LIVIVO - Search results -

Search results

Result 1 - 10 of total 3850

Search options

Article: A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and

Hu, Leihao / He, Canfeng / Mo, Aier / Zhan, Xingkai / Yang, Caizhi / Guo, Wei / Sun, Lingling / Su, Weiwei / Lin, Lizhu

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 3436814

Abstract: Non-small-cell lung cancer (NSCLC) is one of the most prevalent cancers worldwide. A Yi-Fei-San-Jie ...

Abstract	Non-small-cell lung cancer (NSCLC) is one of the most prevalent cancers worldwide. A Yi-Fei-San-Jie formula (YFSJF), widely used in NSCLC treatment in south China, has been validated in clinical studies. However, the pharmacological mechanism behind it remains unclear. In this study, 73 compounds were identified using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), with 58 enrolled in network pharmacology. The protein-protein interaction network, functional enrichment analysis, and compound-target-pathway network were constructed using 74 overlapping targets from 58 drugs and NSCLC. YFSJF has many targets and pathways in the fight against NSCLC. PIK3R1, PIK3CA, and AKT1 were identified as key targets, and the PI3K/AKT pathway was identified as the key pathway. According to the Human Protein Atlas (THPA) database and the Kaplan-Meier Online website, the three key targets had varying expression levels in normal and abnormal tissues and were linked to prognosis. Molecular docking and dynamics simulations verified that hub compounds have a strong affinity with three critical targets. This study revealed multiple compounds, targets, and pathways for YFSJF against NSCLC and suggested that YFSJF might inhibit PIK3R1, PIK3CA, and AKT1 to suppress the PI3K/AKT pathway and play its pharmacological role.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/3436814
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Determination and mechanism of Xiao-Ai Jie-Du decoction against diffuse large B-cell lymphoma: In silico and In vitro studies.

Zhan, Xin-Zhuo / Wei, Tian-Hua / Yin, Yu-Qi / Xu, Jian-Qiao / Yu, Hui / Chen, Xiao-Li / Kong, Xiang-Tu / Sun, Shan-Liang / Li, Nian-Guang / Ni, Hai-Wen

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 2, Page(s) 117271

Abstract: Ethnopharmacological relevance: Xiao-Ai Jie-Du decoction (XAJDD) has been used in clinical ...

Abstract	Ethnopharmacological relevance: Xiao-Ai Jie-Du decoction (XAJDD) has been used in clinical practice to treat diffuse large B-cell lymphoma (DLBCL); its prescriptions vary based on the pathogenesis of patients. Aim of the study: We aimed to determine the core formula of XAJDD and investigate its mechanism of action against DLBCL. Materials and methods: Apriori data mining of 187 clinical cases (including 421 Traditional Chinese Medicines, TCMs) was conducted to retrieve the core formula of XAJDD. Comprehensive in silico modeling was used to identify potential active components and corresponding targets. The potential targets of 16 compounds were identified based on network pharmacology using in silico modeling. Thereafter, experimental determination of the active compounds and their mechanism of action in treating DLBCL was performed using different assays (including CCK-8, Annexin V-FITC/PI double-staining, Western blot, and flow cytometry assays). Results: The core formula of XAJDD included six herbs: Astragalus mongholicus Bunge (Huangqi, family: Fabaceae), Scutellaria barbata D. Don (Banzhilian, family: Lamiaceae), Prunella vulgaris L. (Xiakucao, family: Lamiaceae), Smilax glabra Roxb. (Tufuling, family Smilacaceae) and Fritillaria thunbergii Miq. (Dabei, family: Liliaceae), and Curcuma zanthorrhiza Roxb. (Ezhu, family: Zingiberaceae); Databases including 62 druggable compounds and 38 DLBCL-related structural targets were constructed; ∼0.3 million data points produced by computational modeling based on potential compounds and targets six components from XAJDD, including astibin, folic acid, baicalin, kaempferol, quercetin, and luteolin, significantly inhibited DLBCL cell proliferation, induced apoptosis, and suppressed the expression of key oncogenes. Conclusion: This study provides an integrated strategy for determining the core formula of XAJDD and reveals the molecular mechanisms underlying the treatment of DLBCL, which were consistent with the principle of "monarch (Jun), minister (Chen), adjunctive (Zuo), and guide (Shi)", confirming that XAJDD may serve as a promising natural therapeutic agent against DLBCL.
MeSH term(s)	Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Apoptosis ; Biological Assay ; Blotting, Western ; Computer Simulation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Molecular Docking Simulation
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117271
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE

Cai, Yinhe / Wen, Junmao / Ma, Siwen / Mai, Zhexing / Zhan, Qunzhang / Wang, Yijun / Zhang, Yueyao / Chen, He / Li, Haiyi / Wu, Wei / Li, Rong / Luo, Chuanjin

Frontiers in physiology

2021 Volume 12, Page(s) 666449

Abstract: ... regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable ...

Abstract	Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in different animal models. However, its effects and mechanisms on AS have not been clearly defined. We determined whether HLJDD attenuated atherosclerosis and plaques vulnerability by regulating macrophage polarization in ApoE
Language	English
Publishing date	2021-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.666449
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Positive Effect of Narcissism on Employees' Whistleblowing: The Role of Felt Accountability and Ethical Environment.

Zhan, Xuemei / Jie, Yuan

Psychology research and behavior management

2023 Volume 16, Page(s) 5225–5235

Abstract: Purpose: This study aims to develop a model to explore the effect of narcissism on whistleblowing through felt accountability and to examine the moderating role of organization's ethical environment on this relationship.: Methods: The study was a two- ...

Abstract	Purpose: This study aims to develop a model to explore the effect of narcissism on whistleblowing through felt accountability and to examine the moderating role of organization's ethical environment on this relationship. Methods: The study was a two-wave study involving MBA students. Two surveys were distributed to individuals who work full time at two different times (roughly two weeks apart). A total of 261 individuals completed both questionnaires. Hierarchical linear regression analyses were conducted using SPSS 22.0 to test the hypotheses. Results: The results supported the prediction that felt accountability mediates the positive relationship between narcissism and whistleblowing. The findings also showed that the indirect effect of narcissism on whistleblowing through felt accountability was stronger when individuals perceived organizational environment to be unethical. Conclusion: The study contributes to our understanding of the bright side of narcissism by combining it with research on whistleblowing and explicates how and when narcissistic individuals engage in whistleblowing.
Language	English
Publishing date	2023-12-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S440348
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Microbial glycosylation of antitubercular agent chlorflavonin.

Ren, Jie / Zhan, Jixun

Journal of bioscience and bioengineering

2023 Volume 136, Issue 5, Page(s) 366–373

Abstract: Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous ... ...

Abstract	Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from Aspergillus candidus, a novel halogenated flavonoid with potent antifungal and antitubercular (anti-TB) activities. Unfortunately, the low water-solubility of this molecule may hinder its bioavailability. Glycosylation is an effective method to enhance the polarity of natural products and alter their physicochemical properties. This work focuses on the development of novel water-soluble chlorflavonin derivatives to combat the threat of drug-resistant tuberculosis. In this study, we first increased the production titer of chlorflavonin in A. candidus NRRL 5214 by optimizing the fermentation and purification processes. Next, chlorflavonin-5-O-β-d-glucuronopyranoside (1) and chlorflavonin-7-O-4″-O-methyl-β-d-glucopyranoside (2) were produced from chlorflavonin using Streptomyces chromofuscus ATCC 49982 and Beauveria bassiana ATCC 7159, respectively. Compared to chlorflavonin (4.38 ± 0.54 mg/L in water), the water solubility of the two new glycosides was determined to be 117.86 ± 4.81 mg/L (1) and 124.34 ± 9.13 mg/L (2), respectively. This study provides a promising method to create water-soluble glycosides of chlorflavonin for the development of novel anti-TB drugs.
Language	English
Publishing date	2023-09-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2023.09.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 4728: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Effects of testing speed on the tensile and mode I fracture behavior of specimens printed through the Fused Deposition Modeling technique.

Zhan, Jiangtao / Cai, Jie / Hasani, Reza

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3960

Abstract: Additive Manufacturing (AM) processes are known as revolutionary manufacturing processes that fabricate a part using a 3D model layer upon layer. These techniques gained more attention from various industries due to their advantages like low waste ... ...

Abstract	Additive Manufacturing (AM) processes are known as revolutionary manufacturing processes that fabricate a part using a 3D model layer upon layer. These techniques gained more attention from various industries due to their advantages like low waste material. Also, these processes can produce any part with high degrees of complexity in a short period of time. The Fused Deposition Modeling (FDM) process is a material extrusion-based technique which works by extruding a fine molten polymeric filament through a heated nozzle on the heated platform named printer bed. In this method, some important manufacturing parameters play a crucial role in controlling the mechanical properties and quality of the final fabricated part. However, all printed specimens through the FDM process should be tested based on the standards under some critical circumstances. Thus, in the current research paper, five and three test speeds are considered in tensile and fracture testing procedures, respectively to evaluate how these speeds can affect the mechanical and mode I fracture properties. Also, as the FDM specimens present elastic-plastic behavior, the critical value of J-integral is assumed as a fracture assessment and calculated from the finite element analysis. Among the mechanical properties, ultimate tensile strength is affected significantly by the test speed. For instance, the ultimate tensile strength of FDM specimens is 39.02, 38.58, 42.33, 48.09, and 52.11 for test speeds of 2, 4, 6, 8, and 10 mm/min, respectively. But vice-versa results are detected for the mode I fracture behavior and corresponding values of J for the FDM-PLA specimens. Finally, experimental and numerical results together with comprehensive discussions about the considered speeds and obtained results are reported.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54780-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Improved light and ultraviolet stability of curcumin encapsulated in emulsion gels prepared with corn starch, OSA-starch and whey protein isolate.

Zhan, Siyuan / He, Mohe / Wu, Yanwen / Ouyang, Jie

Food chemistry

2024 Volume 446, Page(s) 138803

Abstract: The objective of this study was to enhance the bioavailability and stability of curcumin (Cur) by encapsulating it in corn starch (CS)/octenylsuccinic acid modified (OSA)-starch-whey protein isolate (WPI) emulsion gels (EGs). As the volume fraction of ... ...

Abstract	The objective of this study was to enhance the bioavailability and stability of curcumin (Cur) by encapsulating it in corn starch (CS)/octenylsuccinic acid modified (OSA)-starch-whey protein isolate (WPI) emulsion gels (EGs). As the volume fraction of the oil phase increased, the droplet size and ζ- potential of the EGs decreased. The encapsulation efficiency and bioavailability of Cur in CS/OSA-starch-WPI EGs with a 60% oil ratio were 96.0% and 67.3%, respectively. The release rate of free fatty acid and the bioavailability of Cur from the EGs after digestion were significantly higher compared to Cur dissolved in oil. EGs with an oil phase volume fraction of 75% and 80% demonstrated greater protection against light irradiation but were less effective against UV irradiation compared to EGs with a 60% oil phase volume fraction. Encapsulation in EGs proved to be an effective method for enhancing the bioavailability and stability of Cur.
MeSH term(s)	Emulsions ; Starch ; Whey Proteins ; Curcumin ; Zea mays ; Gels ; Succinates
Chemical Substances	Emulsions ; Starch (9005-25-8) ; Whey Proteins ; Curcumin (IT942ZTH98) ; octenyl succinate (28805-58-5) ; Gels ; Succinates
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 3634: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ag

Zeng, Zhan-Peng / Lai, Chang-Rong / Zheng, Wei-Jie

Chemical biology & drug design

2024 Volume 103, Issue 3, Page(s) e14501

Abstract: The toxic effects of nanoparticles-silver oxide ( ... ...

Abstract	The toxic effects of nanoparticles-silver oxide (Ag
MeSH term(s)	Osteogenesis ; Tumor Necrosis Factor-alpha/metabolism ; beta Catenin/metabolism ; Catenins/metabolism ; Catenins/pharmacology ; Bone Marrow/metabolism ; Cells, Cultured ; Cell Differentiation ; Mesenchymal Stem Cells/metabolism ; Bone Marrow Cells/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha ; beta Catenin ; Catenins
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14501
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Genes that escape from X-chromosome inactivation and sexual dimorphism of systemic lupus erythematosus.

Qian, Ma / Shao-Lan, Zhou / Jie, Dang / Zheng-Hao, Huo / Zhan-Bing, Ma

Yi chuan = Hereditas

2024 Volume 46, Issue 1, Page(s) 18–33

Abstract: X chromosome inactivation can balance the effects of the two X chromosomes in females, and emerging evidence indicates that numerous genes on the inactivated X chromosome have the potential to evade inactivation. The mechanisms of escape include ... ...

Abstract	X chromosome inactivation can balance the effects of the two X chromosomes in females, and emerging evidence indicates that numerous genes on the inactivated X chromosome have the potential to evade inactivation. The mechanisms of escape include modification of DNA, RNA, histone, epitope, and various regulatory proteins, as well as the spatial structure of chromatin. The study of X chromosome inactivation escape has paved the way for investigating sex dimorphism in human diseases, particularly autoimmune diseases. It has been demonstrated that the presence of TLR7, CD40L, IRAK-1, CXCR3, and CXorf21 significantly contributes to the prevalence of SLE (systemic lupus erythematosus) in females. This article mainly reviews the molecular mechanisms underlying these genes that escape from X-chromosome inactivation and sexual dimorphism of systemic lupus erythematosus. Therefore, elucidating the molecular mechanisms underlying sexual dimorphism in SLE is not only crucial for diagnosing and treating the disease, but also holds theoretical significance in comprehensively understanding the development and regulatory mechanisms of the human immune system.
MeSH term(s)	Female ; Humans ; X Chromosome Inactivation/genetics ; Sex Characteristics ; Lupus Erythematosus, Systemic/genetics ; Chromosomes, Human, X/genetics ; Immune System
Language	English
Publishing date	2024-01-17
Publishing country	China
Document type	Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.23-214
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Precise Determination of Selenium Forms and Contents in Selenium-Enriched Rapeseed Seedlings and Flowering Stalks by HPLC-ICP-MS.

Zhan, Jie-Peng / Qi, Meng / Wang, Chao / Wang, Xin-Fa / Wang, Han-Zhong / Dun, Xiao-Ling

Journal of agricultural and food chemistry

2024

Abstract: Rapeseed ( ...

Abstract	Rapeseed (
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08416
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1172: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito