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  1. Article: Electrocardiography in two subspecies of manatee (Trichechus manatus latirostris and T. m. manatus).

    Siegal-Willott, Jessica / Estrada, Amara / Bonde, Robert / Wong, Arthur / Estrada, Daniel J / Harr, Kendal

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2006  Volume 37, Issue 4, Page(s) 447–453

    Abstract: ... healthy, wild manatees (Trichechus manatus latirostris and T. m. manatus) undergoing routine field ... for all manatees and the following parameters were determined: heart rate and rhythm; P, QRS, and T wave morphology ... amplitude, and duration; and mean electrical axis (MEA). Statistical differences using a t-test for equality ...

    Abstract Electrocardiographic (ECG) measurements were recorded in two subspecies of awake, apparently healthy, wild manatees (Trichechus manatus latirostris and T. m. manatus) undergoing routine field examinations in Florida and Belize. Six unsedated juveniles (dependent and independent calves) and 6 adults were restrained in ventral recumbency for ECG measurements. Six lead ECGs were recorded for all manatees and the following parameters were determined: heart rate and rhythm; P, QRS, and T wave morphology, amplitude, and duration; and mean electrical axis (MEA). Statistical differences using a t-test for equality of means were determined. No statistical difference was seen based on sex or subspecies of manatees in the above measured criteria. Statistical differences existed in heart rate (P = 0.047), P wave duration (P = 0.019), PR interval (P = 0.025), and MEA (P = 0.021) between adult manatees and calves. Our findings revealed normal sinus rhythms, no detectable arrhythmias, prolonged PR and QT intervals, prolonged P wave duration, and small R wave amplitude as compared with cetacea and other marine mammals. This paper documents the techniques for and baseline recordings of ECGs in juvenile and adult free-living manatees. It also demonstrates that continual assessment of cardiac electrical activity in the awake manatee can be completed and can be used to aid veterinarians and biologists in routine health assessment, during procedures, and in detecting the presence of cardiac disease or dysfunction.
    MeSH term(s) Animals ; Animals, Newborn ; Animals, Wild ; Electrocardiography/methods ; Electrocardiography/veterinary ; Female ; Heart Rate/physiology ; Male ; Species Specificity ; Trichechus manatus/physiology
    Language English
    Publishing date 2006-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/05-086.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exceeding the limit for microscopic image translation with a deep learning-based unified framework.

    Dai, Weixing / Wong, Ivy H M / Wong, Terence T W

    PNAS nexus

    2024  Volume 3, Issue 4, Page(s) pgae133

    Abstract: Deep learning algorithms have been widely used in microscopic image translation. The corresponding data-driven models can be trained by supervised or unsupervised learning depending on the availability of paired data. However, general cases are where the ...

    Abstract Deep learning algorithms have been widely used in microscopic image translation. The corresponding data-driven models can be trained by supervised or unsupervised learning depending on the availability of paired data. However, general cases are where the data are only roughly paired such that supervised learning could be invalid due to data unalignment, and unsupervised learning would be less ideal as the roughly paired information is not utilized. In this work, we propose a unified framework (U-Frame) that unifies supervised and unsupervised learning by introducing a tolerance size that can be adjusted automatically according to the degree of data misalignment. Together with the implementation of a global sampling rule, we demonstrate that U-Frame consistently outperforms both supervised and unsupervised learning in all levels of data misalignments (even for perfectly aligned image pairs) in a myriad of image translation applications, including pseudo-optical sectioning, virtual histological staining (with clinical evaluations for cancer diagnosis), improvement of signal-to-noise ratio or resolution, and prediction of fluorescent labels, potentially serving as new standard for image translation.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgae133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effect of location on out-of-hospital cardiac arrests involving older adults in Hong Kong: secondary analysis of a territory-wide cohort.

    Wong, R T M

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29, Issue 2, Page(s) 142–149

    Abstract: Introduction: Most out-of-hospital cardiac arrests in Hong Kong involve older adults. The likelihood of survival varies among locations. This study investigated patient and bystander characteristics, as well as the timing of interventions, that affect ... ...

    Abstract Introduction: Most out-of-hospital cardiac arrests in Hong Kong involve older adults. The likelihood of survival varies among locations. This study investigated patient and bystander characteristics, as well as the timing of interventions, that affect the prevalences of shockable rhythm and survival outcomes among cardiac arrests involving older adults in homes, on streets, and in other public places.
    Methods: This secondary analysis of a territory-wide historical cohort used data collected by the Fire Services Department of Hong Kong from 1 August 2012 to 31 July 2013.
    Results: Bystander cardiopulmonary resuscitation was primarily performed by relatives in homes but not in non-residential locations. The intervals in terms of receipt of emergency medical services (EMS) call, initiation of bystander cardiopulmonary resuscitation, and receipt of defibrillation were longer for cardiac arrests that occurred in homes. The median interval for EMS to reach patients was 3 minutes longer in homes than on streets (P<0.001). Forty-seven percent of patients who developed cardiac arrest on streets had a shockable rhythm within the first 5 minutes after receipt of EMS call. Defibrillation within 15 minutes after receipt of EMS call was an independent predictor of 30-day survival (odds ratio=4.07; P=0.02). Fifty percent of patients who received defibrillation within 5 minutes in non-residential locations survived.
    Conclusion: There were significant location-related differences in patient and bystander characteristics, interventions, and outcomes among cardiac arrests involving older adults. A large proportion of patients had a shockable rhythm in the early period after cardiac arrest. Good survival outcomes in out-of-hospital cardiac arrests involving older adults can be achieved through early bystander defibrillation and intervention.
    MeSH term(s) Humans ; Aged ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Hong Kong/epidemiology ; Cardiopulmonary Resuscitation ; Emergency Medical Services ; Odds Ratio ; Electric Countershock
    Language English
    Publishing date 2023-03-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj209140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mise à jour technique N° 436 : Classification des césariennes au Canada : Critères de Robson modifiés.

    Wong, Karen T / Niles, Kirsten M

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2023  Volume 45, Issue 5, Page(s) 342–345.e1

    Language French
    Publishing date 2023-05-25
    Publishing country Netherlands
    Document type Practice Guideline
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Technical Update No. 436: Classification of Cesarean Deliveries in Canada: The Modified Robson Criteria.

    Wong, Karen T / Niles, Kirsten M

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2023  Volume 45, Issue 5, Page(s) 338–341.e1

    MeSH term(s) Pregnancy ; Humans ; Female ; Cesarean Section ; Canada
    Language English
    Publishing date 2023-03-01
    Publishing country Netherlands
    Document type Review ; Practice Guideline
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2023.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lung cancer diagnosis on virtual histologically stained tissue using weakly supervised learning.

    Chen, Zhenghui / Wong, Ivy H M / Dai, Weixing / Lo, Claudia T K / Wong, Terence T W

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2024  , Page(s) 100487

    Abstract: Lung adenocarcinoma (LUAD) is the most common primary lung cancer and accounts for 40% of all lung cancer cases. The current gold standard for lung cancer analysis is based on the pathologists' interpretation of hematoxylin and eosin (H&E)-stained tissue ...

    Abstract Lung adenocarcinoma (LUAD) is the most common primary lung cancer and accounts for 40% of all lung cancer cases. The current gold standard for lung cancer analysis is based on the pathologists' interpretation of hematoxylin and eosin (H&E)-stained tissue slices viewed under a brightfield microscope or digital slide scanner. Computational pathology using deep learning has been proposed to detect lung cancer on histology images. However, the histological staining workflow to acquire the H&E-stained images and the subsequent cancer diagnosis procedures are labor-intensive and time-consuming with tedious sample preparation steps and repetitive manual interpretation, respectively. In this work, we propose a weakly supervised learning method for LUAD classification on label-free tissue slices with virtual histological staining. The autofluorescence images of label-free tissue with histopathological information can be converted into virtual H&E-stained images by a weakly supervised deep generative model. For the downstream LUAD classification task, we trained the attention-based multiple instance learning (MIL) model with different settings on the open-source LUAD H&E whole-slide images (WSIs) dataset from the Cancer Genome Atlas (TCGA). The model is validated on the 150 H&E WSIs collected from patients in Queen Mary Hospital and Prince of Wales Hospital with an average area under the curve (AUC) of 0.961. The model also achieved an average AUC of 0.973 on 58 virtual H&E WSIs, comparable to the results on 58 standard H&E WSIs with an average AUC of 0.977. The attention heatmaps of virtual H&E and ground truth H&E can indicate tumor regions of LUAD tissue slices. In conclusion, the proposed diagnostic workflow on virtual H&E of label-free tissue is a rapid, cost-effective, and interpretable approach to assist clinicians in postoperative pathological examinations. The method could serve as a blueprint for other label-free imaging modalities and disease contexts.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1016/j.modpat.2024.100487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Benzylic Imine Catenates: Readily Accessible Octahedral Analogues of the Sauvage Catenates This work was supported by the EPSRC. D.A.L. is an EPSRC Advanced Research Fellow (AF/982324). We thank Dr. B. P. Murphy (Manchester Metropolitan University) for useful discussions and Drs. T. J. Kidd, S. M. Lacy (University of Warwick), G. Di Orazio and R. Nasreen (University of Manchester, Institute of Science and Technology) for early ligand design.

    Leigh, David A. / Lusby, Paul J. / Teat, Simon J. / Wilson, Andrew J. / Wong, Jenny K. Y.

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 8, Page(s) 1538–1543

    Language English
    Publishing date 2001-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: John Christopher Thomson: the overlooked physician.

    Wong, T W / Chan-Yeung, M

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29, Issue 3, Page(s) 278–280

    Language English
    Publishing date 2023-06-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj-hkmms202306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Death certificate and death registration in Hong Kong.

    Wong, T W / Chan-Yeung, M

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29, Issue 1, Page(s) 88–90

    MeSH term(s) Humans ; Hong Kong ; Death Certificates
    Language English
    Publishing date 2023-02-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj-hkmms202302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Posterior Hyaloid Discontinuity: A Novel OCT Finding in Vitreomacular Traction.

    Popovic, Marko M / Melo, Isabela Martins / Wong, David T

    Ophthalmology. Retina

    2023  Volume 7, Issue 3, Page(s) 226

    MeSH term(s) Humans ; Tomography, Optical Coherence ; Traction ; Retina ; Retinal Diseases
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2022.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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