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  1. Article ; Online: Chronic appendicitis

    Nanna Holm / Maria Unni Rømer / Elena Markova / Laura Katrine Buskov / Ann-Brit Eg Hansen / Michala Vaaben Rose

    Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-

    two case reports

    2022  Volume 4

    Abstract: Abstract Background Chronic appendicitis is a condition unfamiliar to many physicians and is often referred to as a controversial diagnosis. This can give rise to diagnostic delay. Case presentation We present two cases of chronic appendicitis: a ... ...

    Abstract Abstract Background Chronic appendicitis is a condition unfamiliar to many physicians and is often referred to as a controversial diagnosis. This can give rise to diagnostic delay. Case presentation We present two cases of chronic appendicitis: a Caucasian female aged 21 years and a Caucasian male aged 34 years. The patients had different clinical presentations, which led the initial investigations in very different directions—tropical infectious disease and possible malignancy, respectively. In both cases, radiological imaging was the key investigation leading to the final surprising diagnosis. Conclusion With these two case stories, we wish to draw attention to chronic appendicitis as a possible differential diagnosis in younger patients with chronic or recurrent abdominal pain, particularly if the pain is located in the lower abdomen and is accompanied by fever.
    Keywords Case report ; Chronic appendicitis ; Recurrent abdominal pain ; Radiologic imaging ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Chronic appendicitis: two case reports.

    Holm, Nanna / Rømer, Maria Unni / Markova, Elena / Buskov, Laura Katrine / Hansen, Ann-Brit Eg / Rose, Michala Vaaben

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 51

    Abstract: Background: Chronic appendicitis is a condition unfamiliar to many physicians and is often referred to as a controversial diagnosis. This can give rise to diagnostic delay.: Case presentation: We present two cases of chronic appendicitis: a Caucasian ...

    Abstract Background: Chronic appendicitis is a condition unfamiliar to many physicians and is often referred to as a controversial diagnosis. This can give rise to diagnostic delay.
    Case presentation: We present two cases of chronic appendicitis: a Caucasian female aged 21 years and a Caucasian male aged 34 years. The patients had different clinical presentations, which led the initial investigations in very different directions-tropical infectious disease and possible malignancy, respectively. In both cases, radiological imaging was the key investigation leading to the final surprising diagnosis.
    Conclusion: With these two case stories, we wish to draw attention to chronic appendicitis as a possible differential diagnosis in younger patients with chronic or recurrent abdominal pain, particularly if the pain is located in the lower abdomen and is accompanied by fever.
    MeSH term(s) Abdomen ; Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Adult ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Chronic Disease ; Delayed Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Male ; Young Adult
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03273-2
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  3. Article: 18

    Rose, Michala Vaaben / Kjaer, Anna Sophie L / Markova, Elena / Graff, Jesper

    Diagnostics (Basel, Switzerland)

    2017  Volume 7, Issue 3

    Abstract: We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. ... ...

    Abstract We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. An
    Language English
    Publishing date 2017-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics7030049
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  4. Article ; Online: Potential drug-drug interactions between antiretroviral drugs and comedications, including dietary supplements, among people living with HIV: A clinical survey.

    Tinggaard, Michaela / David, Kim Peter / Gerstoft, Jan / Hansen, Ann-Brit Eg / Kirk, Ole / Lebech, Anne-Mette / Lindhardt, Bjarne Ørskov / Rose, Michala Vaaben / Ryom, Lene / Weis, Nina / Benfield, Thomas

    HIV medicine

    2022  Volume 24, Issue 1, Page(s) 46–54

    Abstract: Objective: Age-related comorbidities, polypharmacy and thereby the risk of potential drug-drug interactions (PDDIs) among people living with HIV (PLWH) have increased over the years. We estimated the prevalence of comedications, including dietary ... ...

    Abstract Objective: Age-related comorbidities, polypharmacy and thereby the risk of potential drug-drug interactions (PDDIs) among people living with HIV (PLWH) have increased over the years. We estimated the prevalence of comedications, including dietary supplements, and evaluated PDDIs among PLWH receiving antiretroviral therapy (ART) in Denmark in an outpatient setting.
    Methods: Information on prescription medication, over-the-counter medication and dietary supplements was obtained from adult PLWH receiving ART attending two outpatient clinics in Denmark. The PDDIs were identified using the University of Liverpool's drug interaction database. Associations between PDDIs and relevant variables were compared using logistic regression models.
    Results: A total of 337 PLWH receiving ART with a median age of 53 years (interquartile range: 45-61) were included; 77% were male and 96% had a HIV-RNA viral load < 50 copies/mL. Twenty-six per cent of participants received five or more comedications and 56% consumed dietary supplements. Co-administration of drugs requiring dose adjustment or monitoring was identified in the medication lists of 52% of participants, and 4.5% were on drugs that should not be co-administered. Male sex [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.0-3.4], being on a protease inhibitor (OR = 4.3, 95% CI: 1.9-9.7), receiving five or more comedications (OR = 3.3, 95% CI: 1.5-7.2), taking over-the-counter medications (OR = 1.9, 95% CI: 1.1-3.3) and dietary supplements (OR = 2.0, 95% CI: 1.2-3.3) were independent predictors of PDDIs.
    Conclusion: Potential drug-drug interactions were common among our study population Our study confirms that polypharmacy and being on a protease inhibitor-based regimen increase the risk of PDDIs considerably and highlights the importance of questioning PLWH about dietary supplement intake.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Anti-Retroviral Agents/therapeutic use ; Polypharmacy ; Drug Interactions ; Prescription Drugs/therapeutic use ; Protease Inhibitors/therapeutic use ; Dietary Supplements
    Chemical Substances Anti-Retroviral Agents ; Prescription Drugs ; Protease Inhibitors
    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13321
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  5. Article ; Online: Perspectives in implementing standardized case definitions for tuberculosis research involving children in a low-income, high-burden setting.

    Holm, Line Lindebo / Rose, Michala Vaaben / Ravn, Pernille

    The Journal of infectious diseases

    2013  Volume 207, Issue 5, Page(s) 870–871

    MeSH term(s) Humans ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2013-03-01
    Publishing country United States
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jis768
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  6. Article ; Online: 18F-FDG PET/CT Findings in a Patient with Chikungunya Virus Infection

    Michala Vaaben Rose / Anna Sophie L. Kjaer / Elena Markova / Jesper Graff

    Diagnostics, Vol 7, Iss 3, p

    2017  Volume 49

    Abstract: We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. An 18F-FDG PET/CT performed four weeks after debut of symptoms revealed pathological 18F-FDG uptake in enlarged lymph nodes on both side of the ... ...

    Abstract We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. An 18F-FDG PET/CT performed four weeks after debut of symptoms revealed pathological 18F-FDG uptake in enlarged lymph nodes on both side of the diaphragm, and inflammation of both shoulder and hip joints. Lymphoma and infection were the main differential diagnoses. Follow-up 18F-FDG PET/CT scan in the patient performed 14 weeks after the abnormal scan, revealed almost complete resolution of the metabolically active disease. This case is to our knowledge the first to demonstrate sequential 18F-FDG PET/CT scan results in a patient with Chikungunya virus infection.
    Keywords 18F-FDG PET/CT ; Chikungunya virus ; infection imaging ; Medicine (General) ; R5-920
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  7. Article ; Online: Ny test til diagnostik af tuberkulose.

    Ravn, Pernille / Rose, Michala Vaaben / Søborg, Bolette / Andersen, Ase Bengård

    Ugeskrift for laeger

    2009  Volume 171, Issue 37, Page(s) 2635–2639

    Abstract: The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not ... ...

    Title translation New diagnostic test for tuberculosis.
    Abstract The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
    MeSH term(s) Adult ; Biomarkers/blood ; Child ; Contact Tracing ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunocompromised Host ; Interferon-gamma/blood ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/isolation & purification ; Risk Factors ; Sensitivity and Specificity ; Tuberculin Test ; Tuberculosis/blood ; Tuberculosis/diagnosis
    Chemical Substances Biomarkers ; Interferon-gamma (82115-62-6)
    Language Danish
    Publishing date 2009-09-07
    Publishing country Denmark
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  8. Article ; Online: A comparison of interferon-γ and IP-10 for the diagnosis of tuberculosis.

    Holm, Line Lindebo / Rose, Michala Vaaben / Kimaro, Godfather / Bygbjerg, Ib C / Mfinanga, Sayoki G / Ravn, Pernille / Ruhwald, Morten

    Pediatrics

    2014  Volume 134, Issue 6, Page(s) e1568–75

    Abstract: Objective: Interferon-γ and IP-10 release assays are diagnostic tests for tuberculosis infection. We have compared the accuracy of IP-10 and QuantiFERON-TB Gold In-tube [QFT-IT] in Tanzanian children suspected of having active tuberculosis (TB).: ... ...

    Abstract Objective: Interferon-γ and IP-10 release assays are diagnostic tests for tuberculosis infection. We have compared the accuracy of IP-10 and QuantiFERON-TB Gold In-tube [QFT-IT] in Tanzanian children suspected of having active tuberculosis (TB).
    Methods: Hospitalized Tanzanian children with symptoms of TB were tested with the QFT-IT and IP-10 tests and retrospectively classified into diagnostic groups. Adults with confirmed TB were assessed in parallel.
    Results: A total of 203 children were included. The median age was 3.0 years (interquartile range: 1.2-7.0), 38% were HIV infected, 36% were aged <2 years, and 58% had a low weight-for-age. IP-10 and QFT-IT test performance was comparable but sensitivity was low: 33% (1 of 3) in children with confirmed TB and 29% (8 of 28) in children with probable TB. Rates of indeterminate responders were high: 29% (59 of 203) for IP-10 and 26% (53 of 203) for QFT-IT. Age <2 years was associated with indeterminate test outcome for both IP-10 (adjusted odds ratio [aOR]: 2.2; P = .02) and QFT-IT (aOR: 2.4; P = .01). TB exposure was associated with positive IP-10 test outcome (aOR: 3.6; P = .01) but not with positive QFT-IT outcome (aOR 1.4; P = .52). In 102 adults, test sensitivity was 80% for both tests (P = .248).
    Conclusions: Although IP-10 and QFT-IT performed well in Tanzanian adults, the tests exhibited an equally poor performance in diagnosing active TB in children. Test performance was especially compromised in young children. Neither test can be recommended for use in hospitalized children in high-burden settings.
    MeSH term(s) Chemokine CXCL10/blood ; Child ; Child, Preschool ; Developing Countries ; Female ; HIV Infections/blood ; HIV Infections/diagnosis ; Humans ; Infant ; Interferon-gamma/blood ; Interferon-gamma Release Tests ; Male ; Opportunistic Infections/blood ; Opportunistic Infections/diagnosis ; Predictive Value of Tests ; Tanzania ; Tuberculosis/diagnosis
    Chemical Substances CXCL10 protein, human ; Chemokine CXCL10 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2014-1570
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  9. Article ; Online: Maeslinger hos to børn og en voksen--udbrud med maeslingevirus genotype B3.

    Hammer, Line / Osá, Elmar / Rose, Michala Vaaben / Böttiger, Blenda / Høgh, Birthe

    Ugeskrift for laeger

    2006  Volume 168, Issue 18, Page(s) 1771–1772

    Abstract: Measles virus genotype B3 was isolated from patients during a measles outbreak in Copenhagen starting January 2006. Here we describe three cases: two children aged 9 and 22 months, respectively, and a 29-year-old man. All three patients were hospitalised. ...

    Title translation Measles in two children and one adult--outbreak of measles genotype B3.
    Abstract Measles virus genotype B3 was isolated from patients during a measles outbreak in Copenhagen starting January 2006. Here we describe three cases: two children aged 9 and 22 months, respectively, and a 29-year-old man. All three patients were hospitalised. Several doctors examined both the children before the diagnosis of measles was established. The patients were not vaccinated against measles. They had not been abroad within the last three weeks. Genotype B3 is endemic in West and Central Africa. The genotype B3 detected in these cases was different from the B3 seen in recent outbreaks in Europe.
    MeSH term(s) Adult ; Denmark/epidemiology ; Disease Outbreaks ; Genotype ; Humans ; Infant ; Male ; Measles/epidemiology ; Measles/pathology ; Measles/virology ; Measles virus/classification ; Measles virus/genetics ; Measles virus/isolation & purification
    Language Danish
    Publishing date 2006-05-01
    Publishing country Denmark
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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