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  1. Article ; Online: Contemporary and Emerging MRI Strategies for Assessing Kidney Allograft Complications: Arterial Stenosis and Parenchymal Injury, From the

    Bane, Octavia / Lewis, Sara C / Lim, Ruth P / Carney, Benjamin W / Shah, Amar / Fananapazir, Ghaneh

    AJR. American journal of roentgenology

    2023  Volume 222, Issue 3, Page(s) e2329418

    Abstract: MRI plays an important role in the evaluation of kidney allografts for vascular complications as well as parenchymal insults. Transplant renal artery stenosis, the most common vascular complication of kidney transplant, can be evaluated by MRA using ... ...

    Abstract MRI plays an important role in the evaluation of kidney allografts for vascular complications as well as parenchymal insults. Transplant renal artery stenosis, the most common vascular complication of kidney transplant, can be evaluated by MRA using gadolinium and nongadolinium contrast agents as well as by unenhanced MRA techniques. Parenchymal injury occurs through a variety of pathways, including graft rejection, acute tubular injury, BK polyomavirus infection, drug-induced interstitial nephritis, and pyelonephritis. Investigational MRI techniques have sought to differentiate among these causes of dysfunction as well as to assess the degree of interstitial fibrosis or tubular atrophy (IFTA)-the common end pathway for all of these processes-which is currently evaluated by invasively obtained core biopsies. Some of these MRI sequences have shown promise in not only assessing the cause of parenchymal injury but also assessing IFTA noninvasively. This review describes current clinically used MRI techniques and previews promising investigational MRI techniques for assessing complications of kidney grafts.
    MeSH term(s) Humans ; Constriction, Pathologic ; Kidney/pathology ; Fibrosis ; Kidney Diseases/etiology ; Graft Rejection/diagnostic imaging ; Allografts/pathology ; Magnetic Resonance Imaging/adverse effects
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.23.29418
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  2. Article ; Online: Multiparametric MRI of Solid Renal Masses: Principles and Applications of Advanced Quantitative and Functional Methods for Tumor Diagnosis and Characterization.

    Laothamatas, Indira / Al Mubarak, Haitham / Reddy, Arthi / Wax, Rebecca / Badani, Ketan / Taouli, Bachir / Bane, Octavia / Lewis, Sara

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 58, Issue 2, Page(s) 342–359

    Abstract: Solid renal masses (SRMs) are increasingly detected and encompass both benign and malignant masses, with renal cell carcinoma (RCC) being the most common malignant SRM. Most patients with SRMs will undergo management without a priori pathologic ... ...

    Abstract Solid renal masses (SRMs) are increasingly detected and encompass both benign and malignant masses, with renal cell carcinoma (RCC) being the most common malignant SRM. Most patients with SRMs will undergo management without a priori pathologic confirmation. There is an unmet need to noninvasively diagnose and characterize RCCs, as significant variability in clinical behavior is observed and a wide range of differing management options exist. Cross-sectional imaging modalities, including magnetic resonance imaging (MRI), are increasingly used for SRM characterization. Multiparametric (mp) MRI techniques can provide insight into tumor biology by probing different physiologic/pathophysiologic processes noninvasively. These include sequences that probe tissue microstructure, including intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and T
    MeSH term(s) Humans ; Multiparametric Magnetic Resonance Imaging ; Contrast Media ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Carcinoma, Renal Cell/diagnostic imaging ; Kidney Neoplasms/diagnostic imaging ; Motion
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28718
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  3. Article ; Online: Precision and Test-Retest Repeatability of Stiffness Measurement with MR Elastography: A Multicenter Phantom Study.

    Ozkaya, Efe / Kennedy, Paul / Chen, Jun / Bane, Octavia / Dillman, Jonathan R / Jhaveri, Kartik S / Ohliger, Michael A / Rossman, Phillip J / Tkach, Jean A / Doucette, John T / Venkatesh, Sudhakar K / Ehman, Richard L / Taouli, Bachir

    Radiology

    2024  Volume 311, Issue 2, Page(s) e233136

    Abstract: Background MR elastography (MRE) has been shown to have excellent performance for noninvasive liver fibrosis staging. However, there is limited knowledge regarding the precision and test-retest repeatability of stiffness measurement with MRE in the ... ...

    Abstract Background MR elastography (MRE) has been shown to have excellent performance for noninvasive liver fibrosis staging. However, there is limited knowledge regarding the precision and test-retest repeatability of stiffness measurement with MRE in the multicenter setting. Purpose To determine the precision and test-retest repeatability of stiffness measurement with MRE across multiple centers using the same phantoms. Materials and Methods In this study, three cylindrical phantoms made of polyvinyl chloride gel mimicking different degrees of liver stiffness in humans (phantoms 1-3: soft, medium, and hard stiffness, respectively) were evaluated. Between January 2021 and January 2022, phantoms were circulated between five different centers and scanned with 10 MRE-equipped clinical 1.5-T and 3-T systems from three major vendors, using two-dimensional (2D) gradient-recalled echo (GRE) imaging and/or 2D spin-echo (SE) echo-planar imaging (EPI). Similar MRE acquisition parameters, hardware, and reconstruction algorithms were used at each center. Mean stiffness was measured by a single observer for each phantom and acquisition on a single section. Stiffness measurement precision and same-session test-retest repeatability were assessed using the coefficient of variation (CV) and the repeatability coefficient (RC), respectively. Results The mean precision represented by the CV was 5.8% (95% CI: 3.8, 7.7) for all phantoms and both sequences combined. For all phantoms, 2D GRE achieved a CV of 4.5% (95% CI: 3.3, 5.7) whereas 2D SE EPI achieved a CV of 7.8% (95% CI: 3.1, 12.6). The mean RC of stiffness measurement was 5.8% (95% CI: 3.7, 7.8) for all phantoms and both sequences combined, 4.9% (95% CI: 2.7, 7.0) for 2D GRE, and 7.0% (95% CI: 2.9, 11.2) for 2D SE EPI (all phantoms). Conclusion MRE had excellent in vitro precision and same-session test-retest repeatability in the multicenter setting when similar imaging protocols, hardware, and reconstruction algorithms were used. © RSNA, 2024
    MeSH term(s) Phantoms, Imaging ; Elasticity Imaging Techniques/methods ; Elasticity Imaging Techniques/instrumentation ; Reproducibility of Results ; Humans ; Liver/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Liver Cirrhosis/diagnostic imaging
    Language English
    Publishing date 2024-05-14
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.233136
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  4. Article ; Online: Emerging Imaging Biomarkers in Crohn Disease.

    Bane, Octavia / Gee, Michael S / Menys, Alex / Dillman, Jonathan R / Taouli, Bachir

    Topics in magnetic resonance imaging : TMRI

    2021  Volume 30, Issue 1, Page(s) 31–41

    Abstract: Abstract: In this review article, we present the latest developments in quantitative imaging biomarkers based on magnetic resonance imaging (MRI), applied to the diagnosis, assessment of response to therapy, and assessment of prognosis of Crohn disease. ...

    Abstract Abstract: In this review article, we present the latest developments in quantitative imaging biomarkers based on magnetic resonance imaging (MRI), applied to the diagnosis, assessment of response to therapy, and assessment of prognosis of Crohn disease. We also discuss the biomarkers' limitations and future prospects. We performed a literature search of clinical and translational research in Crohn disease using diffusion-weighted MRI (DWI-MRI), dynamic contrast-enhanced MRI (DCE-MRI), motility MRI, and magnetization transfer MRI, as well as emerging topics such as T1 mapping, radiomics, and artificial intelligence. These techniques are integrated in and combined with qualitative image assessment of magnetic resonance enterography (MRE) examinations. Quantitative MRI biomarkers add value to MRE qualitative assessment, achieving substantial diagnostic performance (area under receiver-operating curve = 0.8-0.95). The studies reviewed show that the combination of multiple MRI sequences in a multiparametric quantitative fashion provides rich information that may help for better diagnosis, assessment of severity, prognostication, and assessment of response to biological treatment. However, the addition of quantitative sequences to MRE examinations has potential drawbacks, including increased scan time and the need for further validation before being used in therapeutic drug trials as well as the clinic.
    MeSH term(s) Artificial Intelligence ; Biomarkers/metabolism ; Contrast Media ; Crohn Disease/diagnostic imaging ; Crohn Disease/metabolism ; Crohn Disease/pathology ; Humans ; Magnetic Resonance Imaging/methods
    Chemical Substances Biomarkers ; Contrast Media
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1112716-8
    ISSN 1536-1004 ; 0899-3459
    ISSN (online) 1536-1004
    ISSN 0899-3459
    DOI 10.1097/RMR.0000000000000264
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  5. Article ; Online: Characterization of renal masses with MRI-based radiomics: assessment of inter-package and inter-observer reproducibility in a prospective pilot study.

    Al-Mubarak, Haitham / Bane, Octavia / Gillingham, Nicolas / Kyriakakos, Christopher / Abboud, Ghadi / Cuevas, Jordan / Gonzalez, Janette / Meilika, Kirolos / Horowitz, Amir / Huang, Hsin-Hui Vivien / Daza, Jorge / Fauveau, Valentin / Badani, Ketan / Viswanath, Satish E / Taouli, Bachir / Lewis, Sara

    Abdominal radiology (New York)

    2024  

    Abstract: Objectives: To evaluate radiomics features' reproducibility using inter-package/inter-observer measurement analysis in renal masses (RMs) based on MRI and to employ machine learning (ML) models for RM characterization.: Methods: 32 Patients (23M/9F; ... ...

    Abstract Objectives: To evaluate radiomics features' reproducibility using inter-package/inter-observer measurement analysis in renal masses (RMs) based on MRI and to employ machine learning (ML) models for RM characterization.
    Methods: 32 Patients (23M/9F; age 61.8 ± 10.6 years) with RMs (25 renal cell carcinomas (RCC)/7 benign masses; mean size, 3.43 ± 1.73 cm) undergoing resection were prospectively recruited. All patients underwent 1.5 T MRI with T2-weighted (T2-WI), diffusion-weighted (DWI)/apparent diffusion coefficient (ADC), and pre-/post-contrast-enhanced T1-weighted imaging (T1-WI). RMs were manually segmented using volume of interest (VOI) on T2-WI, DWI/ADC, and T1-WI pre-/post-contrast imaging (1-min, 3-min post-injection) by two independent observers using two radiomics software packages for inter-package and inter-observer assessments of shape/histogram/texture features common to both packages (104 features; n = 26 patients). Intra-class correlation coefficients (ICCs) were calculated to assess inter-observer and inter-package reproducibility of radiomics measurements [good (ICC ≥ 0.8)/moderate (ICC = 0.5-0.8)/poor (ICC < 0.5)]. ML models were employed using reproducible features (between observers and packages, ICC > 0.8) to distinguish RCC from benign RM.
    Results: Inter-package comparisons demonstrated that radiomics features from T1-WI-post-contrast had the highest proportion of good/moderate ICCs (54.8-58.6% for T1-WI-1 min), while most features extracted from T2-WI, T1-WI-pre-contrast, and ADC exhibited poor ICCs. Inter-observer comparisons found that radiomics measurements from T1-WI pre/post-contrast and T2-WI had the greatest proportion of features with good/moderate ICCs (95.3-99.1% T1-WI-post-contrast 1-min), while ADC measurements yielded mostly poor ICCs. ML models generated an AUC of 0.71 [95% confidence interval = 0.67-0.75] for diagnosis of RCC vs. benign RM.
    Conclusion: Radiomics features extracted from T1-WI-post-contrast demonstrated greater inter-package and inter-observer reproducibility compared to ADC, with fair accuracy for distinguishing RCC from benign RM.
    Clinical relevance: Knowledge of reproducibility of MRI radiomics features obtained on renal masses will aid in future study design and may enhance the diagnostic utility of radiomics models for renal mass characterization.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-024-04212-z
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  6. Article ; Online: Renal MRI: From Nephron to NMR Signal.

    Bane, Octavia / Seeliger, Erdmann / Cox, Eleanor / Stabinska, Julia / Bechler, Eric / Lewis, Sara / Hickson, LaTonya J / Francis, Sue / Sigmund, Eric / Niendorf, Thoralf

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 58, Issue 6, Page(s) 1660–1679

    Abstract: Renal diseases pose a significant socio-economic burden on healthcare systems. The development of better diagnostics and prognostics is well-recognized as a key strategy to resolve these challenges. Central to these developments are MRI biomarkers, due ... ...

    Abstract Renal diseases pose a significant socio-economic burden on healthcare systems. The development of better diagnostics and prognostics is well-recognized as a key strategy to resolve these challenges. Central to these developments are MRI biomarkers, due to their potential for monitoring of early pathophysiological changes, renal disease progression or treatment effects. The surge in renal MRI involves major cross-domain initiatives, large clinical studies, and educational programs. In parallel with these translational efforts, the need for greater (patho)physiological specificity remains, to enable engagement with clinical nephrologists and increase the associated health impact. The ISMRM 2022 Member Initiated Symposium (MIS) on renal MRI spotlighted this issue with the goal of inspiring more solutions from the ISMRM community. This work is a summary of the MIS presentations devoted to: 1) educating imaging scientists and clinicians on renal (patho)physiology and demands from clinical nephrologists, 2) elucidating the connection of MRI parameters with renal physiology, 3) presenting the current state of leading MR surrogates in assessing renal structure and functions as well as their next generation of innovation, and 4) describing the potential of these imaging markers for providing clinically meaningful renal characterization to guide or supplement clinical decision making. We hope to continue momentum of recent years and introduce new entrants to the development process, connecting (patho)physiology with (bio)physics, and conceiving new clinical applications. We envision this process to benefit from cross-disciplinary collaboration and analogous efforts in other body organs, but also to maximally leverage the unique opportunities of renal physiology. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY STAGE: 2.
    MeSH term(s) Humans ; Kidney/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Kidney Diseases/diagnostic imaging ; Nephrons ; Kidney Function Tests
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28828
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  7. Article ; Online: Experimental Protocols for MRI Mapping of Renal T

    Garteiser, Philippe / Bane, Octavia / Doblas, Sabrina / Friedli, Iris / Hectors, Stefanie / Pagé, Gwenaël / Van Beers, Bernard E / Waterton, John C

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2216, Page(s) 383–402

    Abstract: The water proton longitudinal relaxation time, ... ...

    Abstract The water proton longitudinal relaxation time, T
    MeSH term(s) Animals ; Image Processing, Computer-Assisted/methods ; Kidney/physiology ; Magnetic Resonance Imaging/methods ; Monitoring, Physiologic ; Software
    Language English
    Publishing date 2021-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0978-1_22
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  8. Article ; Online: Analysis Protocols for MRI Mapping of Renal T

    Garteiser, Philippe / Pagé, Gwenaël / Doblas, Sabrina / Bane, Octavia / Hectors, Stefanie / Friedli, Iris / Van Beers, Bernard E / Waterton, John C

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2216, Page(s) 577–590

    Abstract: The computation of ... ...

    Abstract The computation of T
    MeSH term(s) Animals ; Biomarkers/analysis ; Image Processing, Computer-Assisted/methods ; Kidney/physiology ; Magnetic Resonance Imaging/methods ; Mice ; Monitoring, Physiologic/methods ; Rats ; Software
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0978-1_35
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  9. Article ; Online: MRI Mapping of Renal T

    Hectors, Stefanie J / Garteiser, Philippe / Doblas, Sabrina / Pagé, Gwenaël / Van Beers, Bernard E / Waterton, John C / Bane, Octavia

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2216, Page(s) 157–169

    Abstract: In renal MRI, measurement of the ... ...

    Abstract In renal MRI, measurement of the T
    MeSH term(s) Animals ; Biomarkers/analysis ; Humans ; Image Processing, Computer-Assisted/methods ; Kidney/physiology ; Magnetic Resonance Imaging/methods ; Monitoring, Physiologic/methods ; Software
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0978-1_9
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  10. Article ; Online: Magnetic resonance elastography for noninvasive detection of liver fibrosis: is there an added value of 3D acquisition?

    Bhuiyan, Enamul H / Ozkaya, Efe / Kennedy, Paul / Del Hoyo, Juan Lloret / Achkar, Bassam El / Thung, Swan / Lewis, Sara / Bane, Octavia / Taouli, Bachir

    Abdominal radiology (New York)

    2023  Volume 48, Issue 11, Page(s) 3420–3429

    Abstract: Purpose: (1) Assess the diagnostic performance of liver 3D magnetic resonance elastography (MRE) parameters (including stiffness, storage/loss modulus and damping ratio) compared to liver stiffness measured with 2D MRE for noninvasive detection of ... ...

    Abstract Purpose: (1) Assess the diagnostic performance of liver 3D magnetic resonance elastography (MRE) parameters (including stiffness, storage/loss modulus and damping ratio) compared to liver stiffness measured with 2D MRE for noninvasive detection of advanced liver fibrosis (F3-F4) and cirrhosis (F4) in patients with chronic liver disease. (2) Assess the value of serum markers (FIB-4) in detecting advanced liver fibrosis and cirrhosis in the same patients.
    Methods: This was a single center, prospective IRB-approved cross-sectional study that included 49 patients (M/F: 23/26, mean age 50.8 y) with chronic liver disease and concomitant liver biopsy. MRE was acquired at 1.5T using a spin echo-EPI sequence. The following parameters were measured: liver stiffness using 2D MRE (LS-2D) and 3D MRE parameters (LS-3D, liver storage, loss modulus and damping ratio). The Mann-Whitney U test, ROC curve analysis, Spearman correlation and logistic regression were performed to evaluate diagnostic performance of MRE parameters and FIB-4.
    Results: LS-2D and LS-3D had similar diagnostic performance for diagnosis of F3-F4, with AUCs of 0.87 and 0.88, sensitivity of 0.71 and 0.81, specificity of 0.89 for both. For diagnosis of F4, LS-2D and LS-3D had similar performance with AUCs of 0.81 for both, sensitivity of 0.75 and 0.83, and specificity of 0.84 and 0.73, respectively. Additional 3D parameters (storage modulus, loss modulus, damping ratio) had variable performance, with AUC range of 0.59-0.78 for F3-F4; and 0.52-0.70 for F4. FIB-4 had lower diagnostic performance, with AUCs of 0.66 for F3-F4, and 0.68 for F4.
    Conclusion: Our study shows no added value of 3D MRE compared to 2D MRE for detection of advanced fibrosis and cirrhosis, while FIB-4 had lower diagnostic performance.
    MeSH term(s) Humans ; Middle Aged ; Elasticity Imaging Techniques ; Cross-Sectional Studies ; Prospective Studies ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/complications ; Liver/diagnostic imaging ; Liver/pathology ; Liver Diseases/pathology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-023-04036-3
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