitis (AR) and chronic obstructive pulmonary disease (COPD) affect millions worldwide and pose a significant global public health burden. Over the years, changes in land use and climate have increased ... ...

    Abstract Respiratory diseases such as asthma, allergic rhinitis (AR) and chronic obstructive pulmonary disease (COPD) affect millions worldwide and pose a significant global public health burden. Over the years, changes in land use and climate have increased pollen quantity, allergenicity and duration of the pollen season, thus increasing its impact on respiratory disease. Many studies have investigated the associations between short-term ambient pollen (i.e., within days or weeks of exposure) and respiratory outcomes. Here, we reviewed the current evidence on the association between short-term outdoor pollen exposure and thunderstorm asthma (TA), asthma and COPD hospital presentations, general practice (GP) consultations, self-reported respiratory symptoms, lung function changes and their potential effect modifiers. The literature suggests strong evidence of an association between ambient pollen concentrations and almost all respiratory outcomes mentioned above, especially in people with pre-existing respiratory diseases. However, the evidence on sub-clinical lung function changes, COPD, and effect modifiers other than asthma, hay fever and pollen sensitisation are still scarce and requires further exploration. Better understanding of the implications of pollen on respiratory health can aid healthcare professionals to implement appropriate management strategies.
    MeSH term(s) Allergens/adverse effects ; Asthma/epidemiology ; Asthma/etiology ; Humans ; Pollen/adverse effects ; Pulmonary Disease, Chronic Obstructive ; Rhinitis, Allergic, Seasonal/epidemiology ; Rhinitis, Allergic, Seasonal/etiology
    Chemical Substances Allergens
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19127541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Omalizumab in Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis.

    Jin, Meiling / Douglass, Jo A / Elborn, J Stuart / Agarwal, Ritesh / Calhoun, William J / Lazarewicz, Slawomir / Jaumont, Xavier / Yan, Meng

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 3, Page(s) 896–905

    Abstract: Background: An unmet clinical need exists in the management of treatment-refractory allergic bronchopulmonary aspergillosis (ABPA). Omalizumab has shown promising effects in case series and cohort studies; however, evidence to support its routine ... ...

    Abstract Background: An unmet clinical need exists in the management of treatment-refractory allergic bronchopulmonary aspergillosis (ABPA). Omalizumab has shown promising effects in case series and cohort studies; however, evidence to support its routine clinical use is lacking.
    Objective: The aim of this systematic review and meta-analysis was to evaluate the clinical effectiveness and safety of omalizumab in patients with ABPA.
    Methods: We conducted a systematic search across standard databases using specific key words until May 13, 2021. We performed a meta-analysis to compare the effectiveness (exacerbations, oral corticosteroid [OCS] use, lung function, and patient-reported asthma control) and safety of pre- and post-omalizumab treatment. Subgroup analyses were performed for treatment duration and underlying disease.
    Results: In total, 49 studies (n = 267) were included in the qualitative synthesis and 14 case series (n = 186) in the quantitative meta-analysis. Omalizumab treatment significantly reduced the annualized exacerbation rate compared with pretreatment (mean difference, -2.09 [95% CI, -3.07 to -1.11]; P < .01). There was a reduction in OCS use (risk difference, 0.65 [95% CI, 0.46-0.84]; P < .01), an increase in termination of OCS use (risk difference, 0.53 [95% CI, 0.24-0.82]; P < .01), and a reduction in OCS dose (milligrams per day) (mean difference, -14.62 [95% CI, -19.86 to -9.39]; P < .01) in ABPA patients receiving omalizumab. Omalizumab improved FEV
    Conclusions: Omalizumab treatment reduced exacerbations and OCS use, improved lung function and asthma control in patients with ABPA, and was well-tolerated. The results highlight the potential role of omalizumab in the treatment of ABPA.
    MeSH term(s) Humans ; Omalizumab/therapeutic use ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Cystic Fibrosis/drug therapy ; Asthma/drug therapy ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Omalizumab (2P471X1Z11) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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  9. Article ; Online: Safer approaches to therapeutic modulation of TGF-β signaling for respiratory disease.

    Lachapelle, Philippe / Li, Meina / Douglass, Jo / Stewart, Alastair

    Pharmacology & therapeutics

    2018  Volume 187, Page(s) 98–113

    Abstract: The transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is ... ...

    Abstract The transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is established in the most prevalent chronic respiratory diseases including asthma, COPD, lung cancer and idiopathic pulmonary fibrosis. Despite the overwhelming burden of respiratory diseases in the world, new pharmacological therapies have been limited in impact. Although TGF-β inhibition as a therapeutic strategy carries great expectations, the constraints in avoiding compromising the beneficial pleiotropic effects of TGF-β, including the anti-proliferative and immune suppressive effects, have limited the development of effective pharmacological modulators. In this review, we focus on the pathways subserving deleterious and beneficial TGF-β effects to identify strategies for selective modulation of more distal signaling pathways that may result in agents with improved safety/efficacy profiles. Adverse effects of TGF-β inhibitors in respiratory clinical trials are comprehensively reviewed, including those of the marketed TGF-β modulators, pirfenidone and nintedanib. Precise modulation of TGF-β signaling may result in new safer therapies for chronic respiratory diseases.
    MeSH term(s) Animals ; Humans ; Respiratory Tract Diseases/drug therapy ; Respiratory Tract Diseases/metabolism ; Signal Transduction ; Transforming Growth Factor beta/antagonists & inhibitors ; Transforming Growth Factor beta/metabolism
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2018-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2018.02.010
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    Zs.A 1183: Show issues Location:
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  10. Article ; Online: Thunderstorm asthma: an overview of mechanisms and management strategies.

    Thien, Francis / Davies, Janet M / Hew, Mark / Douglass, Jo A / O'Hehir, Robyn E

    Expert review of clinical immunology

    2020  Volume 16, Issue 10, Page(s) 1005–1017

    Abstract: Introduction: Epidemic thunderstorm asthma (ETSA) is due to a complex interaction of environmental and individual susceptibility factors, with outbreaks reported globally over the last four decades. Australia has been particularly susceptible with ... ...

    Abstract Introduction: Epidemic thunderstorm asthma (ETSA) is due to a complex interaction of environmental and individual susceptibility factors, with outbreaks reported globally over the last four decades. Australia has been particularly susceptible with nearly half of episodes reported internationally, culminating in the catastrophic Melbourne 2016 event.
    Areas covered: Reported ETSA episodes are reviewed for common environmental and meteorological risk factors. Allergen aerobiology interaction with thunderstorm activity and rapid weather condition changes is examined. Assessment of the clinical and immunological data highlights risk factors for ETSA presentation, hospital admission, and intensive care admission. Risk factors associated with ETSA deaths are evaluated. Public health strategies, as well as pharmacological and immunological management approaches to reduce individual susceptibility and prevent ETSA are discussed.
    Expert opinion: Improved understanding of the specific meteorological factors predisposing to the greatest risk of ETSA to improve forecasting is required. Better monitoring of aeroallergen levels in areas of greatest geographic risk, with further research into allergen aerobiology underpinning mechanisms of allergen exposure is needed. The role of climate change in increasing the risk of ETSA outbreaks requires further research. Public awareness and education are required to reduce exposure, and to improve uptake of pharmacological and immunological risk reduction and preventive strategies.
    MeSH term(s) Air Pollutants/immunology ; Allergens/immunology ; Asthma/immunology ; Asthma/therapy ; Climate Change ; Desensitization, Immunologic/methods ; Forecasting ; Gene-Environment Interaction ; Humans ; Patient Education as Topic ; Public Health ; Risk ; Weather
    Chemical Substances Air Pollutants ; Allergens
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2021.1826310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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