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Article ; Online: Toward imaging of alpha-synuclein with PET.

Kantarci, Kejal

2023 Volume 186, Issue 16, Page(s) 3327–3329

Abstract: Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and treatment. Reporting in this issue of Cell, Xiang et al. developed a ... ...

Abstract	Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and treatment. Reporting in this issue of Cell, Xiang et al. developed a high-affinity positron emission tomography tracer for alpha-synuclein.
MeSH term(s)	Humans ; alpha-Synuclein ; Lewy Body Disease ; Positron-Emission Tomography/methods ; Radiopharmaceuticals
Chemical Substances	alpha-Synuclein ; Radiopharmaceuticals
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.06.018
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: 2021 marks a new era for Alzheimer's therapeutics.

Kantarci, Kejal

The Lancet. Neurology

2021 Volume 21, Issue 1, Page(s) 3–4

MeSH term(s)	Alzheimer Disease/drug therapy ; Amyloid beta-Peptides ; Humans
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2081241-3
ISSN	1474-4465 ; 1474-4422
ISSN (online)	1474-4465
ISSN	1474-4422
DOI	10.1016/S1474-4422(21)00412-9
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Zs.A 5955: Show issues

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Article ; Online: Menopausal hormone therapy and dementia.

Kantarci, Kejal / Manson, JoAnn E

BMJ (Clinical research ed.)

2023 Volume 381, Page(s) 1404

MeSH term(s)	Humans ; Hormone Replacement Therapy/adverse effects ; Menopause ; Dementia
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.p1404
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Ua VI Zs.10: Show issues

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Article ; Online: Risks and benefits of hormone therapy after menopause for cognitive decline and dementia: A conceptual review.

Rocca, Walter A / Kantarci, Kejal / Faubion, Stephanie S

Maturitas

2024 , Page(s) 108003

Abstract: Objective: The effects on the brain of hormone therapy after the onset of menopause remain uncertain. The effects may be beneficial, neutral, or harmful. We provide a conceptual review of the evidence.: Methods: We 1) provide a brief history of the ... ...

Abstract	Objective: The effects on the brain of hormone therapy after the onset of menopause remain uncertain. The effects may be beneficial, neutral, or harmful. We provide a conceptual review of the evidence. Methods: We 1) provide a brief history of the evidence, 2) discuss some of the interpretations of the evidence, 3) discuss the importance of age at menopause, type of menopause, and presence of vasomotor symptoms, and 4) provide some clinical recommendations. Results: The evidence and the beliefs about hormone therapy and dementia have changed over the last 30 years or more. Five recent observation studies suggested that hormone therapy is associated with an increased risk of dementia, and the association appears not to change with the timing of initiation of therapy. These harmful associations may be explained by a causal effect of hormone therapy on the brain or by several confounding mechanisms. We suggest that the use of hormone therapy should be customized for different subgroups of women. It may be important to subgroup women based on age at onset of menopause, type of menopause, and presence or absence of vasomotor symptoms. In addition, the effects may vary by type, dose, route, and duration of administration of estrogens and by the concurrent use of progestogens. Discussion: The relation of hormone therapy with the risk of dementia is complex. Hormone therapy may have beneficial, neutral, or harmful effects on the brain. Hormone therapy should be guided by the clinical characteristics of the women being treated.
Language	English
Publishing date	2024-04-17
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2024.108003
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Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 575: Show issues

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Article ; Online: Evaluation of Brachial Plexus Nerve Variations in Axilla by Ultrasonography.

Aksu, Hale / Özçelik, Murat / Kantarcı, Damla / Öçmen, Elvan / Kızıl, Ayşe S / Küçükgüçlü, Semih / Erdogan, Kubra

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2024

Abstract: Purpose: The use of ultrasound in peripheral blocks has now become the gold standard. Ultrasound is a method that is easy to apply and most importantly does not carry any risk, and its only disadvantage is based on the skill and knowledge of the ... ...

Abstract	Purpose: The use of ultrasound in peripheral blocks has now become the gold standard. Ultrasound is a method that is easy to apply and most importantly does not carry any risk, and its only disadvantage is based on the skill and knowledge of the practitioner. Injury to vascular structures, which is the most common occurrence in peripheral block applications, has been significantly reduced by the use of ultrasound. The aim of this study is to determine the location of nerve branches and to determine the most common anthropometric parameters in the axillary fossa. In this way, the common anatomy of the axillary BP will be determined and will guide the practitioners while performing the axillary plexus block. Design: Observational Clinical Study. Methods: The patients were positioned with forearm abducted 90 degrees and elbow flexed 90 degrees. Using a high-frequency linear ultrasound probe, it was placed on the lateral border of the pectoralis major muscle in the transverse plane. Pulsation of the axillary artery was visualized and shifted slowly to view the nerves around the artery. The axillary vein was also visualized to facilitate the movement of the transducer and to find the nerve localization more easily. The regions on the prepared wheel were marked. At the same time, demographic information such as gender, age, weight, and height of the patients were also recorded. Findings: 248 patients, 61.3% female and 38.7% male. Our results showed that only 59% were compatible with the most common nerve locations in cadaveric dissections and the locations described in anatomy textbooks. Conclusions: Since there are many anatomical variations, validation of nerves with a nerve stimulator as well as simultaneous visual application under ultrasound guidance will increase the success chance of axillary brachial plexus block and protect it from unwanted complications.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2023.11.002
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Zs.A 2458: Show issues

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Article ; Online: Anti-inflammatory and pro-regenerative effects of a monoterpene glycoside on experimental periodontitis in a rat model of diabetes.

Kuzu, Turan Emre / Öztürk, Kübra / Gürgan, Cem A / Yay, Arzu / Göktepe, Özge / Kantarcı, Alpdoğan

Journal of periodontal research

2023 Volume 58, Issue 5, Page(s) 932–938

Abstract: Objective: Paeoniflorin (Pae) is a monoterpene glycoside with immune-regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to ... ...

Abstract	Objective: Paeoniflorin (Pae) is a monoterpene glycoside with immune-regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to test the hypothesis that Pae had a strong anti-inflammatory effect that prevented bone loss in diabetic periodontitis. Methods: Thirty male Wistar albino rats were randomly divided into control (healthy, n = 10), periodontitis (PD) + diabetes (DM; n = 10), and PD + DM + Pae (n = 10) groups. Ligature-induced periodontitis was created by placing 4-0 silk ligatures around the lower first molars on both sides of the mandibulae. Experimental DM was created via an injection of 50 mg/kg and streptozotocin (STZ). Hyperglycemia was confirmed by the blood glucose levels of rats (>300 mg/dL). The bone mineral density (BMD), trabecular number, trabecular thickness, and bone loss were measured by micro-CT. The expression levels of IL-1β, IL-6, and TNF-α were measured in tissue homogenates by ELISA. Results: The PD + DM + Pae group had significantly less alveolar crest resorption when compared to the PD + DM group. There was also a significant difference between the PD + DM + Pae group compared to PD + DM group in trabecular thickness, BMD, and the number of trabeculae. Pae application led to a statistically significant decrease in IL-1β, IL-6, and TNF-α levels in diabetic periodontitis. Conclusion: Systemic application of Pae suppressed inflammation caused by PD and DM, leading to reduced bone loss and enhanced bone quality.
MeSH term(s)	Rats ; Male ; Animals ; Rats, Wistar ; Diabetes Mellitus, Experimental/complications ; Glycosides/therapeutic use ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Periodontitis/drug therapy ; Alveolar Bone Loss/drug therapy ; Alveolar Bone Loss/prevention & control ; Anti-Inflammatory Agents/therapeutic use ; Monoterpenes/pharmacology ; Monoterpenes/therapeutic use
Chemical Substances	Glycosides ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Anti-Inflammatory Agents ; peoniflorin (21AIQ4EV64) ; Monoterpenes
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	390953-0
ISSN	1600-0765 ; 0022-3484
ISSN (online)	1600-0765
ISSN	0022-3484
DOI	10.1111/jre.13151
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Zs.A 599: Show issues

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Article ; Online: Virtual non-enhanced dual-energy computed tomography reconstruction: a candidate to replace true non-enhanced computed tomography scans in the setting of suspected liver alveolar echinococcosis.

Kantarcı, Mecit / Aydın, Sonay / Kahraman, Ayşegül / Oğul, Hayri / İrgül, Barış / Levent, Akın

Diagnostic and interventional radiology (Ankara, Turkey)

2023 Volume 29, Issue 6, Page(s) 736–740

Abstract: ... sensitivity: 91.3%-100%; 95% CI specificity: 95.3%-100%]. Interrater agreement was k: 0.79. In total, 33 (33 ...

Abstract	Purpose: When a suspected hepatic alveolar echinococcosis (AE) lesion is detected on a contrast enhanced computed tomography (CT) scan, an additional triphasic or non-enhanced CT scan is required to determine the presence of calcification and enhancement. As a result, imaging costs and exposure to ionizing radiation will increase. We can create a non-enhanced series from routine contrast-enhanced images using dual-energy CT (DECT) and virtual non-enhanced (VNE) images. This study's objective is to assess virtual non-enhanced DECT reconstruction as a potential diagnostic tool for hepatic AE. Methods: Triphasic CT scans and a routine dual energy venous phase were acquired using a third-generation DECT system. A commercially available software package was used to generate VNE images. Individual evaluations were conducted by two radiologists. Results: The study population consisted of 100 patients (30 AE, 70 other solid liver masses). All AE cases were diagnosed [no false positives/negatives, 95% confidence interval (CI) sensitivity: 91.3%-100%; 95% CI specificity: 95.3%-100%]. Interrater agreement was k: 0.79. In total, 33 (33.00%) of the patients had AE, which was detected using both true non-enhanced (TNE) and VNE images. The mean dose-length product of a standard triphasic CT was significantly higher than biphasic dual-energy VNE images. Conclusion: In terms of diagnostic confidence, VNE images are comparable with actual non-enhanced imaging when evaluating hepatic AE. Further, VNE images could replace TNE images with a substantial radiation dose reduction. Advances in knowledge: hepatic cystic echinococcosis and AE are serious and severe diseases with high fatality rates and a poor prognosis if managed incorrectly, especially AE. Moreover, VNE images produce equal diagnostic confidence to TNE images for assessing liver AE, with a significant reduction in radiation dose.
MeSH term(s)	Humans ; Echinococcosis, Hepatic/diagnostic imaging ; Radiography, Dual-Energy Scanned Projection/methods ; Tomography, X-Ray Computed/methods ; Retrospective Studies ; Contrast Media
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-04-12
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3612
ISSN (online)	1305-3612
ISSN	1305-3612
DOI	10.4274/dir.2023.221806
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Article: Bilateral Simultaneous Primary Patellar Giant Cell Tumors.

Aydin, Fahri / Ogul, Hayri / Tuncer, Kutsi / Kantarci, Mecit

Indian journal of orthopaedics

2023 Volume 57, Issue 4, Page(s) 608–610

Abstract: Giant cell tumor is a relatively frequent benign bone tumor; that is usually exhibited in the epiphyseo-metaphyseal region of long bones. Computed tomography and magnetic resonance imaging may show cortical thinning and endosteal scalloping of the bone ... ...

Abstract	Giant cell tumor is a relatively frequent benign bone tumor; that is usually exhibited in the epiphyseo-metaphyseal region of long bones. Computed tomography and magnetic resonance imaging may show cortical thinning and endosteal scalloping of the bone cortex in giant cell tumors. In radiologic imaging, the giant cell tumor of the bone is a heterogeneous mass because it contains many components, such as solitary mass, cystic areas, and bleeding. The occurrence of giant cell bone tumor in the patella is a rare condition and in this letter, we have reported the unusual coexistence of giant cell tumor on the bilateral patella at the same time. To the best of our knowledge, there is no reported case in the literature of bilateral patellar giant cell tumors.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-00856-z
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Zs.A 1720: Show issues

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Article ; Online: Decreased glutamine and glutamate: an early biomarker of neurodegeneration.

Zeydan, Burcu / Kantarci, Kejal

International psychogeriatrics

2021 Volume 33, Issue 1, Page(s) 1–2

MeSH term(s)	Biomarkers ; Glutamic Acid ; Glutamine ; Humans
Chemical Substances	Biomarkers ; Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610219001807
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Zs.A 2621: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 513: Show issues

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Article ; Online: Reply to "Amyloid Positron Emission Tomography in Multiple Sclerosis: Between Amyloid Deposition and Myelin Damage".

Zeydan, Burcu / Kantarci, Kejal / Kantarci, Orhun H

Annals of neurology

2020 Volume 87, Issue 6, Page(s) 988–989

MeSH term(s)	Alzheimer Disease ; Amyloid ; Biomarkers ; Humans ; Multiple Sclerosis ; Myelin Sheath ; Positron-Emission Tomography
Chemical Substances	Amyloid ; Biomarkers
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.25758
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Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

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