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  1. Article ; Online: Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

    Barrett, Christopher D / Neal, Matthew D / Schoenecker, Jonathan G / Medcalf, Robert L / Myles, Paul S

    Transfusion

    2024  

    Abstract: Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant ... ...

    Abstract Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant and paradoxical increased risk of death due to bleeding. TXA has level 1 evidence for use as a bleeding reduction agent in isolated orthopedic operations, but in polytrauma patients undergoing orthopedic operations, it is not clear if and when TXA is safe or effective once outside the 3-h window of proven trauma efficacy.
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Tobacco-specific and combustion pollutants in settled house dust in Malta.

    Aquilina, Noel J / Havel, Christopher M / Benowitz, Neal L / Jacob, Peyton

    Journal of environmental exposure assessment

    2022  Volume 1

    Abstract: Aim: Most of the carcinogenic pollutants coming from tobacco smoking or other combustion processes tend to accumulate in settled house dust (SHD) over time. This study evaluated the load of these pollutants in smokers and non-smokers' houses from ... ...

    Abstract Aim: Most of the carcinogenic pollutants coming from tobacco smoking or other combustion processes tend to accumulate in settled house dust (SHD) over time. This study evaluated the load of these pollutants in smokers and non-smokers' houses from relatively fresh SHD collected in five different districts on the island of Malta.
    Methods: An improved, efficient extraction method to obtain three fractions from a 200 mg of SHD was developed. It was validated for the analysis of nicotine and polycyclic aromatic hydrocarbons (PAH) by GC-MS/MS and nicotelline and TSNA by LC-MS/MS. Kruskal-Wallis H tests were used to evaluate differences across districts, while a Mann-Whitney
    Results: For all analytes, no statistical difference was observed across different districts, but, in smokers' houses, 97.9% of the total concentration of all target analytes found in SHD is nicotine, 0.1% is TSNA, and 2.0% is PAH. In non-smokers' houses, nicotine represents 16.8% of the load, while 0.4% and 82.8% are TSNA and PAH, respectively. The carcinogenicity of the PAH mixture in Maltese SHD, expressed as the mean benzo(a)pyrene equivalent (BaP
    Conclusion: Indoor activities, ventilation practices, and infiltration of outdoor pollutants contribute to a complex SHD composition. Although the BaP
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 2771-5949
    ISSN (online) 2771-5949
    DOI 10.20517/jeea.2021.09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vaping THC-O Acetate: Potential for Another EVALI Epidemic.

    Benowitz, Neal L / Havel, Christopher / Jacob, Peyton / O'Shea, Donal F / Wu, Dan / Fowles, Jefferson

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2022  Volume 19, Issue 1, Page(s) 37–39

    MeSH term(s) Humans ; Lung Injury/epidemiology ; Vaping/adverse effects ; Dronabinol ; Disease Outbreaks ; Electronic Nicotine Delivery Systems
    Chemical Substances Dronabinol (7J8897W37S)
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-022-00921-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6682: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Rates and Predictors of Surgery for Lumbar Disc Herniation Between the Military and Civilian Health Care Systems.

    Anderson, Ashley B / Watson, Nora L / Pisano, Alfred J / Neal, Christopher J / Fredricks, Donald J / Helgeson, Melvin D / Brooks, Daniel I / Wagner, Scott C

    Military medicine

    2023  

    Abstract: Study design: Retrospective review (level of evidence III).: Objective: Surgical care patterns for lumbar disc herniation (LDH), a common musculoskeletal condition of high relevance to the Military Health System (MHS), have not been described or ... ...

    Abstract Study design: Retrospective review (level of evidence III).
    Objective: Surgical care patterns for lumbar disc herniation (LDH), a common musculoskeletal condition of high relevance to the Military Health System (MHS), have not been described or compared across the direct care and purchased care MHS components. This study aimed to describe surgery rates in MHS beneficiaries who were diagnosed with LDH in direct care versus purchased care and to evaluate characteristics associated with the location of surgery. Differences in care patterns for LDH may suggest unexpected variation within the centrally managed MHS.
    Methods: We described 1-year rates of surgery among beneficiaries who were diagnosed with LDH in direct care versus purchased care. Among beneficiaries who were diagnosed in direct care and had surgery, multivariable logistic regression models were used to identify characteristics associated with surgery location.
    Results: We identified 726,638 MHS beneficiaries who were diagnosed with LDH in direct care or purchased care during the 9-year study period. One-year surgery rates were 10.1% in beneficiaries who were diagnosed in direct care versus 11.3% in beneficiaries who were diagnosed in purchased care. Among the 7467 patients who were diagnosed in direct care and had surgery within 1 year, characteristics associated with lower probability of surgery in purchased care versus direct care included diagnosing facility type (hospital with a neurosurgery or spine specialty versus clinic (odds ratio [OR], 0.12 (95% CI, 0.10-0.15)), Navy versus Army (OR, 0.24 (95% CI, 0.21-0.28)), and diagnosing facility specialty (Medical Expense and Performance Reporting System) (surgical care (OR, 0.33 (95% CI, 0.27-0.40)) and orthopedic care (OR, 0.39 (95% CI, 0.33-0.46)) versus primary care. The presence of comorbidities was associated with higher probability of surgery in purchased care versus direct care (OR, 1.20 (95% CI, 1.06-1.36)).
    Conclusions: The 1-year rate of surgery for LDH was modestly higher in beneficiaries who were diagnosed in purchased care versus direct care. Among patients who were diagnosed in direct care, several patient-level and facility-level characteristics were associated with receiving surgery in purchased care, suggesting potentially unexpected variation in care utilization across components of the MHS.
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usad004
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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.546: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Biopsychosocial approach to tendinopathy

    Christopher Clifford / Paul Kirwan / Neal L Millar / Seth O'Neill / Carles Pedret / Nathan Edgar

    BMJ Open Sport & Exercise Medicine, Vol 8, Iss

    2022  Volume 3

    Abstract: Tendinopathy describes a spectrum of changes that occur in damaged tendons, leading to pain and reduced function that remains extremely challenging for all clinicians. There is an increasing awareness of the influence that psychological and psychosocial ... ...

    Abstract Tendinopathy describes a spectrum of changes that occur in damaged tendons, leading to pain and reduced function that remains extremely challenging for all clinicians. There is an increasing awareness of the influence that psychological and psychosocial components, such as self-efficacy and fear-avoidance, have on rehabilitation outcomes in musculoskeletal medicine. Although it is widely accepted that psychological/psychosocial factors exist in tendinopathy, there is currently a distinct lack of trials measuring how these factors affect clinical outcomes. Biopsychosocial treatments acknowledge and address the biological, psychological and social contributions to pain and disability are currently seen as the most efficacious approach to chronic pain. Addressing and modulating these factors are crucial in the pathway of personalised treatments in tendinopathy and offer a real opportunity to drive positive outcomes in patients. In this education review, we also provide the current evidence-based guidance on psychological and psychosocial developments in musculoskeletal medicine and how these may be translated to treating tendinopathy using a biopsychosocial model.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Correction: Back et al. A New

    Back, Catherine R / Stennett, Henry L / Williams, Sam E / Wang, Luoyi / Ojeda Gomez, Jorge / Abdulle, Omar M / Duffy, Thomas / Neal, Christopher / Mantell, Judith / Jepson, Mark A / Hendry, Katharine R / Powell, David / Stach, James E M / Essex-Lopresti, Angela E / Willis, Christine L / Curnow, Paul / Race, Paul R

    Marine drugs

    2023  Volume 21, Issue 4

    Abstract: After publication of this article [ ... ]. ...

    Abstract After publication of this article [...].
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040214
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  7. Article: Biopsychosocial approach to tendinopathy.

    Edgar, Nathan / Clifford, Christopher / O'Neill, Seth / Pedret, Carles / Kirwan, Paul / Millar, Neal L

    BMJ open sport & exercise medicine

    2022  Volume 8, Issue 3, Page(s) e001326

    Abstract: Tendinopathy describes a spectrum of changes that occur in damaged tendons, leading to pain and reduced function that remains extremely challenging for all clinicians. There is an increasing awareness of the influence that psychological and psychosocial ... ...

    Abstract Tendinopathy describes a spectrum of changes that occur in damaged tendons, leading to pain and reduced function that remains extremely challenging for all clinicians. There is an increasing awareness of the influence that psychological and psychosocial components, such as self-efficacy and fear-avoidance, have on rehabilitation outcomes in musculoskeletal medicine. Although it is widely accepted that psychological/psychosocial factors exist in tendinopathy, there is currently a distinct lack of trials measuring how these factors affect clinical outcomes. Biopsychosocial treatments acknowledge and address the biological, psychological and social contributions to pain and disability are currently seen as the most efficacious approach to chronic pain. Addressing and modulating these factors are crucial in the pathway of personalised treatments in tendinopathy and offer a real opportunity to drive positive outcomes in patients. In this education review, we also provide the current evidence-based guidance on psychological and psychosocial developments in musculoskeletal medicine and how these may be translated to treating tendinopathy using a biopsychosocial model.
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2022-001326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Interactive Spectral Analysis Tool for Chemical Identification and Quantification of Gas-Phase Species in Complex Spectra.

    Thompson, Christopher J / Gallagher, Neal B / Hughey, Kendall D / Dunlap, Megan K / Myers, Tanya L / Johnson, Timothy J

    Applied spectroscopy

    2023  Volume 77, Issue 6, Page(s) 557–568

    Abstract: A spectral analysis tool has been developed to interactively identify and quantify individual gas-phase species from complex infrared absorbance spectra obtained from laboratory or field data. The SpecQuant program has an intuitive graphical interface ... ...

    Abstract A spectral analysis tool has been developed to interactively identify and quantify individual gas-phase species from complex infrared absorbance spectra obtained from laboratory or field data. The SpecQuant program has an intuitive graphical interface that accommodates both reference and experimental data with varying resolution and instrumental lineshape, as well as algorithms to readily align the wavenumber axis of a sample spectrum with the raster of a reference spectrum. Using a classical least squares model in conjunction with reference spectra such as those from the Pacific Northwest National Laboratory (PNNL) gas-phase infrared database or simulated spectra derived from the HITRAN line-by-line database, the mixing ratio of each identified species is determined along with its associated estimation error. After correcting the wavelength and intensity of the field data, SpecQuant displays the calculated mixing ratio versus the experimental data for each analyte along with the residual spectrum with any or all analyte fits subtracted for visual inspection of the fit and residuals. The software performance for multianalyte quantification was demonstrated using moderate resolution (0.5 cm
    MeSH term(s) Spectroscopy, Fourier Transform Infrared ; Software ; Algorithms
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028231169304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Healthspan Project: A Retrospective Pilot of Biomarkers and Biometric Outcomes after a 6-Month Multi-Modal Wellness Intervention.

    Chun, Elizabeth / Crete, Annie / Neal, Christopher / Joseph, Richard / Pojednic, Rachele

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 6

    Abstract: ... and hsCRP (-1.75 (2.66) mg/L) decreased significantly ( ...

    Abstract Wellness-centric proactive healthcare is increasingly sought after, with individuals frequently embracing complementary modalities to achieve this goal. In this six-month study, healthy adult participants (n = 25) received specific therapies, including whole-body cryotherapy, infrared sauna, and photobiomodulation, along with guidance on physical activity, diet, and alcohol intake. Serum biomarkers were measured for all participants, while a subset also received biometric assessments for body composition (n = 10) and heart rate variability (n = 7). Over the course of the study (mean (SD) follow-up days = 174 (130)), participants exhibited significant improvements in health. LDL cholesterol (-9.77 (15.43) md/dL) and hsCRP (-1.75 (2.66) mg/L) decreased significantly (
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12060676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: In-Office Needle Arthroscopy with Meniscal Repair for Meniscal Lesions of the Knee.

    Kirschner, Noah / Owusu-Sarpong, Stephane / Neal, William H E / Fariyike, Babatunde / Bi, Andrew S / Colasanti, Christopher A / Azam, Mohammad T / Gianakos, Arianna L / Stone, James W / Kennedy, John G

    Arthroscopy techniques

    2023  Volume 12, Issue 10, Page(s) e1821–e1826

    Abstract: Meniscal injuries are a common cause of knee pain and are often an indication for knee arthroscopy, the most common orthopedic surgical procedure in the United States. In-office needle arthroscopy (IONA) is a described technique with the ability to ... ...

    Abstract Meniscal injuries are a common cause of knee pain and are often an indication for knee arthroscopy, the most common orthopedic surgical procedure in the United States. In-office needle arthroscopy (IONA) is a described technique with the ability to diagnose and treat meniscal injuries in the office. IONA allows for diagnosis and treatment at a significantly deceased cost, with both quicker patient recovery, and improved patient satisfaction. The purpose of this technical report is to describe the technique for performing in-office needle arthroscopy for meniscal injuries of the knee, including the technique for obtaining adequate local anesthesia, proper indications, adequate visualization, and the advantages of performing these procedures in the office rather than the operating room.
    Language English
    Publishing date 2023-09-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2023.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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