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  1. Article: Acute, Severe Hepatitis of Unknown Origin: Should We Really Be Afraid of Another Obscure Enemy of Our Children?

    Aricò, Maurizio / Caselli, Désirée

    Pediatric reports

    2022  Volume 14, Issue 2, Page(s) 217–219

    Abstract: On 31 March 2022, Public Health Scotland was alerted to five children aged 3-5 years, presenting to the Glasgow children's hospital with severe hepatitis of unknown etiology within a 3-week period [ ... ]. ...

    Abstract On 31 March 2022, Public Health Scotland was alerted to five children aged 3-5 years, presenting to the Glasgow children's hospital with severe hepatitis of unknown etiology within a 3-week period [...].
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Editorial
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric14020029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute, Severe Hepatitis of Unknown Origin

    Maurizio Aricò / Désirée Caselli

    Pediatric Reports, Vol 14, Iss 29, Pp 217-

    Should We Really Be Afraid of Another Obscure Enemy of Our Children?

    2022  Volume 219

    Abstract: On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years, presenting to the Glasgow children’s hospital with severe hepatitis of unknown etiology within a 3-week period [.] ...

    Abstract On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years, presenting to the Glasgow children’s hospital with severe hepatitis of unknown etiology within a 3-week period [.]
    Keywords n/a ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Policy of vaccination of "fragile children": Results of a survey of 14 Italian children's hospitals.

    Caselli, Désirée / Aricò, Maurizio / Fiasca, Fabiana / Tafuri, Silvio

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 2, Page(s) 2245701

    Abstract: Children with chronic disease are at higher risk of invasive infectious disease, including several vaccine-preventable infections. The Italian Association of Pediatric Hospitals (AOPI) carried out a survey of immunization practices: 14/16 AOPI hospitals ... ...

    Abstract Children with chronic disease are at higher risk of invasive infectious disease, including several vaccine-preventable infections. The Italian Association of Pediatric Hospitals (AOPI) carried out a survey of immunization practices: 14/16 AOPI hospitals completed the survey; 50% of them include 100-199 beds, while 21% have <100 beds. In 12/14 hospitals (86%) all vaccinations included in the National Immunization Plan (plus influenza e COVID-19 vaccines) are available for inpatients, in selected wards (
    MeSH term(s) Humans ; Child ; COVID-19 Vaccines ; Hospitals, Pediatric ; COVID-19/prevention & control ; Vaccination ; Policy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2245701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Appropriate Use of Antibiotic and Principles of Antimicrobial Stewardship in Children.

    Aricò, Melodie O / Valletta, Enrico / Caselli, Désirée

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 4

    Abstract: Antibiotics account for over 10% of the overall drug expense of the National Health System in Italy in 2021. Their use in children is of particular interest on one side, because acute infections are very common in children, while they build their ... ...

    Abstract Antibiotics account for over 10% of the overall drug expense of the National Health System in Italy in 2021. Their use in children is of particular interest on one side, because acute infections are very common in children, while they build their immunologic library of competence; on the other side, although many acute infections are expected and turn out to be of viral origin, caregivers will often ask the family doctor or primary care attending to reassure them by prescribing antibiotic treatment, although it may often be unnecessary. The inappropriate prescription of antibiotics in children may likely be a source not only of undue economic burden for the public health system but also of increasing development of antimicrobial resistance (AMR). Based on those issues, the inappropriate use of antibiotics in children should be avoided to reduce the risks of unnecessary toxicity, increase in health costs, lifelong effects, and selection of resistant organisms causing undue deaths. Antimicrobial stewardship (AMS) describes a coherent set of actions that ensure an optimal use of antimicrobials to improve patient outcomes while limiting the risk of adverse events including AMR. The aim of this paper is to spread some concept of good use of antibiotics for pediatricians or every other physician involved in the choice to prescribe, or not, antibiotics in children. Several actions could be of help in this process, including the following: (1) identify patients with high probability of bacterial infection; (2) collect samples for culture study before starting antibiotic treatment if invasive bacterial infection is suspected; (3) select the appropriate antibiotic molecule based on local resistance and narrow spectrum for the suspected pathogen(s); avoid multi-antibiotic association; prescribe correct dosage; (4) choose the best route of administration (oral vs. parenteral) and the best schedule of administration for every prescription (i.e., multiple administration for beta lactam); (5) schedule clinical and laboratory re-evaluation with the aim to consider therapeutic de-escalation; (6) stop antibiotic administration as soon as possible, avoiding the application of "antibiotic course".
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10040740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: SARS-CoV-2 Vaccination for Children-An Open Issue.

    Caselli, Désirée / Aricò, Maurizio

    Pediatric reports

    2021  Volume 13, Issue 1, Page(s) 95–97

    Abstract: The Covid-19 pandemic is still raging [ ... ]. ...

    Abstract The Covid-19 pandemic is still raging [...].
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Editorial
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric13010013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 Vaccination for Children—An Open Issue

    Désirée Caselli / Maurizio Aricò

    Pediatric Reports, Vol 13, Iss 1, Pp 95-

    2021  Volume 97

    Abstract: The Covid-19 pandemic is still raging [.] ...

    Abstract The Covid-19 pandemic is still raging [.]
    Keywords n/a ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article: 2019-nCoV: Polite with children!

    Caselli, Désirée / Aricò, Maurizio

    Pediatric reports

    2020  Volume 12, Issue 1, Page(s) 8495

    Keywords covid19
    Language English
    Publishing date 2020-02-11
    Publishing country Italy
    Document type Journal Article
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.4081/pr.2020.8495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 2019-nCoV

    Désirée Caselli / Maurizio Aricò

    Pediatric Reports, Vol 12, Iss

    Polite with children!

    2020  Volume 1

    Abstract: A novel epidemic is challenging the global health care system. Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019- nCoV [.]. ...

    Abstract A novel epidemic is challenging the global health care system. Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019- nCoV [.].
    Keywords Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Real-World Use of Dalbavancin for Treatment of Soft Tissue and Bone Infection in Children: Safe, Effective and Hospital-Time Sparing.

    Caselli, Désirée / Mariani, Marcello / Colomba, Claudia / Ferrecchi, Chiara / Cafagno, Claudio / Trotta, Daniela / Carloni, Ines / Dibello, Daniela / Castagnola, Elio / Aricò, Maurizio

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 1

    Abstract: Acute bacterial skin and skin structure infections (ABSSSI) and osteoarticular infections compound the burden of morbidity, mortality and prolonged hospitalizations among gram-positive infections. Dalbavancin, a second-generation, intravenous ... ...

    Abstract Acute bacterial skin and skin structure infections (ABSSSI) and osteoarticular infections compound the burden of morbidity, mortality and prolonged hospitalizations among gram-positive infections. Dalbavancin, a second-generation, intravenous lipoglycopeptide, due to its prolonged half-life, can be a valuable alternative in their treatment when administered as inpatient treatment at the price of an extended hospital stay. Between October 2019 and September 2023, 31 children and adolescents were treated with dalbavancin because of bone and joint infections (n = 12 patients, 39%), ABSSSI (n = 13 patients, 42%), mainly for the limbs, facial cellulitis or complicated ABSSSI (n = 6 patients, 19%), at five Italian pediatric centers. Microbiological study provided gram-positive bacterial isolate in 16 cases, in 11 cases from a positive blood culture; 9 of them were MRSA. Twenty-five patients were initially treated with a different antibiotic therapy: beta-lactam-based in 18 patients (58%), glycopeptide-based in 15 patients (48%) and daptomycin in 6 (19%). The median time that elapsed between admission and start of dalbavancin was 18 days. A total of 61 doses of dalbavancin were administered to the 31 patients: 16 received a single dose while the remaining 15 patients received between two (n = 9) and nine doses. The frequency of administration was weekly in five cases or fortnightly in nine patients. Median length of stay in hospital was 16 days. Median time to discharge after the first dose of dalbavancin was 1 day. Treatment was very well-tolerated: of the 61 administered doses, only four doses, administered to four patients, were associated with an adverse event: drug extravasation during intravenous administration occurred in two patients, with no sequelae; however, in two patients the first administration was stopped soon after infusion start: in one (ID #11), due to headache and vomiting; in another (ID #12) due to a systemic reaction. In both patients, drug infusion was not repeated. None of the remaining 29 patients reported treatment failure (resistant or recurrent disease) or an adverse effect during a median follow-up time of two months. The use of dalbavancin was safe, feasible and also effective in shortening the hospital stay in children and adolescents.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11010078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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