LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 3091

Search options

  1. Book: Endocrine management in the intensive care unit

    Cooper, Mark S. / Venkatesh, Bala

    (Best practice & research : Clinical endocrinology & metabolism ; 25,5)

    2011  

    Author's details Mark S. Cooper ; Bala Venkatesh, guest ed
    Series title Best practice & research : Clinical endocrinology & metabolism ; 25,5
    Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Collection Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Language English
    Size S. 703 - 859 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016993822
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  2. Article ; Online: Recycling glucocorticoids: therapeutic implications of the 11β-HSD1 enzyme system.

    Tsai, Kevin H / Cooper, Mark S

    The Journal of endocrinology

    2023  Volume 258, Issue 3

    Abstract: Endogenous glucocorticoids and commonly used oral glucocorticoids have the property of existing in an inactive and active form in vivo. The inactive form can be converted back to the active form, or 'recycled' in cells and tissues that express the 11β- ... ...

    Abstract Endogenous glucocorticoids and commonly used oral glucocorticoids have the property of existing in an inactive and active form in vivo. The inactive form can be converted back to the active form, or 'recycled' in cells and tissues that express the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This recycling provides an important contribution to the action of glucocorticoids. This review examines the literature relating to the importance of 11β-HSD1 activity during glucocorticoid treatment, with an emphasis on studies examining bone and joint disease and the ability of glucocorticoids to suppress inflammatory damage in models of arthritis. Animal models with global or selective deletion of 11β-HSD1 have determined the extent to which this recycling is important in normal physiology and during treatment with oral glucocorticoids. These studies demonstrate that 11β-HSD1-mediated recycling of inactive glucocorticoids has a substantial action and indeed is responsible for the majority of the effects of orally administered glucocorticoids on a range of tissues. Importantly, the anti-inflammatory actions of glucocorticoids appear largely through this mechanism such that mice that lack 11β-HSD1 are resistant to the anti-inflammatory actions of glucocorticoids. The recognition that to a large extent the circulating inactive counterpart of these glucocorticoids is more important to anti-inflammatory effects than the active glucocorticoid presents novel opportunities to more selectively target glucocorticoids to tissues or to reduce the likely side effects.
    MeSH term(s) Mice ; Animals ; Glucocorticoids/pharmacology ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Bone and Bones
    Chemical Substances Glucocorticoids ; 11-beta-Hydroxysteroid Dehydrogenase Type 1 (EC 1.1.1.146) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-22-0289
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Demystifying adrenal dysfunction in severe illness.

    Cooper, Mark S

    Clinical endocrinology

    2019  Volume 91, Issue 3, Page(s) 372–373

    MeSH term(s) Adrenal Insufficiency ; Cosyntropin ; Glucocorticoids ; Humans ; Pituitary-Adrenal System ; Pneumonia
    Chemical Substances Glucocorticoids ; Cosyntropin (16960-16-0)
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Glucocorticoid-Induced Psychosis in Children and Adolescents: A Systematic Review.

    Fani-Molky, Parisa / Bradley, Jarrod / Cooper, Mark S

    Journal of child and adolescent psychopharmacology

    2023  Volume 33, Issue 3, Page(s) 78–90

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Child ; Humans ; Adolescent ; Male ; Female ; Glucocorticoids/adverse effects ; Prednisone ; Psychotic Disorders/drug therapy ; Antipsychotic Agents/therapeutic use ; Psychotropic Drugs/therapeutic use
    Chemical Substances Glucocorticoids ; Prednisone (VB0R961HZT) ; Antipsychotic Agents ; Psychotropic Drugs
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2022.0077
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Book ; Online: Chapter 2 From the Heritage of African American Slavery to Modern Civil Rights Protection

    Cooper, Phillip J.

    2016  

    Abstract: Promises of justice and equality made in the U.S. Constitution, numerous Amendments, and ... that persist in a nation that proudly points to the words above the entrance to the U.S. Supreme Court ... decisions of the Supreme Court are hallmarks of American civil rights. Yet the realities of inequality remain facts of modern ...

    Abstract Promises of justice and equality made in the U.S. Constitution, numerous Amendments, and decisions of the Supreme Court are hallmarks of American civil rights. Yet the realities of inequality remain facts of modern life for too many Native Americans, African Americans, and Latino Americans, even though state-mandated racial segregation has been outlawed for years. Women still face a variety of forms of discrimination-some subtle and others more overt. There remain many laws that treat people differently because of sexual orientation. People with disabilities are supposed to be protected by a variety of statutes, but many of these policies remain unfulfilled promises. These are just some of the many challenges of civil rights that persist in a nation that proudly points to the words above the entrance to the U.S. Supreme Court that read Equal Justice Under Law.-

    -This text is for current and future public service professionals -whether they are in government agencies, in nonprofit organizations that provide social services for government, or contractors who operate as state actors-who increasingly serve diverse communities with a range of complex challenges, while working and managing within organizations that, fortunately, are themselves more diverse than ever before. For those who work and serve in such settings, civil rights is not an abstract academic study, but a critically important and very practical fact of daily life.-

    This book may also be used on civil rights law, policy, and public administration courses, and each chapter ends with a section on 'Issues for Policy and Practice' to guide an examination of key public policy hurdles in the fight for civil rights as well as the implications for public service practice.  Through an engaging exploration of edited court cases, legislation, and speeches, the reader is encouraged to think critically about civil rights law and policy pertaining to African Americans, Native Americans, Latinos/Latinas, gender, sexual orientation, and disabilities, to learn what civil rights require, but also to come to a more empathetic understanding of how different groups of people experience civil rights and the unique challenges they face
    Size 1 electronic resource ( pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020676490
    ISBN 9781138856523 ; 1138856525
    DOI 10.4324/9781315719566
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  6. Article ; Online: Making waves: The changing tide of cerebral palsy.

    Cooper, Monica S / Fahey, Michael C / Mackay, Mark T

    Journal of paediatrics and child health

    2022  Volume 58, Issue 11, Page(s) 1929–1934

    Abstract: Cerebral palsy (CP) is a broad diagnosis unbound by aetiology and is based on a clinical examination demonstrating abnormalities of movement or posture. CP represents a static neurological condition, provided that neurodegenerative conditions, ... ...

    Abstract Cerebral palsy (CP) is a broad diagnosis unbound by aetiology and is based on a clinical examination demonstrating abnormalities of movement or posture. CP represents a static neurological condition, provided that neurodegenerative conditions, leukoencephalopathies and neuromuscular disorders are excluded. In paediatrics, the genetic conditions associated with CP are rapidly increasing, with primary and overlapping neurodevelopmental conditions perhaps better categorised by the predominant clinical feature such as CP, intellectual disability, autism spectrum disorder or epilepsy. Progress in molecular genetics may challenge what constitutes CP, but a genetic diagnosis does not negate the CP diagnosis. As clinicians working in the field, we discuss the changing tide of CP. Neuroimaging provides essential information through pattern recognition and demonstration of static brain changes. We present examples of children where a layered clinical diagnosis or dual aetiologies are appropriate. We also present examples of children with genetic causes of CP to highlight the challenges and limitations of neuroimaging to provide an aetiological diagnosis. In consultation with a geneticist, access to genomic testing (exome or genome sequencing) is now available in Australia under Medicare billing for children under the age of 10 with dysmorphic features, one or more major structural organ anomalies, (an evolving) intellectual disability or global developmental delay. We encourage the uptake of genomic testing in CP, because it can be difficult to tell whether a child has an environmental or genetic cause for CP. A specific genetic diagnosis may change patient management, reduce guilt and enable more distinctive research in the future to assist with understanding disease mechanisms.
    MeSH term(s) Aged ; Child ; Humans ; Cerebral Palsy/etiology ; Cerebral Palsy/complications ; Intellectual Disability/etiology ; Intellectual Disability/complications ; Autism Spectrum Disorder/complications ; National Health Programs ; Epilepsy
    Language English
    Publishing date 2022-09-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16186
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Paroxysmal Nonepileptic Events in Children With Epilepsy and Cerebral Palsy.

    Cooper, Monica S / Fahey, Michael C / Dagia, Charuta / Reddihough, Dinah / Reid, Susan M / Mackay, Mark T

    Journal of child neurology

    2023  Volume 38, Issue 5, Page(s) 336–346

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Child ; Humans ; Cerebral Palsy/complications ; Retrospective Studies ; Epilepsy/complications ; Seizures/etiology ; Brain Injuries ; Electroencephalography/methods
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/08830738231176055
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe.

    Martin, Claire S / Cooper, Mark S / Hardy, Rowan S

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 733611

    Abstract: The role of tissue specific metabolism of endogenous glucocorticoids (GCs) in the pathogenesis of human disease has been a field of intense interest over the last 20 years, fuelling clinical trials of metabolism inhibitors in the treatment of an array of ...

    Abstract The role of tissue specific metabolism of endogenous glucocorticoids (GCs) in the pathogenesis of human disease has been a field of intense interest over the last 20 years, fuelling clinical trials of metabolism inhibitors in the treatment of an array of metabolic diseases. Localised pre-receptor metabolism of endogenous and therapeutic GCs by the 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes (which interconvert endogenous GCs between their inactive and active forms) are increasingly recognised as being critical in mediating both their positive and negative actions on bone homeostasis. In this review we explore the roles of endogenous and therapeutic GC metabolism by the 11β-HSD enzymes in the context of bone metabolism and bone cell function, and consider future strategies aimed at modulating this system in order to manage and treat various bone diseases.
    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenases/metabolism ; 11-beta-Hydroxysteroid Dehydrogenases/physiology ; Animals ; Bone Development/physiology ; Bone Diseases/etiology ; Bone Diseases/metabolism ; Bone Diseases/pathology ; Bone and Bones/metabolism ; Bone and Bones/physiology ; Glucocorticoids/metabolism ; Glucocorticoids/physiology ; Humans
    Chemical Substances Glucocorticoids ; 11-beta-Hydroxysteroid Dehydrogenases (EC 1.1.1.146)
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.733611
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Challenges and limitations of clinical trials in the adolescent and young adult CNS cancer population: A systematic review.

    Byrne, Emma M / Pascoe, Maeve / Cooper, Diane / Armstrong, Terri S / Gilbert, Mark R

    Neuro-oncology advances

    2023  Volume 6, Issue 1, Page(s) vdad159

    Abstract: Background: The adolescent and young adult (AYA) cancer population, aged 15-39, carries significant morbidity and mortality. Despite growing recognition of unique challenges with this age group, there has been little documentation of unmet needs in ... ...

    Abstract Background: The adolescent and young adult (AYA) cancer population, aged 15-39, carries significant morbidity and mortality. Despite growing recognition of unique challenges with this age group, there has been little documentation of unmet needs in their care, trial participation, and quality of life, particularly in those with primary brain tumors.
    Methods: A systematic literature review of 4 databases was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. Studies included editorials, reviews, and practice guidelines on the challenges and limitations faced by the AYA population. Papers had to address CNS tumors.
    Results: Sixty-eight studies met the inclusion criteria. The challenges and limitations in clinical trials in the AYA population were synthesized into 11 categories: molecular heterogeneity, tumor biology, diagnostic delay, access to care, physician factors, patient factors, primary brain tumor (PBT) factors, accrual, limited trials, long term follow up, and trial design. The published papers' recommendations were categorized based on the target of the recommendation: providers, coordination of care, organizations, accrual, and trial design. The AYA cancer population was found to suffer from unique challenges and barriers to care and the construction of trials.
    Conclusions: The AYA CNS cancer population suffers from unique challenges and barriers to care and construction of trials that make it critical to acknowledge AYAs as a distinct patient population. In addition, AYAs with primary brain tumors are underrecognized and underreported in current literature. More studies in the AYA primary brain tumor patient population are needed to improve their care and participation in trials.
    Language English
    Publishing date 2023-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdad159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: The use of Bayesian Belief Networks (BBNs) to probe deeper into railway safety management systems - Two studies from Great Britain and Italy.

    Cooper, Alistair / Mazzeo, Francesco / Waterson, Patrick / Young, Mark S / Louis, Dominique

    Applied ergonomics

    2023  Volume 109, Page(s) 103968

    Abstract: The importance of Safety Management Systems (SMS) to the railway industry is underlined by the fact that all organisations operating on UK railways are required by law to have one. Analysing SMSs can provide a reliable systemic tool to identify hazards ... ...

    Abstract The importance of Safety Management Systems (SMS) to the railway industry is underlined by the fact that all organisations operating on UK railways are required by law to have one. Analysing SMSs can provide a reliable systemic tool to identify hazards and weaknesses within complex systems like the railway, making it possible to significantly increase safety, reducing the odds of near misses and accidents. However, there is little empirical research evidence to determine the impact on safety of a structured SMS. The current paper describes two studies which use Bayesian Belief Networks (BBN) to conceptualise SMSs and their impact on front-line performance. The paper presents the usefulness of BBNs to compare complex systems and reconcile cultural differences within the railway industry, identifying factors that are deemed vital within Italy and Britain. The two studies allowed us to identify the most influential factors within a SMS and how they interact with each other, as well as the strength of the identified relationships. A BBN is particularly useful in estimating how changing some of the node states (e.g., by making safety leadership present) affected the other factors. The current study showed that safety leadership has an impact on the SMSs of the British and Italian railway industries.
    MeSH term(s) Humans ; United Kingdom ; Bayes Theorem ; Accidents ; Safety Management ; Italy ; Railroads
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2003513-5
    ISSN 1872-9126 ; 0003-6870
    ISSN (online) 1872-9126
    ISSN 0003-6870
    DOI 10.1016/j.apergo.2023.103968
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top