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Article: The Temporal Regulation of S Phase Proteins During G

Grant, Gavin D / Cook, Jeanette G

Advances in experimental medicine and biology

2017 Volume 1042, Page(s) 335–369

Abstract: ... to DNA replication initiation in S phase, a series of essential preparatory events in G ...

Abstract	Successful DNA replication requires intimate coordination with cell-cycle progression. Prior to DNA replication initiation in S phase, a series of essential preparatory events in G
MeSH term(s)	Animals ; Cell Cycle/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cyclin-Dependent Kinases/physiology ; DNA Replication/physiology ; G1 Phase/physiology ; Humans ; Replication Origin ; Retinoblastoma Protein/physiology ; S Phase/physiology
Chemical Substances	Cell Cycle Proteins ; Retinoblastoma Protein ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-10-6955-0_16
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Article ; Online: Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study.

Foschi, V / Bortolotti, D / Doyle, A F / Stratigou, V / Stephens, L / Trivedi, P / Rinaldi, R / Padovan, M / Bortoluzzi, A / Lightstone, L / Cairns, T D / Botto, M / Cook, T H / Rizzo, R / Govoni, M / Pickering, M C

Lupus

2019 Volume 28, Issue 9, Page(s) 1091–1100

Abstract: Background: The study aimed to investigate whether HLA-G antigen is expressed in the kidneys ... of HLA-G in glomeruli, tubules and infiltrating cells was examined and compared between lupus patients ... HLA-G staining was observed in the glomeruli of 20 of 30 samples from patients with LN. The expression ...

Abstract	Background: The study aimed to investigate whether HLA-G antigen is expressed in the kidneys of patients affected by lupus nephritis (LN) and whether its detection in renal biopsies could be adopted as a marker of treatment response and prognosis. Methods: Thirty renal biopsies from patients with LN were selected and analyzed through immunohistochemistry. Laboratory and clinical data were retrospectively collected at baseline, 6 and 12 months and at the latest clinical appointment. A number of patients (63.3%) were treated with rituximab (RTX) +/- methylprednisolone in the induction phase. The expression of HLA-G in glomeruli, tubules and infiltrating cells was examined and compared between lupus patients who achieved either complete or partial renal response and those who did not respond to treatment. Results: HLA-G staining was observed in the glomeruli of 20 of 30 samples from patients with LN. The expression of the antigen was detected in podocytes, along glomerular capillary walls, on parietal glomerular epithelial cells and within the juxtaglomerular apparatus. Seventy per cent of patients whose glomeruli expressed HLA-G achieved partial or complete response at 6 months and 75% at the latest available follow up compared with 30% and 40%, respectively, of those who did not show any expression. The pattern of staining in tubules and infiltrating cells was highly variable precluding any clinical correlation. Conclusion: This study demonstrates that HLA-G is expressed in renal tissue in LN. Our retrospective data suggest that its expression could correlate with response to treatment.
MeSH term(s)	Adult ; Anti-Inflammatory Agents/administration & dosage ; Biopsy ; Female ; Follow-Up Studies ; HLA-G Antigens/immunology ; Humans ; Immunologic Factors/administration & dosage ; Lupus Nephritis/drug therapy ; Lupus Nephritis/immunology ; Male ; Methylprednisolone/administration & dosage ; Middle Aged ; Pilot Projects ; Retrospective Studies ; Rituximab/administration & dosage ; Treatment Outcome ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; HLA-G Antigens ; Immunologic Factors ; Rituximab (4F4X42SYQ6) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/0961203319860582
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Article ; Online: Diterpenoids from Gutierrezia sarothrae and G. microcephala: Chemical diversity, chemophenetics and implications to toxicity in grazing livestock.

Gardner, Dale R / Cook, Daniel / Larsen, Scott W / Stonecipher, Clinton A / Johnson, Robert

Phytochemistry

2020 Volume 178, Page(s) 112465

Abstract: Broom snakeweed (Gutierrezia sarothrae) and threadleaf snakeweed (G. microcephala) are ... reported as occurring in G. sarathorea or G. microcephala, while another eight compounds were previously ...

Abstract	Broom snakeweed (Gutierrezia sarothrae) and threadleaf snakeweed (G. microcephala) are suffrutescent plants found in many parts of western US rangelands and are possibly toxic to grazing livestock. The toxic components are not known, but it has been suggested that the diterpene acids may be both toxic and abortifacient. One hundred sixty-two samples of snakeweed were collected from 55 locations in Colorado, Oklahoma, New Mexico, Texas, Wyoming and Utah and were taxonomically classified. Samples were analyzed by GC-MS in a chemophenetic analysis and grouped into individual chemotypes based on diterpene acid content. The GC-MS profiles were found to be diverse showing at least eight different chemotypes. From each of the chemotypes the major diterpene acids were isolated and characterized by IR, MS and NMR spectroscopy. Twenty-one diterpenoids were identified and found to be a mix of furano, lactone, di-acid and esters of labdane, ent-labdane and chlerodane acids and alcohols. Only four of the 21 compounds isolated had been previously reported as occurring in G. sarathorea or G. microcephala, while another eight compounds were previously reported from other Gutierrezia or related species. Nine of the isolated diterpenoids have not been previously reported and their structure elucidation is reported.
MeSH term(s)	Animals ; Asteraceae ; Diterpenes ; Livestock
Chemical Substances	Diterpenes
Keywords	covid19
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2020.112465
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Article: APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.

Viscusi, Eugene R / Skobieranda, Franck / Soergel, David G / Cook, Emily / Burt, David A / Singla, Neil

Journal of pain research

2019 Volume 12, Page(s) 927–943

Abstract: Purpose: Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide ...

Abstract	Purpose: Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids. Patients and methods: APOLLO-1 (NCT02815709) was a phase III, double-blind, randomized trial in patients with moderate-to-severe pain following bunionectomy. Patients received a loading dose of either placebo, oliceridine (1.5 mg), or morphine (4 mg), followed by demand doses via patient-controlled analgesia (0.1, 0.35, or 0.5 mg oliceridine, 1 mg morphine, or placebo). The primary endpoint compared the proportion of treatment responders through 48 hours for oliceridine regimens and placebo. Secondary outcomes included a composite measure of respiratory safety burden (RSB, representing the cumulative duration of respiratory safety events) and the proportion of treatment responders vs morphine. Results: Effective analgesia was observed for all oliceridine regimens, with responder rates of 50%, 62%, and 65.8% in the 0.1 mg, 0.35 mg, and 0.5 mg regimens, respectively (all Conclusion: Oliceridine is a novel and effective IV analgesic providing rapid analgesia for the relief of moderate-to-severe acute postoperative pain compared to placebo. Additionally, it has a favorable safety and tolerability profile with regard to respiratory and gastrointestinal adverse effects compared to morphine, and may provide a new treatment option for patients with moderate-to-severe postoperative pain where an IV opioid is required.
Language	English
Publishing date	2019-03-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S171013
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Article ; Online: LC-MS/MS Validation of a Residue Analysis Method for Penicillin G and Its Metabolites in Commercial Orange Juice.

Aldeek, Fadi / Canzani, Daniele / Standland, Matthew / Hammack, Walter / Cook, Jo-Marie / Crosswhite, Mark R / Gerard, Ghislain

Journal of AOAC International

2016 Volume 100, Issue 1, Page(s) 189–197

Abstract: ... Of the antibiotics used to treat this disease, penicillin G has been one of the most effective. Because orange ... tandem MS method to screen for penicillin G and its metabolites (penillic and penilloic acids ... at the chemical residue level after treatment. In this method, three spike levels (0.25, 1, and 20 ng/g) were ...

Abstract	Florida citrus depends on a breakthrough in the fight against citrus greening disease. Of the antibiotics used to treat this disease, penicillin G has been one of the most effective. Because orange fruit grown in the state of Florida are mainly used to produce orange juice, we have validated an ultra-HPLC tandem MS method to screen for penicillin G and its metabolites (penillic and penilloic acids) at the chemical residue level after treatment. In this method, three spike levels (0.25, 1, and 20 ng/g) were tested in triplicate. Absolute recoveries for penillic and penilloic acids were 60-75% depending on the matrix used, whereas corrected recoveries of penicillin G using an isotopically labeled internal standard were ~100%. Two product ion transitions per analyte were required for identification, which contributes to a high degree of selectivity.
MeSH term(s)	Chromatography, High Pressure Liquid ; Citrus sinensis ; Fruit and Vegetable Juices/analysis ; Penicillin G/analysis ; Tandem Mass Spectrometry
Chemical Substances	Penicillin G (Q42T66VG0C)
Language	English
Publishing date	2016-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1103149-9
ISSN	1944-7922 ; 1060-3271
ISSN (online)	1944-7922
ISSN	1060-3271
DOI	10.5740/jaoacint.16-0166
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Article ; Online: Identification of Penicillin G Metabolites under Various Environmental Conditions Using UHPLC-MS/MS.

Aldeek, Fadi / Canzani, Daniele / Standland, Matthew / Crosswhite, Mark R / Hammack, Walter / Gerard, Ghislain / Cook, Jo-Marie

Journal of agricultural and food chemistry

2016 Volume 64, Issue 31, Page(s) 6100–6107

Abstract: In this work, we investigate the stability of penicillin G in various conditions including acidic ... greening disease. The identification, confirmation, and quantitation of penicillin G and its various ... Orbitrap and Sciex 6500 QTrap). Our data show that under acidic and alkaline conditions, penicillin G ...

Abstract	In this work, we investigate the stability of penicillin G in various conditions including acidic, alkaline, natural acidic matrices and after treatment of citrus trees that are infected with citrus greening disease. The identification, confirmation, and quantitation of penicillin G and its various metabolites were evaluated using two UHPLC-MS/MS systems with variable capabilities (i.e., Thermo Q Exactive Orbitrap and Sciex 6500 QTrap). Our data show that under acidic and alkaline conditions, penicillin G at 100 ng/mL degrades quickly, with a determined half-life time of approximately 2 h. Penillic acid, penicilloic acid, and penilloic acid are found to be the most abundant metabolites of penicillin G. These major metabolites, along with isopenillic acid, are found when penicillin G is used for treatment of citrus greening infected trees. The findings of this study will provide insight regarding penicillin G residues in agricultural and biological applications.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Chromatography, High Pressure Liquid/methods ; Citrus/chemistry ; Citrus/metabolism ; Half-Life ; Penicillin G/chemistry ; Penicillin G/metabolism ; Plant Diseases/prevention & control ; Tandem Mass Spectrometry/methods
Chemical Substances	Anti-Bacterial Agents ; Penicillin G (Q42T66VG0C)
Language	English
Publishing date	2016-08-10
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.5b06150
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Article ; Online: G protein-coupled receptors as anabolic drug targets in osteoporosis.

Diepenhorst, Natalie / Rueda, Patricia / Cook, Anna E / Pastoureau, Philippe / Sabatini, Massimo / Langmead, Christopher J

Pharmacology & therapeutics

2017 Volume 184, Page(s) 1–12

Abstract: ... teriparatide, mediate their actions via the G protein-coupled calcium-sensing and parathyroid hormone-1 ...

Abstract	Osteoporosis is a progressive bone disorder characterised by imbalance between bone building (anabolism) and resorption (catabolism). Most therapeutics target inhibition of osteoclast-mediated bone resorption, but more recent attention in early drug discovery has focussed on anabolic targets in osteoblasts or their precursors. Two marketed agents that display anabolic properties, strontium ranelate and teriparatide, mediate their actions via the G protein-coupled calcium-sensing and parathyroid hormone-1 receptors, respectively. This review explores their activity, the potential for improved therapeutics targeting these receptors and other putative anabolic GPCR targets, including Smoothened, Wnt/Frizzled, relaxin family peptide, adenosine, cannabinoid, prostaglandin and sphingosine-1-phosphate receptors.
MeSH term(s)	Humans ; Models, Biological ; Molecular Targeted Therapy/methods ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Receptors, G-Protein-Coupled/agonists ; Teriparatide/agonists ; Thiophenes/agonists
Chemical Substances	Receptors, G-Protein-Coupled ; Thiophenes ; strontium ranelate (04NQ160FRU) ; Teriparatide (10T9CSU89I)
Language	English
Publishing date	2017-11-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2017.10.015
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Article ; Online: G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

Lee, Ming-Chin / McCubbin, James A / Christensen, Anne D / Poole, Daniel P / Rajasekhar, Pradeep / Lieu, TinaMarie / Bunnett, Nigel W / Garcia-Caraballo, Sonia / Erickson, Andelain / Brierley, Stuart M / Saleh, Reem / Achuthan, Adrian / Fleetwood, Andrew J / Anderson, Robin L / Hamilton, John A / Cook, Andrew D

Journal of immunology (Baltimore, Md. : 1950)

2017 Volume 198, Issue 9, Page(s) 3565–3575

Abstract: G-CSF or CSF-3, originally defined as a regulator of granulocyte lineage development via its cell ... surface receptor (G-CSFR), can play a role in inflammation, and hence in many pathologies, due ... symptom, the efficacy of an anti-G-CSFR mAb for arthritic pain and disease was compared ...

Abstract	G-CSF or CSF-3, originally defined as a regulator of granulocyte lineage development via its cell surface receptor (G-CSFR), can play a role in inflammation, and hence in many pathologies, due to its effects on mature lineage populations. Given this, and because pain is an extremely important arthritis symptom, the efficacy of an anti-G-CSFR mAb for arthritic pain and disease was compared with that of a neutrophil-depleting mAb, anti-Ly6G, in both adaptive and innate immune-mediated murine models. Pain and disease were ameliorated in Ag-induced arthritis, zymosan-induced arthritis, and methylated BSA/IL-1 arthritis by both prophylactic and therapeutic anti-G-CSFR mAb treatment, whereas only prophylactic anti-Ly6G mAb treatment was effective. Efficacy for pain and disease correlated with reduced joint neutrophil numbers and, importantly, benefits were noted without necessarily the concomitant reduction in circulating neutrophils. Anti-G-CSFR mAb also suppressed zymosan-induced inflammatory pain. A new G-CSF-driven (methylated BSA/G-CSF) arthritis model was established enabling us to demonstrate that pain was blocked by a cyclooxygenase-2 inhibitor, suggesting an indirect effect on neurons. Correspondingly, dorsal root ganglion neurons cultured in G-CSF failed to respond to G-CSF in vitro, and
MeSH term(s)	Animals ; Antibodies, Blocking/therapeutic use ; Antigens, Ly/immunology ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/immunology ; Arthritis, Experimental/therapy ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Cells, Cultured ; Disease Models, Animal ; Granulocyte Colony-Stimulating Factor/metabolism ; Humans ; Immunotherapy/methods ; Leukocyte Reduction Procedures ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/physiology ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/pathology ; Pain Management ; Receptors, Granulocyte Colony-Stimulating Factor/genetics ; Receptors, Granulocyte Colony-Stimulating Factor/immunology ; Receptors, Granulocyte Colony-Stimulating Factor/metabolism
Chemical Substances	Antibodies, Blocking ; Antigens, Ly ; Ly6G antigen, mouse ; Receptors, Granulocyte Colony-Stimulating Factor ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2017-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1602127
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Article ; Online: Cytomegalovirus immunoglobulin G titers do not predict reactivation risk in immunocompetent hosts.

Mansfield, Sara A / Dwivedi, Varun / Elgharably, Haytham / Griessl, Marion / Zimmerman, Peter D / Limaye, Ajit P / Cook, Charles H

Journal of medical virology

2019 Volume 91, Issue 5, Page(s) 836–844

Abstract: ... the hypothesis that serum CMV-specific immunoglobulin G (IgG) correlates with tissue viral load, and might be ...

Abstract	Cytomegalovirus (CMV) reactivation occurs in roughly one-third of immunocompetent patients during critical illness, and is associated with worse outcomes. These outcomes have prompted consideration of early antiviral prophylaxis, but two-third of patients would receive unnecessary treatment. Tissue viral load has been associated with risk of reactivation in murine models, and recent work has suggested a relationship between immune responses to CMV and underlying viral load. We, therefore, sought to confirm the hypothesis that serum CMV-specific immunoglobulin G (IgG) correlates with tissue viral load, and might be used to predict the risk of reactivation during critical illness. We confirm that there is a good correlation between tissue viral load and serum CMV-specific IgG after laboratory infection of inbred mice. Further, we show that naturally infected outbred hosts have variable tissue viral DNA loads that do not correlate well with serum IgG. Perhaps as a consequence, CMV-specific IgG was not predictive of reactivation events in immunocompetent humans. When reactivation did occur, those with the lowest IgG levels had longer durations of reactivation, but IgG quartiles were not associated with differing peak DNAemia. Together our data suggest that CMV-specific IgG titers diverge from tissue viral loads in outbred immunocompetent hosts, and their importance for the control of reactivation events remains unclear.
MeSH term(s)	Animals ; Antibodies, Viral/blood ; Cytomegalovirus Infections/diagnosis ; Disease Models, Animal ; Female ; Immunoglobulin G/blood ; Mice, Inbred BALB C ; Muromegalovirus/immunology ; Viral Load ; Virus Activation
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2019-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25389
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Article ; Online: Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.

Okusaga, Olaoluwa / Fuchs, Dietmar / Reeves, Gloria / Giegling, Ina / Hartmann, Annette M / Konte, Bettina / Friedl, Marion / Groer, Maureen / Cook, Thomas B / Stearns-Yoder, Kelly A / Pandey, Janardan P / Kelly, Deanna L / Hoisington, Andrew J / Lowry, Christopher A / Eaton, William W / Brenner, Lisa A / Rujescu, Dan / Postolache, Teodor T

Psychosomatic medicine

2016 Volume 78, Issue 8, Page(s) 931–939

Abstract: ... Methods: We measured serum antigliadin immunoglobulin G (IgG), KYN, and TRP in 950 patients ...

Abstract	Objective: Several studies have reported an association between nonceliac gluten sensitivity and schizophrenia. Immune and kynurenine (KYN) pathways have also been implicated in the pathophysiology of schizophrenia, and certain proinflammatory immune mediators may increase KYN and reduce tryptophan (TRP) levels. Methods: We measured serum antigliadin immunoglobulin G (IgG), KYN, and TRP in 950 patients with schizophrenia. Patients with antibody level at the 90th percentile or higher of control participants (21.9% of all patients) were classified as having elevated antigliadin IgG. Independent t tests and linear regression models were used to compare TRP, KYN, and KYN-TRP ratio (indicator of TRP metabolism) between patients with and those without elevated antigliadin IgG. The correlation between antigliadin IgG and TRP, KYN, and the ratio was also evaluated in the patients. Results: KYN and KYN-TRP ratio were higher in patients with elevated antigliadin IgG (geometric mean [standard deviation {SD}] = 2.65 [0.25] µmol/L versus 2.25 [0.23] µmol/L [p < .001] and 0.05 [0.26] versus 0.04 [0.25; p = .001] respectively), findings robust to adjustment for potential demographic and clinical confounders. Antigliadin IgG positively correlated with KYN and KYN-TRP ratio (r = 0.12, p < .001; r = 0.11, p = .002). TRP did not differ between the two groups and did not correlate with antigliadin IgG. Conclusions: Our results connect nonceliac gluten sensitivity with the KYN pathway of TRP metabolism in psychotic illness and hint toward potential individualized treatment targets.
MeSH term(s)	Adult ; Female ; Gliadin/immunology ; Humans ; Immunoglobulin G/blood ; Kynurenine/blood ; Male ; Middle Aged ; Schizophrenia/blood ; Schizophrenia/immunology ; Tryptophan/blood
Chemical Substances	Immunoglobulin G ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Gliadin (9007-90-3)
Language	English
Publishing date	2016-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000000352
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