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Article ; Online: O paradigma científico

Taylon Felipe Silva

Revista Espaço Acadêmico, Vol 16, Iss

entre construções e rupturas

2016 Volume 180

Abstract: No percurso histórico da ciência, no processo de construção de conhecimento e análise de fenómenos, várias foram as lentes utilizadas em sua observância, revelando que em sua construção, a ciência sempre terá a presença do homem com forma de viés, que ... ...

Abstract	No percurso histórico da ciência, no processo de construção de conhecimento e análise de fenómenos, várias foram as lentes utilizadas em sua observância, revelando que em sua construção, a ciência sempre terá a presença do homem com forma de viés, que por sua vez também já sofreu influência de construções anteriores. Este trabalho tem como objetivo revisar alguns aspectos da constituição do conhecimento científico e descrever algumas características de eventos que se desenvolveram e ainda se desenvolvem a partir de novos conceitos em torno da própria ciência. Para tanto, a metodologia empregada é uma pesquisa de revisão bibliográfica, com abordagem qualitativa e de base exploratória, no qual se fundamentou, entre outros, nos autores Fernanda Perez Ramos, Thomas Kuhn e John Henry. O estudo permitiu considerar que o Paradigma da Ciência Moderna ao apresentar sinais de exaustão começou a abrir margem para novas concepções epistemológicas. O Paradigma da Ciência Contemporânea surgiu como consequência do advento de um período onde as verdades inquestionáveis e redutivistas até então empregadas não eram mais capazes de suprir as necessidades e questionamentos dos fenômenos propostos. Essa crise paradigmática aparentemente parece estar em vigor nos tempos atuais, representando um período de transitoriedade epistemológica.
Keywords	Ciência ; Paradigma da Ciência Moderna ; Paradigma da Ciência Contemporânea ; Epistemologia ; Social sciences (General) ; H1-99
Language	Portuguese
Publishing date	2016-05-01T00:00:00Z
Publisher	Universidade Estadual de Maringá
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Synergistic Antileishmanial Effect of Oregano Essential Oil and Silver Nanoparticles: Mechanisms of Action on

Alves, Alex Barbosa / da Silva Bortoleti, Bruna Taciane / Tomiotto-Pellissier, Fernanda / Ganaza, Ana Flávia Marques / Gonçalves, Manoela Daiele / Carloto, Amanda Cristina Machado / Rodrigues, Ana Carolina Jacob / Silva, Taylon Felipe / Nakazato, Gerson / Kobayashi, Renata Katsuko Takayama / Lazarin-Bidóia, Danielle / Miranda-Sapla, Milena Menegazzo / Costa, Idessania Nazareth / Pavanelli, Wander Rogério / Conchon-Costa, Ivete

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: American tegumentary leishmaniasis, a zoonotic disease caused by ... ...

Abstract	American tegumentary leishmaniasis, a zoonotic disease caused by the
Language	English
Publishing date	2023-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12050660
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Article ; Online: Corrigendum: Murine Susceptibility to

Tomiotto-Pellissier, Fernanda / Miranda-Sapla, Milena Menegazzo / Silva, Taylon Felipe / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Concato, Virginia Márcia / Rodrigues, Ana Carolina Jacob / Detoni, Mariana Barbosa / Staurengo-Ferrari, Larissa / Verri, Waldiceu Aparecido / Costa, Idessania Nazareth / Panis, Carolina / Conchon-Costa, Ivete / Bordignon, Juliano / Pavanelli, Wander Rogério

Frontiers in cellular and infection microbiology

2022 Volume 11, Page(s) 804809

Abstract: This corrects the article DOI: 10.3389/fcimb.2021.687633.]. ...

Abstract	[This corrects the article DOI: 10.3389/fcimb.2021.687633.].
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.804809
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Article ; Online: Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response.

Silva, Taylon Felipe / Detoni, Mariana Barbosa / Concato-Lopes, Virgínia Márcia / Tomiotto-Pellissier, Fernanda / Miranda-Sapla, Milena Menegazzo / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Rodrigues, Ana Carolina Jacob / Sanfelice, Raquel Arruda / Cruz, Ellen Mayara Souza / Silva, Maria Stacy Dos Santos / Carloto, Amanda Cristina Machado / Bidoia, Danielle Lazarin / Costa, Idessania Nazareth / Pavanelli, Wander Rogério / Conchon-Costa, Ivete

Biochimica et biophysica acta. Molecular basis of disease

2024 Volume 1870, Issue 4, Page(s) 167078

Abstract: Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's ... ...

Abstract	Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's production of insulin or the ability to use it properly, leading to hyperglycemia causing tissue damage and impairing the immune system. Aims: The objective of this work was to evaluate the effects of hyperglycemia and diabetes during Leishmania amazonensis infection and how these conditions alter the immune response to the parasite. Methods: An in vitro hyperglycemic stimulus model using THP-1-derived macrophages and an in vivo experimental diabetes with streptozotocin (STZ) in C57BL/6 mice was employed to investigate the impact of diabetes and hyperglicemia in Leishmania amazonensis infection. Results: We observed that hyperglycemia impair the leishmanicidal capacity of macrophages derived from THP-1 cells and reverse the resistance profile that C57BL/6 mice have against infection by L. amazonensis, inducing more exacerbated lesions compared to non-diabetic animals. In addition, the hyperglycemic stimulus favored the increase of markers related to the phenotype of M2 macrophages. The induction of experimental diabetes in C57BL/6 mice resulted in a failure in the production of nitric oxide (NO) in the face of infection and macrophages from diabetic animals failed to process and present Leishmania antigens, being unable to activate and induce proliferation of antigen-specific lymphocytes. Conclusion: Together, these data demonstrate that diabetes and hyperglycemia can impair the cellular immune response, mainly of macrophages, against infection by parasites of the genus Leishmania.
MeSH term(s)	Animals ; Mice ; Mice, Inbred C57BL ; Leishmaniasis/complications ; Leishmaniasis/parasitology ; Leishmania/physiology ; Macrophages ; Hyperglycemia/complications ; Immunity ; Diabetes Mellitus
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2024.167078
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Article ; Online: Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.

Concato-Lopes, Virginia Marcia / Gonçalves-Lens, Manoela Daiele / Tomiotto-Pellissier, Fernanda / Detoni, Mariana Barbosa / Cruz, Ellen Mayara Souza / Bortoleti, Bruna Taciane da Silva / Carloto, Amanda Cristina Machado / Rodrigues, Ana Carolina Jacob / Silva, Taylon Felipe / Siqueira, Elaine da Silva / de Matos, Ricardo Luís Nascimento / Alves Cardoso, Ian Lucas / Conchon-Costa, Ivete / Lazarin-Bidóia, Danielle / Arakawa, Nilton Syogo / Dekker, Robert F H / Mantovani, Mário Sérgio / Pavanelli, Wander Rogério

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155536

Abstract: Background: Lung cancer, a chronic and heterogeneous disease, is the leading cause of cancer-related death on a global scale. Presently, despite a variety of available treatments, their effectiveness is limited, often resulting in considerable toxicity ... ...

Abstract	Background: Lung cancer, a chronic and heterogeneous disease, is the leading cause of cancer-related death on a global scale. Presently, despite a variety of available treatments, their effectiveness is limited, often resulting in considerable toxicity and adverse effects. Additionally, the development of chemoresistance in cancer cells poses a challenge. Trilobolide-6-O-isobutyrate (TBB), a natural sesquiterpene lactone extracted from Sphagneticola trilobata, has exhibited antitumor effects. Its pharmacological properties in NSCLC lung cancer, however, have not been explored. Purpose: This study evaluated the impact of TBB on the A549 and NCI-H460 tumor cell lines in vitro, examining its antiproliferative properties and initial mechanisms of cell death. Methods: TBB, obtained at 98 % purity from S. trilobata leaves, was characterized using chromatographic techniques. Subsequently, its impact on inhibiting tumor cell proliferation in vitro, TBB-induced cytotoxicity in LLC-MK2, THP-1, AMJ2-C11 cells, as well as its effects on sheep erythrocytes, and the underlying mechanisms of cell death, were assessed. Results: In silico predictions have shown promising drug-likeness potential for TBB, indicating high oral bioavailability and intestinal absorption. Treatment of A549 and NCI-H460 human tumor cells with TBB demonstrated a direct impact, inducing significant morphological and structural alterations. TBB also reduced migratory capacity without causing toxicity at lower concentrations to LLC-MK2, THP-1 and AMJ2-C11 cell lines. This antiproliferative effect correlated with elevated oxidative stress, characterized by increased levels of ROS, superoxide anion radicals and NO, accompanied by a decrease in antioxidant markers: SOD and GSH. TBB-stress-induced led to changes in cell metabolism, fostering the accumulation of lipid droplets and autophagic vacuoles. Stress also resulted in compromised mitochondrial integrity, a crucial aspect of cellular function. Additionally, TBB prompted apoptosis-like cell death through activation of caspase 3/7 stressors. Conclusion: These findings underscore the potential of TBB as a promising candidate for future studies and suggest its viability as an additional component in the development of novel anticancer drugs prototypes.
MeSH term(s)	Humans ; Oxidative Stress/drug effects ; Apoptosis/drug effects ; Lung Neoplasms/drug therapy ; Caspase 3/metabolism ; Cell Line, Tumor ; Caspase 7/metabolism ; Asteraceae/chemistry ; Lactones/pharmacology ; A549 Cells ; Cell Proliferation/drug effects ; Sesquiterpenes/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Plant Leaves/chemistry ; Animals ; Reactive Oxygen Species/metabolism ; Plant Extracts/pharmacology
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; Lactones ; Sesquiterpenes ; Antineoplastic Agents, Phytogenic ; Reactive Oxygen Species ; Plant Extracts ; CASP7 protein, human (EC 3.4.22.-)
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155536
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Article ; Online: Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential.

Cruz, Ellen Mayara Souza / Concato, Virginia Marcia / de Morais, Juliana Maria Bitencourt / Silva, Taylon Felipe / Inoue, Fabricio Seidy Ribeiro / de Souza Cremer, Milena / Bidóia, Danielle Lazarin / Machado, Rayanne Regina Beltrame / de Almeida Chuffa, Luiz Gustavo / Mantovani, Mário Sérgio / Panis, Carolina / Pavanelli, Wander Rogério / Seiva, Fábio Rodrigues Ferreira

Life sciences

2023 Volume 319, Page(s) 121530

Abstract: Aims: Hepatocellular Carcinoma (HCC) is a primary neoplasm derived from hepatocytes with low responsiveness and recurrent chemoresistance. Melatonin is an alternative agent that may be helpful in treating HCC. We aimed to study in HuH 7.5 cells whether ... ...

Abstract	Aims: Hepatocellular Carcinoma (HCC) is a primary neoplasm derived from hepatocytes with low responsiveness and recurrent chemoresistance. Melatonin is an alternative agent that may be helpful in treating HCC. We aimed to study in HuH 7.5 cells whether melatonin treatment exerts antitumor effects and, if so, what cellular responses are induced and involved. Main methods: We evaluated the effects of melatonin on cell cytotoxicity and proliferation, colony formation, morphological and immunohistochemical aspects, and on glucose consumption and lactate release. Key findings: Melatonin reduced cell motility and caused lamellar breakdown, membrane damage, and reduction in microvillus. Immunofluorescence analysis revealed that melatonin reduced TGF and N-cadherin expression, which was further associated with inhibition of epithelial-mesenchymal transition process. In relation to the Warburg-type metabolism, melatonin reduced glucose uptake and lactate production by modulating intracellular lactate dehydrogenase activity. Significance: Our results indicate that melatonin can act upon pyruvate/lactate metabolism, preventing the Warburg effect, which may reflect in the cell architecture. We demonstrated the direct cytotoxic and antiproliferative effect of melatonin on the HuH 7.5 cell line, and suggest that melatonin is a promising candidate to be further tested as an adjuvant to antitumor drugs for HCC treatment.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Cell Line, Tumor ; Lactates
Chemical Substances	Melatonin (JL5DK93RCL) ; Lactates
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.121530
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Article ; Online: Biogenic silver nanoparticles reduce Toxoplasma gondii infection and proliferation in RAW 264.7 macrophages by inducing tumor necrosis factor-alpha and reactive oxygen species production in the cells.

Arruda da Silva Sanfelice, Raquel / Silva, Taylon Felipe / Tomiotto-Pellissier, Fernanda / Bortoleti, Bruna Taciane da Silva / Lazarin-Bidóia, Danielle / Scandorieiro, Sara / Nakazato, Gerson / de Barros, Luiz Daniel / Garcia, João Luis / Verri, Waldiceu Aparecido / Conchon-Costa, Ivete / Pavanelli, Wander Rogério / Costa, Idessania Nazareth

Microbes and infection

2022 Volume 24, Issue 5, Page(s) 104971

Abstract: Owing to the serious adverse effects caused by pyrimethamine and sulfadiazine, the drugs commonly used to treat toxoplasmosis, there is a need for treatment alternatives for this disease. Nanotechnology has enabled significant advances toward this goal. ... ...

Abstract	Owing to the serious adverse effects caused by pyrimethamine and sulfadiazine, the drugs commonly used to treat toxoplasmosis, there is a need for treatment alternatives for this disease. Nanotechnology has enabled significant advances toward this goal. This study was conducted to evaluate the activity of biogenic silver nanoparticles (AgNp-Bio) in RAW 264.7 murine macrophages infected with the RH strain of Toxoplasma gondii. The macrophages were infected with T. gondii tachyzoites and then treated with various concentrations of AgNp-Bio. The cells were evaluated by microscopy, and culture supernatants were collected for ELISA determination of their cytokine concentration. Treatment with 6 μM AgNp-Bio reduced the infection and parasite load in infected RAW 264.7 macrophages without being toxic to the cells. The treatment also induced the synthesis of reactive oxygen species and tumor necrosis factor-alpha (both pro-inflammatory mediators), which resulted in ultrastructural changes in the tachyzoites and their intramacrophagic destruction. Our findings suggest that AgNp-Bio affect T. gondii tachyzoites by activating microbicidal and pro-inflammatory mechanisms and may be a potential alternative treatment for toxoplasmosis.
MeSH term(s)	Animals ; Cell Proliferation ; Macrophages/drug effects ; Macrophages/parasitology ; Metal Nanoparticles ; Mice ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Silver/pharmacology ; Toxoplasma ; Toxoplasmosis/drug therapy ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Silver (3M4G523W1G)
Language	English
Publishing date	2022-03-25
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2022.104971
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Article: Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review

Silva, Taylon Felipe / Tomiotto-Pellissier, Fernanda / Pasquali, Aline Kuhn Sbruzzi / Pinto-Ferreira, Fernanda / Pavanelli, Wander Rogério / Conchon-Costa, Ivete / Navarro, Italmar Teodorico / Caldart, Eloiza Teles

Acta tropica. 2021 Sept., v. 221

2021

Abstract: Leishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis (ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, ... ...

Abstract	Leishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis (ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, mucocutaneous, and visceral involvement, however, the factors that drive the development of different disease forms by the same species are not yet fully known. In the present work, it was systematically reviewed the studies addressing phenotypic and genotypic characteristics of Leishmania (L.) amazonensis isolates causing cutaneous and visceral clinical frames in humans and dogs, comparing the results observed. For this, four research databases were searched for the following keywords: (Leishmania amazonensis AND visceral leishmaniasis) AND (tropism OR virulence OR visceralization OR adaptations OR mutation OR clinical presentation OR resistance OR survival OR wide spectrum). The results revealed that the complexity disease seems to involve the combination of genetic factors of the parasite (as modifications in molecules related to the virulence and metabolism) and also of the host's immune background and status. Nonetheless, the exact mechanism that leads to different clinical manifestations between strains of the same species is still uncertain and future studies must be developed to better elucidate this phenomenon.
Keywords	Leishmania amazonensis ; cutaneous leishmaniasis ; etiological agents ; metabolism ; mutation ; parasites ; phenotype ; systematic review ; virulence ; visceral leishmaniasis ; Brazil
Language	English
Dates of publication	2021-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.106018
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 3,3',5,5'-Tetramethoxybiphenyl-4,4'diol triggers oxidative stress, metabolic changes, and apoptosis-like process by reducing the PI3K/AKT/NF-κB pathway in the NCI-H460 lung cancer cell line.

Concato-Lopes, Virginia Marcia / Silva, Taylon Felipe / Detoni, Mariana Barbosa / Cruz, Ellen Mayara Souza / Gonçalves, Manoela Daiele / da Silva Bortoleti, Bruna Taciane / Tomiotto-Pellissier, Fernanda / Carloto, Amanda Cristina Machado / Madureira, Maria Beatriz / Rodrigues, Ana Carolina Jacob / Schirmann, Jéseka Gabriela / Barbosa-Dekker, Aneli M / Dekker, Robert F H / Conchon-Costa, Ivete / Panis, Carolina / Lazarin-Bidóia, Danielle / Miranda-Sapla, Milena Menegazzo / Mantovani, Mário Sérgio / Pavanelli, Wander R

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 170, Page(s) 115979

Abstract: Lung cancer is one of the leading causes of cancer-related deaths in men and women worldwide. Current treatments have limited efficacy, cause significant side effects, and cells can develop drug resistance. New therapeutic strategies are needed to ... ...

Abstract	Lung cancer is one of the leading causes of cancer-related deaths in men and women worldwide. Current treatments have limited efficacy, cause significant side effects, and cells can develop drug resistance. New therapeutic strategies are needed to discover alternative anticancer agents with high efficacy and low-toxicity. TMBP, a biphenyl obtained by laccase-biotransformation of 2,6-dimethoxyphenol, possesses antitumor activity against A549 adenocarcinoma cells. Without causing damage to sheep erythrocytes and mouse peritoneal macrophages of BALB/c mice. In addition to being classified as a good oral drug according to in-silico studies. This study evaluated the in-vitro cytotoxic effect of TMBP on lung-cancer cell-line NCI-H460 and reports mechanisms on immunomodulation and cell death. TMBP treatment (12.5-200 μM) inhibited cell proliferation at 24, 48, and 72 h. After 24-h treatment, TMBP at IC
MeSH term(s)	Female ; Humans ; Animals ; Mice ; Sheep ; Lung Neoplasms/pathology ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; Apoptosis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Proliferation ; Oxidative Stress ; Stress, Physiological
Chemical Substances	NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Antineoplastic Agents
Language	English
Publishing date	2023-12-06
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115979
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Article ; Online: Recent Advances in Biotransformation by Cunninghamella Species.

Gonçalves, Manoela Daiele / Tomiotto-Pellissier, Fernanda / de Matos, Ricardo Luís Nascimento / Assolini, João Paulo / da Silva Bortoleti, Bruna Taciane / Concato, Virginia Marcia / Silva, Taylon Felipe / Rafael, Janice Aparecida / Pavanelli, Wander Rogério / Conchon-Costa, Ivete / Arakawa, Nilton Syogo

Current drug metabolism

2021 Volume 22, Issue 13, Page(s) 1035–1064

Abstract: The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive ... ...

Abstract	The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.
MeSH term(s)	Biological Factors/metabolism ; Biological Factors/pharmacology ; Biotransformation ; Cunninghamella/physiology ; Drug Discovery/methods ; Fungi/physiology ; Humans ; Metabolism ; Models, Biological ; Xenobiotics/metabolism ; Xenobiotics/pharmacology
Chemical Substances	Biological Factors ; Xenobiotics
Language	English
Publishing date	2021-12-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2064815-7
ISSN	1875-5453 ; 1389-2002
ISSN (online)	1875-5453
ISSN	1389-2002
DOI	10.2174/1389200222666211126100023
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