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  1. Article ; Online: Effects of the oral testosterone undecanoate Kyzatrex™ on ambulatory blood pressure in hypogonadal men.

    White, William B / Bernstein, James S / Rittmaster, Roger / Dhingra, Om

    Journal of clinical hypertension (Greenwich, Conn.)

    2021  Volume 23, Issue 7, Page(s) 1420–1430

    Abstract: Testosterone replacement therapies have been shown to increase blood pressure (BP) in hypogonadal men. We studied the effects of a new formulation of testosterone undecanoate (Kyzatrex™) on ambulatory blood pressure (ABP) and heart rate, in 155 men with ... ...

    Abstract Testosterone replacement therapies have been shown to increase blood pressure (BP) in hypogonadal men. We studied the effects of a new formulation of testosterone undecanoate (Kyzatrex™) on ambulatory blood pressure (ABP) and heart rate, in 155 men with hypogonadism (mean age, 50.5 years, 76.8% white, 36.1% on antihypertensive therapy). The ABP, heart rate and clinical assessments were obtained at baseline and following 120 and 180 days of therapy. Mean changes from baseline in 24-h ambulatory systolic BP of 1.7 mmHg (95% CI, 0.3, 3.1) at day 120 and 1.8 mmHg (95% CI, 0.3, 3.2) at day 180 were observed post-treatment. For those men on antihypertensive drug therapy, increases in mean 24-h systolic BP were greater than those not taking antihypertensive drugs (3.4 vs 0.7 mmHg at day 120 and 3.1 vs 1.0 mmHg at day 180, respectively). Changes from baseline in 24-h diastolic BP and heart rate at day 120 were smaller (<1 mmHg and <1 beat/min, respectively). There were no relationships observed between testosterone concentration or hemoglobin levels with ABP. Multivariable analyses showed that baseline ambulatory BP and antihypertensive therapy were significantly correlated with BP changes. These data demonstrate small increases in ambulatory BP following 120 days on this oral testosterone undecanoate with no further changes at 180 days. Changes in ambulatory BP were minimal in patients not taking antihypertensive therapy.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Male ; Middle Aged ; Testosterone/analogs & derivatives ; Testosterone/pharmacology
    Chemical Substances Antihypertensive Agents ; Testosterone (3XMK78S47O) ; testosterone undecanoate (H16A5VCT9C)
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.14297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antiandrogen treatment of polycystic ovary syndrome.

    Rittmaster, R S

    Endocrinology and metabolism clinics of North America

    1999  Volume 28, Issue 2, Page(s) 409–421

    Abstract: Although hirsutism and androgenetic alopecia are cosmetic problems, they can be psychologically devastating for women. Mechanical hair removal may control the cosmetic appearance of hirsutism, but the underlying problem usually continues to progress. ... ...

    Abstract Although hirsutism and androgenetic alopecia are cosmetic problems, they can be psychologically devastating for women. Mechanical hair removal may control the cosmetic appearance of hirsutism, but the underlying problem usually continues to progress. Topical therapies for androgenetic alopecia provide for modest improvement at best, and no topical therapy has been shown to be effective for hirsutism. Antiandrogens, combined with ovarian suppression, offer the best hope for the improvement of hirsutism and androgenetic alopecia in women with PCOS. Improvement will occur in most women. Unless the underlying cause of the PCOS is corrected, medical therapy will need to be continued indefinitely.
    MeSH term(s) Alopecia/drug therapy ; Alopecia/etiology ; Androgen Antagonists/therapeutic use ; Androgens/biosynthesis ; Cyproterone Acetate/therapeutic use ; Female ; Finasteride/therapeutic use ; Flutamide/therapeutic use ; Hirsutism/drug therapy ; Hirsutism/etiology ; Humans ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Spironolactone/therapeutic use
    Chemical Substances Androgen Antagonists ; Androgens ; Spironolactone (27O7W4T232) ; Cyproterone Acetate (4KM2BN5JHF) ; Finasteride (57GNO57U7G) ; Flutamide (76W6J0943E)
    Language English
    Publishing date 1999-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/s0889-8529(05)70077-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hirsutism.

    Rittmaster, R S

    Lancet (London, England)

    1997  Volume 349, Issue 9046, Page(s) 191–195

    MeSH term(s) Androgens/physiology ; Androgens/secretion ; Diagnosis, Differential ; Hair/growth & development ; Hirsutism/diagnosis ; Hirsutism/etiology ; Hirsutism/physiopathology ; Hirsutism/therapy ; Humans ; Puberty/physiology
    Chemical Substances Androgens
    Language English
    Publishing date 1997-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/S0140-6736(96)07252-2
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  4. Article: Polycystic ovary syndrome, hyperthecosis and the menopause.

    Rittmaster, R S

    Clinical endocrinology

    1997  Volume 46, Issue 2, Page(s) 129–130

    MeSH term(s) Androgens/metabolism ; Cardiovascular Diseases/metabolism ; Female ; Humans ; Insulin/metabolism ; Menopause/metabolism ; Middle Aged ; Ovary/metabolism ; Ovary/pathology ; Polycystic Ovary Syndrome/metabolism ; Polycystic Ovary Syndrome/pathology
    Chemical Substances Androgens ; Insulin
    Language English
    Publishing date 1997-02
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1046/j.1365-2265.1997.8730882.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: 5alpha-reductase inhibitors.

    Rittmaster, R S

    Journal of andrology

    1997  Volume 18, Issue 6, Page(s) 582–587

    MeSH term(s) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/metabolism ; 5-alpha Reductase Inhibitors ; Dihydrotestosterone/metabolism ; Enzyme Inhibitors/pharmacology ; Finasteride/therapeutic use ; Humans ; Male ; Prostate/drug effects ; Prostate/enzymology ; Prostate/pathology ; Prostatic Hyperplasia/drug therapy ; Testosterone/metabolism
    Chemical Substances 5-alpha Reductase Inhibitors ; Enzyme Inhibitors ; Dihydrotestosterone (08J2K08A3Y) ; Testosterone (3XMK78S47O) ; Finasteride (57GNO57U7G) ; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (EC 1.3.99.5)
    Language English
    Publishing date 1997-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604624-1
    ISSN 1939-4640 ; 0196-3635
    ISSN (online) 1939-4640
    ISSN 0196-3635
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  6. Article: Gonadotropin-releasing hormone (GnRH) agonists and estrogen/progestin replacement for the treatment of hirsutism: evaluating the results.

    Rittmaster, R S

    The Journal of clinical endocrinology and metabolism

    1995  Volume 80, Issue 12, Page(s) 3403–3405

    MeSH term(s) Estrogen Replacement Therapy ; Female ; Gonadotropin-Releasing Hormone/agonists ; Hirsutism/drug therapy ; Humans ; Progestins/therapeutic use
    Chemical Substances Progestins ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 1995-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jcem.80.12.8530572
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  7. Article: Clinical review 73: Medical treatment of androgen-dependent hirsutism.

    Rittmaster, R S

    The Journal of clinical endocrinology and metabolism

    1995  Volume 80, Issue 9, Page(s) 2559–2563

    Abstract: Although hirsutism is more a cosmetic and psychosocial problem than a disease, hirsute women are often some of the most grateful patients in an endocrinologist's practice. The combination of mechanical hair removal and judicious use of medications will ... ...

    Abstract Although hirsutism is more a cosmetic and psychosocial problem than a disease, hirsute women are often some of the most grateful patients in an endocrinologist's practice. The combination of mechanical hair removal and judicious use of medications will improve hair growth in most women. Unfortunately, no drug is approved by regulatory agencies in North America for treatment of hirsutism. Well designed comparative studies with objective end points are needed to demonstrate which drugs work best in which hirsute women. Because pharmaceutical companies are reluctant to market drugs for women of child-bearing age, there has been little industry support for such studies.
    MeSH term(s) Adrenal Glands/metabolism ; Androgen Antagonists/therapeutic use ; Androgens/physiology ; Contraceptives, Oral/therapeutic use ; Female ; Gonadotropin-Releasing Hormone/analogs & derivatives ; Hirsutism/diagnosis ; Hirsutism/drug therapy ; Hirsutism/etiology ; Humans ; Ovary/metabolism
    Chemical Substances Androgen Antagonists ; Androgens ; Contraceptives, Oral ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 1995-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jcem.80.9.7673394
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  8. Article: Clinical relevance of testosterone and dihydrotestosterone metabolism in women.

    Rittmaster, R S

    The American journal of medicine

    1995  Volume 98, Issue 1A, Page(s) 17S–21S

    Abstract: Androgens are part of normal female physiology. When they are secreted in excess or when they cause unwanted symptoms such as hirsutism and male-pattern baldness, the term hyperandrogenism is used. In many hyperandrogenic women, there is no well-defined ... ...

    Abstract Androgens are part of normal female physiology. When they are secreted in excess or when they cause unwanted symptoms such as hirsutism and male-pattern baldness, the term hyperandrogenism is used. In many hyperandrogenic women, there is no well-defined hormonal abnormality, but the women are simply on one end of a normal spectrum of androgen secretion and cutaneous androgen sensitivity. To be active in the skin, testosterone must be converted to dihydrotestosterone by the enzyme 5 alpha-reductase. Androgen sensitivity is determined, in part, by 5 alpha-reductase activity in the skin. This is a localized phenomenon, and there is no generalized increase in 5 alpha-reductase activity in these women. Dihydrotestosterone can be converted to glucuronide and sulfate conjugates, including androstanediol glucuronide. These androgen conjugates have been proposed to be serum markers of cutaneous androgen metabolism, but recent evidence indicates that they arise from adrenal precursors and are more likely to be markers of adrenal steroid production and metabolism. Antiandrogens (androgen receptor blockers) are the best medical treatment of cutaneous hyperandrogenism. 5 alpha-Reductase inhibitors have recently been approved for the treatment of benign prostatic hyperplasia, and research is currently underway to determine their effectiveness in treating hirsutism and male-pattern baldness.
    MeSH term(s) Cholestenone 5 alpha-Reductase ; Dihydrotestosterone/metabolism ; Female ; Humans ; Hyperandrogenism/enzymology ; Hyperandrogenism/metabolism ; Oxidoreductases/antagonists & inhibitors ; Testosterone/metabolism
    Chemical Substances Dihydrotestosterone (08J2K08A3Y) ; Testosterone (3XMK78S47O) ; Oxidoreductases (EC 1.-) ; Cholestenone 5 alpha-Reductase (EC 1.3.1.22)
    Language English
    Publishing date 1995-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/s0002-9343(99)80054-0
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  9. Article: Finasteride.

    Rittmaster, R S

    The New England journal of medicine

    1994  Volume 330, Issue 2, Page(s) 120–125

    MeSH term(s) Acne Vulgaris/drug therapy ; Alopecia/drug therapy ; Androgens/analysis ; Finasteride/therapeutic use ; Hirsutism/drug therapy ; Humans ; Male ; Oxidoreductases/antagonists & inhibitors ; Oxidoreductases/deficiency ; Prostate/drug effects ; Prostate/metabolism ; Prostatic Hyperplasia/drug therapy ; Prostatic Neoplasms/drug therapy
    Chemical Substances Androgens ; Finasteride (57GNO57U7G) ; Oxidoreductases (EC 1.-)
    Language English
    Publishing date 1994-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM199401133300208
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  10. Article: Androgen conjugates: physiology and clinical significance.

    Rittmaster, R S

    Endocrine reviews

    1993  Volume 14, Issue 1, Page(s) 121–132

    MeSH term(s) Androgens/chemistry ; Androgens/physiology ; Animals ; Biomarkers/chemistry ; Dihydrotestosterone/metabolism ; Humans
    Chemical Substances Androgens ; Biomarkers ; Dihydrotestosterone (08J2K08A3Y)
    Language English
    Publishing date 1993-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/edrv-14-1-121
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