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Article: Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption.

Gatta, Elisa / Bambini, Francesca / Buoso, Caterina / Gava, Maria / Maltese, Virginia / Anelli, Valentina / Delbarba, Andrea / Pirola, Ilenia / Cappelli, Carlo

Frontiers in endocrinology

2022 Volume 13, Page(s) 1080108

Abstract: Purpose: To describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 ... therapy and drugs known to interfere with L-T4 absorption.: Methods: A PubMed/MEDLINE, Web of Science ... interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies ...

Abstract	Purpose: To describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption. Methods: A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in English and published online up to 31 August 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review. Results: The available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors, calcium or iron supplements, sevelamer, aluminum/magnesium hydroxide and sodium alginate. Conclusion: New formulations can be taken simultaneously with drugs interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies to support these data.
MeSH term(s)	Humans ; Thyroxine/therapeutic use ; Drug Compounding ; Thyroid Gland ; Capsules ; Proton Pump Inhibitors
Chemical Substances	Thyroxine (Q51BO43MG4) ; Capsules ; Proton Pump Inhibitors
Language	English
Publishing date	2022-12-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1080108
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Article: SIMULTANEOUS INTAKE OF LIQUID L-T4 FORMULATION AND IRON SALT: FACT OR FICTION?

Maltese, V / Gatta, E / Facondo, P / Anelli, V / Cavadini, M / Buoso, C / Bambini, F / Delbarba, A / Pirola, I / Cappelli, C

Acta endocrinologica (Bucharest, Romania : 2005)

2023 Volume 19, Issue 1, Page(s) 54–58

Abstract: ... To evaluate the effect of iron salt intake on L-T4 absorption among different L-T4 formulations.: Materials ... Results: The data show an impaired absorption of L-T4 in tablets formulation when taken concomitantly ... with iron salt supplements. These phenomena seem to be circumvented by new L-T4 formulations.: Conclusion ...

Abstract	Context: Hypothyroidism and iron deficiency are among the most common pathologies in population. Therefore, there are a lot of patients assuming both iron salt supplements and levothyroxine therapy. Objective: To evaluate the effect of iron salt intake on L-T4 absorption among different L-T4 formulations. Materials and methods: A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Original studies and reviews written in English and published online up to 21 December 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review. Results: The data show an impaired absorption of L-T4 in tablets formulation when taken concomitantly with iron salt supplements. These phenomena seem to be circumvented by new L-T4 formulations. Conclusion: Liquid L-T4 formulations can be ingested with iron salts, with no impairment of absorption. More studies are necessary to confirm these data for soft-gel capsules L-T4.
Language	English
Publishing date	2023-08-14
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1433812-9
ISSN	1843-066X ; 1841-0987
ISSN (online)	1843-066X
ISSN	1841-0987
DOI	10.4183/aeb.2023.54
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Article ; Online: Il corso della giustizia e il corso della prescrizione del reato durante l’emergenza Covid-19

G.L. Gatta

2020

Abstract: ... la disciplina emergenziale, introdotta dall’art. 83, co. 2 e 4 d.l. 17 marzo 2020, n. 18 (conv. I. 24 aprile ... sui quali già mi sono soffermato, riguardano la ratio e la natura della prescrizione del reato, nonché l’ambito ... ma non meno importante, riguarda l’esercizio della giurisdizione in materia penale – la giustizia come funzione e ...

Abstract	La Corte costituzionale affronterà a metà novembre 2020 una questione di particolare rilievo: se sia compatibile con il principio di irretroattività della legge penale sfavorevole all’agente (art. 25, co. 2 Cost.) la disciplina emergenziale, introdotta dall’art. 83, co. 2 e 4 d.l. 17 marzo 2020, n. 18 (conv. I. 24 aprile 2020, n. 27), che ha stabilito, relativamente ai procedimenti penali, la sospensione del corso della prescrizione del reato. la questione che la Corte costituzionale è chiamata a risolvere non è per nulla semplice, perché coinvolge profili problematici diversi e di particolare rilievo. I più evidenti, sui quali già mi sono soffermato, riguardano la ratio e la natura della prescrizione del reato, nonché l’ambito di applicazione del principio di irretroattività in rapporto all’istituto stesso. Quello forse meno evidente, ma non meno importante, riguarda l’esercizio della giurisdizione in materia penale – la giustizia come funzione e come servizio – in periodi di emergenza. Qualche riflessione conclusiva, a riguardo, può forse essere utile al dibattito in corso. Terremoti, epidemie e guerre sono eventi eccezionali che ostacolano l’esercizio della giurisdizione penale, rendendo difficile, se non impossibile, accertare fatti e responsabilità e rispondere alle attese di giustizia delle vittime. Quando eventi eccezionali impediscono il normale corso dell’attività giudiziaria, l’alternativa per lo Stato è tra alzare bandiera bianca – rinunciando alla pretesa punitiva e alla correlata tutela dei beni giuridici e delle vittime che li incarnano – oppure sospendere, assieme all’attività stessa, la prescrizione del reato. E’ quel che è avvenuto in occasione dell’emergenza sanitaria in corso e, come si è detto, in occasione di terremoti come quello che ha devastato alcuni anni fa l’Abruzzo.
Keywords	prescrizione del reato ; covid-19 ; coronoavirus ; emergenza covid-19 ; emergenza covid e diritto ; giustizia covid ; sospensione prescrizione reato covid ; irretroattività ; legge penale ; principio di irretroattività ; e covid ; statutes of limitations covid-19 ; Settore IUS/17 - Diritto Penale ; covid19
Language	Italian
Publishing date	2020-11-02
Publisher	Associazione Progetto giustizia penale
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H

Franceschelli, Sara / Lanuti, Paola / Ferrone, Alessio / Gatta, Daniela Maria Pia / Speranza, Lorenza / Pesce, Mirko / Grilli, Alfredo / Cacciatore, Ivana / Ricciotti, Emanuela / Di Stefano, Antonio / Miscia, Sebastiano / Felaco, Mario / Patruno, Antonia

Antioxidants (Basel, Switzerland)

2019 Volume 8, Issue 8

Abstract: The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage ...

Abstract	The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson's disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overcome this limitation, we have conjugated LD to the natural antioxidant glutathione (GSH) to form a codrug (GSH-LD). Here we investigated the effect of GSH-LD on H
Language	English
Publishing date	2019-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox8080319
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Article ; Online: Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases.

Cacciatore, Ivana / Marinelli, Lisa / Di Stefano, Antonio / Di Marco, Valerio / Orlando, Giustino / Gabriele, Mirko / Gatta, Daniela Maria Pia / Ferrone, Alessio / Franceschelli, Sara / Speranza, Lorenza / Patruno, Antonia

Neuropeptides

2018 Volume 71, Page(s) 11–20

Abstract: ... obtained by linking glutathione, a well-known antioxidant tripeptide, to L-Dopa. Results demonstrated ...

Abstract	Neurodegenerative diseases share a common pathogenetic mechanism involving aggregation and deposition of misfolded proteins, oxidative stress, metal dyshomeostasis, and glutamate exicitotoxicity, which lead to progressive dysfunction of central nervous system (CNS). A potential strategy to counteract these deleterious events at neuronal level is represented by the employment of a novel class of multi-target therapeutic agents that selectively and simultaneously hit these targets In this paper, we report the metal binding and antioxidant properties of a novel metal-protein attenuating peptide, GSH-LD, a tetrapeptide obtained by linking glutathione, a well-known antioxidant tripeptide, to L-Dopa. Results demonstrated that GSH-LD possesses chelating capabilities in order to selectively target the excess of metals without interfere with metal-containing antioxidant enzymes. Moreover, antioxidant assays revealed a large contribution of GSH-LD to restore the antioxidant defences of damaged neuronal cells.
MeSH term(s)	Animals ; Antioxidants/administration & dosage ; Antioxidants/therapeutic use ; Catalase/metabolism ; Cell Line ; Cell Survival/drug effects ; Chelating Agents/administration & dosage ; Chelating Agents/therapeutic use ; Glutathione/administration & dosage ; Glutathione/therapeutic use ; Humans ; Levodopa/administration & dosage ; Levodopa/therapeutic use ; Neurodegenerative Diseases/drug therapy ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Chelating Agents ; Reactive Oxygen Species ; Levodopa (46627O600J) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2018-06-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	9048-7
ISSN	1532-2785 ; 0143-4179
ISSN (online)	1532-2785
ISSN	0143-4179
DOI	10.1016/j.npep.2018.06.002
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Article ; Online: Tablet and oral liquid L-thyroxine formulation in the treatment of naïve hypothyroid patients with Helicobacter pylori infection.

Ribichini, Danilo / Fiorini, Giulia / Repaci, Andrea / Castelli, Valentina / Gatta, Luigi / Vaira, Dino / Pasquali, Renato

Endocrine

2017 Volume 57, Issue 3, Page(s) 394–401

Abstract: To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve ...

Abstract	To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve hypothyroid subjects with Helicobacter pylori infection. Forty-seven adult naïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients with Helicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B. Helicobacter pylori infection was eradicated after 3 months of LT4 treatment. On group A, after 3 months (before Helicobacter pylori eradication), subjects treated with SOL showed a greater thyroid-stimulating hormone reduction (ΔTSH
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Drug Therapy, Combination ; Dyspepsia/etiology ; Dyspepsia/physiopathology ; Dyspepsia/prevention & control ; Female ; Gastritis/complications ; Gastritis/drug therapy ; Gastritis/microbiology ; Gastritis/physiopathology ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/microbiology ; Helicobacter Infections/physiopathology ; Helicobacter pylori/drug effects ; Helicobacter pylori/physiology ; Hormone Replacement Therapy/adverse effects ; Humans ; Hypothyroidism/blood ; Hypothyroidism/complications ; Hypothyroidism/drug therapy ; Hypothyroidism/microbiology ; Intestinal Absorption ; Male ; Middle Aged ; Pituitary Gland, Anterior/drug effects ; Pituitary Gland, Anterior/secretion ; Severity of Illness Index ; Tablets ; Thyroid Gland/drug effects ; Thyroid Gland/physiopathology ; Thyroid Gland/secretion ; Thyrotropin/blood ; Thyroxine/administration & dosage ; Thyroxine/adverse effects ; Thyroxine/chemistry ; Thyroxine/therapeutic use ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Anti-Ulcer Agents ; Tablets ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-016-1167-3
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Article: Influence of αS1-casein and κ-casein polymorphism on the curd yield of Italian Mediterranean buffalo (Bubalus bubalis L.) milk

Zicarelli, Luigi / Di Palo, Rossella / Napolano, Roberto / Tonhati, Humberto / De Carlo, Ester / Gagliardi, Rosa / Di Luccia, Aldo / la Gatta, Barbara

International dairy journal. 2020 Jan., v. 100

2020

Abstract: The influence of αS1-casein (αS1-CN) and κ-casein (κ-CN) polymorphism on the curd yield and 12 other parameters of milk obtained from 89 Italian Mediterranean buffaloes (IMB) was evaluated. IMB milk carrying αS1-CNB and κ-CNX1 variants resulted in a ... ...

Abstract	The influence of αS1-casein (αS1-CN) and κ-casein (κ-CN) polymorphism on the curd yield and 12 other parameters of milk obtained from 89 Italian Mediterranean buffaloes (IMB) was evaluated. IMB milk carrying αS1-CNB and κ-CNX1 variants resulted in a greater curd yield. For these variants, the greater efficiency was attributable to higher content of proteins but not to milk production. In addition, the greater efficiency in curd yield of IMB milk carrying κ-CNX1 (P < 0.05) or αS1-CNB (P < 0.05) was characterised by a higher real curd yield/estimated curd yield (RCY/ECY) ratio. The IMB milk that exhibited the lowest value of RCY contained the κ-CNX1X2 and αS1-CNAB heterozygotes and κ-CNX2 and αS1-CNA homozygotes. IMB milk carrying κ-CNX1 and αS1-CNB, which presented the highest RCY, can be translated into an economic advantage if milk remuneration was done on the actual yield.
Keywords	Bubalus bubalis ; buffaloes ; heterozygosity ; homozygosity ; milk ; milk production ; wages and remuneration
Language	English
Dates of publication	2020-01
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1076400-8
ISSN	0958-6946
ISSN	0958-6946
DOI	10.1016/j.idairyj.2019.104559
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Editorial: pharmacokinetic and pharmacodynamic model for vonoprazan-a step forward to precision medicine.

Gatta, Luigi

Alimentary pharmacology & therapeutics

2023 Volume 58, Issue 1, Page(s) 110–111

MeSH term(s)	Humans ; Precision Medicine ; Pyrroles ; Sulfonamides
Chemical Substances	1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Pyrroles ; Sulfonamides
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17535
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Article ; Online: Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4'-Geranyloxyferulic Acid Extract from Quinoa Seeds.

Franceschelli, Sara / Gatta, Daniela Maria Pia / Pesce, Mirko / Ferrone, Alessio / Quiles, José Luis / Genovese, Salvatore / Epifano, Francesco / Fiorito, Serena / Taddeo, Vito Alessandro / Patruno, Antonia / Grilli, Alfredo / Felaco, Mario / Speranza, Lorenza

International journal of molecular sciences

2019 Volume 20, Issue 13

Abstract: Chenopodium quinoa ... ...

Abstract	Chenopodium quinoa Wild
MeSH term(s)	Anticarcinogenic Agents/chemistry ; Anticarcinogenic Agents/pharmacology ; Arginine/metabolism ; Cationic Amino Acid Transporter 2/metabolism ; Chenopodium quinoa/chemistry ; Coumaric Acids/chemistry ; Coumaric Acids/pharmacology ; HCT116 Cells ; Humans ; Inflammation/metabolism ; Inflammation/prevention & control ; Neoplasms/metabolism ; Neoplasms/prevention & control ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Seeds/chemistry
Chemical Substances	4'-geranyloxyferulic acid ; Anticarcinogenic Agents ; Cationic Amino Acid Transporter 2 ; Coumaric Acids ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2019-07-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20133262
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Article ; Online: Exploring the larval transcriptome of the common sole (Solea solea L.).

Ferraresso, Serena / Bonaldo, Alessio / Parma, Luca / Cinotti, Stefano / Massi, Paola / Bargelloni, Luca / Gatta, Pier Paolo

BMC genomics

2013 Volume 14, Page(s) 315

Abstract: Background: The common sole (Solea solea) is a promising candidate for European aquaculture; however, the limited knowledge of the physiological mechanisms underlying larval development in this species has hampered the establishment of successful ... ...

Abstract	Background: The common sole (Solea solea) is a promising candidate for European aquaculture; however, the limited knowledge of the physiological mechanisms underlying larval development in this species has hampered the establishment of successful flatfish aquaculture. Although the fact that genomic tools and resources are available for some flatfish species, common sole genomics remains a mostly unexplored field. Here, we report, for the first time, the sequencing and characterisation of the transcriptome of S. solea and its application for the study of molecular mechanisms underlying physiological and morphological changes during larval-to-juvenile transition. Results: The S. solea transcriptome was generated from whole larvae and adult tissues using the Roche 454 platform. The assembly process produced a set of 22,223 Isotigs with an average size of 726 nt, 29 contigs and a total of 203,692 singletons. Of the assembled sequences, 75.2% were annotated with at least one known transcript/protein; these transcripts were then used to develop a custom oligo-DNA microarray. A total of 14,674 oligonucleotide probes (60 nt), representing 12,836 transcripts, were in situ synthesised onto the array using Agilent non-contact ink-jet technology. The microarray platform was used to investigate the gene expression profiles of sole larvae from hatching to the juvenile form. Genes involved in the ontogenesis of the visual system are up-regulated during the early stages of larval development, while muscle development and anaerobic energy pathways increase in expression over time. The gene expression profiles of key transcripts of the thyroid hormones (TH) cascade and the temporal regulation of the GH/IGF1 (growth hormone/insulin-like growth factor I) system suggest a pivotal role of these pathways in fish growth and initiation of metamorphosis. Pre-metamorphic larvae display a distinctive transcriptomic landscape compared to previous and later stages. Our findings highlighted the up-regulation of gene pathways involved in the development of the gastrointestinal system as well as biological processes related to folic acid and retinol metabolism. Additional evidence led to the formation of the hypothesis that molecular mechanisms of cell motility and ECM adhesion may play a role in tissue rearrangement during common sole metamorphosis. Conclusions: Next-generation sequencing provided a good representation of the sole transcriptome, and the combination of different approaches led to the annotation of a high number of transcripts. The construction of a microarray platform for the characterisation of the larval sole transcriptome permitted the definition of the main processes involved in organogenesis and larval growth.
MeSH term(s)	Animals ; Flatfishes/genetics ; Flatfishes/growth & development ; Gene Expression Profiling ; Insulin-Like Growth Factor I/genetics ; Larva/genetics ; Larva/growth & development ; Molecular Sequence Annotation ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Thyroid Hormone/genetics ; Receptors, Thyrotropin/genetics ; Receptors, Thyrotropin-Releasing Hormone/genetics ; Reproducibility of Results ; Time Factors ; Transcription, Genetic
Chemical Substances	RNA, Messenger ; Receptors, Thyroid Hormone ; Receptors, Thyrotropin ; Receptors, Thyrotropin-Releasing Hormone ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2013-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/1471-2164-14-315
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