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Article ; Online: Prévention de l’allo-immunisation anti-RH1 au premier trimestre de la grossesse: recommandations pour la pratique clinique du Collège National des Gynécologues-Obstétriciens Français.

Vigoureux, Solène / Maurice, Paul / Sibiude, Jeanne / Garabedian, Charles / Sananès, Nicolas

Gynecologie, obstetrique, fertilite & senologie

2024

Abstract: Objective: To provide recommendations for the prevention of Rh D alloimmunization in the first trimester of pregnancy.: Materials and methods: The quality of evidence of the literature was assessed following the GRADE methodology with questions ... ...

Title translation	Prevention of Rh D Alloimmunization in the first trimester of the pregnancy: French College of Obstetricians and Gynecologists guidelines for clinical practice.
Abstract	Objective: To provide recommendations for the prevention of Rh D alloimmunization in the first trimester of pregnancy. Materials and methods: The quality of evidence of the literature was assessed following the GRADE methodology with questions formulated in the PICO format (Patients, Intervention, Comparison, Outcome) and outcomes defined a priori and classified according to their importance. An extensive bibliographic search was performed on Pubmed, Cochrane, EMBASE, and Google Scholar databases. The quality of evidence was assessed (high, moderate, low, very low) and a recommendation was formulated: (i) strong, (ii) weak, or (iii) no recommendation. The recommendations were reviewed in two rounds with reviewers from the scientific board of the French College of the OB/GYN (Delphi survey) to select the consensus recommendations. Results: The three recommendations from PICO questions reached agreement using the Delphi method. It is recommended not to administer Rh D immunoglobulin before 12 weeks of gestation to reduce the risk of alloimmunization in case of abortion or miscarriage, in RhD negative patients when the genitor is RhD positive or unknown (Weak recommendation. Very low-quality evidence). It is recommended not to administer Rh D immunoglobulin before 12 weeks of gestation to reduce the risk of alloimmunization in cases of bleeding in an ongoing intrauterine pregnancy (Weak recommendation. Very low-quality evidence). The literature data are insufficient in quality and quantity to determine if the injection of Rh D immunoglobulin reduces the risk of alloimmunization in the case of an ectopic pregnancy (No recommendation. Very low-quality evidence). Conclusion: Even though the quality of evidence from the studies is very low, it is recommended not to administer Rh D immunoglobulin in case of abortion, miscarriage or bleeding before 12 weeks of amenorrhea. The quality of evidence was too low to issue a recommendation regarding ectopic pregnancy.
Language	French
Publishing date	2024-02-26
Publishing country	France
Document type	English Abstract ; Practice Guideline
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.02.026
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Article ; Online: Women satisfaction on choosing the cervical ripening method: Oral misoprostol versus balloon catheter.

Flament, Emeline / Blanc-Petitjean, Pauline / Koch, Antoine / Deruelle, Philippe / Le Ray, Camille / Sananès, Nicolas

European journal of obstetrics & gynecology and reproductive biology: X

2023 Volume 19, Page(s) 100202

Abstract: Objective: Induction of labor concerns about 29 % of women in Unites States and 33 % in Europe. Among the various methods for cervical ripening, the efficacy and safety profiles of oral misoprostol and balloon catheter are comparable, but data in the ... ...

Abstract	Objective: Induction of labor concerns about 29 % of women in Unites States and 33 % in Europe. Among the various methods for cervical ripening, the efficacy and safety profiles of oral misoprostol and balloon catheter are comparable, but data in the literature on maternal satisfaction during induction of labor are few. The objective of this study was to assess the satisfaction of women who chose the method of cervical ripening, i.e. either balloon catheter or oral misoprostol, for induction of labor. Study design: This retrospective study asked women who had undergone induction of labor between February 1, 2020 and February 28, 2021. After receiving verbal and written information, the choice of method between oral misoprostol and balloon catheter was left to the patient's free appreciation. Satisfaction was assessed by means of a questionnaire distributed to all women during their stay in the maternity unit. The principal assessment criterion was based on women' inclination to choose the same cervical ripening method if induction of labor were to prove necessary in a future pregnancy, and their willingness to recommend this method to a friend. Univariate analyses were conducted using Student's t-test, Chi-2 test or Fisher's exact test. Results: On 575 women eligible for analysis, 365 (63.5 %) of these women replied to the satisfaction questionnaire. Of this number, 236 (64.7 %) chose cervical ripening by balloon catheter, and 129 (35.3 %) by oral misoprostol. No significant difference was found between the two groups: 68.2 % of women in the balloon catheter group would opt for the same method of cervical ripening if it proved necessary in a future pregnancy and 64.7% would recommend it to a pregnant friend, versus 65.9 % and 63.6 % in the oral misoprostol group, respectively. Women were overall pleased to be able to choose their method of cervical ripening: 90.5 % of patients in the balloon catheter group and 95.3 % in the oral misoprostol group. Conclusions: When women choose the method of cervical ripening, satisfaction is overall good, irrespective of the method, whether by balloon catheter or misoprostol.
Language	English
Publishing date	2023-06-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1613
ISSN (online)	2590-1613
DOI	10.1016/j.eurox.2023.100202
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Article ; Online: 3D-printed simulator for nasopharyngeal swab collection for COVID-19.

Sananès, Nicolas / Lodi, Massimo / Koch, Antoine / Lecointre, Lise / Sananès, Axel / Lefebvre, Nicolas / Debry, Christian

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2020 Volume 278, Issue 7, Page(s) 2649–2651

Abstract: Introduction: Testing for COVID-19 is a cornerstone of pandemic control. If conducted inappropriately, nasopharyngeal swab collection can be painful and preanalytical sample collection errors may lead to false negative results. Our objective was to ... ...

Abstract	Introduction: Testing for COVID-19 is a cornerstone of pandemic control. If conducted inappropriately, nasopharyngeal swab collection can be painful and preanalytical sample collection errors may lead to false negative results. Our objective was to develop a realistic and easily available synthetic simulator for nasopharyngeal swab collection. Materials and methods: The nasopharyngeal swab collection simulator was designed through different development steps: segmentation, computer-aided design (CAD), and 3D printing. The model was 3D printed using PolyJet technology, which allows multi-material printing using hard and soft materials. Results: The simulator splits in the parasagittal plane close to the septum to allow better visualization and understanding of nasal cavity landmarks. The model is able to simulate the softness and texture of different structural elements. The simulator allows the user to conduct realistic nasopharyngeal swab collection. A colored pad on the posterior wall of the nasopharynx provides real-time feedback to the user. The simulator also permits incorrect swab insertion, which is of obvious benefit from a training perspective. Comprehensive 3D files for printing and full instructions for manufacturing the simulator is freely available online via an open access link. Conclusion: In the context of the COVID-19 pandemic, we developed a nasopharyngeal swab collection simulator which can be produced by 3D printing via an open access link, which offers complete operating instructions.
MeSH term(s)	COVID-19 ; COVID-19 Testing ; Humans ; Nasopharynx ; Pandemics ; Printing, Three-Dimensional ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-020-06454-1
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Article ; Online: Fetoscopic endoluminal tracheal occlusion with Smart-TO balloon: Study protocol to evaluate effectiveness and safety of non-invasive removal.

Sananès, Nicolas / Basurto, David / Cordier, Anne-Gaël / Elie, Caroline / Russo, Francesca Maria / Benachi, Alexandra / Deprest, Jan

PloS one

2023 Volume 18, Issue 3, Page(s) e0273878

Abstract: Introduction: One of the drawbacks of fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia is the need for a second invasive intervention to reestablish airway patency. The "Smart-TO" (Strasbourg University-BSMTI, France) ...

Abstract	Introduction: One of the drawbacks of fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia is the need for a second invasive intervention to reestablish airway patency. The "Smart-TO" (Strasbourg University-BSMTI, France) is a new balloon for FETO, which spontaneously deflates when positioned near a strong magnetic field, e.g., generated by a magnetic resonance image (MRI) scanner. Translational experiments have demonstrated its efficacy and safety. We will now use the Smart-TO balloon for the first time in humans. Our main objective is to evaluate the effectiveness of prenatal deflation of the balloon by the magnetic field generated by an MRI scanner. Material and methods: These studies were first in human (patients) trials conducted in the fetal medicine units of Antoine-Béclère Hospital, France, and UZ Leuven, Belgium. Conceived in parallel, protocols were amended by the local Ethics Committees, resulting in some minor differences. These trials were single-arm interventional feasibility studies. Twenty (France) and 25 (Belgium) participants will have FETO with the Smart-TO balloon. Balloon deflation will be scheduled at 34 weeks or earlier if clinically required. The primary endpoint is the successful deflation of the Smart-TO balloon after exposure to the magnetic field of an MRI. The secondary objective is to report on the safety of the balloon. The percentage of fetuses in whom the balloon is deflated after exposure will be calculated with its 95% confidence interval. Safety will be evaluated by reporting the nature, number, and percentage of serious unexpected or adverse reactions. Conclusion: These first in human (patients) trials may provide the first evidence of the potential to reverse the occlusion by Smart-TO and free the airways non-invasively, as well a safety data.
MeSH term(s)	Pregnancy ; Female ; Humans ; Trachea/diagnostic imaging ; Trachea/surgery ; Fetoscopy/adverse effects ; Fetoscopy/methods ; Hernias, Diaphragmatic, Congenital/diagnostic imaging ; Hernias, Diaphragmatic, Congenital/surgery ; Fetus ; Perinatology ; Balloon Occlusion/adverse effects ; Airway Obstruction/etiology
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0273878
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Article ; Online: Sentilhes L, Sénat MV, Bouchghoul H, Delorme P, Gallot D, Garabedian C, Madar H, Sananès N, Perrotin F, Schmitz T. Réponse de Sentilhes L., Sénat M.V., Bouchghoul H., Delorme P., Gallot D., Garabedian C., Madar H., Sananès L., Perrotin F., Schmitz T., à l’article de Boujenah J. intitulé « La cholestase gravidique : pour une vision holistique de la femme. À propos des examens complémentaires lors du diagnostic ». Gynecol Obstet Fertil 2024;52(6). doi:10.1016/j.gofs.2024.02.023.

Sentilhes, Loïc / Sénat, Marie-Victoire / Bouchghoul, Hanane / Delorme, Pierre / Gallot, Denis / Garabedian, Charles / Madar, Hugo / Sananès, Nicolas / Perrotin, Franck / Schmitz, Thomas

Gynecologie, obstetrique, fertilite & senologie

2024

Title translation	Sentilhes L., Sénat M.V., Bouchghoul H., Delorme P., Gallot D., Garabedian C., Madar H., Sananès L., Perrotin F., Schmitz T., in reply to the article by Boujenah J., entitled "La cholestase gravidique : pour une vision holistique de la femme. À propos des examens complémentaires lors du diagnostic". Gynecol Obstet Fertil 2024;52(6). doi:10.1016/j.gofs.2024.02.023.
Language	French
Publishing date	2024-02-24
Publishing country	France
Document type	Letter
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.02.024
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Article ; Online: Morbidity associated with planned cesarean deliveries performed before the scheduled date: A cohort study.

Sananès, Nicolas / Haller, Laure / Jochum, Floriane / Koch, Antoine / Lecointre, Lise / Rozenberg, Patrick

European journal of obstetrics, gynecology, and reproductive biology

2021 Volume 264, Page(s) 83–87

Abstract: Objective: Women with planned cesareans can require delivery before the scheduled date. However, data describing the morbidity associated with planned cesarean deliveries performed before the originally scheduled date is lacking. The objective of this ... ...

Abstract	Objective: Women with planned cesareans can require delivery before the scheduled date. However, data describing the morbidity associated with planned cesarean deliveries performed before the originally scheduled date is lacking. The objective of this study was to compare the morbidity associated with planned cesarean delivery performed before compared with on the scheduled date. Study design: This retrospective single-center cohort study included all 3595 women with singleton pregnancies and cesarean deliveries after 36 Results: Reasons for performing planned cesarean delivery before the scheduled date were as follows: onset of labor (n = 109; 50.0%), rupture of membranes (n = 85; 39.0%), preeclampsia (n = 9; 4.1%), scar pain in women with a previous cesarean (n = 6; 2.8%), unexplained vaginal bleeding (n = 5; 2.3%), and nonreassuring fetal heart rate (n = 4; 1.8%). Mean gestational age for planned cesarean deliveries before the scheduled date was 38.7 weeks ± 0.8 versus 39.2 weeks ± 0.7 for those performed when scheduled (P < 0.0001). The maternal morbidity composite outcome rate was significantly higher among planned cesareans performed early compared with those on the scheduled date: 18.3% vs 9.7%, respectively, P = 0.0002. It was still higher in the multivariable analysis: aOR 2.17, 95% CI 1.46-3.21, P = 0.0001. The neonatal composite outcome did not differ significantly between the two groups. Conclusion: In planned cesarean deliveries, maternal morbidity is higher for cesareans performed before rather than on the scheduled date. Studies without accurate intent-to-treat analyses underestimate the morbidity associated with planned cesareans. Accordingly, medical records must make it possible to distinguish planned cesarean deliveries performed before the scheduled date from those performed as planned.
Language	English
Publishing date	2021-06-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2021.06.030
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Article ; Online: Fetoscopic endoluminal tracheal occlusion with Smart-TO balloon

Nicolas Sananès / David Basurto / Anne-Gaël Cordier / Caroline Elie / Francesca Maria Russo / Alexandra Benachi / Jan Deprest

PLoS ONE, Vol 18, Iss 3, p e

Study protocol to evaluate effectiveness and safety of non-invasive removal.

2023 Volume 0273878

Abstract: Introduction One of the drawbacks of fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia is the need for a second invasive intervention to reestablish airway patency. The "Smart-TO" (Strasbourg University-BSMTI, France) ... ...

Abstract	Introduction One of the drawbacks of fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia is the need for a second invasive intervention to reestablish airway patency. The "Smart-TO" (Strasbourg University-BSMTI, France) is a new balloon for FETO, which spontaneously deflates when positioned near a strong magnetic field, e.g., generated by a magnetic resonance image (MRI) scanner. Translational experiments have demonstrated its efficacy and safety. We will now use the Smart-TO balloon for the first time in humans. Our main objective is to evaluate the effectiveness of prenatal deflation of the balloon by the magnetic field generated by an MRI scanner. Material and methods These studies were first in human (patients) trials conducted in the fetal medicine units of Antoine-Béclère Hospital, France, and UZ Leuven, Belgium. Conceived in parallel, protocols were amended by the local Ethics Committees, resulting in some minor differences. These trials were single-arm interventional feasibility studies. Twenty (France) and 25 (Belgium) participants will have FETO with the Smart-TO balloon. Balloon deflation will be scheduled at 34 weeks or earlier if clinically required. The primary endpoint is the successful deflation of the Smart-TO balloon after exposure to the magnetic field of an MRI. The secondary objective is to report on the safety of the balloon. The percentage of fetuses in whom the balloon is deflated after exposure will be calculated with its 95% confidence interval. Safety will be evaluated by reporting the nature, number, and percentage of serious unexpected or adverse reactions. Conclusion These first in human (patients) trials may provide the first evidence of the potential to reverse the occlusion by Smart-TO and free the airways non-invasively, as well a safety data.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reply.

Sananès, Nicolas / Kasbaoui, Sidi / Severac, François

American journal of obstetrics and gynecology

2017 Volume 217, Issue 3, Page(s) 382

Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Letter
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2017.05.012
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Article ; Online: Trisomy 22: First and Second Trimester Cytogenetic Analysis and Phenotypic Presentation in a Series of Seven Cases.

Minella, Chris / Jeandidier, Eric / Koch, Antoine / Antal, Maria Cristina / Favre, Romain / Sananes, Nicolas / Weingertner, Anne-Sophie

Fetal diagnosis and therapy

2023 Volume 51, Issue 2, Page(s) 112–124

Abstract: Introduction: Trisomy 22 is a chromosomal disorder rarely encountered prenatally. Even fewer live births are observed and generally correspond to confined placental mosaic trisomy 22, or even more uncommonly, to true fetal mosaic trisomy 22.: Case ... ...

Abstract	Introduction: Trisomy 22 is a chromosomal disorder rarely encountered prenatally. Even fewer live births are observed and generally correspond to confined placental mosaic trisomy 22, or even more uncommonly, to true fetal mosaic trisomy 22. Case presentation: We examine and describe a series of seven cases of trisomy 22 encountered prenatally in terms of their cytogenetic and phenotypic presentations and discuss their interrelationships along with case management and outcomes. We aimed to identify aspects of prenatal data suggestive of fetal trisomy 22 and to determine whether a prognosis can be established from these factors. Conclusion: Our conclusion is that prenatal data elements can provide key elements of information to guide multidisciplinary care and support for the couple and the neonate.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Pregnancy Trimester, Second ; Amniocentesis ; Placenta ; Mosaicism ; Trisomy/diagnosis ; Trisomy/genetics ; Cytogenetic Analysis ; Comparative Genomic Hybridization ; Chromosomes, Human, Pair 22
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000534619
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Article ; Online: Multicentric evaluation of a 3D-printed simulator for COVID- 19 nasopharyngeal swab collection in testing centers.

Lecointre, Lise / Venkatasamy, Aïna / Wehr, Mégane / Koch, Antoine / Sananes, Axel / Debry, Christian / Lodi, Massimo / Sananes, Nicolas

The Journal of infection

2021 Volume 83, Issue 6, Page(s) 709–737

MeSH term(s)	COVID-19 ; Diagnostic Tests, Routine ; Humans ; Nasopharynx ; Printing, Three-Dimensional ; SARS-CoV-2 ; Specimen Handling
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.09.015
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