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  1. Article ; Conference proceedings: CBD-rich Cannabis Sativa on core and comorbid symptoms of autism spectrum disorder: a prospective observational study

    Liz, Alysson Madruga / Bitencourt, Rafael Mariano / Bittencourt, Paulo César Trevisol / Alberti, Raquel / Kock, Kelser de Souza

    Arquivos de Neuro-Psiquiatria

    2023  Volume 81, Issue S 01

    Event/congress SBN Conference 2022, Expo United Curitiba, 2022-11-09
    Language English
    Publishing date 2023-09-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0043-1774486
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Magnetic resonance enterography and intestinal ultrasound for the assessment and monitoring of Crohn's disease.

    Kumar, Shankar / De Kock, Isabelle / Blad, William / Hare, Richard / Pollok, Richard / Taylor, Stuart A

    Journal of Crohn's & colitis

    2024  

    Abstract: Magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) have developed rapidly in the last few decades, emerging as the primary non-invasive options for both diagnosing and monitoring Crohn's disease (CD). In this review, we evaluate the ... ...

    Abstract Magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) have developed rapidly in the last few decades, emerging as the primary non-invasive options for both diagnosing and monitoring Crohn's disease (CD). In this review, we evaluate the pertinent data relating to the use of MRE and IUS in CD. We summarise the key imaging features of CD activity, highlight their increasing role in both the clinical and research settings, and discuss how these modalities fit within the diagnostic pathway. We discuss how they can be used to assess disease activity and treatment responsiveness, including the emergence of activity scores for standardised reporting. Additionally, we address areas of controversy such as the use of contrast agents, the role of diffusion-weighted imaging, and discuss point-of-care ultrasound. We also highlight exciting new developments including the applications of artificial intelligence. Finally, we provide suggestions for future research priorities.
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjae042
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    Zs.A 6634: Show issues Location:
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  3. Article ; Online: IS IT TIME TO REFLECT, NOT ON THE "WHAT" BUT THE "WHY" IN EMERGING WILDLIFE DISEASE RESEARCH?

    Kock, Richard A

    Journal of wildlife diseases

    2018  Volume 55, Issue 1, Page(s) 1–2

    MeSH term(s) Animal Distribution ; Animals ; Animals, Wild ; Birds ; Communicable Diseases, Emerging/urine ; Communicable Diseases, Emerging/veterinary ; Mammals ; Population Density ; Research Design ; Zoonoses
    Language English
    Publishing date 2018-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/2019-01-000
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  4. Article ; Online: Consequences and global risks of highly pathogenic avian influenza outbreaks in poultry in the United Kingdom.

    Haider, Najmul / Kock, Richard / Zumla, Alimuddin / Lee, Shui Shan

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 129, Page(s) 162–164

    MeSH term(s) Humans ; Animals ; Influenza in Birds/epidemiology ; Poultry ; Disease Outbreaks ; United Kingdom/epidemiology ; Poultry Diseases/epidemiology
    Language English
    Publishing date 2023-01-20
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.01.028
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    Zs.A 4516: Show issues Location:
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  5. Article: An Integrated Ecological Niche Modelling Framework for Risk Mapping of Peste des Petits Ruminants Virus Exposure in African Buffalo (

    Carrera-Faja, Laura / Yesson, Chris / Jones, Bryony A / Benfield, Camilla T O / Kock, Richard A

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Peste des petits ruminants (PPR) is a highly contagious viral disease of small ruminants that threatens livelihoods and food security in developing countries and, in some cases, wild ungulate species conservation. The Greater Serengeti-Mara Ecosystem ( ... ...

    Abstract Peste des petits ruminants (PPR) is a highly contagious viral disease of small ruminants that threatens livelihoods and food security in developing countries and, in some cases, wild ungulate species conservation. The Greater Serengeti-Mara Ecosystem (GSME) encompasses one of the major wildlife populations of PPR virus (PPRV)-susceptible species left on earth, although no clinical disease has been reported so far. This study aimed to gain further knowledge about PPRV circulation in the GSME by identifying which factors predict PPRV seropositivity in African buffalo (
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12121423
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  6. Article: Special Issue: Wildlife Microbiology.

    Ushida, Kazunari / Kock, Richard / Sundset, Monica A

    Microorganisms

    2021  Volume 9, Issue 9

    Abstract: Research on the effect of symbiotic microbes on the health of the host through their impact on digestion, the immune system, development, and behavior is accumulating [ ... ]. ...

    Abstract Research on the effect of symbiotic microbes on the health of the host through their impact on digestion, the immune system, development, and behavior is accumulating [...].
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9091968
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  7. Article ; Online: A dataset of small-mammal detections in West Africa and their associated micro-organisms.

    Simons, David / Attfield, Lauren A / Jones, Kate E / Watson-Jones, Deborah / Kock, Richard

    GigaByte (Hong Kong, China)

    2023  Volume 2023, Page(s) gigabyte100

    Abstract: Rodents, a globally distributed and ecologically important mammalian order, serve as hosts for various zoonotic pathogens. However, sampling of rodents and their pathogens suffers from taxonomic and spatial biases. This affects consolidated databases, ... ...

    Abstract Rodents, a globally distributed and ecologically important mammalian order, serve as hosts for various zoonotic pathogens. However, sampling of rodents and their pathogens suffers from taxonomic and spatial biases. This affects consolidated databases, such as IUCN and GBIF, limiting inference regarding the spillover hazard of zoonotic pathogens into human populations. Here, we synthesised data from 127 rodent trapping studies conducted in 14 West African countries between 1964 and 2022. We combined occurrence data with pathogen screening results to produce a dataset containing detection/non-detection data for 65,628 individual small mammals identified to the species level from at least 1,611 trapping sites. We also included 32 microorganisms, identified to the species or genus levels, that are known or potential pathogens. The dataset is formatted to Darwin Core Standard with associated metadata. This dataset can mitigate spatial and taxonomic biases of current databases, improving understanding of rodent-associated zoonotic pathogen spillover across West Africa.
    Language English
    Publishing date 2023-12-04
    Publishing country China
    Document type Journal Article
    ISSN 2709-4715
    ISSN (online) 2709-4715
    DOI 10.46471/gigabyte.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rodent trapping studies as an overlooked information source for understanding endemic and novel zoonotic spillover.

    Simons, David / Attfield, Lauren A / Jones, Kate E / Watson-Jones, Deborah / Kock, Richard

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 1, Page(s) e0010772

    Abstract: ... sampling biases. The current synthesis of contextually rich rodent trapping data enriches available information ...

    Abstract Rodents, a diverse, globally distributed and ecologically important order of mammals are nevertheless important reservoirs of known and novel zoonotic pathogens. Ongoing anthropogenic land use change is altering these species' abundance and distribution, which among zoonotic host species may increase the risk of zoonoses spillover events. A better understanding of the current distribution of rodent species is required to guide attempts to mitigate against potentially increased zoonotic disease hazard and risk. However, available species distribution and host-pathogen association datasets (e.g. IUCN, GBIF, CLOVER) are often taxonomically and spatially biased. Here, we synthesise data from West Africa from 127 rodent trapping studies, published between 1964-2022, as an additional source of information to characterise the range and presence of rodent species and identify the subgroup of species that are potential or known pathogen hosts. We identify that these rodent trapping studies, although biased towards human dominated landscapes across West Africa, can usefully complement current rodent species distribution datasets and we calculate the discrepancies between these datasets. For five regionally important zoonotic pathogens (Arenaviridae spp., Borrelia spp., Lassa mammarenavirus, Leptospira spp. and Toxoplasma gondii), we identify host-pathogen associations that have not been previously reported in host-association datasets. Finally, for these five pathogen groups, we find that the proportion of a rodent hosts range that have been sampled remains small with geographic clustering. A priority should be to sample rodent hosts across a greater geographic range to better characterise current and future risk of zoonotic spillover events. In the interim, studies of spatial pathogen risk informed by rodent distributions must incorporate a measure of the current sampling biases. The current synthesis of contextually rich rodent trapping data enriches available information from IUCN, GBIF and CLOVER which can support a more complete understanding of the hazard of zoonotic spillover events.
    MeSH term(s) Animals ; Humans ; Rodentia ; Information Sources ; Zoonoses/epidemiology ; Mammals ; Host Specificity
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010772
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  9. Article ; Online: The Lrs14 family of DNA-binding proteins as nucleoid-associated proteins in the Crenarchaeal order Sulfolobales.

    De Kock, Veerke / Peeters, Eveline / Baes, Rani

    Molecular microbiology

    2024  

    Abstract: ... cooperative manner, with a slight preference for AT-rich promoter regions, they introduce DNA kinks and are ...

    Abstract Organization of archaeal chromatin combines bacterial, eukaryotic, and unique characteristics. Many archaeal lineages harbor a wide diversity of small and highly expressed nucleoid-associated proteins, which are involved in DNA structuring. In Sulfolobales, representing model organisms within the Crenarchaeota, Sul7d, Cren7, Sul10a, and Sul12a are well-characterized nucleoid-associated proteins. Here, we combine evidence that the Lrs14 family of DNA binders is part of the repertoire of nucleoid-associated proteins in Sulfolobales. Lrs14-encoding genes are widespread within genomes of different members of the Sulfolobales, typically encoded as four to nine homologs per genome. The Lrs14 proteins harbor a winged helix-turn-helix DNA-binding domain and are typified by a coiled-coil dimerization. They are characterized by distinct sequence- and structure-based features, including redox-sensitive motifs and residues targeted for posttranslational modification, allowing a further classification of the family into five conserved clusters. Lrs14-like proteins have unique DNA-organizing properties. By binding to the DNA nonsequence specifically and in a highly cooperative manner, with a slight preference for AT-rich promoter regions, they introduce DNA kinks and are able to affect transcription of adjacent transcription units either positively or negatively. Genes encoding Lrs14-type proteins display considerable differential expression themselves in response to various stress conditions, with certain homologs being specific to a particular stressor. Taken together, we postulate that members of the Lrs14 family can be considered nucleoid-associated proteins in Sulfolobales, combining a DNA-structuring role with a global gene expression role in response to stress conditions.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.15260
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  10. Article ; Online: Structural and chemical degradation mechanisms of pure YSZ and its components ZrO2 and Y2O3 in carbon-rich fuel gases.

    Köck, Eva-Maria / Kogler, Michaela / Götsch, Thomas / Klötzer, Bernhard / Penner, Simon

    Physical chemistry chemical physics : PCCP

    2016  Volume 18, Issue 21, Page(s) 14333–14349

    Abstract: ... in carbon-rich fuel gases with respect to coking/graphitization and (oxy)carbide formation. By combining ... already on the "isolated" oxides under sufficiently fuel-rich conditions, most pronounced in the pure ...

    Abstract Structural and chemical degradation mechanisms of metal-free yttria stabilized zirconia (YSZ-8, 8 mol% Y2O3 in ZrO2) in comparison to its pure oxidic components ZrO2 and Y2O3 have been studied in carbon-rich fuel gases with respect to coking/graphitization and (oxy)carbide formation. By combining operando electrochemical impedance spectroscopy (EIS), operando Fourier-transform infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS), the removal and suppression of CH4- and CO-induced carbon deposits and of those generated in more realistic fuel gas mixtures (syngas, mixtures of CH4 or CO with CO2 and H2O) was examined under SOFC-relevant conditions up to 1273 K and ambient pressures. Surface-near carbidization is a major problem already on the "isolated" (i.e. Nickel-free) cermet components, leading to irreversible changes of the conduction properties. Graphitic carbon deposition takes place already on the "isolated" oxides under sufficiently fuel-rich conditions, most pronounced in the pure gases CH4 and CO, but also significantly in fuel gas mixtures containing H2O and CO2. For YSZ, a comparative quantification of the total amount of deposited carbon in all gases and mixtures is provided and thus yields favorable and detrimental experimental approaches to suppress the carbon formation. In addition, the effectivity and reversibility of removal of the coke/graphite layers was comparably studied in the pure oxidants O2, CO2 and H2O and their effective contribution upon addition to the pure fuel gases CO and CH4 verified.
    Language English
    Publishing date 2016--25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/c6cp02458k
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