LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 12051

Search options

  1. Book ; Online: TAO Conceptual Design Report

    JUNO Collaboration / Abusleme, Angel / Adam, Thomas / Ahmad, Shakeel / Aiello, Sebastiano / Akram, Muhammad / Ali, Nawab / An, Fengpeng / An, Guangpeng / An, Qi / Andronico, Giuseppe / Anfimov, Nikolay / Antonelli, Vito / Antoshkina, Tatiana / Asavapibhop, Burin / de André, João Pedro Athayde Marcondes / Auguste, Didier / Babic, Andrej / Baldini, Wander /
    Barresi, Andrea / Baussan, Eric / Bellato, Marco / Bergnoli, Antonio / Bernieri, Enrico / Biare, David / Birkenfeld, Thilo / Blin, Sylvie / Blum, David / Blyth, Simon / Bolshakova, Anastasia / Bongrand, Mathieu / Bordereau, Clément / Breton, Dominique / Brigatti, Augusto / Brugnera, Riccardo / Budano, Antonio / Buscemi, Mario / Busto, Jose / Butorov, Ilya / Cabrera, Anatael / Cai, Hao / Cai, Xiao / Cai, Yanke / Cai, Zhiyan / Cammi, Antonio / Campeny, Agustin / Cao, Chuanya / Cao, Guofu / Cao, Jun / Caruso, Rossella / Cerna, Cédric / Chakaberia, Irakli / Chang, Jinfan / Chang, Yun / Chen, Pingping / Chen, Po-An / Chen, Shaomin / Chen, Shenjian / Chen, Xurong / Chen, Yi-Wen / Chen, Yixue / Chen, Yu / Chen, Zhang / Cheng, Jie / Cheng, Yaping / Chepurnov, Alexander / Chiesa, Davide / Chimenti, Pietro / Chukanov, Artem / Chuvashova, Anna / Claverie, Gérard / Clementi, Catia / Clerbaux, Barbara / Di Lorenzo, Selma Conforti / Corti, Daniele / Costa, Salvatore / Corso, Flavio Dal / De La Taille, Christophe / Deng, Jiawei / Deng, Zhi / Deng, Ziyan / Depnering, Wilfried / Diaz, Marco / Ding, Xuefeng / Ding, Yayun / Dirgantara, Bayu / Dmitrievsky, Sergey / Dohnal, Tadeas / Donchenko, Georgy / Dong, Jianmeng / Dornic, Damien / Doroshkevich, Evgeny / Dracos, Marcos / Druillole, Frédéric / Du, Shuxian / Dusini, Stefano / Dvorak, Martin / Enqvist, Timo / Enzmann, Heike / Fabbri, Andrea / Fajt, Lukas / Fan, Donghua / Fan, Lei / Fang, Can / Fang, Jian / Fatkina, Anna / Fedoseev, Dmitry / Fekete, Vladko / Feng, Li-Cheng / Feng, Qichun / Ford, Richard / Formozov, Andrey / Fournier, Amélie / Gan, Haonan / Gao, Feng / Garfagnini, Alberto / Göttel, Alexandre / Genster, Christoph / Giammarchi, Marco / Giaz, Agnese / Giudice, Nunzio / Giuliani, Franco / Gonchar, Maxim / Gong, Guanghua / Gong, Hui / Gorchakov, Oleg / Gornushkin, Yuri / Grassi, Marco / Grewing, Christian / Gromov, Maxim / Gromov, Vasily / Gu, Minghao / Gu, Xiaofei / Gu, Yu / Guan, Mengyun / Guardone, Nunzio / Gul, Maria / Guo, Cong / Guo, Jingyuan / Guo, Wanlei / Guo, Xinheng / Guo, Yuhang / Haacke, Michael / Hackspacher, Paul / Hagner, Caren / Han, Ran / Han, Yang / He, Miao / He, Wei / Heinz, Tobias / Hellmuth, Patrick / Heng, Yuekun / Herrera, Rafael / Hong, Daojin / Hou, Shaojing / Hsiung, Yee / Hu, Bei-Zhen / Hu, Hang / Hu, Jianrun / Hu, Jun / Hu, Shouyang / Hu, Tao / Hu, Zhuojun / Huang, Chunhao / Huang, Guihong / Huang, Hanxiong / Huang, Qinhua / Huang, Wenhao / Huang, Xingtao / Huang, Yongbo / Hui, Jiaqi / Huo, Lei / Huo, Wenju / Huss, Cédric / Hussain, Safeer / Insolia, Antonio / Ioannisian, Ara / Isocrate, Roberto / Jen, Kuo-Lun / Ji, Xiaolu / Ji, Xingzhao / Jia, Huihui / Jia, Junji / Jian, Siyu / Jiang, Di / Jiang, Xiaoshan / Jin, Ruyi / Jing, Xiaoping / Jollet, Cécile / Joutsenvaara, Jari / Jungthawan, Sirichok / Kalousis, Leonidas / Kampmann, Philipp / Kang, Li / Karagounis, Michael / Kazarian, Narine / Khan, Amir / Khan, Waseem / Khosonthongkee, Khanchai / Kinz, Patrick / Korablev, Denis / Kouzakov, Konstantin / Krasnoperov, Alexey / Krokhaleva, Svetlana / Krumshteyn, Zinovy / Kruth, Andre / Kutovskiy, Nikolay / Kuusiniemi, Pasi / Lachenmaier, Tobias / Landini, Cecilia / Leblanc, Sébastien / Lefevre, Frederic / Lei, Liping / Lei, Ruiting / Leitner, Rupert / Leung, Jason / Li, Chao / Li, Demin / Li, Fei / Li, Fule / Li, Haitao / Li, Huiling / Li, Jiaqi / Li, Jin / Li, Kaijie / Li, Mengzhao / Li, Nan / Li, Qingjiang / Li, Ruhui / Li, Shanfeng / Li, Shuaijie / Li, Tao / Li, Teng / Li, Weidong / Li, Weiguo / Li, Xiaomei / Li, Xiaonan / Li, Xinglong / Li, Yi / Li, Yufeng / Li, Zhibing / Li, Ziyuan / Liang, Hao / Liang, Jingjing / Liebau, Daniel / Limphirat, Ayut / Limpijumnong, Sukit / Lin, Guey-Lin / Lin, Shengxin / Lin, Tao / Ling, Jiajie / Lippi, Ivano / Liu, Fang / Liu, Haidong / Liu, Hongbang / Liu, Hongjuan / Liu, Hongtao / Liu, Hu / Liu, Hui / Liu, Jianglai / Liu, Jinchang / Liu, Min / Liu, Qian / Liu, Qin / Liu, Runxuan / Liu, Shuangyu / Liu, Shubin / Liu, Shulin / Liu, Xiaowei / Liu, Yan / Lokhov, Alexey / Lombardi, Paolo / Lombardo, Claudio / Loo, Kai / Lu, Chuan / Lu, Haoqi / Lu, Jingbin / Lu, Junguang / Lu, Shuxiang / Lu, Xiaoxu / Lubsandorzhiev, Bayarto / Lubsandorzhiev, Sultim / Ludhova, Livia / Luo, Fengjiao / Luo, Guang / Luo, Pengwei / Luo, Shu / Luo, Wuming / Lyashuk, Vladimir / Ma, Qiumei / Ma, Si / Ma, Xiaoyan / Ma, Xubo / Maalmi, Jihane / Malyshkin, Yury / Mantovani, Fabio / Manzali, Francesco / Mao, Xin / Mao, Yajun / Mari, Stefano M. / Marini, Filippo / Marium, Sadia / Martellini, Cristina / Martin-Chassard, Gisele / Martini, Agnese / Mayilyan, Davit / Müller, Axel / Meng, Yue / Meregaglia, Anselmo / Meroni, Emanuela / Meyhöfer, David / Mezzetto, Mauro / Miller, Jonathan / Miramonti, Lino / Monforte, Salvatore / Montini, Paolo / Montuschi, Michele / Morozov, Nikolay / Muralidharan, Pavithra / Nastasi, Massimiliano / Naumov, Dmitry V. / Naumova, Elena / Nemchenok, Igor / Nikolaev, Alexey / Ning, Feipeng / Ning, Zhe / Nunokawa, Hiroshi / Oberauer, Lothar / Ochoa-Ricoux, Juan Pedro / Olshevskiy, Alexander / Orestano, Domizia / Ortica, Fausto / Pan, Hsiao-Ru / Paoloni, Alessandro / Parkalian, Nina / Parmeggiano, Sergio / Payupol, Teerapat / Pei, Yatian / Pelliccia, Nicomede / Peng, Anguo / Peng, Haiping / Perrot, Frédéric / Petitjean, Pierre-Alexandre / Petrucci, Fabrizio / Rico, Luis Felipe Piñeres / Popov, Artyom / Poussot, Pascal / Pratumwan, Wathan / Previtali, Ezio / Qi, Fazhi / Qi, Ming / Qian, Sen / Qian, Xiaohui / Qiao, Hao / Qin, Zhonghua / Qiu, Shoukang / Rajput, Muhammad / Ranucci, Gioacchino / Raper, Neill / Re, Alessandra / Rebber, Henning / Rebii, Abdel / Ren, Bin / Ren, Jie / Rezinko, Taras / Ricci, Barbara / Robens, Markus / Roche, Mathieu / Rodphai, Narongkiat / Romani, Aldo / Roskovec, Bedřich / Roth, Christian / Ruan, Xiangdong / Ruan, Xichao / Rujirawat, Saroj / Rybnikov, Arseniy / Sadovsky, Andrey / Saggese, Paolo / Salamanna, Giuseppe / Sanfilippo, Simone / Sangka, Anut / Sanguansak, Nuanwan / Sawangwit, Utane / Sawatzki, Julia / Sawy, Fatma / Schever, Michaela / Schuler, Jacky / Schwab, Cédric / Schweizer, Konstantin / Selivanov, Dmitry / Selyunin, Alexandr / Serafini, Andrea / Settanta, Giulio / Settimo, Mariangela / Shahzad, Muhammad / Shi, Gang / Shi, Jingyan / Shi, Yongjiu / Shutov, Vitaly / Sidorenkov, Andrey / Simkovic, Fedor / Sirignano, Chiara / Siripak, Jaruchit / Sisti, Monica / Slupecki, Maciej / Smirnov, Mikhail / Smirnov, Oleg / Sogo-Bezerra, Thiago / Songwadhana, Julanan / Soonthornthum, Boonrucksar / Sotnikov, Albert / Sramek, Ondrej / Sreethawong, Warintorn / Stahl, Achim / Stanco, Luca / Stankevich, Konstantin / Stefanik, Dus / Steiger, Hans / Steinmann, Jochen / Sterr, Tobias / Stock, Matthias Raphael / Strati, Virginia / Studenikin, Alexander / Sun, Gongxing / Sun, Shifeng / Sun, Xilei / Sun, Yongjie / Sun, Yongzhao / Suwonjandee, Narumon / Szelezniak, Michal / Tang, Jian / Tang, Qiang / Tang, Quan / Tang, Xiao / Tietzsch, Alexander / Tkachev, Igor / Tmej, Tomas / Treskov, Konstantin / Triossi, Andrea / Troni, Giancarlo / Trzaska, Wladyslaw / Tuve, Cristina / van Waasen, Stefan / Boom, Johannes Vanden / Vanroyen, Guillaume / Vassilopoulos, Nikolaos / Vedin, Vadim / Verde, Giuseppe / Vialkov, Maxim / Viaud, Benoit / Volpe, Cristina / Vorobel, Vit / Votano, Lucia / Walker, Pablo / Wang, Caishen / Wang, Chung-Hsiang / Wang, En / Wang, Guoli / Wang, Jian / Wang, Jun / Wang, Kunyu / Wang, Lu / Wang, Meifen / Wang, Meng / Wang, Ruiguang / Wang, Siguang / Wang, Wei / Wang, Wenshuai / Wang, Xi / Wang, Xiangyue / Wang, Yangfu / Wang, Yaoguang / Wang, Yi / Wang, Yifang / Wang, Yuanqing / Wang, Yuman / Wang, Zhe / Wang, Zheng / Wang, Zhimin / Wang, Zongyi / Watcharangkool, Apimook / Wei, Lianghong / Wei, Wei / Wei, Yadong / Wen, Liangjian / Wiebusch, Christopher / Wong, Steven Chan-Fai / Wonsak, Bjoern / Wu, Diru / Wu, Fangliang / Wu, Qun / Wu, Wenjie / Wu, Zhi / Wurm, Michael / Wurtz, Jacques / Wysotzki, Christian / Xi, Yufei / Xia, Dongmei / Xie, Yuguang / Xie, Zhangquan / Xing, Zhizhong / Xu, Benda / Xu, Donglian / Xu, Fanrong / Xu, Jilei / Xu, Jing / Xu, Meihang / Xu, Yin / Xu, Yu / Yan, Baojun / Yan, Xiongbo / Yan, Yupeng / Yang, Anbo / Yang, Changgen / Yang, Huan / Yang, Jie / Yang, Lei / Yang, Xiaoyu / Yang, Yifan / Yao, Haifeng / Yasin, Zafar / Ye, Jiaxuan / Ye, Mei / Yegin, Ugur / Yermia, Frédéric / Yi, Peihuai / Yin, Xiangwei / You, Zhengyun / Yu, Boxiang / Yu, Chiye / Yu, Chunxu / Yu, Hongzhao / Yu, Miao / Yu, Xianghui / Yu, Zeyuan / Yuan, Chengzhuo / Yuan, Ying / Yuan, Zhenxiong / Yuan, Ziyi / Yue, Baobiao / Zafar, Noman / Zambanini, Andre / Zeng, Pan / Zeng, Shan / Zeng, Tingxuan / Zeng, Yuda / Zhan, Liang / Zhang, Feiyang / Zhang, Guoqing / Zhang, Haiqiong / Zhang, Honghao / Zhang, Jiawen / Zhang, Jie / Zhang, Jingbo / Zhang, Peng / Zhang, Qingmin / Zhang, Shiqi / Zhang, Tao / Zhang, Xiaomei / Zhang, Xuantong / Zhang, Yan / Zhang, Yinhong / Zhang, Yiyu / Zhang, Yongpeng / Zhang, Yuanyuan / Zhang, Yumei / Zhang, Zhenyu / Zhang, Zhijian / Zhao, Fengyi / Zhao, Jie / Zhao, Rong / Zhao, Shujun / Zhao, Tianchi / Zheng, Dongqin / Zheng, Hua / Zheng, Minshan / Zheng, Yangheng / Zhong, Weirong / Zhou, Jing / Zhou, Li / Zhou, Nan / Zhou, Shun / Zhou, Xiang / Zhu, Jiang / Zhu, Kejun / Zhuang, Honglin / Zong, Liang / Zou, Jiaheng

    A Precision Measurement of the Reactor Antineutrino Spectrum with Sub-percent Energy Resolution

    2020  

    Abstract: The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment ...

    Abstract The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). A ton-level liquid scintillator detector will be placed at about 30 m from a core of the Taishan Nuclear Power Plant. The reactor antineutrino spectrum will be measured with sub-percent energy resolution, to provide a reference spectrum for future reactor neutrino experiments, and to provide a benchmark measurement to test nuclear databases. A spherical acrylic vessel containing 2.8 ton gadolinium-doped liquid scintillator will be viewed by 10 m^2 Silicon Photomultipliers (SiPMs) of >50% photon detection efficiency with almost full coverage. The photoelectron yield is about 4500 per MeV, an order higher than any existing large-scale liquid scintillator detectors. The detector operates at -50 degree C to lower the dark noise of SiPMs to an acceptable level. The detector will measure about 2000 reactor antineutrinos per day, and is designed to be well shielded from cosmogenic backgrounds and ambient radioactivities to have about 10% background-to-signal ratio. The experiment is expected to start operation in 2022.

    Comment: 134 pages, 114 figures
    Keywords Physics - Instrumentation and Detectors ; High Energy Physics - Experiment ; Nuclear Experiment
    Subject code 660
    Publishing date 2020-05-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Sustainable Development Evaluation on the Landscape Design of Industrial Heritage Park: A Case Study of Tao Sichuan, China.

    Meng, Lei / Lin, Bao-Gang / Zhang, Hui-Zhong / Bu, Rui

    Journal of environmental and public health

    2023  Volume 2023, Page(s) 1564614

    Abstract: ... to ensure both sustainable development and social justice. In this study, the Tao Sichuan Creative ...

    Abstract The sustainable development of the urban environmental landscape is a process that integrates resource utilization, ecological benefit, economy, and society and involves elements of culture, society, politics, economy, and individual residents. Citizen participation is increasingly important for the urban landscape design, and therefore, urban environmental landscape studies must be evaluated objectively by the public to ensure both sustainable development and social justice. In this study, the Tao Sichuan Creative Industry Park (the former "Universe Porcelain Factory") in Jingdezhen, Jiangxi province, China, was taken as example, and the implemented landscape reconstruction was evaluated. The analytical hierarchy process was used to collect both expert and public opinions regarding the cultural landscape; then, the weight coefficient of the value index layer of the industrial heritage park was obtained. A comparison of the two groups (experts and the public) showed that the experts do not exactly agree with the perspective of the public: experts prefer the artistic value far more than any other factors, while the public prefers the artistic value, social value, and economic value. Each group prefers different values of the landscape, suggesting that environmental justice should not be biased toward one of these perspectives. Finally, a design optimization principle is proposed according to the results of this study. This principle strengthens the sustainable development concept in the landscape reconstruction of industrial heritage parks, and suggestions are provided for optimizing the allocation of urban public landscape resources.
    MeSH term(s) Conservation of Natural Resources ; Sustainable Development ; China ; Public Opinion ; Industry
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2023/1564614
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Clinical significance of dynamic monitoring of VEGF, SE-CAD, HCY and TNF-α in serum levels in patients with gastric cancer Hai-Tao Cheng1

    Hai-Tao Cheng / Chun-Rong Xiong / Zhong-Hai Yuan

    Journal of Hainan Medical University, Vol 24, Iss 03, Pp 99-

    2018  Volume 102

    Abstract: Objective: To investigate the clinical significance of dynamic monitoring of VEGF, SECAD, HCY and TNF-α in serum levels in patients with gastric cancer. Methods: A total of 94 patients with gastric cancer treated in our hospital from February 2013 to ... ...

    Abstract Objective: To investigate the clinical significance of dynamic monitoring of VEGF, SECAD, HCY and TNF-α in serum levels in patients with gastric cancer. Methods: A total of 94 patients with gastric cancer treated in our hospital from February 2013 to September 2014 were selected as the subjects. Sixty healthy subjects were selected as control group. VEGF, SE-CAD, HCY and TNF-α in serum levels were measured by cyclic enzyme method and enzyme-linked immunosorbent assay (ELISA). The correlation between the serum index and prognosis was analyzed. Results: The levels of Hcy, VEGF, SE-CAD and TNF-α in serum of gastric cancer group were significantly higher than those in control group. 1 month after surgery, levels of Hcy, VEGF, SE-CAD and TNF-α were still higher than those in control group. 3 months after surgery, Hcy, SE-CAD, TNF-α levels reached to the normal range, while VEGF was still higher than the normal range. The levels of Hcy, VEGF, SE-CAD and TNF-α in relapse group were significantly higher than those in non-recurrence group after 3 years of follow-up. Conclusion: The results show that the changes of serum Hcy, VEGF, SECAD and TNF-α level in patients with gastric cancer before and after operation were related to the disease condition and prognosis. The dynamic monitoring of the changes of Hcy, VEGF and TNF-α was helpful to the observation and prognosis.
    Keywords Gastric cancer ; Hcy ; VEGF ; SE-CAD ; TNF-α ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: IL-17A Exacerbates Fibrosis by Promoting the Proinflammatory and Profibrotic Function of Orbital Fibroblasts in TAO.

    Fang, Sijie / Huang, Yazhuo / Wang, Shuaiwei / Zhang, Yidan / Luo, Xuerui / Liu, Luyan / Zhong, Sisi / Liu, Xingtong / Li, Dan / Liang, Rui / Miranda, Piccioni / Gu, Ping / Zhou, Huifang / Fan, Xianqun / Li, Bin

    The Journal of clinical endocrinology and metabolism

    2016  Volume 101, Issue 8, Page(s) 2955–2965

    Abstract: Context: The development of thyroid-associated ophthalmopathy (TAO) is associated with self-immune ... dysfunction. Recent findings in TAO and Graves' disease indicate that IL-17A may also be involved ... in the autoimmunity of TAO.: Objective: We sought to investigate the pathogenic function of IL-17A-producing ...

    Abstract Context: The development of thyroid-associated ophthalmopathy (TAO) is associated with self-immune dysfunction. Recent findings in TAO and Graves' disease indicate that IL-17A may also be involved in the autoimmunity of TAO.
    Objective: We sought to investigate the pathogenic function of IL-17A-producing T cells in TAO.
    Design/setting/participants: Blood samples and orbital fibroblasts (OFs) were collected from TAO patients and healthy subjects.
    Main outcome measures: Flow cytometry, real-time PCR, cytokine-specific ELISA, and Western blotting were performed.
    Results: Here, we showed a significantly higher proportion of IL-17A-producing T cells in TAO patients and the recruitment of both CD4(+) and CD8(+) T cells in TAO orbits. TAO orbital tissues expressed more IL-17A receptor, IL-17A, and its related cytokines, with severe fibrotic change compared with normal controls. Furthermore, we validated that IL-17A could enhance the proinflammatory function of OFs and stimulate the production of extracellular matrix proteins in OFs but not eyelid fibroblasts. The mechanisms involved in this enhancement mainly relied on MAPK activation. Finally, we observed that the deubiquitinase inhibitor vialinin A could down-regulate retinoic acid receptor-related orphan receptor-γt expression and decrease IL-17A level in TAO patients.
    Conclusion: Our observations illustrate the potential pathogenic role of IL-17A-producing T cells in the inflammatory response and fibrosis of TAO. The effect of vialinin A on the reduction of retinoic acid receptor-related orphan receptor-γt level implicates its potential role as a novel therapeutic agent for TAO and other autoimmune disorders in the future.
    MeSH term(s) Case-Control Studies ; Cells, Cultured ; Chemotaxis, Leukocyte/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis/chemically induced ; Graves Ophthalmopathy/metabolism ; Graves Ophthalmopathy/pathology ; Humans ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Interleukin-17/metabolism ; Interleukin-17/pharmacology ; Orbit/metabolism ; Orbit/pathology ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; Vitamin A/pharmacology
    Chemical Substances IL17A protein, human ; Inflammation Mediators ; Interleukin-17 ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2016-1882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Effects of Tao-Hong-Si-Wu decoction on acute blood stasis in rats based on a LC-Q/TOF-MS metabolomics and network approach.

    Ma, Qi / Li, Peng-Ling / Hua, Yong-Li / Ji, Peng / Yao, Wan-Ling / Zhang, Xiao-Song / Zhong, Li-Jia / Wei, Yan-Ming

    Biomedical chromatography : BMC

    2017  

    Abstract: A novel approach using metabolomics coupled with a metabolic network was used to investigate the effects of THSWD on the rat model of acute blood stasis syndrome. Acute blood stasis syndrome was induced by placing the rats in ice-cold water following two ...

    Abstract A novel approach using metabolomics coupled with a metabolic network was used to investigate the effects of THSWD on the rat model of acute blood stasis syndrome. Acute blood stasis syndrome was induced by placing the rats in ice-cold water following two injections with epinephrine. The hemorheological indicators (WBV and PV), and the blood coagulation indicators (TT, PT, APTT, and FIB) were detected. The nonparametric univariate method and multivariate statistical analysis were performed for determining the potential biomarkers. A correlation map was structured between biochemical indicators and hub metabolites to explain the effects mechanism of THSWD. After the administration of THSWD, the levels of WBV, PV, TT, APTT, and FIB returned to levels observed in the control group. According to metabolomics coupled with metabolic network analysis, the intervention of THSWD in rats with acute blood stasis syndrome induced substantial and characteristic changes in their metabolic profiles. Fifteen metabolites were screened, which mainly involved ten pathways and five hub metabolites, namely, L-glutamate, L-phenylalanine, N-acylsphingosine, arachidonic acid and phosphatidate. The biochemical indicators and hub metabolites could be adjusted close to normal levels by THSWD. Therefore, combining metabolomics and metabolic network helped evaluate the effects of THSWD on acute blood stasis.
    Language English
    Publishing date 2017-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.4144
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Chinese herbal medicine formula tao hong si wu decoction protects against cerebral ischemia-reperfusion injury via PI3K/Akt and the Nrf2 signaling pathway.

    Li, Li / Yang, Na / Nin, Ling / Zhao, Zhilong / Chen, Lu / Yu, Jie / Jiang, Zhuyun / Zhong, Zhendong / Zeng, Daiwen / Qi, Hongyi / Xu, Xiaoyu

    Journal of natural medicines

    2014  Volume 69, Issue 1, Page(s) 76–85

    Abstract: The Chinese herbal medicine formula Tao Hong Si Wu decoction (THSWD) is traditionally used ...

    Abstract The Chinese herbal medicine formula Tao Hong Si Wu decoction (THSWD) is traditionally used for the prevention and treatment of ischemic stroke. Transcription factor NF-E2-related factor 2 (Nrf2) regulates a battery of phase II enzymes and is known as the major mechanism of cellular defense against oxidative stress. The present study aimed to explore the potential effect of THSWD on the Nrf2 signaling pathway and the consequent effect during cerebral ischemia-reperfusion (I/R) injury. We found that THSWD reduced infarct volume and improved neurological function in a rat stroke model induced by middle cerebral artery occlusion (MCAO). Additionally, heme oxygenase 1 (HO-1), a key endogenous antioxidant enzyme regulated by Nrf2, was significantly further induced by THSWD in this in vivo model. In neuronal-like PC12 cells, THSWD remarkably up-regulated HO-1 expression and promoted Nrf2 nuclear translocation. Furthermore, phosphatidylinositol 3-kinase (PI3K)/Akt kinase was found to be involved in the upstream of Nrf2 regulation. In an in vitro oxygen-glucose deprivation/reperfusion (OGD-Rep) model, THSWD treatment significantly reduced cell death induced by OGD-Rep insult. Importantly, the protective action was attenuated while PI3K activity was inhibited by a specific inhibitor, LY294002, and the Nrf2 signaling pathway was blocked by antioxidant response element (ARE) decoy oligonucleotides. Collectively, these results demonstrated that THSWD exhibited notable neuroprotective properties in vitro and in vivo and activation of PI3K/Akt and the Nrf2 signaling pathway may be, at least in part, responsible for the protection. This study provides a better understanding of the molecular mechanism underlying the traditional use of the Chinese herbal medicine formula THSWD.
    MeSH term(s) Animals ; Brain Infarction/metabolism ; Brain Infarction/pathology ; Brain Infarction/prevention & control ; Drugs, Chinese Herbal/therapeutic use ; Heme Oxygenase-1/biosynthesis ; Male ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; PC12 Cells ; Phosphatidylinositol 3-Kinase/metabolism ; Protective Agents/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Signal Transduction/drug effects
    Chemical Substances Drugs, Chinese Herbal ; NF-E2-Related Factor 2 ; Protective Agents ; Taohong Siwu decoction II ; Heme Oxygenase-1 (EC 1.14.14.18) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
    Language English
    Publishing date 2014-08-23
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-014-0865-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Book: Tao shu she shi zai pei

    Liu, Xiujie / Chen, Zhong

    (Quan guo "xing huo ji hua" cong shu ; Guo shu she shi zai pei cong shu)

    1998  

    Title variant Taoshu sheshi zaipei
    Author's details Liu Xiujie, Chen Zhong teng bian zhu
    Series title Quan guo "xing huo ji hua" cong shu
    Guo shu she shi zai pei cong shu
    Keywords Peach
    Language Chinese
    Size 6, 171 p., [4] p. of plates :, ill. (some col.) ;, 19 cm.
    Edition Di 1 ban.
    Publisher Zhongguo ling ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing shi
    Document type Book
    ISBN 7503820063 ; 9787503820069
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article: Chinese herbal medicine formula Tao Hong Si Wu decoction protects against cerebral ischemia–reperfusion injury via PI3K/Akt and the Nrf2 signaling pathway

    Li, Li / Yang, Na / Nin, Ling / Zhao, Zhilong / Chen, Lu / Yu, Jie / Jiang, Zhuyun / Zhong, Zhendong / Zeng, Daiwen / Qi, Hongyi / Xu, Xiaoyu

    Natural medicines. 2015 Jan., v. 69, no. 1

    2015  

    Abstract: The Chinese herbal medicine formula Tao Hong Si Wu decoction (THSWD) is traditionally used ...

    Abstract The Chinese herbal medicine formula Tao Hong Si Wu decoction (THSWD) is traditionally used for the prevention and treatment of ischemic stroke. Transcription factor NF-E2-related factor 2 (Nrf2) regulates a battery of phase II enzymes and is known as the major mechanism of cellular defense against oxidative stress. The present study aimed to explore the potential effect of THSWD on the Nrf2 signaling pathway and the consequent effect during cerebral ischemia−reperfusion (I/R) injury. We found that THSWD reduced infarct volume and improved neurological function in a rat stroke model induced by middle cerebral artery occlusion (MCAO). Additionally, heme oxygenase 1 (HO-1), a key endogenous antioxidant enzyme regulated by Nrf2, was significantly further induced by THSWD in this in vivo model. In neuronal-like PC12 cells, THSWD remarkably up-regulated HO-1 expression and promoted Nrf2 nuclear translocation. Furthermore, phosphatidylinositol 3-kinase (PI3K)/Akt kinase was found to be involved in the upstream of Nrf2 regulation. In an in vitro oxygen−glucose deprivation/reperfusion (OGD-Rep) model, THSWD treatment significantly reduced cell death induced by OGD-Rep insult. Importantly, the protective action was attenuated while PI3K activity was inhibited by a specific inhibitor, LY294002, and the Nrf2 signaling pathway was blocked by antioxidant response element (ARE) decoy oligonucleotides. Collectively, these results demonstrated that THSWD exhibited notable neuroprotective properties in vitro and in vivo and activation of PI3K/Akt and the Nrf2 signaling pathway may be, at least in part, responsible for the protection. This study provides a better understanding of the molecular mechanism underlying the traditional use of the Chinese herbal medicine formula THSWD.
    Keywords animal models ; antioxidants ; heme oxygenase (biliverdin-producing) ; herbal medicines ; infarction ; neuroprotective effect ; oligonucleotides ; oxidative stress ; phosphatidylinositol 3-kinase ; rats ; signal transduction ; silicon ; stroke ; transcription factors
    Language English
    Dates of publication 2015-01
    Size p. 76-85.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1201350-x
    ISSN 1340-3443
    ISSN 1340-3443
    DOI 10.1007/s11418-014-0865-5
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  9. Book: Mi hou tao you zhi feng chan zhou nian guan li ji shu

    Wang, Rencai / Lü, Changping / Zhong, Caihong

    2000  

    Author's details Wang Rencai zhu bian ; bian zhu zhe Wang Rencai, Lü Changping, Zhong Caihong
    Keywords Kiwifruit.
    Language Chinese
    Size 2, 2, 143 p. :, ill. ;, 20 cm.
    Edition Di 1 ban.
    Publisher Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing shi
    Document type Book
    ISBN 7109062015 ; 9787109062016
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  10. Article ; Online: Efficient method for modeling large-scale arrays of optical nanoresonators based on the coupling theory of quasinormal mode.

    Tao, Qiyong / Su, Yuhang / Tao, Can / Zhong, Ying / Liu, Haitao

    Optics express

    2024  Volume 32, Issue 5, Page(s) 7171–7184

    Abstract: We propose an efficient method for calculating the electromagnetic field of a large-scale array of optical nanoresonators based on the coupling theory of quasinormal mode (QNM). In this method, two approaches of the scattered-field reconstruction and ... ...

    Abstract We propose an efficient method for calculating the electromagnetic field of a large-scale array of optical nanoresonators based on the coupling theory of quasinormal mode (QNM). In this method, two approaches of the scattered-field reconstruction and stationary-phase-principle calculated plane-wave expansion are developed to obtain the regularized QNM (RQNM) in different regions. This accurate and efficient calculation of RQNM resolves the far-field divergence issue of QNMs in the QNM-coupling theory, thus enabling a rapid computation of the electromagnetic field of a large-scale array of optical nanoresonators, which is a challenging task for full-wave numerical methods. Using this method, we consider the numerical example of the radiation problem of a single point source in a large-scale periodic array of optical nanoantennas. In comparison to full-wave numerical methods, this method significantly reduces the computation time by 1∼2 orders of magnitude while maintaining accuracy. The high computational efficiency and physical intuitiveness of the method enables to clarify the impact of array size (exceeding 50 × 50 wavelengths), period and field-coupling range (far beyond the tight-binding approximation) on the optical response. The proposed method and results can provide an efficient tool and guidance for the design of large-scale arrays of optical nanoresonators.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.515087
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top