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  1. Article ; Online: Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination.

    Pozzi, Chiara / Azzolini, Elena / Rescigno, Maria

    European physical journal plus

    2023  Volume 138, Issue 2, Page(s) 140

    Abstract: To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, ... ...

    Abstract To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, particularly in individuals with anosmia/dysgeusia. Moreover, analyzing a smaller cohort (124 healthcare employees of which 57 had a previous history of SARS-CoV-2 exposure) vaccinated with two doses of Comirnaty vaccine, we observed that in symptomatic subjects previously exposed to SARS-CoV-2 one dose vaccine was sufficient to stimulate very high levels of antibodies, suggesting that these subjects should take only one dose of vaccine.
    Language English
    Publishing date 2023-02-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2190-5444
    ISSN (online) 2190-5444
    DOI 10.1140/epjp/s13360-023-03732-9
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  2. Article ; Online: Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients.

    Pozzi, Marco / Vantaggiato, Chiara / Brivio, Francesca / Orso, Genny / Bassi, Maria Teresa

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 13

    Abstract: The metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous research showed that antipsychotics with different adverse effects in patients cause similar alterations ... ...

    Abstract The metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous research showed that antipsychotics with different adverse effects in patients cause similar alterations in vitro, suggesting the low clinical usefulness of cellular studies. Moreover, the inhibition of peripheral AMPK was suggested as potential aetiopathogenic mechanisms of olanzapine, and different effects on autophagy were reported for several antipsychotics. We thus assessed, in clinically-relevant culture conditions, the aetiopathogenic mechanisms of olanzapine, risperidone and ziprasidone, antipsychotics with respectively high, medium, low metabolic risk in patients, finding relevant differences among them. We highlighted that: olanzapine impairs lysosomal function affecting autophagy and autophagosome clearance, and increasing intracellular lipids and sterols; ziprasidone activates AMPK increasing the autophagic flux and reducing intracellular lipids; risperidone increases lipid accumulation, while it does not affect lysosomal function. These in vitro differences align with their different impact on patients. We also provided evidence that metformin add-on improved autophagy in olanzapine-treated cells and reduced lipid accumulation induced by both risperidone and olanzapine in an AMPK-dependent way; metformin also increased the production of bile acids to eliminate cholesterol accumulations caused by olanzapine. These results have different clinical implications. We demonstrated that antipsychotics with different metabolic impacts on patients actually have different mechanisms of action, thus supporting the possibility of a personalised antipsychotic treatment. Moreover, we found that metformin can fully revert the phenotype caused by risperidone but not the one caused by olanzapine, that still activates SREBP2.
    MeSH term(s) Humans ; Risperidone/pharmacology ; Olanzapine/pharmacology ; AMP-Activated Protein Kinases ; Antipsychotic Agents/adverse effects ; Autophagy ; Sterols ; Lysosomes ; Metformin
    Chemical Substances Risperidone (L6UH7ZF8HC) ; Olanzapine (N7U69T4SZR) ; ziprasidone (6UKA5VEJ6X) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antipsychotic Agents ; Sterols ; Metformin (9100L32L2N)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02686-x
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  3. Article ; Online: A Serial Mediation Model of Insecure Attachment and Psychological Distress: The Role of Dispositional Shame and Shame-Coping Styles.

    Remondi, Chiara / Casu, Giulia / Pozzi, Camilla / Greco, Francesco / Gremigni, Paola / Brugnera, Agostino

    International journal of environmental research and public health

    2023  Volume 20, Issue 4

    Abstract: Shame is an intense, difficult to regulate, self-conscious emotion that predicts aspects of poor psychological functioning and is also strongly related to early relationships. Attachment insecurities, which constitute non-specific risk factors for ... ...

    Abstract Shame is an intense, difficult to regulate, self-conscious emotion that predicts aspects of poor psychological functioning and is also strongly related to early relationships. Attachment insecurities, which constitute non-specific risk factors for psychological maladjustment, have been associated with an individual's tendency to experience shame. In this study, we sought to examine the serial mediating roles of dispositional shame and shame-coping styles (i.e., attack other, attack self, withdrawal and avoidance) in the association between anxious and avoidant attachment, and psychological distress. Using a cross-sectional design, self-reported data were collected. The study sample included 978 respondents (57% female) with a mean age of 32.17 ± 13.48 years. The results of the path analysis indicated that both attachment dimensions were sequentially associated with dispositional shame and then with the attack self shame-coping style, which was, in turn, positively related to psychological distress. Further, attachment insecurities were sequentially associated with dispositional shame and then with the avoidance shame-coping style, which was, in turn, negatively related to psychological distress. The model was gender invariant, suggesting that the serial mediation worked in a similar way for men and women. The practical implications of these findings are discussed.
    MeSH term(s) Male ; Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Cross-Sectional Studies ; Adaptation, Psychological ; Shame ; Mental Disorders/psychology ; Psychological Distress
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043193
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  4. Article ; Online: Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers.

    Azzolini, Elena / Levi, Riccardo / Sarti, Riccardo / Pozzi, Chiara / Mollura, Maximiliano / Mantovani, Alberto / Rescigno, Maria

    JAMA

    2022  Volume 328, Issue 7, Page(s) 676–678

    MeSH term(s) BNT162 Vaccine ; COVID-19/complications ; COVID-19/prevention & control ; Health Personnel ; Hospitalization ; Humans ; Vaccination
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.11691
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts.

    Del Vecchio Del Vecchio, Jasmin / Hanafi, Ibrahem / Pozzi, Nicoló Gabriele / Capetian, Philipp / Isaias, Ioannis U / Haufe, Stefan / Palmisano, Chiara

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 4

    Abstract: Low-frequency oscillatory patterns of pallidal local field potentials (LFPs) have been proposed as a physiomarker for dystonia and hold the promise for personalized adaptive deep brain stimulation. Head tremor, a low-frequency involuntary rhythmic ... ...

    Abstract Low-frequency oscillatory patterns of pallidal local field potentials (LFPs) have been proposed as a physiomarker for dystonia and hold the promise for personalized adaptive deep brain stimulation. Head tremor, a low-frequency involuntary rhythmic movement typical of cervical dystonia, may cause movement artifacts in LFP signals, compromising the reliability of low-frequency oscillations as biomarkers for adaptive neurostimulation. We investigated chronic pallidal LFPs with the Percept
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10040476
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  6. Article ; Online: A simplified Italian translation of the international prostate symptom score twists the reality in the aging male with lower urinary tract symptoms.

    Bertolo, Riccardo / Cipriani, Chiara / Pozzi, Luca / Bove, Pierluigi

    Prostate cancer and prostatic diseases

    2020  Volume 23, Issue 3, Page(s) 534–536

    MeSH term(s) Aged ; Aging/physiology ; Educational Status ; Health Literacy ; Humans ; Italy ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/physiopathology ; Male ; Prospective Studies ; Prostate/physiopathology ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/physiopathology ; Self Report ; Severity of Illness Index ; Translations
    Language English
    Publishing date 2020-01-13
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-020-0203-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5277: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females?

    Azzolini, Elena / Mollura, Maximiliano / Pozzi, Chiara / Ubaldi, Leonardo / Mantovani, Alberto / Selmi, Carlo / Barbieri, Riccardo / Rescigno, Maria

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: An important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females ... ...

    Abstract An important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females often suffer more adverse consequences than males. Here, we analyzed the adverse events (AEs) of the Comirnaty vaccine in a population of 2385 healthcare workers as a function of age, sex, COVID-19 history and BMI. Using logistic regression analysis, we showed that these variables may contribute to the development of AEs, particularly in young subjects, females and individuals with a BMI below 25 kg/m
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030505
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  8. Article: Functionally Relevant Cytokine/Receptor Axes in Myelofibrosis.

    Pozzi, Giulia / Carubbi, Cecilia / Cerreto, Giacomo Maria / Scacchi, Chiara / Cortellazzi, Samuele / Vitale, Marco / Masselli, Elena

    Biomedicines

    2023  Volume 11, Issue 9

    Abstract: Dysregulated inflammatory signaling is a key feature of myeloproliferative neoplasms (MPNs), most notably of myelofibrosis (MF). Indeed, MF is considered the prototype of onco-inflammatory hematologic cancers. While increased levels of circulatory and ... ...

    Abstract Dysregulated inflammatory signaling is a key feature of myeloproliferative neoplasms (MPNs), most notably of myelofibrosis (MF). Indeed, MF is considered the prototype of onco-inflammatory hematologic cancers. While increased levels of circulatory and bone marrow cytokines are a well-established feature of all MPNs, a very recent body of literature is intriguingly pinpointing the selective overexpression of cytokine receptors by MF hematopoietic stem and progenitor cells (HSPCs), which, by contrast, are nearly absent or scarcely expressed in essential thrombocythemia (ET) or polycythemia vera (PV) cells. This new evidence suggests that MF CD34
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11092462
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  9. Article ; Online: Association Between Duration of SARS-CoV-2 Positivity and Long COVID.

    Pozzi, Chiara / Sarti, Riccardo / Levi, Riccardo / Mollura, Maximiliano / Azzolini, Elena / Barbieri, Riccardo / Mantovani, Alberto / Rescigno, Maria

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 11, Page(s) 1531–1533

    Abstract: In an observational study, we analyzed 1293 healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which 34.1% developed postacute sequelae of SARS-CoV-2 infection (also known as long COVID). Using a ... ...

    Abstract In an observational study, we analyzed 1293 healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which 34.1% developed postacute sequelae of SARS-CoV-2 infection (also known as long COVID). Using a multivariate logistic regression model, we demonstrate that the likelihood of developing long COVID in infected individuals rises with the increasing of duration of infection and that 3 doses of the BNT162b2 vaccine are protective, even during the Omicron wave.
    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; SARS-CoV-2 ; BNT162 Vaccine ; Disease Progression
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad434
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  10. Article ; Online: A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin.

    Quadri, Roberto / Rotondo, Giuseppe / Sertic, Sarah / Pozzi, Sara / dell'Oca, Maria Chiara / Guerrini, Luisa / Muzi-Falconi, Marco

    iScience

    2023  Volume 26, Issue 10, Page(s) 108011

    Abstract: Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not only mediate chromosome segregation, but also defines the axis of cellular division, thus ... ...

    Abstract Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not only mediate chromosome segregation, but also defines the axis of cellular division, thus determining tissue morphology. Functional spindle orientation relies on precise actin dynamics, shaped in mitosis by the LIMK1-Cofilin axis. The kinase Haspin acts as a guardian of faithful chromosome segregation that ensures amphitelic chromosome attachment and prevents unscheduled cohesin cleavage. Here, we report an unprecedented role for Haspin in the determination of spindle orientation in mitosis. We show that, during mitosis, Haspin regulates Rho-ROCK activity through ARHGAP11A, a poorly characterized GAP, and that ROCK is in turn responsible for the mitotic activation of LIMK1 and stabilization of the actin cytoskeleton, thus supporting a functional spindle orientation. By exploiting 3D cell cultures, we show that this pathway is pivotal for the establishment of a morphologically functional tissue.
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108011
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