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  1. Article ; Online: David K. C. Cooper, MD, PhD: Professor of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, PA.

    Cooper, David K C

    Transplantation

    2015  Volume 99, Issue 7, Page(s) 1310–1311

    MeSH term(s) Animals ; Biomedical Research/history ; Biomedical Research/trends ; Career Choice ; Forecasting ; History, 20th Century ; History, 21st Century ; Humans ; Organ Transplantation/history ; Organ Transplantation/trends ; Time Factors ; Transplantation, Heterologous/trends
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Editorial ; Historical Article ; Interview ; Portraits
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000000819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Clinical xenotransplantation

    Cooper, David K. C. / Byrne, Guerard

    pathways and progress in the transplantation of organs and tissues between species

    2020  

    Abstract: This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical ...

    Author's details David K. C. Cooper, Guerard Byrne, editors
    Abstract This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
    MeSH term(s) Transplantation, Heterologous.
    Keywords Xenografts ; Transplantation, Heterologous
    Subject code 617.95
    Language English
    Size 1 online resource (XXIX, 306 p. 82 illus., 59 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-49127-7 ; 3-030-49126-9 ; 978-3-030-49127-7 ; 978-3-030-49126-0
    DOI 10.1007/978-3-030-49127-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Clinical Pig Heart Xenotransplantation-Where Do We Go From Here?

    Cooper, David K C / Cozzi, Emanuele

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12592

    MeSH term(s) Animals ; Swine ; Transplantation, Heterologous ; Animals, Genetically Modified ; Graft Rejection ; Heart ; Thorax
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Invited commentary.

    Cooper, David K C

    Xenotransplantation

    2022  Volume 29, Issue 1, Page(s) e12737

    Language English
    Publishing date 2022-02-15
    Publishing country Denmark
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1236298-0
    ISSN 1399-3089 ; 0908-665X
    ISSN (online) 1399-3089
    ISSN 0908-665X
    DOI 10.1111/xen.12737
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  5. Article ; Online: Xenotransplantation-A Basic Science Perspective.

    Cooper, David K C / Hara, Hidetaka

    Kidney360

    2023  Volume 4, Issue 8, Page(s) 1147–1149

    MeSH term(s) Transplantation, Heterologous ; Research
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: The brain dead organ donor

    Novitzky, Dimitri / Cooper, David K. C.

    pathophysiology and management

    2013  

    Title variant The brain-dead organ donor
    Author's details Dimitri Novitzky ; David K. C. Cooper ed
    Language English
    Size XVI, 368 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017535668
    ISBN 978-1-4614-4303-2 ; 1-4614-4303-2 ; 9781461443049 ; 1461443040
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 5138 order for loan Magazin

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  7. Article ; Online: Advancing Xenotransplantation to the Clinic: How Relevant Is the Pig-to-nonhuman Primate Kidney Transplantation Model Today?

    Cooper, David K C

    Transplantation

    2022  Volume 106, Issue 9, Page(s) 1717–1719

    MeSH term(s) Animals ; Animals, Genetically Modified ; Graft Rejection/prevention & control ; Graft Survival ; Kidney Transplantation ; Primates ; Swine ; Transplantation, Heterologous
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Editorial
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings ; Online: P-wave velocities and applied bed thickness and velocity changes for synthetic seismograms, ODP Leg 188 and Leg 119 sites, supplementary data to: Handwerger, David A; Cooper, Alan K; O'Brien, Philip E; Williams, Trevor; Barr, Samantha R; Dunbar, Robert B; Leventer, Amy; Jarrard, Richard D (2004): Synthetic seismograms linking ODP sites to seismic profiles, continental rise and shelf of Prydz Bay, Antarctica. In: Cooper, AK; O'Brien, PE; Richter, C (eds.) Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 188, 1-28

    Handwerger, David A / Barr, Samantha R / Cooper, Alan K / Dunbar, Robert B / Jarrard, Richard D / Leventer, Amy / O'Brien, Philip E / Williams, Trevor

    2004  

    Abstract: Synthetic seismograms provide a crucial link between lithologic variations within a drill hole and reflectors on seismic profiles crossing the site. In essence, they provide a ground-truth for the interpretation of seismic data. Using a combination of ... ...

    Abstract Synthetic seismograms provide a crucial link between lithologic variations within a drill hole and reflectors on seismic profiles crossing the site. In essence, they provide a ground-truth for the interpretation of seismic data. Using a combination of core and logging data, we created synthetic seismograms for Ocean Drilling Program Sites 1165 and 1166, drilled during Leg 188, and Site 742, drilled during Leg 119, all in Prydz Bay, Antarctica. Results from Site 1165 suggest that coring penetrated a target reflector initially thought to represent the onset of drift sedimentation, but the lithologic change across the boundary does not show a change from predrift to drift sediments. The origin of a shallow reflector packet in the seismic line across Site 1166 and a line connecting Sites 1166 and 742 was resolved into its constituent sources, as this reflector occurs in a region of large-scale, narrowly spaced impedance changes. Furthermore, Site 1166 was situated in a fluvio-deltaic system with widely variable geology, and bed thickness changes were estimated between the site and both seismic lines.
    Language English
    Dates of publication 2004-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.188.010.2004
    DOI 10.1594/PANGAEA.780548
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Patient informed consent for a clinical trial of gene-edited pig kidney transplantation: A representative consent form.

    Cooper, David K C

    Xenotransplantation

    2022  Volume 30, Issue 1, Page(s) e12790

    Abstract: When clinical trials of gene-edited pig organ transplantation are initiated, the consent form that the patient is requested to sign will be an important document. Consent to receive a pig xenograft will have significant differences when compared with the ...

    Abstract When clinical trials of gene-edited pig organ transplantation are initiated, the consent form that the patient is requested to sign will be an important document. Consent to receive a pig xenograft will have significant differences when compared with the requirements of most experimental clinical procedures. We here suggest a consent form for pig kidney transplantation that addresses the major points that will be required and hope it will provide a basis for discussion and future modification, if necessary. There is purposely some repetition in the document, but we believe this is necessary to ensure that the patient has a clear understanding of what he/she is consenting to.
    MeSH term(s) Female ; Humans ; Swine ; Animals ; Consent Forms ; Kidney Transplantation ; Gene Editing ; Transplantation, Heterologous ; Informed Consent
    Language English
    Publishing date 2022-11-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1236298-0
    ISSN 1399-3089 ; 0908-665X
    ISSN (online) 1399-3089
    ISSN 0908-665X
    DOI 10.1111/xen.12790
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  10. Article ; Online: Recent progress in the pig-to-nonhuman primate kidney transplantation model: Report of a symposium.

    Cooper, David K C

    Xenotransplantation

    2022  Volume 29, Issue 1, Page(s) e12728

    Abstract: Three excellent presentations at an industry-sponsored symposium at the (virtual) congress of the combined IXA/CTRMS (September 23-25, 2021) were directed to the value and limitations of the pig-to-nonhuman primate (NHP) kidney transplantation model. ... ...

    Abstract Three excellent presentations at an industry-sponsored symposium at the (virtual) congress of the combined IXA/CTRMS (September 23-25, 2021) were directed to the value and limitations of the pig-to-nonhuman primate (NHP) kidney transplantation model. Daniel Firl and James Markmann provided a meta-analysis comparing the results of kidney allotransplantation and xenotransplantation in NHPs during the past 25 years. Remarkably, the authors had identified 73 published reports that included 910 individual experiments. Although recipient survival after allotransplantation was longer, the superiority over the survival of xenografts was less than anticipated. Given the excellent short- and medium-term results of clinical kidney allotransplantation today, these data provide hope that the results of clinical pig kidney xenotransplantation may prove significantly better than in NHPs. The authors identified several factors that were shown to statistically influence the success or failure of xenotransplantation. Jean Kwun provided valuable information relating to the longstanding question of whether the survival of a pig organ would be jeopardized if transplanted into an allosensitized recipient. He demonstrated that pig kidney transplantation in an HLA-sensitized patient may be at a disadvantage, although multiple genetic engineering of the organ-source pig significantly delayed rejection. In the initial clinical trials, therefore, it would seem wise to exclude any patient with evidence of anti-HLA antibodies. Andrew Adams reported longer survival (>1 year) of Rhesus monkeys with life-supporting pig kidney grafts than has been achieved previously. Although not consistently achieved, these excellent results were obtained with an anti-CD154mAb-based regimen after CD4
    MeSH term(s) Animals ; Animals, Genetically Modified ; Graft Rejection ; Humans ; Kidney Transplantation/methods ; Primates ; Swine ; Transplantation, Heterologous/methods
    Language English
    Publishing date 2022-01-10
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236298-0
    ISSN 1399-3089 ; 0908-665X
    ISSN (online) 1399-3089
    ISSN 0908-665X
    DOI 10.1111/xen.12728
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