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Article ; Online: Secondary laryngeal and pulmonary syphilis: A case report.

Borriello, Silvia / Delmonte, Sergio / Bisciari, Tiziana / Mastorino, Luca / Ribero, Simone / Quaglino, Pietro

Journal of the European Academy of Dermatology and Venereology : JEADV

2024

Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19835
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Article ; Online: Exploring the role of epigenetic alterations and non-coding RNAs in melanoma pathogenesis and therapeutic strategies.

Rubatto, Marco / Borriello, Silvia / Sciamarrelli, Nadia / Pala, Valentina / Tonella, Luca / Ribero, Simone / Quaglino, Pietro

Melanoma research

2023 Volume 33, Issue 6, Page(s) 462–474

Abstract: Melanoma is a rare but highly lethal type of skin cancer whose incidence is increasing globally. Melanoma is characterized by high resistance to therapy and relapse. Despite significant advances in the treatment of metastatic melanoma, many patients ... ...

Abstract	Melanoma is a rare but highly lethal type of skin cancer whose incidence is increasing globally. Melanoma is characterized by high resistance to therapy and relapse. Despite significant advances in the treatment of metastatic melanoma, many patients experience progression due to resistance mechanisms. Epigenetic changes, including alterations in chromatin remodeling, DNA methylation, histone modifications, and non-coding RNA rearrangements, contribute to neoplastic transformation, metastasis, and drug resistance in melanoma. This review summarizes current research on epigenetic mechanisms in melanoma and their therapeutic potential. Specifically, we discuss the role of histone acetylation and methylation in gene expression regulation and melanoma pathobiology, as well as the promising results of HDAC inhibitors and DNMT inhibitors in clinical trials. We also examine the dysregulation of non-coding RNA, particularly miRNAs, and their potential as targets for melanoma therapy. Finally, we highlight the challenges of epigenetic therapies, such as the complexity of epigenetic mechanisms combined with immunotherapies and the need for combination therapies to overcome drug resistance. In conclusion, epigenetic changes may be reversible, and the use of combination therapy between traditional therapies and epigenetically targeted drugs could be a viable solution to reverse the increasing number of patients who develop treatment resistance or even prevent it. While several clinical trials are underway, the complexity of these mechanisms presents a significant challenge to the development of effective therapies. Further research is needed to fully understand the role of epigenetic mechanisms in melanoma and to develop more effective and targeted therapies.
MeSH term(s)	Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Neoplasm Recurrence, Local/genetics ; DNA Methylation ; Epigenesis, Genetic ; MicroRNAs/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-10-02
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000926
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Article: Rheological Properties, Particle Size Distribution and Physical Stability of Novel Refined Pumpkin Seed Oil Creams with Oleogel and Lucuma Powder.

Borriello, Angela / Miele, Nicoletta Antonella / Masi, Paolo / Cavella, Silvana

Foods (Basel, Switzerland)

2022 Volume 11, Issue 13

Abstract: This research aimed to develop new hazelnut and pumpkin seed oil-based creams and to assess the effect of different fat and sugar phases on the structure and physical properties of those creams at different refining degrees. In this study, three novel ... ...

Abstract	This research aimed to develop new hazelnut and pumpkin seed oil-based creams and to assess the effect of different fat and sugar phases on the structure and physical properties of those creams at different refining degrees. In this study, three novel spreadable creams were prepared in a stirred ball-mill: CBS with cocoa butter, pumpkin seed oil and saccharose; OS with pumpkin seed oil and carnauba wax-basedoleogel and saccharose; OLS with oleogel, saccharose and Lucuma powder. OS and CBS creams reached a D90 value lower than 30 µm at 150 min of refining, the OLS cream showed the highest D90 value, with a particle size distribution and a rheological behaviour little affected by the refining time. The OS and CBS creams differed in yield stress, indicating that the attractive particle-particle interactions are affected not only by the particle size, but also by fat composition. Moreover, all the creams showed solid-like behaviour and a good tolerance to deformation rate, a high oil-binding capacity and a good physical stability. Thus, it is possible to reformulate spreadable creams with healthier nutritional profiles.
Language	English
Publishing date	2022-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11131844
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Article ; Online: [Examination of Urinary Sediment in a Patient with Lupus-Like HIV-Associated Immune Complex Kidney Disease (HIVICK) - Case Report and Review of the Literature].

Borriello, Gianmarco / Nigro, Michelangelo / D'Angiò, Pierluigi / Laurino, Simona / Gigliotti, Andrea / Viggiano, Davide / Gigliotti, Giuseppe

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2024 Volume 41, Issue 1

Abstract: Renal involvement is very common in patients with HIV infection. The phenotype varies from the most frequently "collapsing" variant of focal and segmental glomerulosclerosis (FSGS) to "lupus-like HIV-immune complex kidney disease" (HIVICK). The latter is ...

Abstract	Renal involvement is very common in patients with HIV infection. The phenotype varies from the most frequently "collapsing" variant of focal and segmental glomerulosclerosis (FSGS) to "lupus-like HIV-immune complex kidney disease" (HIVICK). The latter is characterized by a histological picture that recalls lupus nephropathy. Through a clinical case, we underline the importance of urinary sediment analysis in patients with suspected glomerulopathy. Findings such as the characteristic cells that show the typical appearance of Herpes virus (HSV) infection or LE cells have significantly supported the diagnosis of HIVICK. In light of the present observations, we suggest systematically carrying out a cytological examination of the urinary sediment to confirm diagnostic hypotheses of rare pathologies.
MeSH term(s)	Humans ; HIV Infections/complications ; HIV Infections/pathology ; Antigen-Antibody Complex ; HIV ; Kidney/pathology ; Glomerulosclerosis, Focal Segmental/pathology ; Kidney Diseases/pathology
Chemical Substances	Antigen-Antibody Complex
Language	Italian
Publishing date	2024-02-28
Publishing country	Italy
Document type	Review ; Case Reports ; English Abstract
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article: Novel pumpkin seed oil-based oleogels: development and physical characterization

Borriello, A. / Masi, P. / Cavella, S.

LWT - food science and technology

2021 Volume 152, Issue -, Page(s) 112165

Language	English
Document type	Article
ZDB-ID	2169058-3
ISSN	0023-6438
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Ocular Ultrasonography in Healthy Calves with Different Transducers

Borriello, Giuliano / Valentini, Flaminia / Rampinelli, Mauro / Ferrini, Sara / Cagnotti, Giulia / D’angelo, Antonio / Bellino, Claudio

Animals. 2023 Feb. 19, v. 13, no. 4

2023

Abstract: ... probes measuring the same biometric parameter) comparisons were performed using Student’s t-test and ... the Mann–Whitney U test. Statistical significance was set at p ≤ 0.05. Intragroup comparison revealed ... and the vertical (85 out of 320, 26%) (p ≤ 0.001) scans were obtained with the convex transducer ...

Abstract	Ocular ultrasonography is seldom performed in cattle. Here, we compared three ultrasound probes (linear, convex, transrectal gynecological) for the measurement of eight eye biometry parameters on vertical and horizontal scans. The sample population was 20 healthy calves (n = 10 Holstein, n = 10 Piedmontese breed). Intragroup (same probe for vertical vs. horizontal scanning) and intergroup (different probes measuring the same biometric parameter) comparisons were performed using Student’s t-test and the Mann–Whitney U test. Statistical significance was set at p ≤ 0.05. Intragroup comparison revealed few significant differences. Ultrasound examination with the convex transducer detected more differences than either of the two other probes on vertical (linear six out of eight; transrectal gynecological four out of eight) and horizontal (linear six out of eight; transrectal gynecological six out of eight) scans. Similar results were obtained for both breeds. More non-valuable parameters on the horizontal (77 out of 320, 24%) and the vertical (85 out of 320, 26%) (p ≤ 0.001) scans were obtained with the convex transducer. Both linear transducers were found comparable for ocular ultrasonography in field conditions. However, given its widespread application in the field, the transrectal gynecological transducer may offer veterinarians the added advantage of familiarity and ease-of-use without any additional costs.
Keywords	Holstein ; Piedmontese ; biometry ; cattle ; eyes ; ultrasonics ; ultrasonography
Language	English
Dates of publication	2023-0219
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13040742
Database	NAL-Catalogue (AGRICOLA)

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Article: Classic and new strategies for the treatment of advanced melanoma and non-melanoma skin cancer.

Rubatto, Marco / Sciamarrelli, Nadia / Borriello, Silvia / Pala, Valentina / Mastorino, Luca / Tonella, Luca / Ribero, Simone / Quaglino, Pietro

Frontiers in medicine

2023 Volume 9, Page(s) 959289

Abstract: Advanced melanoma and non-melanoma skin cancers (NMSCs) are burdened with a dismal prognosis. To improve the survival of these patients, studies on immunotherapy and target therapies in melanoma and NMSCs are rapidly increasing. BRAF and MEK inhibitors ... ...

Abstract	Advanced melanoma and non-melanoma skin cancers (NMSCs) are burdened with a dismal prognosis. To improve the survival of these patients, studies on immunotherapy and target therapies in melanoma and NMSCs are rapidly increasing. BRAF and MEK inhibitors improve clinical outcomes, and anti-PD1 therapy demonstrates better results than chemotherapy or anti-CTLA4 therapy in terms of the survival of patients with advanced melanoma. In recent years, the combination therapy of nivolumab plus ipilimumab has gained ground in studies for its survival and response rate benefits in patients with advanced melanoma. In addition, neoadjuvant treatment for stages III and IV melanoma, either as monotherapy or combination therapy, has recently been discussed. Another promising strategy evaluated in recent studies is the triple combination of anti-PD-1/PD-L1 immunotherapy and anti-BRAF plus anti-MEK targeted therapy. On the contrary, in advanced and metastatic BCC, successful therapeutic strategies, such as vismodegib and sonidegib, are based on the inhibition of aberrant activation of the Hedgehog signaling pathway. In these patients, anti-PD-1 therapy with cemiplimab should be reserved as the second-line therapy in case of disease progression or poor response. In patients with locally advanced or metastatic SCC, who are not candidates for surgery or radiotherapy, anti-PD1 agents such as cemiplimab, pembrolizumab, and cosibelimab (CK-301) have shown significant results in terms of response rate. PD-1/PD-L1 inhibitors, such as avelumab, have also been used in Merkel carcinoma, achieving responses in half of the patients with advanced disease. The latest prospect emerging for MCC is the locoregional approach involving the injection of drugs that can stimulate the immune system. Two of the most promising molecules used in combination with immunotherapy are cavrotolimod (a Toll-like receptor 9 agonist) and a Toll-like receptor 7/8 agonist. Another area of study is cellular immunotherapy with natural killer cells stimulated with an IL-15 analog or CD4/CD8 cells stimulated with tumor neoantigens. Neoadjuvant treatment with cemiplimab in CSCCs and nivolumab in MCCs has shown promising results. Despite the successes of these new drugs, the new challenges ahead will be to select patients who will benefit from these treatments based on biomarkers and parameters of the tumor microenvironment.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.959289
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Article ; Online: [Collapsing Glomerulopathy Secondary to Anabolic Steroids for Bodybuilding: A Case Series].

Passaro, Roberta / D'Angiò, Pierluigi / Laurino, Simona / Gigliotti, Giuseppe / Massa, Antonio / Mancini, Antonio / Gonnella, Annalisa / Giammarino, Anna / Borriello, Gianmarco

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2023 Volume 40, Issue 5

Abstract: The abuse of anabolic androgenic steroids (AAS) for competitive (and non-competitive) purposes for bodybuilding practice is increasingly common. The consequences of these substances on the various organs are only partially known. Cases of FSGS following ... ...

Abstract	The abuse of anabolic androgenic steroids (AAS) for competitive (and non-competitive) purposes for bodybuilding practice is increasingly common. The consequences of these substances on the various organs are only partially known. Cases of FSGS following the use of AAS have been reported in the literature, even with evolution to ESKD. We describe three cases of bodybuilding athletes who presented alterations in renal function indices after taking AAS for a long time. Three renal biopsies were performed with histological diagnosis of FSGS collapsing variant. We examine the lesions observed on histological examination. Two athletes had rapid progression of renal disease requiring replacement therapy. The third one continues conservative treatment for chronic renal failure. We discuss the risks related to the intake of doping substances and how bodybuilders are exposed to different causes of kidney damage: anabolic steroids, supplements, and a high-protein diet.
MeSH term(s)	Humans ; Anabolic Androgenic Steroids ; Glomerulosclerosis, Focal Segmental ; Anabolic Agents/adverse effects ; Testosterone Congeners/adverse effects ; Kidney Diseases
Chemical Substances	Anabolic Androgenic Steroids ; Anabolic Agents ; Testosterone Congeners
Language	Italian
Publishing date	2023-10-26
Publishing country	Italy
Document type	Case Reports ; English Abstract
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Effectiveness of biological therapy in reducing psoriasis-related cardiovascular risk.

Boskovic, Sara / Borriello, Silvia / D'Ascenzo, Fabrizio / Sciamarrelli, Nadia / Rosset, Francois / Mastorino, Luca / Paolo, Dapavo / Bocchino, Pier Paolo / De Filippo, Ovidio / Ribero, Simone / De Ferrari, Gaetano / Quaglino, Pietro

Expert opinion on biological therapy

2024 Volume 24, Issue 4, Page(s) 217–219

MeSH term(s)	Humans ; Psoriasis/drug therapy ; Cardiovascular Diseases/prevention & control ; Biological Therapy/adverse effects ; Heart Disease Risk Factors
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Editorial
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2024.2337242
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Article ; Online: Identifying definite patterns of unmet needs in patients with multiple sclerosis using unsupervised machine learning.

Maida, Elisabetta / Abbadessa, Gianmarco / Cocco, Eleonora / Valentino, Paola / Lerede, Annalaura / Frau, Jessica / Miele, Giuseppina / Bile, Floriana / Vercellino, Marco / Patti, Francesco / Borriello, Giovanna / Cavalla, Paola / Sparaco, Maddalena / Lavorgna, Luigi / Bonavita, Simona

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2024

Abstract: Introduction: People with multiple sclerosis (PwMS) exhibit a spectrum of needs that extend beyond solely disease-related determinants. Investigating unmet needs from the patient perspective may address daily difficulties and optimize care. Our aim was ... ...

Abstract	Introduction: People with multiple sclerosis (PwMS) exhibit a spectrum of needs that extend beyond solely disease-related determinants. Investigating unmet needs from the patient perspective may address daily difficulties and optimize care. Our aim was to identify patterns of unmet needs among PwMS and their determinants. Methods: We conducted a cross-sectional multicentre study. Data were collected through an anonymous, self-administered online form. To cluster PwMS according to their main unmet needs, we performed agglomerative hierarchical clustering algorithm. Principal component analysis (PCA) was applied to visualize cluster distribution. Pairwise comparisons were used to evaluate demographics and clinical distribution among clusters. Results: Out of 1764 mailed questionnaires, we received 690 responses. Access to primary care was the main contributor to the overall unmet need burden. Four patterns were identified: cluster C1, 'information-seekers with few unmet needs'; cluster C2, 'high unmet needs'; cluster C3, 'socially and assistance-dependent'; cluster C4, 'self-sufficient with few unmet needs'. PCA identified two main components in determining the patterns: the 'public sphere' (access to information and care) and the 'private sphere' (need for assistance and social life). Older age, lower education, longer disease duration and higher disability characterized clusters with more unmet needs in the private sphere. However, demographic and clinical factors failed in explaining the four identified patterns. Conclusion: Our study identified four unmet need patterns among PwMS, emphasizing the importance of personalized care. While clinical and demographic factors provide some insight, additional variables warrant further investigation to fully understand unmet needs in PwMS.
Language	English
Publishing date	2024-02-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-024-07416-9
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