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Article ; Online: Correction to: Deep attenuation transducer to measure liver stiffness in obese patients with liver disease.

Hirooka, Masashi / Koizumi, Yohei / Nakamura, Yoshiko / Yano, Ryo / Hirooka, Kana / Morita, Makoto / Imai, Yusuke / Tokumoto, Yoshio / Abe, Masanori / Hiasa, Yoichi

Journal of medical ultrasonics (2001)

2024

Language	English
Publishing date	2024-03-05
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01423-1
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Article ; Online: New Possibilities for Evaluating the Development of Age-Related Pathologies Using the Dynamical Network Biomarkers Theory.

Akagi, Kazutaka / Koizumi, Keiichi / Kadowaki, Makoto / Kitajima, Isao / Saito, Shigeru

Cells

2023 Volume 12, Issue 18

Abstract: Aging is the slowest process in a living organism. During this process, mortality rate increases exponentially due to the accumulation of damage at the cellular level. Cellular senescence is a well-established hallmark of aging, as well as a promising ... ...

Abstract	Aging is the slowest process in a living organism. During this process, mortality rate increases exponentially due to the accumulation of damage at the cellular level. Cellular senescence is a well-established hallmark of aging, as well as a promising target for preventing aging and age-related diseases. However, mapping the senescent cells in tissues is extremely challenging, as their low abundance, lack of specific markers, and variability arise from heterogeneity. Hence, methodologies for identifying or predicting the development of senescent cells are necessary for achieving healthy aging. A new wave of bioinformatic methodologies based on mathematics/physics theories have been proposed to be applied to aging biology, which is altering the way we approach our understand of aging. Here, we discuss the dynamical network biomarkers (DNB) theory, which allows for the prediction of state transition in complex systems such as living organisms, as well as usage of Raman spectroscopy that offers a non-invasive and label-free imaging, and provide a perspective on potential applications for the study of aging.
MeSH term(s)	Cellular Senescence ; Biomarkers ; Computational Biology ; Healthy Aging
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-09-17
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12182297
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Article ; Online: Tyrosinase-Related Protein2 Peptide with Replacement of N-Terminus Residue by Cysteine Binds to H-2K

Irie, Hitomi / Morita, Koji / Matsuda, Miyu / Koizumi, Makoto / Mochizuki, Shinichi

Bioconjugate chemistry

2023 Volume 34, Issue 2, Page(s) 433–442

Abstract: Recent studies have shown the potent efficacy of peptide-based vaccines for cancer immunotherapy. Immunological performance is optimized through the co-delivery of adjuvant and antigenic peptide molecules to antigen-presenting cells simultaneously. In ... ...

Abstract	Recent studies have shown the potent efficacy of peptide-based vaccines for cancer immunotherapy. Immunological performance is optimized through the co-delivery of adjuvant and antigenic peptide molecules to antigen-presenting cells simultaneously. In our previous study, we showed that a conjugate consisting of 40-mer CpG-DNA and an antigenic ovalbumin peptide through disulfide bonding could efficiently induce ovalbumin-specific cytotoxic T lymphocyte (CTL) responses in vivo. In this study, based on the conjugation design, we prepared a conjugate consisting of 30-mer CpG-DNA (CpG30) and a cancer antigenic peptide of Tyrosinase-related protein 2 (TRP2
MeSH term(s)	Animals ; Mice ; Antigens/pharmacology ; Cysteine/metabolism ; DNA/metabolism ; Mice, Inbred C57BL ; Monophenol Monooxygenase/metabolism ; Neoplasms/metabolism ; Ovalbumin ; Peptide Fragments/metabolism ; Peptides/metabolism ; T-Lymphocytes, Cytotoxic ; CpG Islands
Chemical Substances	Antigens ; Cysteine (K848JZ4886) ; DNA (9007-49-2) ; Monophenol Monooxygenase (EC 1.14.18.1) ; Ovalbumin (9006-59-1) ; Peptide Fragments ; Peptides
Language	English
Publishing date	2023-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.2c00592
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Article ; Online: Acute liver failure due to herpes simplex viral hepatitis diagnosed by skin lesions and blood tests: a case report.

Shionoya, Kento / Kako, Makoto / Masuda, Sakue / Makazu, Makomo / Koizumi, Kazuya

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 338

Abstract: Background: The incidence of acute liver failure from herpes simplex virus is rare.: Case presentation: A 71-year-old Japanese man was diagnosed with acute liver failure and was transferred to our hospital. Steroid therapy, plasma exchange, and ... ...

Abstract	Background: The incidence of acute liver failure from herpes simplex virus is rare. Case presentation: A 71-year-old Japanese man was diagnosed with acute liver failure and was transferred to our hospital. Steroid therapy, plasma exchange, and hemodiafiltration were started for liver failure, and antimicrobial therapy was initiated for pneumonia. Staphylococcus epidermidis was detected in blood culture. Skin rash appeared; a positive anti-herpes simplex virus result led to the diagnosis of acute liver failure from herpes simplex virus. Hence, acyclovir was started. After blood tests improved, treatments for acute liver failure were discontinued. Antimicrobial therapy was continued; however, he died. In this case, persistent bacteremia and drug-induced liver damage due to acyclovir may have contributed to his death. Conclusions: Acute liver failure can lead to complications and death. Thus, careful observation is crucial, even if the patient has shown some improvements.
MeSH term(s)	Male ; Humans ; Aged ; Antiviral Agents/therapeutic use ; Herpes Simplex/complications ; Herpes Simplex/diagnosis ; Herpes Simplex/drug therapy ; Acyclovir/therapeutic use ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/drug therapy ; Hepatitis, Viral, Human/complications ; Hepatitis, Viral, Human/diagnosis ; Hepatitis, Viral, Human/drug therapy
Chemical Substances	Antiviral Agents ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04083-w
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Article ; Online: Novel deterministic epidemic model considering mass vaccination and lockdown against coronavirus disease 2019 spread in Israel: a numerical study.

Utamura, Motoaki / Koizumi, Makoto / Kirikami, Seiichi

Biology methods & protocols

2022 Volume 7, Issue 1, Page(s) bpac023

Abstract: Why public health intervention by the Israeli government against coronavirus disease 2019 spread has been successful while the majority of other countries are still coping with it? To give a quantitative answer, a simple numerical epidemic model is ... ...

Abstract	Why public health intervention by the Israeli government against coronavirus disease 2019 spread has been successful while the majority of other countries are still coping with it? To give a quantitative answer, a simple numerical epidemic model is prepared to simulate the entire trend of various infection-related variables considering the first and second vaccination campaigns against the alpha variant and simultaneous lockdown. This model is an extension of our previously published deterministic physical model, that is Apparent Time Lag Model, which aims at predicting an entire trend of variables in a single epidemic. The time series data of both vaccine dose ratio and lockdown period are employed in the model. Predictions have been compared with observed data in terms of daily new cases, isolated people, infections at large and effective reproductive number, and, further, the model is verified. Moreover, parameter survey calculations for several scenarios have clarified the synergy effects of vaccination and lockdown. In particular, the key element of Israel's success has been suggested to lie in a high-dose vaccination rate that prevents the onset of a rebound in daily new cases on the rescission of the lockdown.
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ISSN	2396-8923
ISSN (online)	2396-8923
DOI	10.1093/biomethods/bpac023
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Article ; Online: Kawasaki disease with intervertebral disc calcification and torticollis.

Koizumi, Keiichi / Fujihara, Hiroyuki / Makino, Koichi / Yamamoto, Jin / Watanabe, Nagakazu / Nakamura, Makoto

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15537

MeSH term(s)	Humans ; Torticollis/diagnosis ; Torticollis/etiology ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Tomography, X-Ray Computed ; Intervertebral Disc
Language	English
Publishing date	2023-03-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15537
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Article ; Online: Infection spread simulation technology in a mixed state of multi variant viruses

Makoto Koizumi / Motoaki Utamura / Seiichi Kirikami

AIMS Public Health, Vol 9, Iss 1, Pp 17-

2022 Volume 25

Abstract: ATLM (Apparent Time Lag Model) was extended to simulate the spread of infection in a mixed state of the variant virus and original wild type. It is applied to the 4th wave of infection spread in Tokyo, and (1) the 4th wave bottoms out near the end of the ...

Abstract	ATLM (Apparent Time Lag Model) was extended to simulate the spread of infection in a mixed state of the variant virus and original wild type. It is applied to the 4th wave of infection spread in Tokyo, and (1) the 4th wave bottoms out near the end of the state of emergency, and the number of infected people increases again. (2) The rate of increase will be mainly by d strain (L452R) virus, while the increase by a strain (N501Y) virus will be suppressed. (3) It is anticipated that the infection will spread during the Olympic Games. (4) When variant viruses compete, the infection of highly infectious virus rises sharply while the infection by weakly infectious ones has converged. (5) It is effective as an infection control measure to find an infected person early and shorten the period from infection to quarantine by PCR test or antigen test as a measure other than the vaccine.
Keywords	variant coronavirus ; covid-19 ; epidemiological model ; prediction ; multi-variant virus ; delay differential equation ; Public aspects of medicine ; RA1-1270
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	AIMS Press
Document type	Article ; Online
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Article ; Online: Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy.

Oshima, Yusuke / Haruki, Takayuki / Koizumi, Keiichi / Yonezawa, Shota / Taketani, Akinori / Kadowaki, Makoto / Saito, Shigeru

International journal of molecular sciences

2023 Volume 24, Issue 15

Abstract: Raman spectroscopy shows great potential for practical clinical applications. By analyzing the structure and composition of molecules through real-time, non-destructive measurements of the scattered light from living cells and tissues, it offers valuable ...

Abstract	Raman spectroscopy shows great potential for practical clinical applications. By analyzing the structure and composition of molecules through real-time, non-destructive measurements of the scattered light from living cells and tissues, it offers valuable insights. The Raman spectral data directly link to the molecular composition of the cells and tissues and provides a "molecular fingerprint" for various disease states. This review focuses on the practical and clinical applications of Raman spectroscopy, especially in the early detection of human diseases. Identifying predisease, which marks the transition from a healthy to a disease state, is crucial for effective interventions to prevent disease onset. Raman spectroscopy can reveal biological processes occurring during the transition states and may eventually detect the molecular dynamics in predisease conditions.
MeSH term(s)	Spectrum Analysis, Raman ; Humans ; Early Diagnosis ; Cells/chemistry
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241512170
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Article ; Online: A Case of Drug-induced Liver Injury Considered Steroid-resistant and Histologically Diagnosed with Vanishing Bile Duct Syndrome.

Shionoya, Kento / Kobayashi, Masahiro / Kako, Makoto / Masuda, Sakue / Makazu, Makomo / Koizumi, Kazuya

Internal medicine (Tokyo, Japan)

2023

Abstract: Vanishing bile duct syndrome (VBDS) is characterized by bile duct degeneration and necrosis, which result in bile duct loss and bile stasis. A 70-year-old man had malaise after receiving celecoxib. Laboratory tests revealed elevated hepatobiliary enzymes. ...

Abstract	Vanishing bile duct syndrome (VBDS) is characterized by bile duct degeneration and necrosis, which result in bile duct loss and bile stasis. A 70-year-old man had malaise after receiving celecoxib. Laboratory tests revealed elevated hepatobiliary enzymes. His condition worsened without response to medical treatment, and he was transferred to our hospital. A liver biopsy revealed severe bile duct injury and mild cholestasis. He was diagnosed with celecoxib-induced VBDS and underwent bilirubin adsorption therapy. However, his condition continued to deteriorate, and he died. An autopsy showed that liver regeneration was poor, and bile duct loss was exacerbated. The pathological autopsy findings were consistent with VBDS.
Language	English
Publishing date	2023-11-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2427-23
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Article ; Online: Long-term intraocular pressure-lowering efficacy and safety of ripasudil-brimonidine fixed-dose combination for glaucoma and ocular hypertension: a multicentre, open-label, phase 3 study.

Tanihara, Hidenobu / Yamamoto, Tetsuya / Aihara, Makoto / Koizumi, Noriko / Fukushima, Atsuki / Kawakita, Koji / Kojima, Satoshi / Nakamura, Toka / Suganami, Hideki

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2024

Abstract: Purpose: To evaluate the long-term efficacy and safety of ripasudil-brimonidine fixed-dose combination (RBFC), a new intraocular pressure (IOP)-lowering medication for glaucoma and ocular hypertension (OHT).: Methods: This prospective, multicentre ( ... ...

Abstract	Purpose: To evaluate the long-term efficacy and safety of ripasudil-brimonidine fixed-dose combination (RBFC), a new intraocular pressure (IOP)-lowering medication for glaucoma and ocular hypertension (OHT). Methods: This prospective, multicentre (23 sites in Japan), open-label study enrolled patients with primary open-angle glaucoma (POAG), OHT or exfoliative glaucoma and assigned them to one of four combination therapy cohorts, based on previous treatment(s) received: prostaglandin (PG) analogue (Cohort 1); PG analogue and beta-adrenoceptor blocker (β-blocker) (Cohort 2); PG analogue, β-blocker and carbonic anhydrase inhibitor (Cohort 3); or other/no treatment (Cohort 4). After a ≥ 4-week screening period, eligible patients received twice-daily RBFC for 52 weeks in addition to the treatments they were already receiving. Efficacy was assessed by change in IOP from baseline through week 52. Adverse events and adverse drug reactions (ADRs) were monitored throughout. Results: In total, 179 patients from Cohort 1 (n = 48), Cohort 2 (n = 44), Cohort 3 (n = 41) and Cohort 4 (n = 46) entered the RBFC treatment period. For all cohorts, mean IOP was significantly reduced at 11:00 (2 h after instillation of RBFC) through week 52 with the changes from baseline at week 52 of - 2.7 to - 4.1 mmHg across cohorts; all p < 0.001. Common ADRs were conjunctival hyperaemia (58%), allergic conjunctivitis (18%) and blepharitis (17%), most of which were mild in severity. Conclusion: These data demonstrated the long-term efficacy and safety of RBFC, both alone and in combination with other anti-glaucoma agents. RBFC may offer a new treatment option for the long-term management of glaucoma and OHT. Trial registration: Japan Registry of Clinical Trials Identifier: jRCT2080225063. Date of registration: 17 February 2020.
Language	English
Publishing date	2024-03-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-024-06388-y
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