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Article ; Online: Histological and morphometrical evaluation of the urethral wall after bioresorbable stent implantation in male New Zealand White Rabbits: A preliminary study.

Skonieczna-Kurpiel, Joanna / Madej, Jan P / Klekiel, Tomasz / Mackiewicz, Agnieszka / Będziński, Romuald / Noszczyk-Nowak, Agnieszka / Piasecki, Tomasz / Ceccopieri, Cassandra

Histology and histopathology

2024 , Page(s) 18722

Abstract: The aim of the study was the histological and morphometrical evaluation of the urethral wall at three time points after bioresorbable stent implantation in male New Zealand White Rabbits. The research was performed on 26 male New Zealand White rabbits ... ...

Abstract	The aim of the study was the histological and morphometrical evaluation of the urethral wall at three time points after bioresorbable stent implantation in male New Zealand White Rabbits. The research was performed on 26 male New Zealand White rabbits aged 3-4 months and weighing 2.1-3.0 kg. Two models of bioresorbable sodium alginate-based stents were developed and implanted into the urethral lumen for one (T1), three (T3), and six weeks (T6). Sections of 5 µm thickness were cut from the urethra at intervals of 2 mm. The sliced sections were stained with hematoxylin-eosin (H&E), Van Gieson's (VG), Von Kossa, and Movat-Russell modified pentachrome (MOVAT) staining methods. The study provided valuable information for future models of urethral stents. The first model of the stent failed to fit the requirements due to inadequate mechanical properties. It curled up on itself losing the ability to adhere to the animals' urethra and was bioresorbed three weeks after implantation. The more rigid no. 2 stent was effective in widening the urethral lumen but did not biodegrade during the experiment. A comprehensive assessment of the second model's properties of biosorption and biointegration requires an extended observation of at least 12 months for an in depth morphological analysis. Stent migration is not likely to be caused solely by the mechanical properties of the urethra or urinary flow but mainly by muscle contraction of the organ wall.
Language	English
Publishing date	2024-02-19
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-722
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Article ; Online: Registered incidence of acute upper respiratory tract infections diagnosed by primary care physicians in Poland - 5-year retrospective analysis of the national health insurance database.

Paciepnik, Iwona / Bąk, Agata / Leoszkiewicz, Katarzyna / Windak, Adam / Madej, Tomasz / Marek, Oleszczyk / Studziński, Krzysztof / Tomasik, Tomasz

Annals of agricultural and environmental medicine : AAEM

2024 Volume 31, Issue 1, Page(s) 100–113

Abstract: Introduction and objective: Upper respiratory tract infection (URTIs), caused by a variety of viruses and sometimes by bacteria, represents the most common acute illness in primary health care. The aim of the study was to explore the registered ... ...

Abstract	Introduction and objective: Upper respiratory tract infection (URTIs), caused by a variety of viruses and sometimes by bacteria, represents the most common acute illness in primary health care. The aim of the study was to explore the registered incidence of URTIs in Poland in the period between 2015-2019, and its burden on the health care system. Material and methods: A retrospective analysis was carried out of all medical encounters in Poland registered within the national billing database of public healthcare services. Medical services provided due to acute URTIs were classified according to the ICD-10 codes. Registered Incidence Rate (RIR) was calculated yearly, in a 100,000 population. A generalised additive model was used to calculate the Incidence Rate Ratio (IRR). Results: In the analysed 5-year period, acute URTI was diagnosed in 24.3 million patients (61.7% of the whole population registered in PHC). The RIR of all acute URTIs in PHC was 50,762/100,000/year. Nearly 99% of consultations in this group of patients were provided by PHC physicians. Only 0.8% were referred to an OSC consultation and 0.4% were hospitalised. In PHC, indeterminate URTIs were most frequently diagnosed. The estimated IRR for children aged 1-4 years was 1.65 (95% CI: 1.64; 1.66, p<0.01) and for men 0.79 (95% CI: 0.79; 0.79; p<0.01). In the studied period, the number of patients consulted for acute URTI decreased slightly in PHC, but significantly in specialist services. Conclusions: The registered incidence of URTIs in Poland burdens mainly PHC physicians. Women and children aged 1-4 years are more frequent users of medical services related to URTIs. It appears that strategies for increasing patient empowerment to provide efficient self-care reducing the utilisation of PHC services are needed.
MeSH term(s)	Male ; Child ; Humans ; Female ; Incidence ; Retrospective Studies ; Physicians, Primary Care ; Poland/epidemiology ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1215115-4
ISSN	1898-2263 ; 1232-1966
ISSN (online)	1898-2263
ISSN	1232-1966
DOI	10.26444/aaem/183993
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Article: Tribological Performance of Anti-Wear Coatings on Tools for Forming Aluminium Alloy Sheets Used for Producing Pull-Off Caps.

Czapla, Kamil / Żaba, Krzysztof / Kot, Marcin / Nejman, Ilona / Madej, Marcin / Trzepieciński, Tomasz

Materials (Basel, Switzerland)

2023 Volume 16, Issue 19

Abstract: Ensuring adequate reliability of the production process of packaging closures has made it necessary to study the effect of annealing and varnishing variants on the strength and structural properties of the stock material. As a test material, EN AW-5052- ... ...

Abstract	Ensuring adequate reliability of the production process of packaging closures has made it necessary to study the effect of annealing and varnishing variants on the strength and structural properties of the stock material. As a test material, EN AW-5052-H28 aluminium alloy sheets with a thickness of 0.21 mm were used. The surface treatment of the test material involved varnishing the sheet metal surface using various varnishes and soaking the sheet metal. The coefficient of friction and the abrasion resistance of the coatings were determined using the T-21 ball-and-disc tribotester. The tested sheets were subjected to tribological analysis by the T-05 roller-block tribotester using countersamples made of Caldie and Sverker 21 tool steels. The results of the tests showed differences in mechanical and structural properties depending on the method of sample preparation. Based on the test results, significant differences in the adhesion of anti-wear coatings were found. The results revealed that the most favourable friction conditions are provided by the CrN coating. The (AlTi)N interlayer in the (AlTi)N/(AlCr)N coating adheres to the substrate over the entire tested area and no detachment from its surface was observed, which proves good bonding at the substrate/coating interface. The tested AlTiN/TiAlSiXN coating is characterised by a more homogeneous, compact microstructure compared to the (AlTi)N/(AlCr)N coating.
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16196465
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Article: Limbal Approach Phacovitrectomy to Treat Cataract with Clinically Significant Asteroid Hyalosis-Presentation of the Technique and Preliminary Results.

Rozegnał-Madej, Agnieszka / Wlaź, Aleksandra / Żarnowski, Tomasz

Journal of clinical medicine

2021 Volume 10, Issue 15

Abstract: Purpose: To assess preliminarily the efficacy and safety of a relatively new surgical modification of phacovitrectomy in eyes with cataract and visually significant asteroid hyalosis (AH).: Materials and methods: Prospective, noncomparative, ... ...

Abstract	Purpose: To assess preliminarily the efficacy and safety of a relatively new surgical modification of phacovitrectomy in eyes with cataract and visually significant asteroid hyalosis (AH). Materials and methods: Prospective, noncomparative, interventional case series of six eyes of six patients (mean age 75.6 years; 1 woman, 5 men) with cataract and visually significant AH treated with a novel surgical technique-a phacoemulsification with anterior vitrectomy through posterior capsulorhexis and intraocular lens (IOL) implantation. Main outcome measures were: best-corrected visual acuity (BCVA), intraocular pressure (IOP), IOL centration, complications. Mean follow-up was 39.17 ± 4.31 months. Results: The mean BCVA (Snellen) improved from 0.26 ± 0.18 to 0.73 ± 0.33 at the end of the follow-up. IOP was in the normal range, and no problems with IOL fixation were observed at the end of the follow-up. No post-operative complications, retinal detachment, retinal tears, macular edema or prolonged inflammation were observed. Conclusions: The presented new surgical technique seems to be a safe and efficacious method to treat cataract with visually significant asteroid hyalosis.
Language	English
Publishing date	2021-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10153338
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Article: 3D imaging options and ultrasound contrast agents for the ultrasound assessment of pediatric rheumatic patients.

Madej, Tomasz

Journal of ultrasonography

2013 Volume 13, Issue 55, Page(s) 431–437

Abstract: The application of 3D imaging in pediatric rheumatology helps to make the assessment of inflammatory changes more objective and to estimate accurately their volume and the actual response to treatment in the course of follow-up examinations. Additional ... ...

Abstract	The application of 3D imaging in pediatric rheumatology helps to make the assessment of inflammatory changes more objective and to estimate accurately their volume and the actual response to treatment in the course of follow-up examinations. Additional interesting opportunities are opened up by the vascularity analysis with the help of power Doppler and color Doppler in 3D imaging. Contrast-enhanced ultrasound examinations enable a more sensitive assessment of the vascularity of inflamed structures of the locomotor system, and a more accurate analysis of treatment's effect on changes in vascularity, and thereby the inflammation process activity, as compared to the classical options of power and color Doppler. The equipment required, time limitations, as well as the high price in the case of contrast-enhanced ultrasound, contribute to the fact that the 3D analysis of inflammatory changes and contrast-enhanced ultrasound examinations are not routinely applied for pediatric patients.
Language	English
Publishing date	2013-12-30
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2843824-3
ISSN	2084-8404
ISSN	2084-8404
DOI	10.15557/JoU.2013.0046
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Article ; Online: Limbal Approach Phacovitrectomy to Treat Cataract with Clinically Significant Asteroid Hyalosis—Presentation of the Technique and Preliminary Results

Agnieszka Rozegnał-Madej / Aleksandra Wlaź / Tomasz Żarnowski

Journal of Clinical Medicine, Vol 10, Iss 3338, p

2021 Volume 3338

Abstract: Purpose: To assess preliminarily the efficacy and safety of a relatively new surgical modification of phacovitrectomy in eyes with cataract and visually significant asteroid hyalosis (AH). Materials and methods: Prospective, noncomparative, ... ...

Abstract	Purpose: To assess preliminarily the efficacy and safety of a relatively new surgical modification of phacovitrectomy in eyes with cataract and visually significant asteroid hyalosis (AH). Materials and methods: Prospective, noncomparative, interventional case series of six eyes of six patients (mean age 75.6 years; 1 woman, 5 men) with cataract and visually significant AH treated with a novel surgical technique—a phacoemulsification with anterior vitrectomy through posterior capsulorhexis and intraocular lens (IOL) implantation. Main outcome measures were: best-corrected visual acuity (BCVA), intraocular pressure (IOP), IOL centration, complications. Mean follow-up was 39.17 ± 4.31 months. Results: The mean BCVA (Snellen) improved from 0.26 ± 0.18 to 0.73 ± 0.33 at the end of the follow-up. IOP was in the normal range, and no problems with IOL fixation were observed at the end of the follow-up. No post-operative complications, retinal detachment, retinal tears, macular edema or prolonged inflammation were observed. Conclusions: The presented new surgical technique seems to be a safe and efficacious method to treat cataract with visually significant asteroid hyalosis.
Keywords	cataract ; asteroid hyalosis ; phacovitrectomy ; new surgical technique ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: 3D imaging options and ultrasound contrast agents for the ultrasound assessment of pediatric rheumatic patients

Tomasz Madej

Journal of Ultrasonography, Vol 13, Iss 55, Pp 431-

2013 Volume 437

Abstract	The application of 3D imaging in pediatric rheumatology helps to make the assessment of inflammatory changes more objective and to estimate accurately their volume and the actual response to treatment in the course of follow-up examinations. Additional interesting opportunities are opened up by the vascularity analysis with the help of power Doppler and color Doppler in 3D imaging. Contrast-enhanced ultrasound examinations enable a more sensitive assessment of the vascularity of inflamed structures of the locomotor system, and a more accurate analysis of treatment’s effect on changes in vascularity, and thereby the inflammation process activity, as compared to the classical options of power and color Doppler. The equipment required, time limitations, as well as the high price in the case of contrast-enhanced ultrasound, contribute to the fact that the 3D analysis of inflammatory changes and contrast-enhanced ultrasound examinations are not routinely applied for pediatric patients.
Keywords	ultrasound ; 3D imaging ; ultrasound contrast agents ; juvenile idiopathic arthritis ; Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intraocular lens power calculations in eyes with pseudoexfoliation syndrome.

Wlaź, Aleksandra / Kustra, Agnieszka / Rozegnał-Madej, Agnieszka / Żarnowski, Tomasz

Scientific reports

2021 Volume 11, Issue 1, Page(s) 19071

Abstract: To compare refractive outcomes after cataract surgery in pseudoexfoliation syndrome (PEX) and control eyes and to investigate the accuracy of 3 intraocular lens (IOL) calculation formulas in these eyes. In this prospective comparative study 42 eyes (PEX ... ...

Abstract	To compare refractive outcomes after cataract surgery in pseudoexfoliation syndrome (PEX) and control eyes and to investigate the accuracy of 3 intraocular lens (IOL) calculation formulas in these eyes. In this prospective comparative study 42 eyes (PEX group) and 38 eyes (control group) of 80 patients were included. The follow-up was 3 months. The refractive prediction error (RPE), mean absolute error (MAE), median absolute error (MedAE) and the percentages of eyes within ± 0.25 D, ± 0.5 D, ± 1.0 D and ± 2.0 D of prediction error were calculated. Three IOL calculation formulas (SRK/T, Barrett Universal II and Hill-RBF) were evaluated. PEX produced statistically significantly higher mean absolute errors and lower percentages of eyes within ± 0.5 D than control eyes in all investigated IOL calculation formulas. There were no statistically significant differences in the median absolute errors between the 3 formulas in either PEX or control eyes. Refractive outcomes after cataract surgery are statistically significantly worse in PEX than in control eyes. All three IOL calculation formulas produced similar results in both PEX and control eyes.Trial registration: ClinicalTrials.gov registration number NCT04783909.
MeSH term(s)	Case-Control Studies ; Cataract Extraction/methods ; Exfoliation Syndrome/physiopathology ; Exfoliation Syndrome/surgery ; Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Prospective Studies ; Visual Acuity
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-98675-5
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Article ; Online: Glutathione S-Transferase P1 Genetic Variant's Influence on the HbA1c Level in Type Two Diabetic Patients.

Orlewska, Katarzyna / Klusek, Justyna / Głuszek, Stanisław / Klusek, Jolanta / Witczak, Bartosz / Wawszczak, Monika / Madej, Łukasz / Marzec, Michał Tomasz / Orlewska, Ewa

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: GST (glutathione S-transferases) are capable of influencing glucose homeostasis, probably through regulation of the response to oxidant stress. The aim of our study was to investigate the relationship between GSTP1 gene polymorphism and glycated ... ...

Abstract	GST (glutathione S-transferases) are capable of influencing glucose homeostasis, probably through regulation of the response to oxidant stress. The aim of our study was to investigate the relationship between GSTP1 gene polymorphism and glycated hemoglobin (HbA1c) levels in type two diabetic (T2D) patients. A total of 307 T2D patients were included. Analysis of the GSTP1 gene polymorphism (rs1695) was conducted using the TaqMan qPCR method endpoint genotyping. HbA1c was determined using a COBAS 6000 autoanalyzer. A univariable linear regression and multivariable linear regression model were used to investigate the association between mean HbA1c level and GSTP1 gene polymorphism, age at T2D diagnosis, T2D duration, therapy with insulin, gender, BMI, smoking status. GSTP1 Val/Val genotype, age at T2D diagnosis, T2D duration and therapy with insulin were statistically significant contributors to HbA1c levels (p < 0.05). Multivariable regression analysis revealed that GSTP1 (Val/Val vs. Ile/Ile) was associated with higher HbA1c even after adjustment for variables that showed a statistically significant relationship with HbA1c in univariable analyses (p = 0.024). The results suggest that GSTP polymorphism may be one of the risk factors for higher HbA1c in T2D patients. Our study is limited by the relatively small sample size, cross-sectional design, and lack of inclusion of other oxidative stress-related genetic variants.
MeSH term(s)	Humans ; Child, Preschool ; Glutathione Transferase/genetics ; Glycated Hemoglobin ; Cross-Sectional Studies ; Glutathione S-Transferase pi/genetics ; Genotype ; Insulins ; Diabetes Mellitus, Type 2/genetics ; Genetic Predisposition to Disease ; Case-Control Studies
Chemical Substances	Glutathione Transferase (EC 2.5.1.18) ; Glycated Hemoglobin ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Insulins
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021520
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Article ; Online: Intraocular lens power calculations in eyes with pseudoexfoliation syndrome

Aleksandra Wlaź / Agnieszka Kustra / Agnieszka Rozegnał-Madej / Tomasz Żarnowski

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract To compare refractive outcomes after cataract surgery in pseudoexfoliation syndrome (PEX) and control eyes and to investigate the accuracy of 3 intraocular lens (IOL) calculation formulas in these eyes. In this prospective comparative study 42 ... ...

Abstract	Abstract To compare refractive outcomes after cataract surgery in pseudoexfoliation syndrome (PEX) and control eyes and to investigate the accuracy of 3 intraocular lens (IOL) calculation formulas in these eyes. In this prospective comparative study 42 eyes (PEX group) and 38 eyes (control group) of 80 patients were included. The follow-up was 3 months. The refractive prediction error (RPE), mean absolute error (MAE), median absolute error (MedAE) and the percentages of eyes within ± 0.25 D, ± 0.5 D, ± 1.0 D and ± 2.0 D of prediction error were calculated. Three IOL calculation formulas (SRK/T, Barrett Universal II and Hill-RBF) were evaluated. PEX produced statistically significantly higher mean absolute errors and lower percentages of eyes within ± 0.5 D than control eyes in all investigated IOL calculation formulas. There were no statistically significant differences in the median absolute errors between the 3 formulas in either PEX or control eyes. Refractive outcomes after cataract surgery are statistically significantly worse in PEX than in control eyes. All three IOL calculation formulas produced similar results in both PEX and control eyes. Trial registration: ClinicalTrials.gov registration number NCT04783909.
Keywords	Medicine ; R ; Science ; Q
Subject code	290
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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