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Article: Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway.

Wang, Yutao / Zhao, Xin / Xiao, Mengjie / Lin, Xiaoying / Chen, Qiaolian / Qin, Shengle / Ti, Huihui / Yang, Zifeng

2023 Volume 9, Issue 3, Page(s) e14649

Abstract: Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat ...

Abstract	Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis. The genes corresponding to the targets were retrieved using GeneCards and TTD database. The herb-compound-target network was constructed by Cytoscape. The target protein-protein interaction network was built using STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of QT granule to IAV were performed for further study. The regulation to different signaling transduction events and cytokine/chemokine expression of QT granule was evaluated using Western blotting and real-time qPCR. Totally, 47 compounds were identified and effect of QT granule on cell STAT1/3 signaling pathways was confirmed by A549 cell model. The efficiency of QT granule on host cell contributes to its clinical application and mechanism research.
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14649
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qingjie decoction attenuated E.coli-induced diarrhea by regulating energy metabolism and alleviating inflammation based on network analysis and metabolomics.

Fan, Yi-Meng / Zhao, Qing-Yu / Wei, Yuan-Yuan / Wang, Hui-Ru / Ga, Yu / Zhang, Yan-Nan / Hao, Zhi-Hui

Journal of ethnopharmacology

2023 Volume 318, Issue Pt A, Page(s) 116806

Abstract: ... in clinical practice, and E. coli is one of the main causative agents. Although Qingjie decoction (QJD) has ...

Abstract	Ethnopharmacological relevance: Diarrhea is a frequently encountered gastrointestinal complication in clinical practice, and E. coli is one of the main causative agents. Although Qingjie decoction (QJD) has been shown to be highly effective in treating diarrhea by eliminating heat-toxin, the underlying molecular mechanisms and pathways of QJD remain unclear. Aim of review: The aim of this research was to explore the effects and fundamental mechanism of QJD on diarrhea induced by E.coli in rats. Materials and methods: Initially, we used UHPLC-MS/MS analysis to identify the chemical composition of QJD. Then, we constructed a visualization network using network pharmacology. Next, we utilized metabolomics to identify differentially expressed metabolites of QJD that are effective in treating diarrhea. Results: The chemical composition of QJD was analyzed using UHPLC-MS/MS, which identified a total of 292 components. Using a network pharmacology approach, 127 bioactive compounds of QJD were screened, targeting 171 potential diarrhea treatment targets. TNF-α, IL-6, IL-1β, and CAT were identified as important targets through visualizing the PPI network. Enrichment analysis demonstrated significant enrichment in the TNF signaling pathway, IL-17 signaling pathway, and PI3K-Akt signaling pathway. QJD showed beneficial effects, such as increased body weight, decreased fecal water content, and reduced inflammatory cell infiltration in the duodenum and colon, as well as maintaining the structure of the duodenum and colon. Metabolomic analysis revealed 32 differentially expressed metabolites in the control, model and QJD-H groups, including glucose, valine, and cysteine. Functional analysis indicated that differential metabolites were related to energy metabolism, including glucose metabolism, TCA cycle, and amino acid metabolism. Conclusion: QJD significantly increased body weight, decreased water content in feces, relieved inflammatory cell infiltration, maintained the structure of duodenum and colon. Combining network analysis and metabolomics, QJD exerted therapeutic effects by inhibiting inflammation and oxidative stress, regulating glucose metabolism, tricarboxylic acid metabolism, and amino acid metabolism.
MeSH term(s)	Animals ; Rats ; Escherichia coli ; Phosphatidylinositol 3-Kinases ; Tandem Mass Spectrometry ; Metabolomics ; Energy Metabolism ; Diarrhea/chemically induced ; Diarrhea/drug therapy ; Cysteine ; Glucose ; Inflammation ; Body Weight ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Cysteine (K848JZ4886) ; Glucose (IY9XDZ35W2) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-07-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116806
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Article: Based on the Network Pharmacology to Investigate the Mechanism of Qingjie Fuzheng Granules against Colorectal Cancer.

Fang, Yi / Yang, Chi / Lu, Yao / Wei, Lihui / Zhao, Jinyan / Lu, Lisha / Lin, Jiumao

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7242640

Abstract: Qingjie Fuzheng granules (QFG) exert an anticancer effect against colorectal cancers (CRC ...

Abstract	Qingjie Fuzheng granules (QFG) exert an anticancer effect against colorectal cancers (CRC). However, the pharmacological molecular mechanisms are still unclear. This study was aimed to establish a simple method to predict targets of QFG against CRC by the network pharmacology strategy. 461 compounds and 1559 targets in QFG were enriched by BATMAN-TCM. 21 of the common targets were obtained by the groups of "Jun," "Chen," "Zuo," and "Shi" medicine in QFG. The enrichment analyses of GO functional terms, KEGG pathway, and OMIM/TTD diseases displayed the targets in the different and complementary effects of four functional medicines in QFG. Then, 613 differential targets for QFG in CRC were identified. GO functional terms and KEGG pathway analyses showed that QFG regulated the inflammatory function and lipid metabolic process. There were also targets that played a role in the binding to the receptors in membranes, in the activation of the transportation signal, and provided pain relief by regulation of the neural related pathways. Next, the protein-protein interaction network was analyzed, and the levels of the predicted targets in CRC primary tumor were explored, and 7 candidate targets of QFG against CRC were obtained. Furthermore, with real-time PCR and enzyme-linked immunosorbent assay (ELISA) analysis, downregulation of dopamine D2 receptor (DRD2) and interleukin-6 (IL-6), and upregulation of interleukin-10 (IL-10) were identified following the treatment of QFG. At last, the survival and prognosis of the potential targets of QFG in CRC patients were analyzed by GenomicScape, and IL-6 was suggested to be an index for the regulation of QFG in CRC. These results might elucidate the possible antitumor mechanism of QFG and highlight the candidate therapeutic targets and the application direction in clinical treatment for QFG.
Language	English
Publishing date	2022-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7242640
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway

Yutao Wang / Xin Zhao / Mengjie Xiao / Xiaoying Lin / Qiaolian Chen / Shengle Qin / Huihui Ti / Zifeng Yang

Heliyon, Vol 9, Iss 3, Pp e14649- (2023)

2023

Abstract: Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat ...

Abstract	Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis. The genes corresponding to the targets were retrieved using GeneCards and TTD database. The herb–compound–target network was constructed by Cytoscape. The target protein–protein interaction network was built using STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of QT granule to IAV were performed for further study. The regulation to different signaling transduction events and cytokine/chemokine expression of QT granule was evaluated using Western blotting and real-time qPCR. Totally, 47 compounds were identified and effect of QT granule on cell STAT1/3 signaling pathways was confirmed by A549 cell model. The efficiency of QT granule on host cell contributes to its clinical application and mechanism research.
Keywords	Qingjie-Tuire granule ; Anti-Influenza ; Traditional Chinese medicine ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	572
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway

Wang, Yutao / Zhao, Xin / Xiao, Mengjie / Lin, Xiaoying / Chen, Qiaolian / Qin, Shengle / Ti, Huihui / Yang, Zifeng

Heliyon. 2023 Mar., v. 9, no. 3 p.e14649-

2023

Abstract: Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat ...

Abstract	Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis. The genes corresponding to the targets were retrieved using GeneCards and TTD database. The herb-compound-target network was constructed by Cytoscape. The target protein-protein interaction network was built using STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of QT granule to IAV were performed for further study. The regulation to different signaling transduction events and cytokine/chemokine expression of QT granule was evaluated using Western blotting and real-time qPCR. Totally, 47 compounds were identified and effect of QT granule on cell STAT1/3 signaling pathways was confirmed by A549 cell model. The efficiency of QT granule on host cell contributes to its clinical application and mechanism research.
Keywords	chemokines ; gene ontology ; genome ; influenza ; models ; pharmacology ; protein-protein interactions ; Qingjie-Tuire granule ; Anti-Influenza ; Traditional Chinese medicine
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14649
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.

Huang, Bin / Lu, Yao / Gui, Mengxuan / Guan, Jianhua / Lin, Minghe / Zhao, Jinyan / Mao, Qianqian / Lin, Jiumao

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 137, Page(s) 111331

Abstract: Scope: To investigate the effect of Qingjie Fuzheng Granule (QFG) on lymphangiogenesis and ...

Abstract	Scope: To investigate the effect of Qingjie Fuzheng Granule (QFG) on lymphangiogenesis and lymphatic metastasis in colorectal cancer. Methods: The effects of QFG on the expression and secretion of vascular endothelial growth factor-C (VEGF-C) in HCT-116 cells were investigated both in vitro and in vivo. HCT-116 cells were treated with different concentrations (0.2, 0.5, and 1.0 mg/mL) of QFG. The VEGF-C expression level was determined using RT-qPCR and western blotting, and the VEGF-C concentration in supernatant was measured by ELISA. Tumor xenograft models of HCT-116 cells were generated using BALB/c nude mice, and the mice were randomly divided into a control group (gavaged with normal saline) and QFG group (gavaged with 2 g/kg QFG). The effect of QFG on tumor growth was evaluated by comparing the volume and weight of tumors between two groups. Immunohistochemistry (IHC) and RT-qPCR were performed to detect the expression levels of VEGF-C, vascular endothelial growth factor receptor 3 (VEGFR-3), and LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1). ELISA was performed to measure the concentration of serum VEGF-C. TMT proteomics technology and Reactome pathway analysis were used to explore the mechanism of QFG inhibiting lymphangiogenesis in tumor. The VEGF-C (5 ng/mL)-stimulated human lymphatic endothelial cell (HLEC) model was conducted to evaluate the effect of QFG on lymphangiogenesis in vitro. The model cells were treated with different concentrations (0.2, 0.5, and 1.0 mg/mL) of QFG. Cell viability was then determined using an MTT assay. The cell migration, invasion, and tube-formation ability were analyzed using transwell migration, matrigel invasion and tube formation assays, respectively. The underlying mechanism was uncovered, the levels of VEGFR-3, matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9), p-PI3K/PI3K, p-AKT/AKT and p-mTOR/ mTOR were detected using western blotting. Results: QFG significantly reduced VEGF-C expression and secretion in HCT-116 cells. QFG evidently suppressed in vivo tumor growth and the expression of VEGF-C, VEGFR-3, and LYVE-1. The serum VEGF-C level was also reduced by QFG. Moreover, TMT proteomics technology and Reactome pathway analysis identified 95 differentially expressed protein and multiple enriched pathway about matrix metalloproteinase and extracellular matrix, which is direct associate with lymphangiogenesis. In vitro experiment, QFG inhibited the viability, migration, invasion and tube formation of HLECs. Additionally, QFG reduced the VEGFR-3, MMP-2, MMP-9 expression levels, and the p-PI3K/PI3K, p-AKT/AKT, p-mTOR/ mTOR ratios. Conclusion: QFG can exert its effect on both tumor cells and HLECs, exhibiting ani- lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway pathway.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Cell Line ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Endothelial Cells/drug effects ; Humans ; Lymphangiogenesis/drug effects ; Matrix Metalloproteinase Inhibitors/pharmacology ; Membrane Transport Proteins/drug effects ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Oncogene Protein v-akt/drug effects ; Phosphatidylinositol 3-Kinases/drug effects ; Signal Transduction/drug effects ; Vascular Endothelial Growth Factor C/drug effects ; Vascular Endothelial Growth Factor Receptor-3/drug effects
Chemical Substances	Angiogenesis Inhibitors ; Matrix Metalloproteinase Inhibitors ; Membrane Transport Proteins ; Vascular Endothelial Growth Factor C ; Xlkd1 protein, mouse ; vascular endothelial growth factor C, mouse ; Vascular Endothelial Growth Factor Receptor-3 (EC 2.7.10.1) ; Oncogene Protein v-akt (EC 2.7.11.1)
Language	English
Publishing date	2021-02-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qingjie decoction attenuated E.coli-induced diarrhea by regulating energy metabolism and alleviating inflammation based on network analysis and metabolomics

Fan, Yi-meng / Zhao, Qingyu / Wei, Yuan-yuan / Wang, Hui-ru / Ga, Yu / Zhang, Yan-nan / Hao, Zhihui

Journal of Ethnopharmacology. 2023 July 17, p.116806-

2023 , Page(s) 116806–

Abstract: ... coli is one of the main causative agents. Although Qingjie decoction (QJD) has been shown to be highly ...

Abstract	Diarrhea is a frequently encountered gastrointestinal complication in clinical practice, and E. coli is one of the main causative agents. Although Qingjie decoction (QJD) has been shown to be highly effective in treating diarrhea by eliminating heat-toxin, the underlying molecular mechanisms and pathways of QJD remain unclear. The aim of this research was to explore the effects and fundamental mechanism of QJD on diarrhea induced by E.coli in rats. Initially, we used UHPLC-MS/MS analysis to identify the chemical composition of QJD. Then, we constructed a visualization network using network pharmacology. Next, we utilized metabolomics to identify differentially expressed metabolites of QJD that are effective in treating diarrhea. The chemical composition of QJD was analyzed using UHPLC-MS/MS, which identified a total of 292 components. Using a network pharmacology approach, 127 bioactive compounds of QJD were screened, targeting 171 potential diarrhea treatment targets. TNF-α, IL-6, IL-1β, and CAT were identified as important targets through visualizing the PPI network. Enrichment analysis demonstrated significant enrichment in the TNF signaling pathway, IL-17 signaling pathway, and PI3K-Akt signaling pathway. QJD showed beneficial effects, such as increased body weight, decreased fecal water content, and reduced inflammatory cell infiltration in the duodenum and colon, as well as maintaining the structure of the duodenum and colon. Metabolomic analysis revealed 32 differentially expressed metabolites in the control, model and QJD-H groups, including glucose, valine, and cysteine. Functional analysis indicated that differential metabolites were related to energy metabolism, including glucose metabolism, TCA cycle, and amino acid metabolism. QJD significantly increased body weight, decreased water content in feces, relieved inflammatory cell infiltration, maintained the structure of duodenum and colon. Combining network analysis and metabolomics, QJD exerted therapeutic effects by inhibiting inflammation and oxidative stress, regulating glucose metabolism, tricarboxylic acid metabolism, and amino acid metabolism.
Keywords	Escherichia coli ; amino acid metabolism ; body weight ; colon ; cysteine ; diarrhea ; duodenum ; energy metabolism ; feces ; gene expression regulation ; glucose ; inflammation ; interleukin-17 ; interleukin-6 ; metabolites ; metabolomics ; models ; oxidative stress ; pharmacology ; therapeutics ; traditional medicine ; tricarboxylic acid cycle ; valine ; water content ; Qingjie decoction ; Network analysis ; Mechanism ; E. coli ; QJD ; CNS ; TCM ; FBS ; SD ; T-SOD ; CAT ; H&E ; DAVID ; TRAF6
Language	English
Dates of publication	2023-0717
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116806
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Based on the Network Pharmacology to Investigate the Mechanism of Qingjie Fuzheng Granules against Colorectal Cancer

Yi Fang / Chi Yang / Yao Lu / Lihui Wei / Jinyan Zhao / Lisha Lu / Jiumao Lin

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Qingjie Fuzheng granules (QFG) exert an anticancer effect against colorectal cancers (CRC ...

Abstract	Qingjie Fuzheng granules (QFG) exert an anticancer effect against colorectal cancers (CRC). However, the pharmacological molecular mechanisms are still unclear. This study was aimed to establish a simple method to predict targets of QFG against CRC by the network pharmacology strategy. 461 compounds and 1559 targets in QFG were enriched by BATMAN-TCM. 21 of the common targets were obtained by the groups of “Jun,” “Chen,” “Zuo,” and “Shi” medicine in QFG. The enrichment analyses of GO functional terms, KEGG pathway, and OMIM/TTD diseases displayed the targets in the different and complementary effects of four functional medicines in QFG. Then, 613 differential targets for QFG in CRC were identified. GO functional terms and KEGG pathway analyses showed that QFG regulated the inflammatory function and lipid metabolic process. There were also targets that played a role in the binding to the receptors in membranes, in the activation of the transportation signal, and provided pain relief by regulation of the neural related pathways. Next, the protein-protein interaction network was analyzed, and the levels of the predicted targets in CRC primary tumor were explored, and 7 candidate targets of QFG against CRC were obtained. Furthermore, with real-time PCR and enzyme-linked immunosorbent assay (ELISA) analysis, downregulation of dopamine D2 receptor (DRD2) and interleukin-6 (IL-6), and upregulation of interleukin-10 (IL-10) were identified following the treatment of QFG. At last, the survival and prognosis of the potential targets of QFG in CRC patients were analyzed by GenomicScape, and IL-6 was suggested to be an index for the regulation of QFG in CRC. These results might elucidate the possible antitumor mechanism of QFG and highlight the candidate therapeutic targets and the application direction in clinical treatment for QFG.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring multiple mechanisms of Qingjie Fanggan prescription for prevention and treatment of influenza based on systems pharmacology.

Gao, Kai / Song, Yan-Ping / Du, Xia / Chen, Hao / Zhao, Lin-Tao

Computational biology and chemistry

2020 Volume 88, Page(s) 107307

Abstract: ... pharmacology approach to reveal the underlying molecular mechanisms of Qingjie Fanggan prescription (QFP ...

Abstract	Influenza is a type of acute disease characterized by strong contagiousness and short incubation period, which have posed a large potential threat to public health. Traditional Chinese Medicine (TCM) advocates to the aim of combating complex diseases from a holistic view, which has shown effectiveness in anti-influenza. However, the mechanism of TCM prescription remains puzzling. Here, we applied a system pharmacology approach to reveal the underlying molecular mechanisms of Qingjie Fanggan prescription (QFP) in the prevention and treatment of influenza. In this study, we identified 228 potential active compounds by means of absorption, distribution, metabolism, and excretion (ADME) evaluation system and literature research. Then, the targets of the potential active compounds were predicted by using the WES (Weighted Ensemble Similarity) method, and the influenza-related targets were obtained according to some existing gene databases. Next, an herb-component-target network was constructed to further dissect the multi-directional therapeutic approach for QFP. Meanwhile, we also performed gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation analysis on 344 potential targets. Finally, a target-pathway network was constructed to further dissect the core pathways and targets in treatment of influenza for QFP. And the key components and targets were docked by AutoDock Vina to explore their binding mode. All of these demonstrated that QFP had multi-scale curative activity in regulating influenza-related biological processes, which facilitates the application of traditional medicine in modern medicine.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Gene Ontology ; Humans ; Influenza, Human/drug therapy ; Influenza, Human/genetics ; Medicine, Chinese Traditional ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-06-20
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2020.107307
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficacy and safety of Qinxiang Qingjie oral solution for the treatment of influenza in children: a randomized, double-blind, multicenter clinical trial.

Hu, Siyuan / Ma, Rong / Shen, Kunling / Xin, Deli / Li, Xinmin / Xu, Baoping / Zhao, Xiaobing / Feng, Ziwei / Yan, Yongbin / Xue, Zheng / Zhang, Baoqing / Li, Xueming / Zheng, Yanmei / Zhou, Hongxia / Wu, Liqun / Yang, Lili / Xu, Hua / Shao, Rongchang / Yin, Yong /

Zhong, Chengliang / Li, Han / Cai, Qiuhan / Xu, Yaqian

Translational pediatrics

2020 Volume 11, Issue 6, Page(s) 987–1000

Abstract: Background: Qinxiang Qingjie (QXQJ), an oral solution containing various Chinese herbs, is ...

Abstract	Background: Qinxiang Qingjie (QXQJ), an oral solution containing various Chinese herbs, is indicated for pediatric upper respiratory tract infections. The treatment of influenza also shows potential advantages in shortening the duration of illness and improving symptoms. However, there is still a lack of high-quality clinical evidence to support this. The trial was to explore the efficacy and safety of QXQJ for treating pediatric influenza and provide an evidence-based basis for expanding its applicability. Methods: A randomized, double-blind, double-dummy, positive-controlled, multicenter clinical trial was conducted in 14 hospitals in China. Children aged 1-13 years with influenza and "exterior and interior heat syndromes" as defined by traditional Chinese medicine (TCM) were randomly assigned to two groups with 1:1 radio. Children in the test group received QXQJ oral solution and oseltamivir simulant, while the control group received oseltamivir phosphate granules and QXQJ simulant. The duration of treatment was five days, followed by a two-day follow-up period. The primary endpoint was the clinical recovery time. Secondary endpoints included the time to defervescence, incidences of complications and severe or critical influenza, negative conversion rate, improvement of TCM syndromes, and safety profiles of the therapeutics, which mainly contained the adverse clinical events and adverse drug reactions. Results: A total of 231 children were randomized to either the QXQJ (n=117) or oseltamivir (n=114) group. The FAS and PPS results showed that both groups experienced a median clinical recovery time of three days (P>0.05). The median time to defervescence of both groups were 36 hours in FAS and PPS (P>0.05), and two groups did not differ in terms of the other secondary endpoints (P>0.05). 14 patients (12.39%) in the QXQJ group and 14 patients (12.50%) in the oseltamivir group reported at least one adverse event, respectively. One serious adverse event occurred in the QXQJ group. There was no significant difference in the incidence of adverse events or adverse drug reactions between the groups. Conclusions: The efficacy of QXQJ oral solution was comparable to that of oseltamivir for treating influenza in children, with an acceptable safety profile. Trial registration: Chinese Clinical Trial Registry ChiCTR1900021060.
Language	English
Publishing date	2020-04-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-22-201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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