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Article: Art therapy as a comprehensive complementary treatment for Parkinson's disease.

Ettinger, Tom / Berberian, Marygrace / Acosta, Ikuko / Cucca, Alberto / Feigin, Andrew / Genovese, Danilo / Pollen, Travis / Rieders, Julianne / Kilachand, Rohita / Gomez, Clara / Kaimal, Girija / Biagioni, Milton / Di Rocco, Alessandro / Ghilardi, Felice M / Rizzo, John-Ross

Frontiers in human neuroscience

2023 Volume 17, Page(s) 1110531

Abstract: Introduction: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Complementary and alternative therapies are increasingly utilized to address its complex multisystem symptomatology. Art therapy involves motoric action and ... ...

Abstract	Introduction: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Complementary and alternative therapies are increasingly utilized to address its complex multisystem symptomatology. Art therapy involves motoric action and visuospatial processing while promoting broad biopsychosocial wellness. The process involves hedonic absorption, which provides an escape from otherwise persistent and cumulative PD symptoms, refreshing internal resources. It involves the expression in nonverbal form of multilayered psychological and somatic phenomena; once these are externalized in a symbolic arts medium, they can be explored, understood, integrated, and reorganized through verbal dialogue, effecting relief and positive change. Methods: 42 participants with mild to moderate PD were treated with 20 sessions of group art therapy. They were assessed before and after therapy with a novel arts-based instrument developed to match the treatment modality for maximum sensitivity. The House-Tree-Person PD Scale (HTP-PDS) assesses motoric and visuospatial processing-core PD symptoms-as well as cognition (thought and logic), affect/mood, motivation, self (including body-image, self-image, and self- efficacy), interpersonal functioning, creativity, and overall level of functioning. It was hypothesized that art therapy will ameliorate core PD symptoms and that this will correlate with improvements in all other variables. Results: HTP-PDS scores across all symptoms and variables improved significantly, though causality among variables was indeterminate. Discussion: Art therapy is a clinically efficacious complementary treatment for PD. Further research is warranted to disentangle causal pathways among the aforementioned variables, and additionally, to isolate and examine the multiple, discrete healing mechanisms believed to operate simultaneously in art therapy.
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2023.1110531
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Article ; Online: Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity.

Rocco-Machado, N / Cosentino-Gomes, D / Nascimento, M T / Paes-Vieira, L / Khan, Y A / Mittra, B / Andrews, N W / Meyer-Fernandes, J R

Free radical biology & medicine

2019 Volume 143, Page(s) 341–353

Abstract: Leishmania amazonensis is one of leishmaniasis' causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a ... ...

Abstract	Leishmania amazonensis is one of leishmaniasis' causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na
MeSH term(s)	FMN Reductase/metabolism ; HEK293 Cells ; Heme/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Iron/metabolism ; Leishmania/enzymology ; Leishmania/growth & development ; Leishmaniasis/metabolism ; Leishmaniasis/parasitology ; Mitochondria/metabolism ; Mitochondria/parasitology ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Oxidation-Reduction ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism
Chemical Substances	Protozoan Proteins ; Heme (42VZT0U6YR) ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7) ; FMN Reductase (EC 1.5.1.38) ; NADPH Oxidases (EC 1.6.3.-) ; ferric citrate iron reductase (EC 1.6.99.-)
Language	English
Publishing date	2019-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2019.08.026
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Article ; Online: Use of Routine Environmental Monitoring Data to Establish a Dose-based Compliance System for a Low-level Radioactive Waste Disposal Site.

Rood, Arthur S / Grogan, Helen A / Mohler, H Justin / Rocco, James R / Caffrey, Emily A / Mangini, Colby / Cartwright, Jay / Matthews, Travis / Shaw, Chris / Packard, Mark E / Till, John E

Health physics

2019 Volume 118, Issue 1, Page(s) 1–17

Abstract: A dose-based compliance methodology was developed for Waste Control Specialists, LLC, low-level radioactive waste facility in Andrews, Texas, that allows routine environmental measurement data to be evaluated not only at the end of a year to determine ... ...

Abstract	A dose-based compliance methodology was developed for Waste Control Specialists, LLC, low-level radioactive waste facility in Andrews, Texas, that allows routine environmental measurement data to be evaluated not only at the end of a year to determine regulatory compliance, but also throughout the year as new data become available, providing a continuous assessment of the facility. The first step in the methodology is a screening step to determine the potential presence of site emissions in the environment, and screening levels are established for each environmental media sampled. The screening accounts for spatial variations observed in background for soil and temporal fluctuations observed in background for air. For groundwater, the natural activity concentrations in groundwater wells at the facility are highly variable, and therefore the methodology uses ratios for screening levels. The methodology compares the ratio of gross alpha to U + U to identify potentially abnormal alpha activity and the ratio of U to U to identify the potential presence of depleted uranium. Compliance evaluation is conducted for any samples that fail the screening step. Compliance evaluation uses the radionuclide-specific measurements to first determine (1) if the dose exceeds the background dose and if so, (2) the dose consequences, so that the appropriate investigation or action occurs. The compliance evaluation is applied to all environmental samples throughout the year and on an annual basis to determine regulatory compliance. The methodology is implemented in a cloud-based software application that is also made accessible to the regulator. The benefits of the methodology over the existing system are presented.
MeSH term(s)	Air Pollutants, Radioactive/analysis ; Environmental Monitoring/standards ; Groundwater/chemistry ; Humans ; Models, Theoretical ; Radiation Monitoring/methods ; Radiation Protection/legislation & jurisprudence ; Radiation Protection/standards ; Radioactive Waste/analysis ; Uranium/analysis ; Waste Disposal Facilities/legislation & jurisprudence ; Waste Disposal Facilities/standards ; Water Pollutants, Radioactive/analysis
Chemical Substances	Air Pollutants, Radioactive ; Radioactive Waste ; Water Pollutants, Radioactive ; Uranium (4OC371KSTK)
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2406-5
ISSN	1538-5159 ; 0017-9078
ISSN (online)	1538-5159
ISSN	0017-9078
DOI	10.1097/HP.0000000000001116
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Article ; Online: Hydrogen Isotopic Composition of Hydrous Minerals in Asteroid Ryugu

The Astrophysical Journal Letters, 946 (2)

2023

Abstract: Rock fragments of the Cb-type asteroid Ryugu returned to Earth by the JAXA Hayabusa2 mission share mineralogical, chemical, and isotopic properties with the Ivuna-type (CI) carbonaceous chondrites. Similar to CI chondrites, these fragments underwent ... ...

Abstract	Rock fragments of the Cb-type asteroid Ryugu returned to Earth by the JAXA Hayabusa2 mission share mineralogical, chemical, and isotopic properties with the Ivuna-type (CI) carbonaceous chondrites. Similar to CI chondrites, these fragments underwent extensive aqueous alteration and consist predominantly of hydrous minerals likely formed in the presence of liquid water on the Ryugu parent asteroid. Here we present an in situ analytical survey performed by secondary ion mass spectrometry from which we have estimated the D/H ratio of Ryugu's hydrous minerals, D/HRyugu, to be [165 ± 19] × 10⁻⁶, which corresponds to δDRyugu = +59 ± 121‰ (2σ). The hydrous mineral D/HRyugu's values for the two sampling sites on Ryugu are similar; they are also similar to the estimated D/H ratio of hydrous minerals in the CI chondrites Orgueil and Alais. This result reinforces a link between Ryugu and CI chondrites and an inference that Ryugu's samples, which avoided terrestrial contamination, are our best proxy to estimate the composition of water at the origin of hydrous minerals in CI-like material. Based on this data and recent literature studies, the contribution of CI chondrites to the hydrogen of Earth's surficial reservoirs is evaluated to be ∼3%. We conclude that the water responsible for the alteration of Ryugu's rocks was derived from water ice precursors inherited from the interstellar medium; the ice partially re-equilibrated its hydrogen with the nebular H₂ before being accreted on the Ryugu's parent asteroid. ISSN:1967-2014 ISSN:2041-8213
Keywords	Carbonaceous chondrites ; Earth (planet) ; Asteroids ; Ice composition ; Solar system ; Small Solar System bodies ; Planetary science ; Chondrites ; Meteorites ; Meteorite composition
Subject code	550
Language	English
Publishing date	2023-04-04
Publisher	IOP Publishing
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intraoperative opioid exposure, tumour genomic alterations, and survival differences in people with lung adenocarcinoma.

Connolly, James G / Tan, Kay See / Mastrogiacomo, Brooke / Dycoco, Joseph / Caso, Raul / Jones, Gregory D / McCormick, Patrick J / Sanchez-Vega, Francisco / Irie, Takeshi / Scarpa, Joseph R / Gupta, Hersh V / Adusumilli, Prasad S / Rocco, Gaetano / Isbell, James M / Bott, Matthew J / Fischer, Gregory W / Jones, David R / Mincer, Joshua S

British journal of anaesthesia

2021 Volume 127, Issue 1, Page(s) 75–84

Abstract: Background: Opioids have been linked to worse oncologic outcomes in surgical patients. Studies in certain cancer types have identified associations between survival and intra-tumoural opioid receptor gene alterations, but no study has investigated ... ...

Abstract	Background: Opioids have been linked to worse oncologic outcomes in surgical patients. Studies in certain cancer types have identified associations between survival and intra-tumoural opioid receptor gene alterations, but no study has investigated whether the tumour genome interacts with opioid exposure to affect survival. We sought to determine whether intraoperative opioid exposure is associated with recurrence-specific survival and overall survival in early-stage lung adenocarcinoma, and whether selected tumour genomics are associated with this relationship. Associations between ketamine and dexmedetomidine and outcomes were also studied. Methods: Surgical patients (N=740) with pathological stage I-III lung adenocarcinoma and next-generation sequencing data were retrospectively reviewed from a prospectively maintained database. Results: On multivariable analysis, ketamine administration was protective for recurrence-specific survival (hazard ratio = 0.44, 95% confidence interval 0.24-0.80; P=0.007), compared with no adjunct. Higher intraoperative oral morphine milligram equivalents were significantly associated with worse overall survival (hazard ratio=1.09/10 morphine milligram equivalents, 95% confidence interval 1.02-1.17; P=0.010). Significant interaction effects were found between morphine milligram equivalents and fraction genome altered and morphine milligram equivalents and CDKN2A, such that higher fraction genome altered or CDKN2A alterations were associated with worse overall survival at higher morphine milligram equivalents (P=0.044 and P=0.052, respectively). In contrast, alterations in the Wnt (P=0.029) and Hippo (P=0.040) oncogenic pathways were associated with improved recurrence-specific survival at higher morphine milligram equivalents, compared with unaltered pathways. Conclusions: Intraoperative opioid exposure is associated with worse overall survival, whereas ketamine exposure is associated with improved recurrence-specific survival in patients with early-stage lung adenocarcinoma. This is the first study to investigate tumour-specific genomic interactions with intraoperative opioid administration to modify survival associations.
MeSH term(s)	Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/mortality ; Adenocarcinoma of Lung/surgery ; Aged ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Female ; Genomics/trends ; Humans ; Intraoperative Care/adverse effects ; Intraoperative Care/trends ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/genetics ; Pain, Postoperative/prevention & control ; Prospective Studies ; Retrospective Studies ; Survival Rate/trends
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-06-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2021.03.030
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Article ; Online: Intraoperative ketorolac may interact with patient-specific tumour genomics to modify recurrence risk in lung adenocarcinoma: an exploratory analysis.

Connolly, James G / Scarpa, Joseph R / Gupta, Hersh V / Tan, Kay See / Mastrogiacomo, Brooke / Dycoco, Joseph / Caso, Raul / Jones, Gregory D / Sanchez-Vega, Francisco / Adusumilli, Prasad S / Rocco, Gaetano / Isbell, James M / Bott, Matthew J / Irie, Takeshi / McCormick, Patrick J / Fischer, Gregory W / Jones, David R / Mincer, Joshua S

British journal of anaesthesia

2021 Volume 127, Issue 3, Page(s) e82–e85

MeSH term(s)	Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/mortality ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/surgery ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Biomarkers, Tumor/genetics ; Gene Regulatory Networks ; Genomics ; Humans ; Intraoperative Care ; Ketorolac/administration & dosage ; Ketorolac/adverse effects ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; NF-E2-Related Factor 2/genetics ; Neoplasm Recurrence, Local ; Pneumonectomy/adverse effects ; Pneumonectomy/mortality ; Proto-Oncogene Proteins c-mdm2/genetics ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Biomarkers, Tumor ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Ketorolac (YZI5105V0L)
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2021.05.032
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Article: APOL1

Freedman, Barry I / Rocco, Michael V / Bates, Jeffrey T / Chonchol, Michel / Hawfield, Amret T / Lash, James P / Papademetriou, Vasilios / Sedor, John R / Servilla, Karen / Kimmel, Paul L / Wall, Barry M / Pajewski, Nicholas M

Kidney international reports

2017 Volume 2, Issue 4, Page(s) 713–720

Abstract: Introduction: Relationships between apolipoprotein L1 gene (: Methods: Cox proportional hazards regression models were employed adjusting for age, sex, African ancestry proportion, and treatment group (systolic blood pressure target of <120 mm Hg ... ...

Abstract	Introduction: Relationships between apolipoprotein L1 gene ( Methods: Cox proportional hazards regression models were employed adjusting for age, sex, African ancestry proportion, and treatment group (systolic blood pressure target of <120 mm Hg versus <140 mm Hg). Results: Fourteen percent of participants had two Conclusion: APOL1
Language	English
Publishing date	2017-03-31
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN	2468-0249
DOI	10.1016/j.ekir.2017.03.008
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Article: Nitazoxanide in Patients Hospitalized With COVID-19 Pneumonia: A Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial.

Rocco, Patricia R M / Silva, Pedro L / Cruz, Fernanda F / Tierno, Paulo F G M M / Rabello, Eucir / Junior, Jéfiton Cordeiro / Haag, Firmino / de Ávila, Renata E / da Silva, Joana D G / Mamede, Mariana M S / Buchele, Konrad S / Barbosa, Luiz C V / Cabral, Anna C / Junqueira, Antônio A F / Araújo-Filho, João A / da Costa, Lucianna A T J / Alvarenga, Pedro P M / Moura, Alexandre S / Carajeleascow, Ricardo /

de Oliveira, Mirella C / Silva, Roberta G F / Soares, Cynthia R P / Fernandes, Ana Paula S M / Fonseca, Flavio Guimarães / Camargos, Vidyleison Neves / Reis, Julia de Souza / Franchini, Kleber G / Luiz, Ronir R / Morais, Sirlei / Sverdloff, Carlos / Martins, Camila Marinelli / Felix, Nathane S / Mattos-Silva, Paula / Nogueira, Caroline M B / Caldeira, Dayene A F / Pelosi, Paolo / Lapa-E-Silva, José R

Frontiers in medicine

2022 Volume 9, Page(s) 844728

Abstract: Background: Nitazoxanide exerts antiviral activity : Methods: A multicentre, randomized, double-blind, placebo-controlled trial was conducted in 19 hospitals in Brazil. Hospitalized adult patients requiring supplemental oxygen, with COVID-19 symptoms ...

Abstract	Background: Nitazoxanide exerts antiviral activity Methods: A multicentre, randomized, double-blind, placebo-controlled trial was conducted in 19 hospitals in Brazil. Hospitalized adult patients requiring supplemental oxygen, with COVID-19 symptoms and a chest computed tomography scan suggestive of viral pneumonia or positive RT-PCR test for COVID-19 were enrolled. Patients were randomized 1:1 to receive nitazoxanide (500 mg) or placebo, 3 times daily, for 5 days, and were followed for 14 days. The primary outcome was intensive care unit admission due to the need for invasive mechanical ventilation. Secondary outcomes included clinical improvement, hospital discharge, oxygen requirements, death, and adverse events within 14 days. Results: Of the 498 patients, 405 (202 in the nitazoxanide group and 203 in the placebo group) were included in the analyses. Admission to the intensive care unit did not differ between the groups (hazard ratio [95% confidence interval], 0.68 [0.38-1.20], Conclusions: Nitazoxanide, compared with placebo, did not prevent admission to the intensive care unit for patients hospitalized with COVID-19 pneumonia. Clinical trial registration: Brazilian Registry of Clinical Trials (REBEC) RBR88bs9x; ClinicalTrials.gov, NCT04561219.
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.844728
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Article ; Online: Statement of Retraction. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. Diabetes 2009;58:2910-2919. DOI: 10.2337/db08-0506. PMID: 19696185.

Prada, Patricia O / Ropelle, Eduardo R / Mourão, Rosa H / de Souza, Claudio T / Pauli, Jose R / Cintra, Dennys E / Schenka, André / Rocco, Silvana A / Rittner, Roberto / Franchini, Kleber G / Vassallo, José / Velloso, Lício A / Carvalheira, José B / Saad, Mario J A

Diabetes

2017 Volume 66, Issue 7, Page(s) 2059

Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db17-rt07a
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Article ; Online: Expression of Concern. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. Diabetes 2009;58:2910-2919. DOI: 10.2337/db08-0506. PMID: 19696185.

Diabetes

2017 Volume 66, Issue 4, Page(s) 1098

Language	English
Publishing date	2017-02-10
Publishing country	United States
Document type	Journal Article ; Expression of Concern
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db17-ec04a
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