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Article ; Online: Diagnostic dilemma in a 3-year-old girl with acute nephritic syndrome and hematologic abnormalities: Questions.

Innocenti, Samantha / Bernardi, Silvia / Prévot, Maud / Saldmann, Antonin / Tusseau, Maud / Belot, Alexandre / Duong Van Huyen, Jean-Paul / Boyer, Olivia

Pediatric nephrology (Berlin, Germany)

2022 Volume 38, Issue 7, Page(s) 2065–2067

MeSH term(s)	Female ; Humans ; Child, Preschool ; Nephritis ; Glomerulonephritis/diagnosis ; Hematologic Diseases
Language	English
Publishing date	2022-10-17
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-022-05733-9
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Zs.A 2196: Show issues

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Article ; Online: Diagnostic dilemma in a 3-year-old girl with acute nephritic syndrome and hematologic abnormalities: Answers.

Innocenti, Samantha / Bernardi, Silvia / Prévot, Maud / Saldmann, Antonin / Tusseau, Maud / Belot, Alexandre / Duong Van Huyen, Jean-Paul / Boyer, Olivia

Pediatric nephrology (Berlin, Germany)

2022 Volume 38, Issue 7, Page(s) 2069–2076

MeSH term(s)	Female ; Humans ; Child, Preschool ; Nephritis ; Glomerulonephritis ; Lupus Erythematosus, Systemic ; Lupus Nephritis/diagnosis
Language	English
Publishing date	2022-10-17
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-022-05752-6
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Zs.A 2196: Show issues

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Article ; Online: 25-Hydroxyvitamin D concentrations in COVID-19 patients hospitalized in intensive care unit during the first wave and the second wave of the pandemic.

Saldmann, Antonin / Stoclin, Annabelle / Hamada, Sophie Rym / Cholley, Bernard / Houillier, Pascal / Baron, Stéphanie / Prot-Bertoye, Caroline / Travers, Simon / Friedlander, Gérard / Jannot, Anne-Sophie / Souberbielle, Jean-Claude / Courbebaisse, Marie

Clinical chemistry and laboratory medicine

2021 Volume 59, Issue 6, Page(s) e255–e258

MeSH term(s)	COVID-19 ; Critical Illness ; Humans ; Intensive Care Units ; Pandemics ; SARS-CoV-2 ; Vitamin D/analogs & derivatives ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-03-03
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2021-0207
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Zs.A 121: Show issues

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Article ; Online: Beyond the concept of cold and hot tumors for the development of novel predictive biomarkers and the rational design of immunotherapy combination.

De Guillebon, Eleonore / Dardenne, Antoine / Saldmann, Antonin / Séguier, Sylvie / Tran, Thi / Paolini, Lea / Lebbe, Celeste / Tartour, Eric

International journal of cancer

2020 Volume 147, Issue 6, Page(s) 1509–1518

Abstract: Immunotherapy has revolutionized the management of cancers. At the end of 2018, 1,716 clinical trials assessed regimen that combine program death-1 (PD-1)/program death ligand-1 (PD-L1) blockers with other cancer therapies (tyrosine kinase inhibitor, ... ...

Abstract	Immunotherapy has revolutionized the management of cancers. At the end of 2018, 1,716 clinical trials assessed regimen that combine program death-1 (PD-1)/program death ligand-1 (PD-L1) blockers with other cancer therapies (tyrosine kinase inhibitor, chemotherapy and radiotherapy). There is a contrast between these clinical dynamics and the difficulty of identifying biomarkers to better select patients that could benefit from immunotherapy. In this context, different tumor classifications have been proposed to try to better stratify patients. They rely on the characteristics of the tumor microenvironment and led first to divide them into hot and cold tumors. In this review, we aim to demonstrate the limitations of this classification focusing on the differential significance of subpopulations of intratumor CD8 + T cells. We also underline novel mechanisms of resistance to anti-PD-1/PD-L1 blockade, focusing on myeloid cells, hypoxia and tumor immunoediting under treatment. Understanding the mechanisms of resistance to immune-checkpoint inhibitor is indeed a powerful research driver that allows further identification of novel biomarkers, drug development and bring a rational to innovative therapeutic combinations.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B7-H1 Antigen/analysis ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/immunology ; Biomarkers, Tumor/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/immunology ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Lymphocytes, Tumor-Infiltrating/immunology ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/immunology ; Programmed Cell Death 1 Receptor/analysis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Chemical Substances	B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; Immune Checkpoint Inhibitors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.32889
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Plasma CD27, a Surrogate of the Intratumoral CD27-CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma.

Benhamouda, Nadine / Sam, Ikuan / Epaillard, Nicolas / Gey, Alain / Phan, Letuan / Pham, Hang Phuong / Gruel, Nadège / Saldmann, Antonin / Pineau, Joséphine / Hasan, Milena / Quiniou, Valentin / Nevoret, Camille / Verkarre, Virginie / Libri, Valentina / Mella, Sebastien / Granier, Clémence / Broudin, Chloe / Ravel, Patrice / De Guillebon, Eléonore /

Mauge, Laetitia / Helley, Dominique / Jabla, Bernd / Chaput, Nathalie / Albiges, Laurence / Katsahian, Sandrine / Adam, Julien / Mejean, Arnaud / Adotevi, Olivier / Vano, Yann A / Oudard, Stéphane / Tartour, Eric

Clinical cancer research : an official journal of the American Association for Cancer Research

2022 Volume 28, Issue 22, Page(s) 4983–4994

Abstract: Purpose: CD70 is a costimulatory molecule known to activate CD27-expressing T cells. CD27-CD70 interaction leads to the release of soluble CD27 (sCD27). Clear-cell renal cell carcinoma (ccRCC) expresses the highest levels of CD70 among all solid tumors; ...

Abstract	Purpose: CD70 is a costimulatory molecule known to activate CD27-expressing T cells. CD27-CD70 interaction leads to the release of soluble CD27 (sCD27). Clear-cell renal cell carcinoma (ccRCC) expresses the highest levels of CD70 among all solid tumors; however, the clinical consequences of CD70 expression remain unclear. Experimental design: Tumor tissue from 25 patients with ccRCC was assessed for the expression of CD27 and CD70 in situ using multiplex immunofluorescence. CD27+ T-cell phenotypes in tumors were analyzed by flow cytometry and their gene expression profile were analyzed by single-cell RNA sequencing then confirmed with public data. Baseline sCD27 was measured in 81 patients with renal cell carcinoma (RCC) treated with immunotherapy (35 for training cohort and 46 for validation cohort). Results: In the tumor microenvironment, CD27+ T cells interacted with CD70-expressing tumor cells. Compared with CD27- T cells, CD27+ T cells exhibited an apoptotic and dysfunctional signature. In patients with RCC, the intratumoral CD27-CD70 interaction was significantly correlated with the plasma sCD27 concentration. High sCD27 levels predicted poor overall survival in patients with RCC treated with anti-programmed cell death protein 1 in both the training and validation cohorts but not in patients treated with antiangiogenic therapy. Conclusions: In conclusion, we demonstrated that sCD27, a surrogate marker of T-cell dysfunction, is a predictive biomarker of resistance to immunotherapy in RCC. Given the frequent expression of CD70 and CD27 in solid tumors, our findings may be extended to other tumors.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; CD27 Ligand/genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics ; Immunotherapy ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Tumor Microenvironment
Chemical Substances	CD27 Ligand ; Tumor Necrosis Factor Receptor Superfamily, Member 7 ; CD70 protein, human
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-0905
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Zs.A 4223: Show issues

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Article ; Online: Human catalase gene promoter haplotype and cardiometabolic improvement after bariatric surgery.

Alili, Rohia / Nivet-Antoine, Valérie / Saldmann, Antonin / Golmard, Jean-Louis / Cottart, Charles-Henry / Laguillier, Christelle / Giral, Philippe / Beaudeux, Jean-Louis / Bouillot, Jean-Luc / Poitou, Christine / Clément, Karine / Hébert-Schuster, Marylise

Gene

2018 Volume 656, Page(s) 17–21

Abstract: Although its powerful impact on most co-morbidities has been widely demonstrated, the metabolic outcomes of bariatric surgery (BS) show a great heterogeneity among patients. Haplotypes of one of the major antioxidant enzyme, catalase (CAT), are ... ...

Abstract	Although its powerful impact on most co-morbidities has been widely demonstrated, the metabolic outcomes of bariatric surgery (BS) show a great heterogeneity among patients. Haplotypes of one of the major antioxidant enzyme, catalase (CAT), are associated with hypertension, dyslipidemia, and diabetes. The haplotype referred to as CAT1 includes homozygous carriers of CATH1 [-844G,-89A,-20T], whereas CAT2 haplotype includes heterozygous carriers (CATH1/CATH2) and CATH2 homozygous [-844A,-89T,-20C]. The aim of our study was to evaluate the impact of CAT1 and CAT2 haplotypes on traditional cardiovascular and metabolic markers one year after BS in a women population. The 294 women with a body mass index (BMI) >35 kg/m2 were followed-up for one year after BS, monitoring their anthropometric, metabolic and inflammatory parameters. CAT1 patients had significantly improved diastolic blood pressure (DBP) and Creactive protein (CRP) levels compared to CAT2 one year after BS. In untreated women at baseline, the change of CRP one year after BS was higher in CAT1 patients. In the population of women receiving at least one anti-lipidic, anti-hypertensive or anti-diabetic treatment at baseline, DBP and fat mass were lower one year after BS in CAT1 patients and the greater change of fat mass was associated with a higher change of adiponectin. The results highlight the beneficial impact of the CAT1 haplotype on traditional cardiovascular and metabolic parameters after BS. Our findings suggest that the CAT1 haplotype could be implicated in the level of metabolic and cardiovascular improvement after BS.
MeSH term(s)	Adult ; Bariatric Surgery/rehabilitation ; Blood Glucose/genetics ; Blood Glucose/metabolism ; Cardiovascular System/physiopathology ; Catalase/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/prevention & control ; Dyslipidemias/genetics ; Dyslipidemias/prevention & control ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Hypertension/genetics ; Hypertension/prevention & control ; Male ; Middle Aged ; Obesity, Morbid/genetics ; Obesity, Morbid/metabolism ; Obesity, Morbid/physiopathology ; Obesity, Morbid/surgery ; Promoter Regions, Genetic
Chemical Substances	Blood Glucose ; Catalase (EC 1.11.1.6)
Language	English
Publishing date	2018-05-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2018.02.064
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Zs.A 1357: Show issues

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Article: Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.

Granier, Clemence / De Guillebon, Eleonore / Blanc, Charlotte / Roussel, Helene / Badoual, Cecile / Colin, Elia / Saldmann, Antonin / Gey, Alain / Oudard, Stephane / Tartour, Eric

ESMO open

2017 Volume 2, Issue 2, Page(s) e000213

Abstract: The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already ...

Abstract	The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already constitute approved targets in cancer therapy and, since 2011, have opened a new area of antitumour immunotherapy. Many antibodies targeting other inhibitory receptors (Tim-3, VISTA, Lag-3 and so on) or activating costimulatory molecules (OX40, GITR and so on) are under evaluation. These antibodies have multiple mechanisms of action. At the cellular level, these antibodies restore the activation signalling pathway and reprogram T cell metabolism. Tumour cells become resistant to apoptosis when an intracellular PD-L1 signalling is blocked. CD8
Language	English
Publishing date	2017-07-03
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-7029
ISSN	2059-7029
DOI	10.1136/esmoopen-2017-000213
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Article ; Online: Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells.

Granier, Clémence / Vinatier, Emeline / Colin, Elia / Mandavit, Marion / Dariane, Charles / Verkarre, Virginie / Biard, Lucie / El Zein, Rami / Lesaffre, Corinne / Galy-Fauroux, Isabelle / Roussel, Hélène / De Guillebon, Eléonore / Blanc, Charlotte / Saldmann, Antonin / Badoual, Cécile / Gey, Alain / Tartour, Éric

Journal of visualized experiments : JoVE

2018 , Issue 132

Abstract: Immune cells are important components of the tumor microenvironment and influence tumor growth and evolution at all stages of carcinogenesis. Notably, it is now well established that the immune infiltrate in human tumors can correlate with prognosis and ... ...

Abstract	Immune cells are important components of the tumor microenvironment and influence tumor growth and evolution at all stages of carcinogenesis. Notably, it is now well established that the immune infiltrate in human tumors can correlate with prognosis and response to therapy. The analysis of the immune infiltrate in the tumor microenvironment has become a major challenge for the classification of patients and the response to treatment. The co-expression of inhibitory receptors such as Program Cell Death Protein 1 (PD1; also known as CD279), Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4), T-Cell Immunoglobulin and Mucin Containing Protein-3 (Tim-3; also known as CD366), and Lymphocyte Activation Gene 3 (Lag-3; also known as CD223), is a hallmark of T cell exhaustion. We developed a multiparametric in situ immunofluorescence staining to identify and quantify at the cellular level the co-expression of these inhibitory receptors. On a retrospective series of frozen tissue of renal cell carcinomas (RCC), using a fluorescence multispectral imaging technology coupled with an image analysis software, it was found that co-expression of PD-1 and Tim-3 on tumor infiltrating CD8
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/immunology ; Carcinoma, Renal Cell/pathology ; Female ; Fluorescent Antibody Technique/methods ; Humans ; Male ; Programmed Cell Death 1 Receptor/metabolism ; Retrospective Studies ; Tumor Microenvironment
Chemical Substances	Programmed Cell Death 1 Receptor
Language	English
Publishing date	2018-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/56606
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Article ; Online: Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.

Dragon-Durey, Marie-Agnès / Chen, Xiaoyi / Kirilovsky, Amos / Ben Hamouda, Nadine / El Sissy, Carine / Russick, Jules / Charpentier, Etienne / Binois, Yannick / Marliot, Florence / Meylan, Maxime / Granier, Clémence / Pere, Hélène / Saldmann, Antonin / Rance, Bastien / Jannot, Anne Sophie / Baron, Stéphanie / Chebbi, Mouna / Fayol, Antoine / Josseaume, Nathalie /

Rives-Lange, Claire / Tharaux, Pierre-Louis / Cholley, Bernard / Diehl, Jean-Luc / Arlet, Jean-Benoît / Azizi, Michel / Karras, Alexandre / Czernichow, Sébastien / Smadja, David M / Hulot, Jean-Sébastien / Cremer, Isabelle / Tartour, Eric / Mousseaux, Elie / Pagès, Franck

PloS one

2021 Volume 16, Issue 5, Page(s) e0252026

Abstract: To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital ... ...

Abstract	To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.
MeSH term(s)	Aged ; Biomarkers/metabolism ; Body Mass Index ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Chemokines/blood ; Chemokines/metabolism ; Cytokines/blood ; Cytokines/metabolism ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units ; Liver/diagnostic imaging ; Liver/physiopathology ; Lung/diagnostic imaging ; Lung/physiopathology ; Male ; Middle Aged ; Obesity/complications ; Obesity/pathology ; Prospective Studies ; RNA, Viral/blood ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Chemical Substances	Biomarkers ; Chemokines ; Cytokines ; RNA, Viral
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0252026
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Article ; Online: Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.

Marie-Agnès Dragon-Durey / Xiaoyi Chen / Amos Kirilovsky / Nadine Ben Hamouda / Carine El Sissy / Jules Russick / Etienne Charpentier / Yannick Binois / Florence Marliot / Maxime Meylan / Clémence Granier / Hélène Pere / Antonin Saldmann / Bastien Rance / Anne Sophie Jannot / Stéphanie Baron / Mouna Chebbi / Antoine Fayol / Nathalie Josseaume /

Claire Rives-Lange / Pierre-Louis Tharaux / Bernard Cholley / Jean-Luc Diehl / Jean-Benoît Arlet / Michel Azizi / Alexandre Karras / Sébastien Czernichow / David M Smadja / Jean-Sébastien Hulot / Isabelle Cremer / Eric Tartour / Elie Mousseaux / Franck Pagès

PLoS ONE, Vol 16, Iss 5, p e

2021 Volume 0252026

Abstract	To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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