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  1. Article ; Online: Effective treatment based on monitoring bESR1 mutations - Authors' reply.

    Bidard, Francois-Clément / Hardy-Bessard, Anne-Claire / Delaloge, Suzette

    The Lancet. Oncology

    2023  Volume 24, Issue 1, Page(s) e4

    MeSH term(s) Humans ; Mutation ; Treatment Outcome
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00745-8
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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  2. Article ; Online: Expanding biomarkers for PARP inhibitors.

    Coussy, Florence / Bidard, Francois-Clement

    Nature cancer

    2022  Volume 3, Issue 10, Page(s) 1141–1143

    MeSH term(s) Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Phthalazines ; Antineoplastic Agents/pharmacology ; Biomarkers
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Phthalazines ; Antineoplastic Agents ; Biomarkers
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-022-00440-8
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  3. Article ; Online: Could a Long-Acting Prodrug of SN-38 be Efficacious in Sacituzumab Govitecan-Resistant Tumors?

    Santi, Daniel V / Ashley, Gary W / Cabel, Luc / Bidard, Francois-Clement

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2024  Volume 38, Issue 2, Page(s) 171–176

    Abstract: We previously proposed that sacituzumab govitecan (SG, Trodelvy®) likely acts as a simple prodrug of systemic SN-38 as well as an antibody drug conjugate (ADC). In the present commentary, we assess whether a long-acting SN-38 prodrug, such as PLX038, ... ...

    Abstract We previously proposed that sacituzumab govitecan (SG, Trodelvy®) likely acts as a simple prodrug of systemic SN-38 as well as an antibody drug conjugate (ADC). In the present commentary, we assess whether a long-acting SN-38 prodrug, such as PLX038, might be efficacious in SG-resistant patients. We first describe possible mechanisms of action of SG, with new insights on pharmacokinetics and TROP2 receptor occupancy. We argue that SG is not an optimal conventional ADC and that the amount of systemic SN-38 spontaneously hydrolyzed from the ADC is so high it must have activity. Then, we describe the concept of time-over-target as related to the pharmacology of SG and PLX038 as SN-38 prodrugs. To be clear, we are not in any way suggesting that PLX038 or any SN-38 prodrug is superior to SG as an anticancer agent. Clearly, SG has the benefit over antigen-independent SN-38 prodrugs in that it targets cells with the TROP2 receptor. However, we surmise that PLX038 should be a more efficacious and less toxic prodrug of systemic SN-38 than SG. Finally, we suggest possible mechanisms of SG resistance and how PLX038 might perform in the context of each. Taken together, we argue that-contrary to many opinions-SG does not exclusively act as a conventional ADC, and propose that PLX038 may be efficacious in some settings of SG-resistance.
    MeSH term(s) Humans ; Irinotecan/pharmacology ; Irinotecan/therapeutic use ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Antigens, Neoplasm ; Neoplasms/drug therapy ; Immunoconjugates/pharmacology ; Immunoconjugates/therapeutic use ; Camptothecin/analogs & derivatives ; Antibodies, Monoclonal, Humanized
    Chemical Substances sacituzumab govitecan (M9BYU8XDQ6) ; Irinotecan (7673326042) ; Prodrugs ; Antigens, Neoplasm ; Immunoconjugates ; Camptothecin (XT3Z54Z28A) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-024-00643-8
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    Zs.A 4112: Show issues Location:
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  4. Article ; Online: Reply to R. Nishihara et al.

    Bidard, Francois-Clement / Kaklamani, Virginia / Bardia, Aditya

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 36, Page(s) 4281–4282

    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01768
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  5. Article: Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?

    Santi, Daniel V / Cabel, Luc / Bidard, François-Clément

    Annals of translational medicine

    2021  Volume 9, Issue 14, Page(s) 1113

    Language English
    Publishing date 2021-08-25
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-1103
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  6. Article ; Online: Circulating Tumor Cells, a Tremendous Prognostic Factor in Inflammatory Breast Cancer.

    Bidard, François-Clément

    Journal of the National Cancer Institute

    2015  Volume 107, Issue 11, Page(s) djv281

    MeSH term(s) Biomarkers, Tumor/blood ; Female ; Humans ; Inflammatory Breast Neoplasms/pathology ; Neoplastic Cells, Circulating ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015-09-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djv281
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    Uh III Zs.131: Show issues Location:
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  7. Article ; Online: Enhancer rewiring in tumors: an opportunity for therapeutic intervention.

    Richart, Laia / Bidard, François-Clément / Margueron, Raphaël

    Oncogene

    2021  Volume 40, Issue 20, Page(s) 3475–3491

    Abstract: Enhancers are cis-regulatory sequences that fine-tune expression of their target genes in a spatiotemporal manner. They are recognized by sequence-specific transcription factors, which in turn recruit transcriptional coactivators that facilitate ... ...

    Abstract Enhancers are cis-regulatory sequences that fine-tune expression of their target genes in a spatiotemporal manner. They are recognized by sequence-specific transcription factors, which in turn recruit transcriptional coactivators that facilitate transcription by promoting assembly and activation of the basal transcriptional machinery. Their functional importance is underscored by the fact that they are often the target of genetic and nongenetic events in human disease that disrupt their sequence, interactome, activation potential, and/or chromatin environment. Dysregulation of transcription and addiction to transcriptional effectors that interact with and modulate enhancer activity are common features of cancer cells and are amenable to therapeutic intervention. Here, we discuss the current knowledge on enhancer biology, the broad spectrum of mechanisms that lead to their malfunction in tumor cells, and recent progress in developing drugs that efficaciously target their dependencies.
    MeSH term(s) Animals ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Enhancer Elements, Genetic ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances BRD4 protein, human ; Cell Cycle Proteins ; Transcription Factors
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-021-01793-7
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    Zs.A 2218: Show issues Location:
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  8. Article ; Online: Cancer du sein et microangiopathies thrombotiques paranéoplasiques.

    Alhenc-Gelas, Marion / Bidard, François-Clément

    Bulletin du cancer

    2021  Volume 108, Issue 7-8, Page(s) 730–739

    Abstract: Thrombotic Microangiopathies (TM) have been described since the 1960s. They are characterized by presence of mechanical haemolytic anemia associated with peripheral thrombocytopenia. TM in cancer can be related to several causes, whose cancer himself: ... ...

    Title translation Breast cancer-related thrombotic microangiopathy: A review.
    Abstract Thrombotic Microangiopathies (TM) have been described since the 1960s. They are characterized by presence of mechanical haemolytic anemia associated with peripheral thrombocytopenia. TM in cancer can be related to several causes, whose cancer himself: cancer-related microangiopathic haemolytic anaemia (MAHA). Incidence of cancer related MAHA remains unknown. Cancer-related MAHA are mainly observed in mucin-producer adenocarcinomas, such as gastric (half of reported cases) and breast cancer. We conducted a review of all original published cases of TM reported in breast cancer, and we specifically investigated BC-MAHA cases. A Medline search identified 158 MAHA cases including 118 BC-MAHA, and 40 drug-related MAHA. Most of BC-MAHA occur in disseminated cancers, mainly with medullar involvement, and/or bone metastasis. Patients typically suffer from poor general state, bone pain, and/or dyspnea. Laboratory abnormalities such as myelemia or erythromyelemia in peripheral blood are frequently observed. Incidence of coagulation disorders is increased, compared to other MAHA causes. BC-MAHA prognosis is dramatically poor. Treatments classically used in other MAHA causes, such as plasmapheresis or immunoglobulins, are inefficient. Urgent anti-neoplastic therapy may be the only effective treatment, associated to symptomatic therapies (transfusions, blood pressure control).
    MeSH term(s) Adenocarcinoma/metabolism ; Anemia, Hemolytic/complications ; Anemia, Hemolytic/epidemiology ; Anemia, Hemolytic/mortality ; Anemia, Hemolytic/therapy ; Blood Coagulation Disorders/epidemiology ; Bone Neoplasms/secondary ; Breast Neoplasms/complications ; Breast Neoplasms/metabolism ; Female ; Humans ; Incidence ; Mucins/biosynthesis ; Thrombocytopenia/complications ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/therapy
    Chemical Substances Mucins
    Language French
    Publishing date 2021-05-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2021.03.017
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    Uh III Zs.15: Show issues Location:
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  9. Article: Insights from ASCO 2023.

    Hartkopf, Andreas / Janni, Wolfgang / Banys-Paluchowski, Maggie / Bidard, Francois-Clement / Thomssen, Christoph

    Breast care (Basel, Switzerland)

    2023  Volume 18, Issue 6, Page(s) 493–496

    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000533788
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  10. Article: Impact of circulating tumor DNA early detection and serial monitoring in the management of stage I to III colorectal cancer.

    Bello Roufai, Diana / Bidard, François-Clément

    Annals of translational medicine

    2020  Volume 7, Issue Suppl 8, Page(s) S315

    Language English
    Publishing date 2020-01-27
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.10.30
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