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  1. Article ; Online: To screen or not to screen: how to find and identify very early arthritis.

    Villeneuve, Edith

    Best practice & research. Clinical rheumatology

    2013  Volume 27, Issue 4, Page(s) 487–497

    Abstract: There is accumulating evidence demonstrating that early treatment leads to better outcomes in rheumatoid arthritis. In order to be treated early, patients thus need to be identified at the earliest possible stage. This means identifying patients with ... ...

    Abstract There is accumulating evidence demonstrating that early treatment leads to better outcomes in rheumatoid arthritis. In order to be treated early, patients thus need to be identified at the earliest possible stage. This means identifying patients with rheumatoid arthritis at their earliest clinical signs but it could also mean screening for healthy individuals at high risk of developing rheumatoid arthritis. The different tools available to screen for these individuals are reviewed here and their relevance is discussed.
    MeSH term(s) Arthritis, Rheumatoid/classification ; Arthritis, Rheumatoid/diagnosis ; Early Diagnosis ; Humans ; Risk Factors
    Language English
    Publishing date 2013-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2013.09.006
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  2. Article ; Online: In reply: Is an intravenous bolus of dexmedetomidine really a safe and effective option in treating shivering following neuraxial anesthesia?

    Lamontagne, Christina / Lesage, Sandra / Villeneuve, Édith / Lidzborski, Elsa / Derstenfeld, Alex / Crochetière, Chantal

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2019  Volume 67, Issue 1, Page(s) 145

    MeSH term(s) Anesthesia ; Anesthesiology ; Cesarean Section ; Dexmedetomidine ; Female ; Humans ; Pregnancy ; Shivering
    Chemical Substances Dexmedetomidine (67VB76HONO)
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-019-01430-8
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  3. Article ; Online: Uncoupling of disease activity and structural damage. Does it matter clinically?

    Villeneuve, Edith / Haraoui, Boulos

    Annals of the rheumatic diseases

    2013  Volume 72, Issue 1, Page(s) 1–2

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Biological Products/therapeutic use ; Disease Progression ; Humans ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Biological Products
    Language English
    Publishing date 2013-01
    Publishing country England
    Document type Editorial
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2012-202650
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  4. Article: Evaluation of Vaso-occlusive Crisis Management With Patient-Controlled Analgesia in Children With Sickle Cell Disease Requiring Hospitalization.

    Arbitre, Claire / Pastore, Yves / Bailey, Benoit / Kleiber, Niina / Robitaille, Nancy / Villeneuve, Edith / Viau, Annie / Bergeron, Marie-Joelle / Trottier, Evelyne D

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2021  Volume 26, Issue 6, Page(s) 615–623

    Abstract: Objective: The aim of this study was to review the use of patient-controlled analgesia (PCA) in sickle cell disease (SCD) for pediatric patients with vaso-occlusive crisis (VOC) in our institution and to compare the effect of early vs late PCA start on ... ...

    Abstract Objective: The aim of this study was to review the use of patient-controlled analgesia (PCA) in sickle cell disease (SCD) for pediatric patients with vaso-occlusive crisis (VOC) in our institution and to compare the effect of early vs late PCA start on pain relief and LOS.
    Methods: This retrospective study included all pediatric patients treated with PCA for a severe VOC from 2010 to 2016. "Early-PCA" was defined as start of PCA within 48 hours of arrival. Time to reach adequate analgesia was defined as the time to reach 2 consecutive pain scores less than 5/10 at 4-hour interval.
    Results: During the study period, 46 patients presented 87 episodes of VOC treated with PCA. Sixty-three patients with VOC were treated with Early-PCA and 24 with Late-PCA. Both groups were comparable except for median pain score at admission; the Early-PCA group had higher scores: 9.0/10 vs 7.0/10. Time to reach adequate analgesia could be evaluated only in a subset of patients (n = 32) but was shorter in the Early-PCA group with a median difference of 41.0 hours (95% CI -82.0 to -6.0). Early-PCA was associated with a median reduction in LOS of 3.4 days (95% CI -4.9 to -1.9). There was no difference between the 2 groups in terms of side effects and occurrence of acute chest syndrome during hospitalization.
    Conclusions: In this study, a reduced time to reach adequate analgesia and LOS was noted in the Early-PCA group for severe VOC. A prospective study is required to confirm these results.
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-26.6.615
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  5. Article: Clinical Use of an Order Protocol for Distress in Pediatric Palliative Care.

    Marquis, Marc-Antoine / Daoust, Lysanne / Villeneuve, Edith / Ducruet, Thierry / Humbert, Nago / Gauvin, France

    Healthcare (Basel, Switzerland)

    2019  Volume 7, Issue 1

    Abstract: Several children receiving palliative care experience dyspnea and pain. An order protocol for distress (OPD) is available at Sainte-Justine Hospital, aimed at alleviating respiratory distress, pain and anxiety in pediatric palliative care patients. This ... ...

    Abstract Several children receiving palliative care experience dyspnea and pain. An order protocol for distress (OPD) is available at Sainte-Justine Hospital, aimed at alleviating respiratory distress, pain and anxiety in pediatric palliative care patients. This study evaluates the clinical use of the OPD at Sainte-Justine Hospital, through a retrospective chart review of all patients for whom the OPD was prescribed between September 2009 and September 2012. Effectiveness of the OPD was assessed using chart documentation of the patient's symptoms, or the modified Borg scale. Safety of the OPD was evaluated by measuring the time between administration of the first medication and the patient's death, and clinical evolution of the patient as recorded in the chart. One hundred and four (104) patients were included in the study. The OPD was administered at least once to 78 (75%) patients. A total of 350 episodes of administration occurred, mainly for respiratory distress (89%). Relief was provided in 90% of cases. The interval between administration of the first protocol and death was 17 h; the interval was longer in children with cancer compared to other illnesses (
    Language English
    Publishing date 2019-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare7010003
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  6. Article ; Online: Intravenous dexmedetomidine for the treatment of shivering during Cesarean delivery under neuraxial anesthesia: a randomized-controlled trial.

    Lamontagne, Christina / Lesage, Sandra / Villeneuve, Edith / Lidzborski, Elsa / Derstenfeld, Alex / Crochetière, Chantal

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2019  Volume 66, Issue 7, Page(s) 762–771

    Abstract: Purpose: About 55% of patients undergoing a Cesarean delivery under spinal or epidural anesthesia will experience shivering, which may interfere with the monitoring of vital signs. Recent studies have shown that dexmedetomidine could potentially help to ...

    Title translation Administration de dexmédétomidine intraveineuse pour le traitement des frissons pendant un accouchement par césarienne sous anesthésie neuraxiale : une étude randomisée contrôlée.
    Abstract Purpose: About 55% of patients undergoing a Cesarean delivery under spinal or epidural anesthesia will experience shivering, which may interfere with the monitoring of vital signs. Recent studies have shown that dexmedetomidine could potentially help to alleviate shivering associated with anesthesia. We investigated whether dexmedetomidine, an alpha 2-adrenergic agonist, reduces the duration of shivering associated with neuraxial anesthesia during Cesarean delivery.
    Methods: Eighty parturients undergoing Cesarean delivery under neuraxial anesthesia and experiencing shivering were enlisted in this prospective, randomized, double-blind trial. After childbirth, the intervention group (n = 40) received a single intravenous bolus of dexmedetomidine (30 µg) while the control group (n = 40) received saline. Randomization and allocation were based on a computer-generated list. The primary outcome measure was the time required for an observable decrease in shivering after the intervention.
    Results: One hundred fifty-five patients were recruited, 80 of whom presented with shivering and were randomized. Our study showed that dexmedetomidine reduced the mean (standard deviation) duration of shivering after a single intravenous bolus to 2.6 (2.1) min after dexmedetomidine from 17.9 (12.6) min after saline (difference in means, -15.3 min; 95% confidence interval [CI], -11.2 to -19.4). The effect of dexmedetomidine persisted 15 min after the bolus was administered, as shivering had completely stopped in 90% of the patients in the intervention group vs 22.5% in the control group (relative risk, 4.0; 95% CI, 2.2 to 7.2). No adverse effects, including bradycardia, were observed.
    Conclusion: A single intravenous bolus of dexmedetomidine decreased the duration of shivering for up to 15 min during Cesarean delivery under neuraxial anesthesia.
    Trial registration: www.clinicaltrials.gov (NCT02384343); registered 10 March, 2015.
    MeSH term(s) Administration, Intravenous ; Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Adult ; Anesthesia, Epidural/methods ; Anesthesia, Obstetrical/methods ; Anesthesia, Spinal/methods ; Cesarean Section/methods ; Dexmedetomidine/administration & dosage ; Double-Blind Method ; Female ; Humans ; Pregnancy ; Prospective Studies ; Shivering/drug effects
    Chemical Substances Adrenergic alpha-2 Receptor Agonists ; Dexmedetomidine (67VB76HONO)
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-019-01354-3
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    Zs.A 109: Show issues Location:
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  7. Article ; Online: Clinical Use of an Order Protocol for Distress in Pediatric Palliative Care

    Marc-Antoine Marquis / Lysanne Daoust / Edith Villeneuve / Thierry Ducruet / Nago Humbert / France Gauvin

    Healthcare, Vol 7, Iss 1, p

    2019  Volume 3

    Abstract: Several children receiving palliative care experience dyspnea and pain. An order protocol for distress (OPD) is available at Sainte-Justine Hospital, aimed at alleviating respiratory distress, pain and anxiety in pediatric palliative care patients. This ... ...

    Abstract Several children receiving palliative care experience dyspnea and pain. An order protocol for distress (OPD) is available at Sainte-Justine Hospital, aimed at alleviating respiratory distress, pain and anxiety in pediatric palliative care patients. This study evaluates the clinical use of the OPD at Sainte-Justine Hospital, through a retrospective chart review of all patients for whom the OPD was prescribed between September 2009 and September 2012. Effectiveness of the OPD was assessed using chart documentation of the patient’s symptoms, or the modified Borg scale. Safety of the OPD was evaluated by measuring the time between administration of the first medication and the patient’s death, and clinical evolution of the patient as recorded in the chart. One hundred and four (104) patients were included in the study. The OPD was administered at least once to 78 (75%) patients. A total of 350 episodes of administration occurred, mainly for respiratory distress (89%). Relief was provided in 90% of cases. The interval between administration of the first protocol and death was 17 h; the interval was longer in children with cancer compared to other illnesses (p = 0.02). Data from this study support the effectiveness and safety of using an OPD for children receiving palliative care.
    Keywords pediatric palliative care ; dyspnea ; pain control ; order protocol ; end of life care ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Intrabone infusion for allogeneic umbilical cord blood transplantation in children.

    Vairy, Stephanie / Louis, Isabelle / Vachon, Marie-France / Richer, Johanne / Teira, Pierre / Cellot, Sonia / Villeneuve, Edith / Haddad, Elie / Duval, Michel / Bittencourt, Henrique

    Bone marrow transplantation

    2021  Volume 56, Issue 8, Page(s) 1937–1943

    Abstract: Umbilical cord blood transplantation (UCBT) has been used to treat malignant and non-malignant diseases. UCBT offers the advantages of easy procurement and acceptable partial HLA mismatches, but also shows delayed hematopoietic and immunological ... ...

    Abstract Umbilical cord blood transplantation (UCBT) has been used to treat malignant and non-malignant diseases. UCBT offers the advantages of easy procurement and acceptable partial HLA mismatches, but also shows delayed hematopoietic and immunological recoveries. We postulated that an intrabone (IB) infusion of cord blood could provide a faster short- and long-term engraftment in a pediatric population with malignant and non-malignant hematologic diseases. We conducted this phase I-II single arm, exploratory clinical trial (NCT01711788) from 2012 to 2016 in a single center. Fifteen patients aged from 1.9 to 16.4 years received an IB UCBT. Median time to neutrophils and platelet recoveries were 18 days (range: 13-36 days) and 42 days (range: 26-107 days), respectively. Rate of severe acute GVH grade was low, with only one patient with grade III aGVH. Relapse occurred in 5 patients (38.5%) and TRM occurred in 1 patient. This leads to 6 years EFS and OS of 66.7% and 80% respectively. In conclusion, IB UCBT is safe and well-tolerated in children and hematological recovery compared similarly to the results obtained with IV UCBT.
    MeSH term(s) Child ; Cord Blood Stem Cell Transplantation ; Fetal Blood ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Humans ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01275-0
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  9. Article ; Online: To switch or to change class-the biologic dilemma in rheumatoid arthritis.

    Villeneuve, Edith / Haraoui, Boulos

    Nature reviews. Rheumatology

    2010  Volume 6, Issue 5, Page(s) 301–305

    Abstract: The management of rheumatoid arthritis has greatly improved in the past decade, owing to new treatment strategies and the introduction of agents that inhibit tumor necrosis factor (TNF). Unfortunately, a substantial proportion of patients will ... ...

    Abstract The management of rheumatoid arthritis has greatly improved in the past decade, owing to new treatment strategies and the introduction of agents that inhibit tumor necrosis factor (TNF). Unfortunately, a substantial proportion of patients will discontinue therapy with their first TNF inhibitor for various reasons (for example, non-response, loss of efficacy, or toxicity). Until recently, treatment options for these patients were limited and most rheumatologists chose to switch to treatment with an alternative TNF inhibitor. However, biologic agents with different modes of action have now become available. Hence, the dilemma now facing rheumatologists presented with patients who fail to respond to anti-TNF therapy is whether to switch to an alternative TNF inhibitor or to change to a biologic agent of a different drug class. This article discusses the evidence relating to these two options.
    MeSH term(s) Antirheumatic Agents/classification ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Humans ; Immunologic Factors/therapeutic use ; Randomized Controlled Trials as Topic ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Antirheumatic Agents ; Immunologic Factors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2010-04-13
    Publishing country United States
    Document type Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2010.45
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  10. Article: Rheumatoid arthritis: what has changed?

    Villeneuve, Edith / Emery, Paul

    Skeletal radiology

    2008  Volume 38, Issue 2, Page(s) 109–112

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/therapy ; Biological Products/therapeutic use ; Disease Progression ; Early Diagnosis ; Humans ; Life Style ; Patient Education as Topic ; Physical Therapy Modalities ; Prognosis ; Remission Induction
    Chemical Substances Biological Products
    Language English
    Publishing date 2008-07-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-008-0579-4
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