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  1. Book ; Online ; E-Book: Ratgeber Schmerzmittel

    Schwarzer, Andreas / Maier, Christoph

    Substanzen, Indikationen, Nebenwirkungen

    2022  

    Author's details Andreas Schwarzer, Christoph Maier
    Keywords Pain medicine ; Family medicine
    Subject code 616.0472
    Language German
    Size 1 Online-Ressource (XIV, 161 Seiten), Illustrationen
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021687225
    ISBN 978-3-662-64577-2 ; 9783662645765 ; 3-662-64577-7 ; 3662645769
    DOI 10.1007/978-3-662-64577-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Playing the Bagpipes - A Risk Factor for Glaucoma Progression?

    Schwarzer, Petra / Gerding, Heinrich / Hergeldzhieva, Tatyana / Goldblum, David / Tappeiner, Christoph

    Klinische Monatsblatter fur Augenheilkunde

    2024  Volume 241, Issue 4, Page(s) 344–346

    Title translation Dudelsackspielen – ein Risikofaktor für die Glaukomprogression?
    MeSH term(s) Humans ; Risk Factors ; Disease Progression ; Glaucoma/etiology ; Glaucoma/physiopathology
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2188-5364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.20: Show issues Location:
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  3. Article ; Online: Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy.

    Widmann, Melanie / Lieb, Andreas / Mutti, Anna / Schwarzer, Christoph

    Epilepsy research

    2023  Volume 197, Page(s) 107235

    Abstract: In the quest for novel treatments for patients with drug-resistant seizures, poor water solubility of potential drug candidates is a frequent obstacle. Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a ... ...

    Abstract In the quest for novel treatments for patients with drug-resistant seizures, poor water solubility of potential drug candidates is a frequent obstacle. Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a confounding influence in epilepsy research, reporting both pro- and antiepileptic effects. In this study, we aim to clarify the effects of DMSO on epileptiform activity in one of the most frequently studied models of chronic epilepsy, the intrahippocampal kainic acid (IHKA) mouse model, and in a model of acute seizures. We show that 100 % DMSO (in a volume of 1.5 µl/g corresponding to 1651 mg/kg) causes a significant short-term anti-seizure effect in epileptic IHKA mice of both sexes, but does not affect the threshold of acute seizures induced by pentylenetetrazol (PTZ). These findings highlight that the choice of solvent and appropriate vehicle control is crucial to minimize undesirable misleading effects and that drug candidates exclusively soluble in 100 % DMSO need to be modified for better solubility already at initial testing.
    MeSH term(s) Humans ; Male ; Female ; Animals ; Mice ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/drug therapy ; Dimethyl Sulfoxide/adverse effects ; Hippocampus ; Epilepsy ; Solvents/adverse effects ; Disease Models, Animal ; Kainic Acid/toxicity
    Chemical Substances Dimethyl Sulfoxide (YOW8V9698H) ; Solvents ; Kainic Acid (SIV03811UC)
    Language English
    Publishing date 2023-09-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2023.107235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Kappa Opioid Receptor System in Temporal Lobe Epilepsy.

    Zangrandi, Luca / Schwarzer, Christoph

    Handbook of experimental pharmacology

    2021  Volume 271, Page(s) 379–400

    Abstract: Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients frequently develop cognitive deficits and emotional blunting along progression of the disease. The high incidence of refractoriness to ... ...

    Abstract Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients frequently develop cognitive deficits and emotional blunting along progression of the disease. The high incidence of refractoriness to antiepileptic drugs and a frequent lack of admissibility to surgery pose an unmet medical challenge. In the urgent quest for novel treatment strategies, neuropeptides and their receptors are interesting candidates. However, their therapeutic potential has not yet been fully exploited. This chapter focuses on the functional role of the dynorphins (Dyns) and the kappa opioid receptor (KOR) system in temporal lobe epilepsy and the hippocampus.Genetic polymorphisms in the prepro-dynorphin (pDyn) gene causing lower levels of Dyns in humans and pDyn gene knockout in mice increase the risk to develop epilepsy. This suggests a role of Dyns and KOR as modulators of neuronal excitability. Indeed, KOR agonists induce inhibition of presynaptic neurotransmitter release, as well as postsynaptic hyperpolarization in glutamatergic neurons, both producing anticonvulsant effects.The development of new approaches to modulate the complex KOR signalling cascade (e.g. biased agonism and gene therapy) opens up new exciting therapeutic opportunities with regard to seizure control and epilepsy. Potential adverse side effects of KOR agonists may be minimized through functional selectivity or locally restricted treatment. Preclinical data suggest a high potential of such approaches to control seizures.
    MeSH term(s) Animals ; Dynorphins ; Epilepsy ; Epilepsy, Temporal Lobe/drug therapy ; Hippocampus ; Humans ; Mice ; Receptors, Opioid, kappa
    Chemical Substances Receptors, Opioid, kappa ; Dynorphins (74913-18-1)
    Language English
    Publishing date 2021-03-12
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  5. Article ; Online: Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications.

    Widmann, Melanie / Lieb, Andreas / Fogli, Barbara / Steck, Angela / Mutti, Anna / Schwarzer, Christoph

    Experimental neurology

    2024  Volume 376, Page(s) 114749

    Abstract: Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic ...

    Abstract Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures in males. Here, we investigated the IHKA model in female mice, in particular drug-resistance of HPDs and the influence of antiseizure medications (ASMs) on the power spectrum. After injecting kainic acid (KA) unilaterally into the hippocampus of female mice, we monitored the development of epileptiform activity by local field potential (LFP) recordings. Subsequently, we evaluated the effect of the commonly prescribed ASMs lamotrigine (LTG), oxcarbazepine (OXC) and levetiracetam (LEV), as well as the benzodiazepine diazepam (DZP) with a focus on HPDs and power spectral analysis and assessed neuropathological alterations of the hippocampus. In the IHKA model, female mice replicated key features of human TLE as previously described in males. Importantly, HPDs in female mice did not respond to commonly prescribed ASMs in line with the drug-resistance in males, thus representing a suitable model of drug-resistant seizures. Intriguingly, we observed an increased occurrence of generalized seizures after LTG. Power spectral analysis revealed a pronounced increase in the delta frequency range after the higher dose of 30 mg/kg LTG. DZP abolished HPDs and caused a marked reduction over a wide frequency range (delta, theta, and alpha) of the power spectrum. By characterizing the IHKA model of TLE in female mice we address an important gap in basic research. Considering the special challenges complicating the therapeutic management of epilepsy in women, inclusion of females in preclinical studies is imperative. A well-characterized female model is a prerequisite for the development of novel therapeutic strategies tailored to sex-specific needs and for studies on the effect of epilepsy and ASMs during pregnancy.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2024.114749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 184: Show issues Location:
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  6. Article ; Online: Erfolgreiche Behandlung einer therapierefraktären Akanthamöben-Keratitis mit systemischem Miltefosin und topischem Voriconazol.

    Schwarzer, Petra / Blaser, Frank / Sellner, Miriam / Rauthe, Stephan Christian / Tandogan, Tamer / Tappeiner, Christoph / Goldblum, David

    Klinische Monatsblatter fur Augenheilkunde

    2024  Volume 241, Issue 4, Page(s) 406–408

    Title translation Successful Treatment of Therapy-refractory Acanthamoeba Keratitis with Systemic Miltefosine and Topical Voriconazole.
    MeSH term(s) Humans ; Voriconazole/administration & dosage ; Voriconazole/therapeutic use ; Acanthamoeba Keratitis/drug therapy ; Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/administration & dosage ; Phosphorylcholine/therapeutic use ; Treatment Outcome ; Administration, Topical ; Antiprotozoal Agents/administration & dosage ; Antiprotozoal Agents/therapeutic use ; Male ; Antifungal Agents/therapeutic use ; Drug Therapy, Combination ; Female ; Adult
    Chemical Substances Voriconazole (JFU09I87TR) ; miltefosine (53EY29W7EC) ; Phosphorylcholine (107-73-3) ; Antiprotozoal Agents ; Antifungal Agents
    Language German
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2196-6011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.20: Show issues Location:
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  7. Article: Photoinduced host-to-guest electron transfer in a self-assembled coordination cage.

    Ganta, Sudhakar / Borter, Jan-Hendrik / Drechsler, Christoph / Holstein, Julian J / Schwarzer, Dirk / Clever, Guido H

    Organic chemistry frontiers : an international journal of organic chemistry

    2022  Volume 9, Issue 20, Page(s) 5485–5493

    Abstract: ... A [ ... ...

    Abstract A [Pd
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ISSN 2052-4110
    ISSN 2052-4110
    DOI 10.1039/d2qo01339h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluation of the SH-SY5Y cell line as an

    Zanker, Jeanette / Hüser, Daniela / Savy, Adrien / Lázaro-Petri, Sara / Hammer, Eva-Maria / Schwarzer, Christoph / Heilbronn, Regine

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1280556

    Abstract: Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, ...

    Abstract Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However,
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1280556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System.

    Chen, Chongguang / Widmann, Melanie / Schwarzer, Christoph / Liu-Chen, Lee-Yuan

    Handbook of experimental pharmacology

    2021  Volume 271, Page(s) 23–38

    Abstract: Antibodies are important tools for protein and peptide research, including for the kappa opioid receptor (KOR) and dynorphins (Dyns). Well-characterized antibodies are essential for rigorous and reproducible research. However, lack of validation of ... ...

    Abstract Antibodies are important tools for protein and peptide research, including for the kappa opioid receptor (KOR) and dynorphins (Dyns). Well-characterized antibodies are essential for rigorous and reproducible research. However, lack of validation of antibody specificity has been thought to contribute significantly to the reproducibility crisis in biomedical research. Since 2003, many scientific journals have required documentation of validation of antibody specificity and use of knockout mouse tissues as a negative control is strongly recommended. Lack of specificity of antibodies against many G protein-coupled receptors (GPCRs) after extensive testing has been well-documented, but antibodies generated against partial sequences of the KOR have not been similarly investigated. For the dynorphins, differential processing has been described in distinct brain areas, resulting in controversial findings in immunohistochemistry (IHC) when different antibodies were used. In this chapter, we summarized accepted approaches for validation of antibody specificity. We discussed two KOR antibodies most commonly used in IHC and described generation and characterization of KOR antibodies and phospho-KOR specific antibodies in western blotting or immunoblotting (IB). In addition, applying antibodies targeting prodynorphin or mature dynorphin A illustrates the diversity of results obtained regarding the distribution of dynorphins in distinct brain areas.
    MeSH term(s) Animals ; Brain/metabolism ; Dynorphins ; Mice ; Mice, Knockout ; Receptors, Opioid, kappa ; Reproducibility of Results
    Chemical Substances Receptors, Opioid, kappa ; Dynorphins (74913-18-1)
    Language English
    Publishing date 2021-05-25
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  10. Article: The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.

    Burtscher, Johannes / Schwarzer, Christoph

    Frontiers in molecular neuroscience

    2017  Volume 10, Page(s) 245

    Abstract: Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease. The high incidence of resistance to ... ...

    Abstract Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease. The high incidence of resistance to antiepileptic drugs and a frequent lack of admissibility to surgery poses an unmet medical challenge. In the urgent quest of novel treatment strategies, neuropeptides are interesting candidates, however, their therapeutic potential has not yet been exploited. This review focuses on the functional role of the endogenous opioid system with respect to temporal lobe epilepsy, specifically in the hippocampus. The role of dynorphins and kappa opioid receptors (KOPr) as modulators of neuronal excitability is well understood: both the reduced release of glutamate as well of postsynaptic hyperpolarization were shown in glutamatergic neurons. In line with this, low levels of dynorphin in humans and mice increase the risk of epilepsy development. The role of enkephalins is not understood so well. On one hand, some agonists of the delta opioid receptors (DOPr) display pro-convulsant properties probably through inhibition of GABAergic interneurons. On the other hand, enkephalins play a neuro-protective role under hypoxic or anoxic conditions, most probably through positive effects on mitochondrial function. Despite the supposed absence of endorphins in the hippocampus, exogenous activation of the mu opioid receptors (MOPr) induces pro-convulsant effects. Recently-expanded knowledge of the complex ways opioid receptors ligands elicit their effects (including biased agonism, mixed binding, and opioid receptor heteromers), opens up exciting new therapeutic potentials with regards to seizures and epilepsy. Potential adverse side effects of KOPr agonists may be minimized through functional selectivity. Preclinical data suggest a high potential of such compounds to control seizures, with a strong predictive validity toward human patients. The discovery of DOPr-agonists without proconvulsant potential stimulates the research on the therapeutic use of neuroprotective potential of the enkephalin/DOPr system.
    Language English
    Publishing date 2017-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2017.00245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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