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Article ; Online: A Rare Diagnosis of Infiltrative Muscle Disease in a Patient With Multiple Joint Pain and Fever.

Kim, Chang Guk / Kim, Yeo Ju / Paik, Seungsam / Bae, Sang-Cheol

2024

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is characterized by excessive immune activation. ...

Abstract	Hemophagocytic lymphohistiocytosis (HLH) is characterized by excessive immune activation.
Language	English
Publishing date	2024-03-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.2023-0882
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article: Characterization of Nonaflatoxigenic

Jun, Sang-Cheol / Kim, Yu-Kyung / Han, Kap-Hoon

Mycobiology

2022 Volume 50, Issue 6, Page(s) 408–419

Abstract: Filamentous fungi that could be classified ... ...

Abstract	Filamentous fungi that could be classified into
Language	English
Publishing date	2022-12-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2631580-4
ISSN	2092-9323 ; 1229-8093
ISSN (online)	2092-9323
ISSN	1229-8093
DOI	10.1080/12298093.2022.2156139
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Article ; Online: Fever of unknown origin caused by hemophagocytic lymphohistiocytosis associated with diffuse large B-cell lymphoma.

Kim, Min-Sun / Kim, Bohyun / Kim, Han-Jo / Lee, Sang-Cheol

The Korean journal of internal medicine

2023 Volume 38, Issue 3, Page(s) 448–449

MeSH term(s)	Humans ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Fever of Unknown Origin/etiology ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/pathology
Language	English
Publishing date	2023-04-07
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2023.025
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Article: Analysis of Effect of Intensity of Aerobic Exercise on Cognitive and Motor Functions and Neurotrophic Factor Expression Patterns in an Alzheimer's Disease Rat Model.

Lee, Do-Youn / Im, Sang-Cheol / Kang, Na-Yeon / Kim, Kyoung

Journal of personalized medicine

2023 Volume 13, Issue 11

Abstract: The effect of aerobic exercise at different intensities on Alzheimer's disease (AD) still remains unclear. We investigated the effect of aerobic exercise at different intensities on cognitive and motor functions and neurotrophic factor expression. Thirty- ...

Abstract	The effect of aerobic exercise at different intensities on Alzheimer's disease (AD) still remains unclear. We investigated the effect of aerobic exercise at different intensities on cognitive and motor functions and neurotrophic factor expression. Thirty-two AD-induced rats were randomly assigned to control (CG), low-intensity (Group I), medium-intensity (Group II), and high-intensity (Group III) exercise groups. Each group, except for the CG, performed aerobic exercise for 20 min a day five times a week. After performing aerobic exercise for 4 weeks, their cognitive and motor functions and neurotrophic factor expression patterns were analyzed and compared between the groups. All variables of cognitive and motor functions and neurotrophic factor expression were significantly improved in Groups I, II, and III compared to those in the CG (
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13111622
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Article ; Online: Anti-Tumor Efficacy of Oleuropein-Loaded ZnO/Au Mesoporous Silica Nanoparticle in 5-FU-Resistant Colorectal Cancer Cells.

Park, Sang Mi / Kim, Da Yeon / Lee, Kyeong Hyeon / Shin, Yong-Il / Han, Sang-Cheol / Kwon, Sang-Mo

International journal of nanomedicine

2024 Volume 19, Page(s) 2675–2690

Abstract: Purpose: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible ... ...

Abstract	Purpose: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible nanomedicine system with high efficacy and biocompatibility by synthesizing mesoporous silica nanoparticle (MSN)-structured ZnO and gold ions. Oleuropein (OLP) is a phenolic compound derived from olive leaves that exerts anti-cancer effects. Therefore, we synthesized OLP-loaded ZnO/Au MSNs (ZnO/Au/OLP MSNs) and examined their anti-cancer effects on 5-FU-resistant CRC cells. Methods: ZnO/Au MSNs were synthesized and functionalized, and their physical and chemical compositions were characterized using UV-visible spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM). Their effects were assessed in terms of cellular proliferation capacity, migration and invasion ability, colony-forming ability, spheroid-forming ability, reactive oxygen species (ROS) production, and mitochondrial membrane depolarization. Results: ZnO/Au MSNs were mostly composed of various ions containing ZnO and gold ions, had a spheroid phenotype, and exhibited no cytotoxicity. ZnO/Au/OLP MSNs reduced cell viability and CSC formation and induced apoptosis of 5-FU-resistant CRC cells via necrosis via ROS accumulation and DNA fragmentation. Conclusion: ZnO/Au/OLP MSNs exhibited anti-cancer activity by upregulating necrosis. These results revealed that ZnO/Au/OLP MSNs are a novel drug delivery system for 5-FU CRC therapy.
MeSH term(s)	Humans ; Zinc Oxide ; Silicon Dioxide/chemistry ; Reactive Oxygen Species ; Nanoparticles/chemistry ; Fluorouracil/pharmacology ; Necrosis ; Gold/chemistry ; Ions ; Colorectal Neoplasms/drug therapy ; Porosity ; Iridoid Glucosides
Chemical Substances	Zinc Oxide (SOI2LOH54Z) ; oleuropein (2O4553545L) ; Silicon Dioxide (7631-86-9) ; Reactive Oxygen Species ; Fluorouracil (U3P01618RT) ; Gold (7440-57-5) ; Ions ; Iridoid Glucosides
Language	English
Publishing date	2024-03-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S439392
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Zs.A 6606: Show issues

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Article ; Online: Effects of trunk stabilization exercises using laser pointer visual feedback in patients with chronic stroke: A randomized controlled study.

Kim, Kyoung-Il / Im, Sang-Cheol / Kim, Kyoung

Technology and health care : official journal of the European Society for Engineering and Medicine

2022 Volume 31, Issue 2, Page(s) 471–483

Abstract: Background: Many previous studies have cited the importance of trunk stabilization exercises in patients with stroke. However, the evidence for optimal trunk stabilization exercises for patients with stroke is still lacking.: Objective: To ... ...

Abstract	Background: Many previous studies have cited the importance of trunk stabilization exercises in patients with stroke. However, the evidence for optimal trunk stabilization exercises for patients with stroke is still lacking. Objective: To investigate the effects of laser pointer visual feedback in trunk stabilization exercises that are important for improving trunk dysfunction in patients with stroke. Methods: In total, 30 patients with chronic stroke were randomly assigned to experimental and control groups. The experimental group underwent a traditional stroke rehabilitation program and trunk stabilization exercises using laser pointer visual feedback. The control group underwent a traditional stroke rehabilitation program and trunk stabilization exercises without visual feedback. Pre- and postintervention results after 6 weeks were evaluated using the Berg Balance Scale, static and dynamic plantar pressure, 10-m walk test, and the Korean version of the Fall Efficacy Scale. The results were analyzed using a general linear repeated measurement model. Results: Both groups showed significant improvements in BBS scores, static plantar pressure, dynamic plantar pressure, 10 MWT, and K-FES scores after 6 weeks of intervention (P< 0.05). Compared to the control group, significant improvements were observed in the experimental group in the Berg Balance Scale scores, dynamic paretic posterior plantar pressure, 10-m walk test, and Korean version of the Fall Efficacy Scale scores (P< 0.025). Conclusion: Our results demonstrated the effectiveness of visual feedback during trunk stabilization exercises for resolving trunk dysfunction in patients with stroke. Trunk stabilization exercises using laser pointer visual feedback have been found to be more effective in balance, walking, and fall efficacy in patients with stroke.
MeSH term(s)	Humans ; Feedback, Sensory ; Torso ; Stroke ; Stroke Rehabilitation/methods ; Exercise Therapy/methods ; Postural Balance
Language	English
Publishing date	2022-09-19
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-220100
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Zs.A 3846: Show issues

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Article: Identification of isomeric cyclo(leu-pro) produced by

Kim, Jiwon / Kim, Jin-Cheol / Sang, Mee Kyung

Frontiers in microbiology

2023 Volume 14, Page(s) 1230345

Abstract: ... ...

Abstract	Pseudomonas
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1230345
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Article ; Online: Surface-Engineered Titanium with Nanoceria to Enhance Soft Tissue Integration Via Reactive Oxygen Species Modulation and Nanotopographical Sensing.

Shim, Hye-Won / Kurian, Amal George / Lee, Jiwon / Lee, Sang-Cheol / Kim, Hae-Won / Singh, Rajendra K / Lee, Jung-Hwan

ACS applied materials & interfaces

2024 Volume 16, Issue 11, Page(s) 13622–13639

Abstract: The design of implantable biomaterials involves precise tuning of surface features because the early cellular fate on such engineered surfaces is highly influenced by many physicochemical factors [roughness, hydrophilicity, reactive oxygen species (ROS) ... ...

Abstract	The design of implantable biomaterials involves precise tuning of surface features because the early cellular fate on such engineered surfaces is highly influenced by many physicochemical factors [roughness, hydrophilicity, reactive oxygen species (ROS) responsiveness, etc.]. Herein, to enhance soft tissue integration for successful implantation, Ti substrates decorated with uniform layers of nanoceria (Ce), called Ti@Ce, were optimally developed by a simple and cost-effective in situ immersion coating technique. The characterization of Ti@Ce shows a uniform Ce distribution with enhanced roughness (∼3-fold increase) and hydrophilicity (∼4-fold increase) and adopted ROS-scavenging capacity by nanoceria coating. When human gingival fibroblasts were seeded on Ti@Ce under oxidative stress conditions, Ti@Ce supported cellular adhesion, spreading, and survivability by its cellular ROS-scavenging capacity. Mechanistically, the unique nanocoating resulted in higher expression of amphiphysin (a nanotopology sensor), paxillin (a focal adhesion protein), and cell adhesive proteins (collagen-1 and fibronectin). Ti@Ce also led to global chromatin condensation by decreasing histone 3 acetylation as an early differentiation feature. Transcriptome analysis by RNA sequencing confirmed the chromatin remodeling, antiapoptosis, antioxidant, cell adhesion, and TGF-β signaling-related gene signatures in Ti@Ce. As key fibroblast transcription (co)factors, Ti@Ce promotes serum response factor and MRTF-α nucleus localization. Considering all of this, it is proposed that the surface engineering approach using Ce could improve the biological properties of Ti implants, supporting their functioning at soft tissue interfaces and utilization as a bioactive implant for clinical conditions such as peri-implantitis.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Titanium/pharmacology ; Titanium/chemistry ; Cells, Cultured ; Surface Properties ; Cell Adhesion/physiology ; Fibroblasts/metabolism ; Cerium
Chemical Substances	Reactive Oxygen Species ; Titanium (D1JT611TNE) ; ceric oxide (619G5K328Y) ; Cerium (30K4522N6T)
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c02119
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Article ; Online: Recent advances in understanding the genetic basis of systemic lupus erythematosus.

Ha, Eunji / Bae, Sang-Cheol / Kim, Kwangwoo

Seminars in immunopathology

2021 Volume 44, Issue 1, Page(s) 29–46

Abstract: Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly 180 reported susceptibility loci that have been identified mostly by genome- ...

Abstract	Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly 180 reported susceptibility loci that have been identified mostly by genome-wide association studies (GWASs) and account for approximately 30% of genetic heritability. A vast majority of risk variants reside in non-coding regions, which makes it quite challenging to interpret their functional implications in the SLE-affected immune system, suggesting the importance of understanding cell type-specific epigenetic regulation around SLE GWAS variants. The latest genetic studies have been highly fruitful as several dozens of SLE loci were newly discovered in the last few years and many loci have come to be understood in systemic approaches integrating GWAS signals with other biological resources. In this review, we summarize SLE-associated genetic variants in both the major histocompatibility complex (MHC) and non-MHC loci, examining polygenetic risk scores for SLE and their associations with clinical features. Finally, variant-driven pathogenetic functions underlying genetic associations are described, coupled with discussion about challenges and future directions in genetic studies on SLE.
MeSH term(s)	Epigenesis, Genetic ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Lupus Erythematosus, Systemic/etiology ; Lupus Erythematosus, Systemic/genetics ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2021-11-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2316828-6
ISSN	1863-2300 ; 1863-2297
ISSN (online)	1863-2300
ISSN	1863-2297
DOI	10.1007/s00281-021-00900-w
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Zs.A 1425: Show issues

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Article ; Online: Effects of a combination of scapular stabilization and thoracic extension exercises for office workers with forward head posture on the craniovertebral angle, respiration, pain, and disability: A randomized-controlled trial.

Kang, Na-Yeon / Im, Sang-Cheol / Kim, Kyoung

Turkish journal of physical medicine and rehabilitation

2021 Volume 67, Issue 3, Page(s) 291–299

Abstract: Objectives: This study aims to investigate how exercise programs not directly applied to the cervical spine affect office workers with forward head posture (FHP).: Patients and methods: Between March 2018 and June 2018, a total of 32 office workers ... ...

Abstract	Objectives: This study aims to investigate how exercise programs not directly applied to the cervical spine affect office workers with forward head posture (FHP). Patients and methods: Between March 2018 and June 2018, a total of 32 office workers with FHP (13 males, 19 females; mean age 36.63 years; range, 23 to 57 years) were randomized either to experimental (n=16) or control groups (n=16). Scapular stabilization and thoracic extension exercises were applied to the experimental group and cervical stabilization and stretching exercises to the control group. The results of the pre-intervention and after six weeks measurement of the craniovertebral angle (CVA), respiration, pain, and disability were compared and analyzed. Results: For intra-group comparison, both groups showed significant differences (p<0.05) in CVA, forced expiratory volume at 1 sec (FEV1), Visual Analog Scale (VAS), and neck disability index at pre- and post-intervention, while only the experimental group showed a significant difference (p<0.05) in maximum inspiratory pressure, maximum expiratory pressure, and forced vital capacity. For inter-group comparison, a significant difference (p<0.05) between FEV1 and VAS was observed. Conclusion: The combination of scapular stabilization and thoracic extension exercises, not directly applied to the cervical spine, has an effect on improving the posture, respiration, neck pain, and disability in office workers with FHP.
Language	English
Publishing date	2021-09-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2712472-1
ISSN	2587-1250 ; 2587-1250 ; 1308-6316
ISSN (online)	2587-1250
ISSN	2587-1250 ; 1308-6316
DOI	10.5606/tftrd.2021.6397
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