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Article ; Online: Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats.

Abrial, Erika / Etievant, Adeline / Bétry, Cécile / Scarna, Hélène / Lucas, Guillaume / Haddjeri, Nasser / Lambás-Señas, Laura

Progress in neuro-psychopharmacology & biological psychiatry

2013 Volume 43, Page(s) 40–48

Abstract: ... are still unknown. In recent years, protein kinase C (PKC) has emerged as a potential key player ... tamoxifen (80 mg/kg, i.p.) and chelerythrine (3 mg/kg, s.c.) attenuated amphetamine-induced hyperlocomotion ... chronic exposure to tamoxifen (10 mg/kg/day, i.p., for 14 days) or chelerythrine (0.3 mg/kg/day, s.c ...

Abstract	The neurobiological mechanisms underlying the pathophysiology and therapeutics of bipolar disorder are still unknown. In recent years, protein kinase C (PKC) has emerged as a potential key player in mania. To further investigate the role of this signaling system in mood regulation, we examined the effects of PKC modulators in behavioral tests modeling several facets of bipolar disorder and in adult hippocampal cell proliferation in rats. Our results showed that a single injection of the PKC inhibitors tamoxifen (80 mg/kg, i.p.) and chelerythrine (3 mg/kg, s.c.) attenuated amphetamine-induced hyperlocomotion and decreased risk-taking behavior, supporting the efficacy of PKC blockade in acute mania. Moreover, chronic exposure to tamoxifen (10 mg/kg/day, i.p., for 14 days) or chelerythrine (0.3 mg/kg/day, s.c., for 14 days) caused depressive-like behavior in the forced swim test, and resulted in a reduction of cell proliferation in the dentate gyrus of the hippocampus. Finally, we showed that, contrary to the PKC inhibitors, the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced risk-taking behavior and induced an antidepressant-like effect. Taken together, these findings support the involvement of PKC in regulating opposite facets of bipolar disorder, and emphasize a major role for PKC in this disease.
MeSH term(s)	Affect/physiology ; Animals ; Antimetabolites ; Anxiety/psychology ; Behavior, Animal/physiology ; Bipolar Disorder/psychology ; Bromodeoxyuridine ; Cell Count ; Cell Proliferation ; Central Nervous System Stimulants/antagonists & inhibitors ; Central Nervous System Stimulants/pharmacology ; Dentate Gyrus/cytology ; Dentate Gyrus/drug effects ; Depression/psychology ; Dextroamphetamine/antagonists & inhibitors ; Dextroamphetamine/pharmacology ; Hippocampus/cytology ; Immunohistochemistry ; Microinjections ; Motor Activity/drug effects ; Neuronal Plasticity/physiology ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/physiology ; Protein Kinase Inhibitors/pharmacology ; Rats ; Risk-Taking ; Signal Transduction/physiology ; Stereotaxic Techniques ; Swimming/psychology
Chemical Substances	Antimetabolites ; Central Nervous System Stimulants ; Protein Kinase Inhibitors ; Protein Kinase C (EC 2.7.11.13) ; Bromodeoxyuridine (G34N38R2N1) ; Dextroamphetamine (TZ47U051FI)
Language	English
Publishing date	2013-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2012.11.015
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Article ; Online: Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania.

Abrial, Erika / Bétourné, Alexandre / Etiévant, Adeline / Lucas, Guillaume / Scarna, Hélène / Lambás-Señas, Laura / Haddjeri, Nasser

The international journal of neuropsychopharmacology

2014 Volume 18, Issue 2

Abstract: ... molecule protein kinase C (PKC) in mania.: Methods: Using sleep deprivation (SD) as an animal model ...

Abstract	Background: Recent studies revealed that bipolar disorder may be associated with deficits of neuroplasticity. Additionally, accumulating evidence has implicated alterations of the intracellular signaling molecule protein kinase C (PKC) in mania. Methods: Using sleep deprivation (SD) as an animal model of mania, this study aimed to examine the possible relationship between PKC and neuroplasticity in mania. Rats were subjected to SD for 72 h and tested behaviorally. In parallel, SD-induced changes in hippocampal cell proliferation were evaluated with bromodeoxyuridine (BrdU) labeling. We then examined the effects of the mood stabilizer lithium, the antipsychotic agent aripiprazole, and the PKC inhibitors chelerythrine and tamoxifen on both behavioral and cell proliferation impairments induced by SD. The antidepressant fluoxetine was used as a negative control. Results: We found that SD triggered the manic-like behaviors such as hyperlocomotion and increased sleep latency, and reduced hippocampal cell proliferation. These alterations were counteracted by an acute administration of lithium and aripiprazole but not of fluoxetine, and only a single administration of aripiprazole increased cell proliferation on its own. Importantly, SD rats exhibited increased levels of phosphorylated synaptosomal-associated protein 25 (SNAP-25) in the hippocampus and prefrontal cortex, suggesting PKC overactivity. Moreover, PKC inhibitors attenuated manic-like behaviors and rescued cell proliferation deficits induced by SD. Conclusions: Our findings confirm the relevance of SD as a model of mania, and provide evidence that antimanic agents are also able to prevent SD-induced decrease of hippocampal cell proliferation. Furthermore, they emphasize the therapeutic potential of PKC inhibitors, as revealed by their antimanic-like and pro-proliferative properties.
MeSH term(s)	Animals ; Antidepressive Agents, Second-Generation/pharmacology ; Antimanic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Aripiprazole ; Benzophenanthridines/pharmacology ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Disease Models, Animal ; Fluoxetine/pharmacology ; Hippocampus/drug effects ; Hippocampus/physiopathology ; Lithium Chloride/pharmacology ; Male ; Piperazines/pharmacology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Kinase Inhibitors/pharmacology ; Quinolones/pharmacology ; Rats, Sprague-Dawley ; Sleep Deprivation ; Tamoxifen/pharmacology
Chemical Substances	Antidepressive Agents, Second-Generation ; Antimanic Agents ; Antipsychotic Agents ; Benzophenanthridines ; Piperazines ; Protein Kinase Inhibitors ; Quinolones ; Fluoxetine (01K63SUP8D) ; Tamoxifen (094ZI81Y45) ; Aripiprazole (82VFR53I78) ; chelerythrine (E3B045W6X0) ; Protein Kinase C (EC 2.7.11.13) ; Lithium Chloride (G4962QA067)
Language	English
Publishing date	2014-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1440129-0
ISSN	1469-5111 ; 1461-1457
ISSN (online)	1469-5111
ISSN	1461-1457
DOI	10.1093/ijnp/pyu031
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Article ; Online: The challenge of reducing macroplastic pollution: Testing the effectiveness of a river boom under real environmental conditions.

Blettler, Martín C M / Agustini, Ever / Abrial, Elie / Piacentini, Rubén / Garello, Nicolás / Wantzen, Karl M / Vega, Marcelo G / Espinola, Luis A

The Science of the total environment

2023 Volume 870, Page(s) 161941

Abstract: ... the effectiveness of a boom under realistic conditions for several configurations and treatments (including "C-shape ... different polymers. The global effectiveness of the tested C-shape boom was lower than expected under ...

Abstract	Improving collection technologies is crucial to develop effective and economically feasible solutions for catching plastic from riverine environments. However, floating booms are being constructed and deployed in river around the world without rigorously testing its effectiveness. In this study, we tested the effectiveness of a boom under realistic conditions for several configurations and treatments (including "C-shape" and "Slash-shape" configurations). For this, we used the same macroplastics that leak out of waste management channels in order to be as realistic as possible. In total we used 52 plastic articles of 13 different polymers. The global effectiveness of the tested C-shape boom was lower than expected under such conditions (around 37 % of retention). The effectiveness of the Slash-shape boom was considerably worst (<10 %). However, the effectiveness varies greatly according to the particular characteristics of the plastic articles (i.e., shape and polymer composition), ranged from 0 to 100 %. For example, the boom could be 100 % effective retaining plastics such as Stylofoam trays and cups, 40-20 % for food-wrappers but 0 % for disposable plates and spoons, straws, monofilament fishing lines, packaging straps, hoses, pipes, elastic bands, etc. It seems that to have a reasonable catch-effectiveness and be cost-efficient, boom designs need to be improved and tested under different environmental conditions before to reach the market. In addition, it is unrealistic to select only high buoyancy plastics for testing them.
Language	English
Publishing date	2023-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161941
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Article ; Online: Benign Brenner tumour of the ovary: CT and MRI features.

Montoriol, P-F / Hordonneau, C / Boudinaud, C / Molnar, I / Abrial, C / Kossai, M

Clinical radiology

2021 Volume 76, Issue 8, Page(s) 593–598

Abstract: Aim: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) features of benign Brenner tumours (BBT) of the ovary.: Material and methods: This was a retrospective two-centre study comprising 35 female patients with a definitive ...

Abstract	Aim: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) features of benign Brenner tumours (BBT) of the ovary. Material and methods: This was a retrospective two-centre study comprising 35 female patients with a definitive diagnosis of BBT at histology in whom CT and/or MRI examinations had been performed. Two experienced radiologists reviewed the CT and MRI features of 39 ovarian BBT retrospectively with consensus reading. The morphological appearance and size of each tumour were recorded. The presence or absence of calcifications within the solid portion was noted at CT. The reviewed characteristics at MRI included qualitative assessment of the signal intensity of the solid portion on diffusion sequence and contrast enhancement, compared to that of the myometrium. Results: CT and MRI images were available for 27 and 28 lesions, respectively. Sixteen patients had both CT and MRI examinations. BBT were unilateral in 89% of patients, and 49% of lesions were solid and 51% were mixed. Calcifications were depicted at CT in 70.4% of lesions. When present, the cystic portion was multilocular in 85% of cases and corresponded to a mucinous lesion in 74% of cases. Enhancement of the solid portion at MRI was inferior or equal to that of the myometrium in 89% of cases and signal on high b-values diffusion images was deemed low or moderate in 93% of cases. Conclusion: The combined CT and MRI findings of a unilateral fibrous ovarian mass containing punctate calcifications often associated with a multilocular cyst suggest the diagnosis of ovarian BBT.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brenner Tumor/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Ovarian Neoplasms/diagnostic imaging ; Ovary/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2021-04-28
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2021.03.018
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Article ; Online: RFID trial: localization of non-palpable breast lesions using radiofrequency identification tags or wire.

Veyssiere, Hugo / Dressaire, Margot / Pete, Raphaël / Pinard, Céleste / Molnar, Ioana / Abrial, Catherine / Ginzac, Angeline / Durando, Xavier / Tekath, Marielle

BMC cancer

2023 Volume 23, Issue 1, Page(s) 679

Abstract: Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women. Approximately 50% of breast cancers are discovered at an early stage in patients for whom conservative surgery is indicated. Intraoperative ...

Abstract	Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women. Approximately 50% of breast cancers are discovered at an early stage in patients for whom conservative surgery is indicated. Intraoperative localization of non-palpable breast lesions is generally accomplished using a hook wire to mark the area of concern under ultrasound or stereotactic localization. But this technique has several drawbacks (painful, stressful…). We propose the use of a wire-free breast lesion system using miniature radiofrequency identification (RFID) tags. This technique could improve patient comfort and surgical comfort for surgeons. We therefore propose a study to assess the interest of introducing the RFID localization technique at the Jean PERRIN comprehensive cancer center. Methods: This is a single-center prospective trial designed to assess the interest in introducing the RFID localization technique at the Jean Perrin center. It aims to show the superiority of the RFID technique in terms of patient tolerance compared to the gold-standard (hook wire). A sequential inclusion in time will be performed: 20 inclusions in the gold-standard group, then 20 patients in the RFID group before repeating the inclusion scheme. Any patient requiring preoperative localization will receive a senology consultation. The RFID tag will be placed during this consultation. The hook wire localization will be done the day before the surgery. Patients will fill out a Hospital Anxiety and Depression scale (HAD) questionnaire at the time of inclusion. They will then fill out a satisfaction questionnaire in 2 steps: during the placement of the device (RFID tag or hook wire) or during the postoperative consultation at 1 month. Radiologists and surgeons will fill out a questionnaire to evaluate the localization technique, respectively after the localization and surgery procedures. Discussion: The RFID study is the first study in France which specifically assesses the interest of the RFID localization in terms of patients comfort. Patient comfort is one of the key elements to take into consideration when managing patients in oncology and new technologies such as RFID tags could improve it. Trial registration: ClinicalTrials.gov ID; NCT04750889 registered on February 11, 2021.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; France ; Prospective Studies ; Radio Frequency Identification Device/methods ; Ultrasonography
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11190-w
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Article: Fishers' knowledge on a large floodplain river in South America. Contributions for sustainable management of inland fisheries.

Rabuffetti, Ana P / Espínola, Luis A / Amsler, Pablo / Ferreira, Patricio / Abrial, Elie / Blettler, Martin C M / Amsler, Mario L

Reviews in fish biology and fisheries

2022 , Page(s) 1–20

Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1498719-3
ISSN	1573-5184 ; 0960-3166
ISSN (online)	1573-5184
ISSN	0960-3166
DOI	10.1007/s11160-022-09722-x
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Article ; Online: Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation.

Abrial, Maryline / Basu, Sandeep / Huang, Mengmeng / Butty, Vincent / Schwertner, Asya / Jeffrey, Spencer / Jordan, Daniel / Burns, Caroline E / Burns, C Geoffrey

Disease models & mechanisms

2022 Volume 15, Issue 3

Abstract: Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages of ... ...

Abstract	Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages of cross-species disease modeling, animal models of aortic root aneurysm are largely restricted to genetically engineered mice. Here, we report that zebrafish devoid of the genes encoding latent-transforming growth factor beta-binding protein 1 and 3 (ltbp1 and ltbp3, respectively) develop rapid and severe aneurysm of the outflow tract (OFT), the aortic root equivalent. Similar to syndromic aneurysm tissue, the distended OFTs display evidence for paradoxical hyperactivated TGFβ signaling. RNA-sequencing revealed significant overlap between the molecular signatures of disease tissue from mutant zebrafish and a mouse model of Marfan syndrome. Moreover, chemical inhibition of TGFβ signaling in wild-type animals phenocopied mutants but chemical activation did not, demonstrating that TGFβ signaling is protective against aneurysm. Human relevance is supported by recent studies implicating genetic lesions in LTBP3 and, potentially, LTBP1 as heritable causes of aortic root aneurysm. Ultimately, our data demonstrate that zebrafish can now be leveraged to interrogate thoracic aneurysmal disease and identify novel lead compounds through small-molecule suppressor screens. This article has an associated First Person interview with the first author of the paper.
MeSH term(s)	Animals ; Aortic Aneurysm, Thoracic/genetics ; Aortic Aneurysm, Thoracic/metabolism ; Aortic Aneurysm, Thoracic/pathology ; Dilatation ; Humans ; Larva/metabolism ; Latent TGF-beta Binding Proteins/genetics ; Latent TGF-beta Binding Proteins/metabolism ; Marfan Syndrome/pathology ; Mice ; Transforming Growth Factor beta/metabolism ; Zebrafish/metabolism ; Zebrafish Proteins/metabolism
Chemical Substances	Latent TGF-beta Binding Proteins ; Ltbp3 protein, zebrafish ; Transforming Growth Factor beta ; Zebrafish Proteins
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.046979
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Article: Hydroecological implication of long-term flow variations in the middle Paraná river floodplain

Abrial, Elie / Lorenzón, Rodrigo E. / Rabuffetti, Ana P. / Blettler, Martin C.M. / Espínola, Luis A.

Journal of hydrology. 2021 Dec., v. 603

2021

Abstract: The Paraná River is ranked among the top-ten major rivers of the world. During the last century, the expansion of agriculture and the construction of large dams strongly modified the upper basin but the middle and lower sections are still among the few ... ...

Abstract	The Paraná River is ranked among the top-ten major rivers of the world. During the last century, the expansion of agriculture and the construction of large dams strongly modified the upper basin but the middle and lower sections are still among the few free-flowing river reaches of this magnitude in the world. However, the great anthropic pressure in the upper basin coupled with the climate variability of the past fifty years affected the hydrology of the lower reaches. In this study, we analyzed the hydrological characteristics of the flow regime from 1905 to 2019. Based on 10 m-resolution satellite images, we performed a cartography of the surface waters covering 15% of the Middle Paraná River floodplain and we analyzed the processes of connectivity for each 50 cm of the river height. We related the hydrological changes with the landscape analyses and discussed their potential implication on the ecosystem functioning. In other words, we highlighted how a regional disturbance in a large river basin affects some hydro-geomorphological processes several hundreds of kilometers downstream, which potentially involves long-term alterations of the structural and functional components of the biota.
Keywords	anthropogenic activities ; basins ; cartography ; climate ; ecosystems ; floodplains ; landscapes ; rivers ; satellites ; watersheds
Language	English
Dates of publication	2021-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2021.126957
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Article ; Online: Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity.

Legrand, Anne-Flore / Lucifora, Julie / Lacombe, Benoît / Ménard, Camille / Michelet, Maud / Foca, Adrien / Abrial, Pauline / Salvetti, Anna / Rivoire, Michel / Lotteau, Vincent / Durantel, David / André, Patrice / Ramière, Christophe

Hepatology communications

2023 Volume 7, Issue 5

Abstract: Background and aims: HDV, a satellite of HBV, is responsible for the most severe form of human viral hepatitis, for which curative therapy is still awaited. Both HBV and HDV use the hepatic transporter of bile acids (ie, Na+-taurocholate cotransporting ... ...

Abstract	Background and aims: HDV, a satellite of HBV, is responsible for the most severe form of human viral hepatitis, for which curative therapy is still awaited. Both HBV and HDV use the hepatic transporter of bile acids (ie, Na+-taurocholate cotransporting polypeptide) to enter hepatocytes. We have previously shown that ligands of the farnesoid-X-receptor alpha (FXR), a master regulator of bile acids metabolism, inhibit HBV replication. Here we asked whether FXR ligands can also control HDV infection. Approach and results: In vitro HDV monoinfections or HDV/HBV coinfections and superinfections were performed in differentiated HepaRG cells (dHepaRG) and primary human hepatocytes. Following treatment with FXR ligands, HDV RNAs and antigens were analyzed by RT-qPCR, northern blot, immunofluorescence, and western blot. Virus secretion was studied by RNA quantification in supernatants, and the infectivity of secreted HDV particles was measured by reinfection of naive HuH7.5-Na+-taurocholate cotransporting polypeptide cells. In HDV/HBV superinfection models, a 10-day treatment with FXR ligand GW4064 decreased intracellular HDV RNAs by 60% and 40% in dHepaRG cells and primary human hepatocytes, respectively. Both HDV genomic and antigenomic RNAs were affected by treatment, which also reduced the amount of intracellular delta antigen. This antiviral effect was also observed in HDV monoinfected dHepaRG cells, abolished by FXR loss of function, and reproduced with other FXR ligands. In HBV/HDV coinfected dHepaRG cells, HDV secretion was decreased by 60% and virion-specific infectivity by >95%. Conclusions: FXR ligands both inhibit directly (ie, independently of anti-HBV activity) and indirectly (ie, dependently of anti-HBV activity) the replication, secretion, and infectivity of HDV. The overall anti-HDV activity was superior to that obtained with interferon-α, highlighting the therapeutic potential of FXR ligands in HDV-infected patients.
MeSH term(s)	Humans ; Hepatitis B virus/genetics ; Ligands ; Bile Acids and Salts ; Virion/metabolism ; Taurocholic Acid/metabolism ; Peptides
Chemical Substances	Ligands ; Bile Acids and Salts ; Taurocholic Acid (5E090O0G3Z) ; Peptides
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000078
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Article ; Online: Chemogenetic activation of prefrontal astroglia enhances recognition memory performance in rat.

Delcourte, Sarah / Bouloufa, Amel / Rovera, Renaud / Bétry, Cécile / Abrial, Erika / Dkhissi-Benyahya, Ouria / Heinrich, Christophe / Marcy, Guillaume / Raineteau, Olivier / Haddjeri, Nasser / Lucas, Guillaume / Etiévant, Adeline

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 166, Page(s) 115384

Abstract: Prefrontal cortex (PFC) inputs to the hippocampus are supposed to be critical in memory processes. Astrocytes are involved in several brain functions, such as homeostasis, neurotransmission, synaptogenesis. However, their role in PFC-mediated modulation ... ...

Abstract	Prefrontal cortex (PFC) inputs to the hippocampus are supposed to be critical in memory processes. Astrocytes are involved in several brain functions, such as homeostasis, neurotransmission, synaptogenesis. However, their role in PFC-mediated modulation of memory has yet to be studied. The present study aims at uncovering the role of PFC astroglia in memory performance and synaptic plasticity in the hippocampus. Using chemogenetic and lesions approaches of infralimbic PFC (IL-PFC) astrocytes, we evaluated memory performance in the novel object recognition task (NOR) and dorsal hippocampus synaptic plasticity. We uncovered a surprising role of PFC astroglia in modulating object recognition memory. In opposition to the astroglia PFC lesion, we show that chemogenetic activation of IL-PFC astrocytes increased memory performance in the novel object recognition task and facilitated in vivo dorsal hippocampus synaptic metaplasticity. These results redefine the involvement of PFC in recognition mnemonic processing, uncovering an important role of PFC astroglia.
MeSH term(s)	Animals ; Rats ; Astrocytes ; Recognition, Psychology ; Cognition ; Memory ; Hippocampus
Language	English
Publishing date	2023-08-31
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115384
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