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  1. Article ; Online: Characteristics of traumatic cataract wound dehiscence.

    Kloek, Carolyn E / Andreoli, Michael T / Andreoli, Christopher M

    American journal of ophthalmology

    2011  Volume 152, Issue 2, Page(s) 229–233

    Abstract: Purpose: To characterize the clinical course of cataract wound dehiscence.: Design: Retrospective, comparative case series.: Methods: Charts of open globe injuries (848 injuries in 846 patients) treated surgically at the Massachusetts Eye and Ear ... ...

    Abstract Purpose: To characterize the clinical course of cataract wound dehiscence.
    Design: Retrospective, comparative case series.
    Methods: Charts of open globe injuries (848 injuries in 846 patients) treated surgically at the Massachusetts Eye and Ear Infirmary between 2000 and 2009 were retrospectively reviewed. Time from original surgery to wound dehiscence, type of initial surgery, Ocular Trauma Score, age, gender, mechanism of injury, and visual acuity were analyzed.
    Results: Of 846 patients with 848 open globe injuries, 63 experienced cataract wound dehiscence. The majority of these cataract wounds (89%) were extracapsular cataract extraction (ECCE), with only 7 (11%) phacoemulsification wounds. The mean patient age in the wound rupture group was 78.2 years. Female patients comprised the majority (67%) of this subpopulation. The most common mechanisms of injury were fall (65%), blunt trauma (23%), and motor vehicle accident (7%). The median raw ocular trauma score was 47 in wound dehiscence patients. Visual acuity at presentation was light perception in the wound dehiscence group. The best postoperative visual acuity was significantly worse in the wound dehiscence group (hand motion) than in the remaining patients (20/40; P=.0002). When considering the phacoemulsification patients alone, these patients fared much better, with a median postoperative vision of 20/60.
    Conclusions: Despite recent advances in cataract surgery, wound dehiscence remains a significant source of visual disability, mainly in the geriatric population. Rupture ECCE wound patients have a poor visual prognosis. Fortunately, patients with phacoemulsification site dehiscence appear to regain the majority of their vision after open globe repair.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Cataract Extraction ; Child ; Child, Preschool ; Eye Injuries, Penetrating/diagnosis ; Eye Injuries, Penetrating/epidemiology ; Eye Injuries, Penetrating/surgery ; Female ; Humans ; Infant ; Male ; Middle Aged ; Retrospective Studies ; Sclera/injuries ; Sex Distribution ; Surgical Wound Dehiscence/diagnosis ; Surgical Wound Dehiscence/epidemiology ; Surgical Wound Dehiscence/surgery ; Trauma Severity Indices ; Visual Acuity/physiology ; Young Adult
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2011.01.044
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  2. Article ; Online: Contribution of amygdala CRF neurons to chronic pain.

    Andreoli, Matthew / Marketkar, Tanvi / Dimitrov, Eugene

    Experimental neurology

    2017  Volume 298, Issue Pt A, Page(s) 1–12

    Abstract: We investigated the role of amygdala corticotropin-releasing factor (CRF) neurons in the perturbations of descending pain inhibition caused by neuropathic pain. Forced swim increased the tail-flick response latency in uninjured mice, a phenomenon known ... ...

    Abstract We investigated the role of amygdala corticotropin-releasing factor (CRF) neurons in the perturbations of descending pain inhibition caused by neuropathic pain. Forced swim increased the tail-flick response latency in uninjured mice, a phenomenon known as stress-induced analgesia (SIA) but did not change the tail-flick response latency in mice with neuropathic pain caused by sciatic nerve constriction. Neuropathic pain also increased the expression of CRF in the central amygdala (CeAmy) and ΔFosB in the dorsal horn of the spinal cord. Next, we injected the CeAmy of CRF-cre mice with cre activated AAV-DREADD (Designer Receptors Exclusively Activated by Designer Drugs) vectors. Activation of CRF neurons by DREADD/Gq did not affect the impaired SIA but inhibition of CRF neurons by DREADD/Gi restored SIA and decreased allodynia in mice with neuropathic pain. The possible downstream circuitry involved in the regulation of SIA was investigated by combined injections of retrograde cre-virus (CAV2-cre) into the locus ceruleus (LC) and cre activated AAV-diphtheria toxin (AAV-FLEX-DTX) virus into the CeAmy. The viral injections were followed by a sciatic nerve constriction ipsilateral or contralateral to the injections. Ablation of amygdala projections to the LC on the side of injury but not on the opposite side, completely restored SIA, decreased allodynia and decreased ΔFosB expression in the spinal cord in mice with neuropathic pain. The possible lateralization of SIA impairment to the side of injury was confirmed by an experiment in which unilateral inhibition of the LC decreased SIA even in uninjured mice. The current view in the field of pain research attributes the process of pain chronification to abnormal functioning of descending pain inhibition. Our results demonstrate that the continuous activity of CRF neurons brought about by persistent pain leads to impaired SIA, which is a symptom of dysregulation of descending pain inhibition. Therefore, an over-activation of amygdala CRF neurons is very likely an important contributing factor for pain chronification.
    MeSH term(s) Amygdala/metabolism ; Amygdala/pathology ; Animals ; Chronic Pain/metabolism ; Chronic Pain/pathology ; Corticotropin-Releasing Hormone/biosynthesis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Pain Measurement/methods ; Pain Threshold/physiology
    Chemical Substances Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2017.08.010
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  3. Article ; Online: Retrospective data analysis of animal poisoning events in Liguria.

    Avolio, R / Andreoli, T / Ercolini, C / Mignone, W / Beltrame, R / Razzuoli, E / Modesto, P / Zoppi, S / Crescio, M I / Ostorero, F / Gili, M / Abete, M C / Meloni, D / Dellepiane, M

    Veterinary and animal science

    2021  Volume 13, Page(s) 100178

    Abstract: Intentional poisoning represents a serious risk to domestic and wild animals, and it can be an environmental and human health issue as well . This paper is a retrospective study, which covers a decade, based on animal poisoning cases and poisoned baits ... ...

    Abstract Intentional poisoning represents a serious risk to domestic and wild animals, and it can be an environmental and human health issue as well . This paper is a retrospective study, which covers a decade, based on animal poisoning cases and poisoned baits that were submitted for diagnostic examinations to the Veterinary Medical Research Institute for Piedmont, Liguria and the Aosta Valley (IZS-PLVA) in Liguria region. All data were collected through a passive surveillance system introduced in Italy by a decree of the Ministry of Health in January 2009. 43.2% of the animal poisoning cases were confirmed by toxicological analysis, whereas toxic agents were detected in 31.1% of the baits. The most affected animal species were dogs and cats, followed by synanthropic birds,. Only 4% of the total poisoning events analysed involved wild animals and cases of livestock poisoning were minimal. An increased number of cases in January, March, April and August was noticed, but no seasonal trend was detected. The most affected areas were the ones with the highest level of urbanization and population density. The major cause of the poisonings and the most common substances detected in the examined baits were anticoagulants whereas cholinesterase inhibitors, organochlorine pesticides and carbamates were detected in a minor number of cases. This study raises concerns about deliberate animal poisoning in ligurian region and highlights the necessity to fight this phenomenon as it endangers animals, humans and environment.
    Language English
    Publishing date 2021-05-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-943X
    ISSN (online) 2451-943X
    DOI 10.1016/j.vas.2021.100178
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  4. Article: Living well with kidney disease by patient and care partner empowerment: kidney health for everyone everywhere.

    Kalantar-Zadeh, K / Li, P K T / Tantisattamo, E / Kumaraswami, L / Liakopoulos, V / Lui, S F / Ulasi, I / Andreoli, S / Balducci, A / Dupuis, S / Harris, T / Hradsky, A / Knight, R / Kumar, S / Ng, M / Poidevin, A / Saadi, G / Tong, A

    Hong Kong medical journal = Xianggang yi xue za zhi

    2021  Volume 27, Issue 2, Page(s) 97–98

    MeSH term(s) Caregivers ; Health Services Accessibility ; Humans ; Kidney ; Kidney Diseases
    Language English
    Publishing date 2021-04-20
    Publishing country China
    Document type Editorial
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj209122
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  5. Article ; Online: Impact of COVID-19 and COVID-19 vaccination on high-risk patients with antiphospholipid syndrome: a nationwide survey.

    Pengo, Vittorio / Del Ross, Teresa / Tonello, Marta / Andreoli, Laura / Tincani, Angela / Gresele, Paolo / Silvestri, Elena / Simioni, Paolo / Campello, Elena / Hoxha, Ariela / Falanga, Anna / Ghirarduzzi, Angelo / Denas, Gentian

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue SI2, Page(s) SI136–SI142

    Abstract: Objectives: Patients with APS and triple-positive for aPL are at high risk of recurrent events. As COVID-19 and COVID-19 vaccination may induce thrombotic complications, the objective of the study was to assess the course of COVID-19 and adverse events ... ...

    Abstract Objectives: Patients with APS and triple-positive for aPL are at high risk of recurrent events. As COVID-19 and COVID-19 vaccination may induce thrombotic complications, the objective of the study was to assess the course of COVID-19 and adverse events after vaccination in these patients.
    Methods: This is a nationwide multicentre survey conducted in nine APS referral centres by means of a questionnaire. Included patients are thrombotic APS with triple-positive aPL confirmed 12 weeks apart. Reference specialist physicians used a four-graded scale of severity for COVID-19 [from 0 (asymptomatic) to 3 (hospitalization in intensive care unit)] and a six-graded scale for adverse reactions to vaccination [from 0 (transient local injection site sign/symptoms) to 5 (potentially life-threatening reactions)]. Outcomes were considered within a 30-day period.
    Results: Out of 161 patients interviewed, 18 (11%) had COVID-19. All of them fully recovered without any progression to severe disease nor thromboembolic event. A total of 146 patients received the first (92%) and 129 (80%) the second dose of vaccine; side effects were minimal and, in most cases (83% after the first and 68% after the second vaccination) limited to a sore arm. Fifteen patients (9%) were unvaccinated. Most of them raised doubts on the need for vaccination, complained of poor safety and in general were reluctant about COVID-19 vaccination.
    Conclusion: Patients with triple-positive thrombotic APS did not suffer from severe COVID-19 outcomes. Importantly, COVID-19 vaccination was well tolerated. These data may reassure patients and physicians and contribute to reducing hesitancy in unvaccinated patients.
    MeSH term(s) Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Surveys and Questionnaires ; Thrombosis/epidemiology ; Thrombosis/etiology ; Vaccination/adverse effects
    Chemical Substances Antibodies, Antiphospholipid ; COVID-19 Vaccines
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac224
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  6. Article ; Online: New bioelectrical impedance vector references and phase angle centile curves in 4,367 adults: The need for an urgent update after 30 years.

    Campa, Francesco / Coratella, Giuseppe / Cerullo, Giuseppe / Stagi, Silvia / Paoli, Samuele / Marini, Sofia / Grigoletto, Alessia / Moroni, Alessia / Petri, Cristian / Andreoli, Angela / Ceolin, Chiara / Degan, Raffaella / Izzicupo, Pascal / Sergi, Giuseppe / Mascherini, Gabriele / Micheletti Cremasco, Margherita / Marini, Elisabetta / Toselli, Stefania / Moro, Tatiana /
    Paoli, Antonio

    Clinical nutrition (Edinburgh, Scotland)

    2023  Volume 42, Issue 9, Page(s) 1749–1758

    Abstract: Background & aims: The bioelectrical impedance vector analysis (BIVA) represents a qualitative analysis of body composition. The vector, defined by resistance (R) and reactance (Xc) standardized by stature, can be evaluated compared to the 50%,75%, and ... ...

    Abstract Background & aims: The bioelectrical impedance vector analysis (BIVA) represents a qualitative analysis of body composition. The vector, defined by resistance (R) and reactance (Xc) standardized by stature, can be evaluated compared to the 50%,75%, and 95% tolerance ellipses representative of the reference populations. The tolerance ellipses for healthy adults have been provided in 1995 and were developed by mixing underage, adult, and elderly subjects, possibly misrepresenting the actual adult population. The current multicentric, cross-sectional study aimed to provide new tolerance ellipses specific for the general adult population and as a secondary aim to present centile curves for the bioelectrical phase angle.
    Methods: R, Xc, and phase angle were measured in 2137 and 2230 males and females using phase-sensitive foot-to-hand analyzers at 50 kHz. A minimum of 35 subjects were included for each sex and age category from 18 to 65 years.
    Results: The new mean vectors showed a leftward shift on the R-Xc graph with respect to the former reference values (males: F = 75.3; p < 0.001; females: F = 36.6, p < 0.001). The results provided new 3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 97th percentile curves for phase angle, identifying time point phases of decrement (males: -0.03° per year at 33.0-51.0 years and -0.05° per year after 51 years; females: -0.03° per year from 37.2 to 57.9 years).
    Conclusions: Compared to the original references, the new data are characterized by a different distribution within the R-Xc graph with a higher phase angle. Thirty years after the BIVA invention, the current study presents new tolerance ellipses and phase angle reference values for the adult population.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Aged ; Adolescent ; Young Adult ; Middle Aged ; Electric Impedance ; Cross-Sectional Studies ; Body Composition ; Reference Values ; Body Height
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2023.07.025
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  7. Article: Water homeostasis-facts and uncertainties.

    Culpepper, R M / Andreoli, T E

    The Western journal of medicine

    2008  Volume 131, Issue 5, Page(s) 436–437

    Language English
    Publishing date 2008-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
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  8. Article: The polyuric syndromes.

    Andreoli, T E

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2001  Volume 16 Suppl 6, Page(s) 10–12

    MeSH term(s) Brain Diseases/etiology ; Diabetes Insipidus/physiopathology ; Homeostasis ; Humans ; Hypernatremia/complications ; Hypernatremia/therapy ; Polyuria/classification ; Polyuria/physiopathology ; Syndrome ; Water/metabolism
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2001
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/16.suppl_6.10
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  9. Article ; Online: Tertiary Nanosystem Composed of Graphene Quantum Dots, Levofloxacin and Silver Nitrate for Microbiological Control.

    Vieira, Thamires Oliveira / Ricci-Junior, Eduardo / de Barros, Aline Oiveira da Silva / Rebelo Alencar, Luciana Magalhães / Ferreira, Marcia Regina Spuri / de Jesus Andreoli Pinto, Terezinha / Santos-Oliveira, Ralph / de Holanda Saboya Souza, Diego

    Recent advances in drug delivery and formulation

    2022  Volume 16, Issue 3, Page(s) 234–240

    Abstract: Background: Infectious diseases have the highest mortality rate in the world and these numbers are associated with scarce and/or ineffective diagnosis and bacterial resistance. Currently, with the development of new pharmaceutical formulations, ... ...

    Abstract Background: Infectious diseases have the highest mortality rate in the world and these numbers are associated with scarce and/or ineffective diagnosis and bacterial resistance. Currently, with the development of new pharmaceutical formulations, nanotechnology is gaining prominence.
    Methods: Nanomicelles were produced by ultrasonication. The particle size and shape were evaluated by scanning electron microscopy and confirmed by dynamic light scattering, also thermogravimetric analysis was performed to evaluate the thermal stability. Finally, antibacterial activity has been performed.
    Results: The results showed that a rod-shaped nanosystem, with 316.1 nm and PDI of 0.243 was formed. The nanosystem was efficient against Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis subsp. spizizenii with MIC inferior to 0.98 and a synergistic effect between silver graphene quantum dots and levofloxacin was observed.
    Conclusion: The nanosystem produced may rise as a promising agent against the bacterial threat, especially regarding bacterial resistance.
    MeSH term(s) Levofloxacin/pharmacology ; Graphite ; Silver Nitrate ; Microbial Sensitivity Tests ; Quantum Dots ; Metal Nanoparticles
    Chemical Substances Levofloxacin (6GNT3Y5LMF) ; Graphite (7782-42-5) ; Silver Nitrate (95IT3W8JZE) ; silver graphene
    Language English
    Publishing date 2022-07-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-3886
    ISSN (online) 2667-3886
    DOI 10.2174/2667387816666220715121107
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  10. Article: Free radicals and oxidative stress.

    Andreoli, T E

    The American journal of medicine

    2000  Volume 108, Issue 8, Page(s) 650–651

    MeSH term(s) Animals ; Free Radicals/adverse effects ; Free Radicals/metabolism ; Humans ; Oxidative Stress ; Superoxide Dismutase/metabolism
    Chemical Substances Free Radicals ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2000-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/s0002-9343(00)00418-6
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