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  1. Book ; Online ; E-Book: Alice in Wonderland Syndrome

    Blom, Jan Dirk

    2020  

    Author's details Jan Dirk Blom
    Keywords Psychiatry ; Neurology  ; Clinical psychology
    Subject code 616.89
    Language English
    Size 1 Online-Ressource (vi, 221 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020336445
    ISBN 978-3-030-18609-8 ; 9783030186081 ; 3-030-18609-1 ; 3030186083
    DOI 10.1007/978-3-030-18609-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A report card for healthy aging in South Africa.

    Blom, Dirk J

    Cardiovascular journal of Africa

    2022  Volume 33, Issue 4, Page(s) 167–168

    MeSH term(s) Healthy Aging ; Humans ; South Africa/epidemiology
    Language English
    Publishing date 2022-10-04
    Publishing country South Africa
    Document type Editorial
    ZDB-ID 2383233-2
    ISSN 1680-0745 ; 1996-3467 ; 1015-9657 ; 1995-1892
    ISSN (online) 1680-0745 ; 1996-3467
    ISSN 1015-9657 ; 1995-1892
    DOI 10.5830/CVJA-2022-047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Hallucinations

    Blom, Jan Dirk / Sommer, Iris E. C.

    research and practice

    2012  

    Author's details Jan Dirk Blom ; Iris E. C. Sommer
    Language English
    Size XVII, 424 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017102441
    ISBN 978-1-4614-0958-8 ; 1-4614-0958-6 ; 9781461409595 ; 1461409594
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 407 order for loan Magazin

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  4. Article ; Online: The Diagnostic Spectrum of Sexual Hallucinations.

    Blom, Jan Dirk / van Veen, Rosemarij J B / van Rooijen, Emma H C / Slotema, Christina W

    Harvard review of psychiatry

    2024  Volume 32, Issue 1, Page(s) 1–14

    Abstract: Abstract: Sexual hallucinations are little known, yet often extremely burdening, phenomena. In this systematic review, we summarize what is known about their phenomenology, prevalence, etiopathology, ensuing distress, and treatment options. Sexual ... ...

    Abstract Abstract: Sexual hallucinations are little known, yet often extremely burdening, phenomena. In this systematic review, we summarize what is known about their phenomenology, prevalence, etiopathology, ensuing distress, and treatment options. Sexual hallucinations can be experienced as genital or orgasmic sensations, although other sensory modalities can also be involved. With the notable exception of orgasmic auras in the context of epilepsy, sexual hallucinations tend to be distressing and embarrassing in nature. Our analysis of 79 studies (together describing 390 patients) indicates that sexual hallucinations are more frequent in women than in men, with a sex ratio of 1.4:1, and that they are most prevalent in schizophrenia spectrum disorders, with rates ranging from 1.4% in recently admitted patients to 44% in chronically hospitalized patients. Other underlying conditions include epilepsy, the incubus phenomenon (possibly the most prevalent cause in the general population, associated with sleep paralysis), narcolepsy, and sedative use. As regards the sedative context, we found more medicolegal than purely medical cases, which sadly underlines that not all sexually explicit sensations experienced in anesthesia practice are indeed hallucinations. In the absence of evidence-based treatment protocols for sexual hallucinations, practice-based guidelines tend to focus on the underlying condition. Further research is needed, especially in the fields of substance abuse, posttraumatic stress disorder, and borderline personality disorder, where only anecdotal information on sexual hallucinations is available. Moreover, awareness of sexual hallucinations among health professionals needs to be improved in order to facilitate counseling, diagnosis, and treatment.
    MeSH term(s) Female ; Humans ; Male ; Borderline Personality Disorder ; Epilepsy ; Hallucinations/diagnosis ; Hallucinations/epidemiology ; Hallucinations/etiology ; Health Personnel ; Hypnotics and Sedatives ; Sexual Arousal
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 1174775-4
    ISSN 1465-7309 ; 1067-3229
    ISSN (online) 1465-7309
    ISSN 1067-3229
    DOI 10.1097/HRP.0000000000000388
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  5. Book ; Thesis: Decon-structing schizophrenia

    Blom, Jan Dirk

    an analysis of the epistemic and nonepistemic values that govern the biomedical schizophrenia concept

    2003  

    Author's details door Johannes Dirk Blom
    Language English ; Dutch
    Size 301 S.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leiden, Univ., Diss., 2003
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT015542961
    ISBN 90-5352-953-7 ; 978-90-5352-953-9
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria.

    Hesse, Reinhardt / Raal, Frederick J / Blom, Dirk J / George, Jaya A

    Circulation. Genomic and precision medicine

    2022  Volume 15, Issue 5, Page(s) e003324

    Abstract: Background: Familial hypercholesterolemia (FH) is a common genetic disorder and, if not diagnosed and treated early, results in premature cardiovascular disease. Most individuals with FH are undiagnosed and machine learning offers a new prospect to ... ...

    Abstract Background: Familial hypercholesterolemia (FH) is a common genetic disorder and, if not diagnosed and treated early, results in premature cardiovascular disease. Most individuals with FH are undiagnosed and machine learning offers a new prospect to improve FH identification. Our objective was to create a machine learning model from basic lipid profile data with better screening performance than LDL-C (low-density lipoprotein cholesterol) cutoff levels and diagnostic performance comparable to the Dutch Lipid Clinic Network criteria.
    Methods: The model was developed combining logistic regression, deep learning, and random forest classification and trained on a 70% split of a data set of individuals clinically suspected of having FH. Model performance, as well as that of the LDL-C cutoff and Dutch Lipid Clinic Network criteria, were assessed on the internal 30% testing data set and an external data set by comparing the area under the receiver operator characteristic (AUROC) curves. All methodologies were measured against the gold standard of FH diagnosis by mutation identification. Furthermore, the model was also tested on 2 lower prevalence data sets.
    Results: The machine learning model achieved an AUROC curve of 0.711 on the external data set (n=1376; FH prevalence=64%), which was superior to the LDL-C cutoff (AUROC=0.642) and comparable to the Dutch Lipid Clinic Network criteria (AUROC=0.705). The model performed even better when tested on the medium-prevalence (n=2655; FH prevalence=20%) and low-prevalence (n=1616; FH prevalence=1%) data sets, with AUROC curve values of 0.801 and 0.856, respectively.
    Conclusions: Despite absence of clinical information, the model better identified genetically confirmed FH in a cohort of individuals suspected of having FH than LDL-C cutoff values and was comparable to the Dutch Lipid Clinic Network criteria. The model achieved higher accuracy when tested on 2 cohorts with lower FH prevalence. The application of machine learning is, therefore, a promising tool in both the screening for, and diagnosis of, individuals with FH.
    MeSH term(s) Humans ; Cholesterol, LDL ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Mutation ; Area Under Curve ; Machine Learning
    Chemical Substances Cholesterol, LDL
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-8300
    ISSN (online) 2574-8300
    DOI 10.1161/CIRCGEN.121.003324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic and Mechanistic Insights into the Modulation of Circulating Lipoprotein (a) Concentration by Apolipoprotein E Isoforms.

    Chemello, Kévin / Blom, Dirk J / Marais, A David / Lambert, Gilles / Blanchard, Valentin

    Current atherosclerosis reports

    2022  Volume 24, Issue 6, Page(s) 399–405

    Abstract: Purpose of review: Lipoprotein (a) [Lp(a)] is a highly atherogenic lipoprotein species. A unique feature of Lp(a) is the strong genetic determination of its concentration. The LPA gene is responsible for up to 90% of the variance in Lp(a), but other ... ...

    Abstract Purpose of review: Lipoprotein (a) [Lp(a)] is a highly atherogenic lipoprotein species. A unique feature of Lp(a) is the strong genetic determination of its concentration. The LPA gene is responsible for up to 90% of the variance in Lp(a), but other genes also have an impact.
    Recent findings: Genome-wide associations studies indicate that the APOE gene, encoding apolipoprotein E (apoE), is the second most important locus modulating Lp(a) concentrations. Population studies clearly show that carriers of the apoE2 variant (ε2) display reduced Lp(a) levels, the lowest concentrations being observed in ε2/ε2 homozygotes. This genotype can lead predisposed adults to develop dysbetalipoproteinemia, a lipid disorder characterized by sharp elevations in cholesterol and triglycerides. However, dysbetalipoproteinemia does not significantly modulate circulating Lp(a). Mechanistically, apoE appears to impair the production but not the catabolism of Lp(a). These observations underline the complexity of Lp(a) metabolism and provide key insights into the pathways governing Lp(a) synthesis and secretion.
    MeSH term(s) Adult ; Apolipoproteins E/genetics ; Genotype ; Humans ; Hyperlipoproteinemia Type III/genetics ; Lipoprotein(a)/genetics ; Lipoprotein(a)/metabolism ; Protein Isoforms/genetics
    Chemical Substances Apolipoproteins E ; Lipoprotein(a) ; Protein Isoforms
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-022-01016-8
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  8. Article: Musical hallucinations, secondary delusions, and lack of insight: results from a cohort study.

    Buijk, Milou A / Lauw, René F / Coebergh, Jan Adriaan F / Bouachmir, Ouarda / Linszen, Mascha M J / Blom, Jan Dirk

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1253625

    Abstract: Introduction: Although musical hallucinations do not tend to be accompanied by delusions, occasionally patients persistently accuse others of being responsible for causing the music they perceive, sometimes with severe social consequences such as ... ...

    Abstract Introduction: Although musical hallucinations do not tend to be accompanied by delusions, occasionally patients persistently accuse others of being responsible for causing the music they perceive, sometimes with severe social consequences such as frequently calling the police or moving house. In this study we seek to broaden our understanding of this rare type of musical hallucination that comes with secondary delusions and lack of insight, and to explore associations, underlying mechanisms, and treatment possibilities.
    Methods: The present study is part of a cohort study on musical hallucinations carried out in the Netherlands from 2010 through 2023. Participants underwent testing with the aid of the
    Results: Five patients out of a group of
    Conclusion: The pathophysiological process underlying musical hallucinations is multifactorial in nature. We consider cognitive impairment the most likely contributing factor of the secondary delusions and lack of insight encountered in our patients, and antipsychotics the most beneficial treatment. On the basis of these small numbers, no definite conclusions can be drawn, so further research is needed to elucidate the underlying mechanisms and to develop evidence-based treatment methods for people experiencing this rare and debilitating combination of symptoms. Since the black box warning of risperidone cautions against the use of this drug in elderly persons with dementia, a proper comparison with the efficacy and safety of other antipsychotics for this group is paramount.
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1253625
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  9. Article ; Online: Computational biomechanics: a potential new tool for the vascular surgeon in personalized management.

    Khinsoe, Georgia / Bappoo, Nikhilesh / Kelsey, Lachlan J / Blom, Dirk / Doyle, Barry J / Jansen, Shirley

    ANZ journal of surgery

    2020  Volume 92, Issue 6, Page(s) 1308–1311

    MeSH term(s) Biomechanical Phenomena ; Humans ; Surgeons
    Language English
    Publishing date 2020-11-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17476
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  10. Article ; Online: Anacetrapib in familial hypercholesterolaemia: pros and cons.

    Raal, Frederick J / Blom, Dirk J

    Lancet (London, England)

    2015  Volume 385, Issue 9983, Page(s) 2124–2126

    MeSH term(s) Anticholesteremic Agents/therapeutic use ; Female ; Humans ; Hyperlipoproteinemia Type II/drug therapy ; Male ; Oxazolidinones/therapeutic use
    Chemical Substances Anticholesteremic Agents ; Oxazolidinones
    Language English
    Publishing date 2015-05-30
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(14)62315-1
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