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Article ; Online: Context-dependent attentional spotlight in pulvinar-V1 interaction.

Chen, Nihong / Ai, Hailin / Lu, Xincheng

2023 Volume 279, Page(s) 120341

Abstract: Spatial attention is often described as a mental spotlight that enhances information processing at the attended location. Using fMRI, we investigated background connectivity between the pulvinar and V1 in relation to focused versus diffused attention ... ...

Abstract	Spatial attention is often described as a mental spotlight that enhances information processing at the attended location. Using fMRI, we investigated background connectivity between the pulvinar and V1 in relation to focused versus diffused attention allocation, in weak and strong crowding contexts. Our findings revealed that focused attention led to enhanced correlations between the pulvinar and V1. Notably, this modulation was initiated by the pulvinar, and the strength of the modulation was dependent on the saliency of the target. These findings suggest that the pulvinar initiates information reweighting to V1, which underlies attentional selection in cluttered scenes.
MeSH term(s)	Humans ; Pulvinar/diagnostic imaging ; Cognition ; Diffusion
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120341
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

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Article ; Online: Seeing in crowds: Averaging first, then max.

Lu, Xincheng / Jiang, Ruijie / Song, Meng / Wu, Yiting / Ge, Yiran / Chen, Nihong

Psychonomic bulletin & review

2024

Abstract: Crowding, a fundamental limit in object recognition, is believed to result from excessive integration of nearby items in peripheral vision. To understand its pooling mechanisms, we measured subjects' internal response distributions in an orientation ... ...

Abstract	Crowding, a fundamental limit in object recognition, is believed to result from excessive integration of nearby items in peripheral vision. To understand its pooling mechanisms, we measured subjects' internal response distributions in an orientation crowding task. Contrary to the prediction of an averaging model, we observed a pattern suggesting that the perceptual judgement is made based on choosing the largest response across the noise-perturbed items. A model featuring first-stage averaging and second-stage signed-max operation predicts the diverse errors made by human observers under various signal strength levels. These findings suggest that different rules operate to resolve the bottleneck at early and high-level stages of visual processing, implementing a combination of linear and nonlinear pooling strategies.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2031311-1
ISSN	1531-5320 ; 1069-9384
ISSN (online)	1531-5320
ISSN	1069-9384
DOI	10.3758/s13423-024-02468-6
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Article ; Online: Construction of 2D sandwich-like Na

Sun, Rui / Dong, Siyang / Guo, Xincheng / Xia, Peng / Lu, Shengjun / Zhang, Yufei / Fan, Haosen

Journal of colloid and interface science

2023 Volume 655, Page(s) 226–233

Abstract: Aqueous zinc ion batteries (AZIBs) have attained enormous attention in the last few years. The cathode materials of aqueous zinc ion batteries play a vital effect in their electrochemical and battery properties. In this manuscript, Sandwich-like MXene@ ... ...

Abstract	Aqueous zinc ion batteries (AZIBs) have attained enormous attention in the last few years. The cathode materials of aqueous zinc ion batteries play a vital effect in their electrochemical and battery properties. In this manuscript, Sandwich-like MXene@Na
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.11.020
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Article ; Online: Computer-assisted intraoral approach in the management of infected comminuted mandibular fractures: Technical notes.

Lu, Ruohuang / Huang, Jiang / Zuo, Liang / Guo, Xincheng

Journal of stomatology, oral and maxillofacial surgery

2022 Volume 123, Issue 6, Page(s) 634–638

Abstract: In the extraoral approach for mandibular fractures, facial scars and facial nerve injury are common complications. Herein, we introduce an improved surgical technique to reduce fragments of infected comminuted mandibular fractures with the assistance of ... ...

Abstract	In the extraoral approach for mandibular fractures, facial scars and facial nerve injury are common complications. Herein, we introduce an improved surgical technique to reduce fragments of infected comminuted mandibular fractures with the assistance of computer software. Firstly, the model was reset by 3-dimensional (3D) printing, and then the titanium plate was reconstructed on the model. Finally, open reduction and internal fixation through intraoral approach. This method can effectively control infection, reduce facial scars and avoid the risk of facial nerve injury.
MeSH term(s)	Humans ; Mandibular Fractures/surgery ; Facial Nerve Injuries ; Cicatrix ; Retrospective Studies ; Fractures, Comminuted/surgery ; Computers
Language	English
Publishing date	2022-06-18
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2022.06.011
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Article ; Online: Structural determinants for tRNA selective cleavage by RNase 2/EDN.

Li, Jiarui / Kang, Xincheng / Guidi, Irene / Lu, Lu / Fernández-Millán, Pablo / Prats-Ejarque, Guillem / Boix, Ester

Structure (London, England : 1993)

2024 Volume 32, Issue 3, Page(s) 328–341.e4

Abstract: tRNA-derived fragments (tRFs) have emerged as key players of immunoregulation. Some RNase A superfamily members participate in the shaping of the tRFs population. By comparing wild-type and knockout macrophage cell lines, our previous work revealed that ... ...

Abstract	tRNA-derived fragments (tRFs) have emerged as key players of immunoregulation. Some RNase A superfamily members participate in the shaping of the tRFs population. By comparing wild-type and knockout macrophage cell lines, our previous work revealed that RNase 2 can selectively cleave tRNAs. Here, we confirm the in vitro protein cleavage pattern by screening of synthetic tRNAs, single-mutant variants, and anticodon-loop DNA/RNA hairpins. By sequencing of tRF products, we identified the cleavage selectivity of recombinant RNase 2 with base specificity at B
MeSH term(s)	Anticodon ; RNA, Transfer/chemistry ; Endoribonucleases/genetics ; RNA
Chemical Substances	ribonuclease U (EC 3.1.27.-) ; Anticodon ; RNA, Transfer (9014-25-9) ; Endoribonucleases (EC 3.1.-) ; RNA (63231-63-0)
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2023.12.012
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Zs.A 4141: Show issues

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Article ; Online: Temperature and pressure sensitive ionic conductive triple-network hydrogel for high-durability dual signal sensors.

He, Weidi / Guo, Xincheng / Xia, Peng / Lu, Shengjun / Zhang, Yufei / Fan, Haosen

Journal of colloid and interface science

2023 Volume 647, Page(s) 456–466

Abstract: In this work, the fabrication of strengthened triple network hydrogels was successfully achieved based on in-situ polymerization of polyacrylamide by combining both chemical and physical cross-linking methods. The ion conductive phase of lithium chloride ...

Abstract	In this work, the fabrication of strengthened triple network hydrogels was successfully achieved based on in-situ polymerization of polyacrylamide by combining both chemical and physical cross-linking methods. The ion conductive phase of lithium chloride (LiCl) and solvent in the hydrogel were regulated through soaking solution. The pressure and temperature sensing behavior and durability of the hydrogel were investigated. The hydrogel containing 1 mol/L LiCl and 30 %v/v glycerol displayed a pressure sensitivity of 4.16 kPa
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.149
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Article ; Online: V-shaped Folded Nasolabial Flap in the Repair of the Anterior Buccal Mucosal Defect.

Lu, Ruohuang / Huang, Jiang / Guo, Xincheng

The Journal of craniofacial surgery

2022 Volume 34, Issue 2, Page(s) e108–e111

Abstract: Objective: To investigate the efficacy of V-shaped folded nasolabial flap in the repair of small-sized and medium-sized defects of the anterior buccal mucosa.: Methods: From March 2019 to December 2021, 9 cases of male patients with anterior buccal ... ...

Abstract	Objective: To investigate the efficacy of V-shaped folded nasolabial flap in the repair of small-sized and medium-sized defects of the anterior buccal mucosa. Methods: From March 2019 to December 2021, 9 cases of male patients with anterior buccal mucosal lesions were enrolled in this study. After the lesions were completely excised, the mucosa and part of the buccal mucosal defect were left. A transverse V-shaped folded nasolabial flap was created with the pedicle located at the corner of the mouth and the long axis along the nasolabial fold. The lower part was lifted from the end to the pedicle. Next, from the level of the superficial musculo-aponeurotic system, the upper and lower parts were lifted from the end to the pedicle, and the V-shaped flap was folded and turned over through the buccal tunnel to repair the mucosal defect. The extraoral donor site was directly pulled and sutured. Results: The nasolabial flap survived in 9 patients, and the wounds inside and outside the mouth healed at stage I. The postoperative follow-up time was 4 to 32 months, and the patients had no recurrence, with symmetrical buccal shape, and no traction and deformation in the affected buccal organs. In addition, the linear scar had no obvious hyperplasia and was hidden in the affected nasolabial folds, without symptoms of buccal nerve injury, and the shape of the corner of the mouth was normal. The width and opening degree of oral fissure were not significantly reduced compared with those before operation. Meanwhile, the intraoral flap was thin and flat, and healed well with the surrounding mucosa, without obvious flap contracture, buccal bite, or incomplete closure. Conclusion: Overall, V-shaped folded nasolabial flap has the advantages of flexible design, simple preparation, reliable blood supply, and protection of the donor site, which may be one of the effective methods for repairing small-sized and medium-sized defects in the anterior buccal mucosa.
MeSH term(s)	Humans ; Male ; Mouth Mucosa ; Mouth ; Cicatrix ; Contracture ; Nasolabial Fold
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000008803
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: A Quantitative Detection Algorithm for Multi-Test Line Lateral Flow Immunoassay Applied in Smartphones.

Zhang, Shenglan / Jiang, Xincheng / Lu, Siqi / Yang, Guangtian / Wu, Shaojie / Chen, Liqiang / Pan, Hongcheng

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 14

Abstract: The traditional lateral flow immunoassay (LFIA) detection method suffers from issues such as unstable detection results and low quantitative accuracy. In this study, we propose a novel multi-test line lateral flow immunoassay quantitative detection ... ...

Abstract	The traditional lateral flow immunoassay (LFIA) detection method suffers from issues such as unstable detection results and low quantitative accuracy. In this study, we propose a novel multi-test line lateral flow immunoassay quantitative detection method using smartphone-based SAA immunoassay strips. Following the utilization of image processing techniques to extract and analyze the pigments on the immunoassay strips, quantitative analysis of the detection results was conducted. Experimental setups with controlled lighting conditions in a dark box were designed to capture samples using smartphones with different specifications for analysis. The algorithm's sensitivity and robustness were validated by introducing noise to the samples, and the detection performance on immunoassay strips using different algorithms was determined. The experimental results demonstrate that the proposed lateral flow immunoassay quantitative detection method based on image processing techniques achieves an accuracy rate of 94.23% on 260 samples, which is comparable to the traditional methods but with higher stability and lower algorithm complexity.
MeSH term(s)	Smartphone ; Algorithms ; Immunoassay/methods ; Image Processing, Computer-Assisted ; Limit of Detection
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23146401
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Article ; Online: Rab3a attenuates spinal cord injury by mediating vesicle release.

Yang, Yuhao / Liu, Ziqiao / Lu, Yang / Yu, Xincheng / Zhu, Rui / Cai, Xingda / Lin, Jinghua / Wang, Zemin / Zha, Dingsheng

Brain research bulletin

2024 Volume 208, Page(s) 110884

Abstract: Background: Rab3a regulates vesicle secretion and transport. Emerging evidences have shown that extracellular vesicles (EVs) can reach target lesions of injured spinal cords and exert a positive effect on these lesions. However, the molecular mechanism ... ...

Abstract	Background: Rab3a regulates vesicle secretion and transport. Emerging evidences have shown that extracellular vesicles (EVs) can reach target lesions of injured spinal cords and exert a positive effect on these lesions. However, the molecular mechanism by which Rab3a regulates vesicle secretion to ameliorate spinal cord injury (SCI) is not fully understood. Methods: An SCI rat model was established which was used to examine the pathological changes and Rab3a expression in spinal cord tissue. Rab3a was overexpressed in the model rats to demonstrate its effect on SCI repair. Rab3a was also knocked down in neuronal cells to verify its role in vesicle secretion and neuronal cells. The binding protein of Rab3a was identified by Co-IP and mass spectrometry. Results: Rab3a was significantly downregulated in SCI rats and Rab3a overexpression promoted SCI repair. Rab3a knockdown inhibited the secretion of neuronal cell-derived EVs. Compared to the EVs from the equal number of control neuronal cells, EVs from Rab3a-knockdown neuronal cells promoted M1 macrophage polarization, which in turn, promoted neuronal cell apoptosis. Mechanistically, STXBP1 was identified as a binding protein of Rab3a, and their interaction promoted the secretion of neuronal cell-derived EVs. Furthermore, METTL2b was significantly downregulated in SCI rats, and METTL2b knockdown significantly reduced Rab3a protein expression. Conclusion: These results suggest that Rab3a promotes the secretion of neuronal cell-derived EVs by interacting with its binding protein STXBP1. Neuronal cells-derived EVs inhibited the polarization of M1 macrophages in the spinal cord microenvironment, thereby promoting SCI repair. Our findings provide a theoretical basis for the clinical treatment of SCI.
MeSH term(s)	Animals ; Rats ; Macrophages/metabolism ; Spinal Cord/metabolism ; Spinal Cord Injuries/metabolism
Chemical Substances	Rab3a protein, rat
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2024.110884
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Zs.A 1243: Show issues

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Article ; Online: Bridging biological and food monitoring: A colorimetric and fluorescent dual-mode sensor based on N-doped carbon dots for detection of pH and histamine.

Zhang, Xiaoran / Wang, Jing / Hasan, Elias / Sun, Xincheng / Asif, Muhammad / Aziz, Ayesha / Lu, Wenjing / Dong, Chuan / Shuang, Shaomin

Journal of hazardous materials

2024 Volume 470, Page(s) 134271

Abstract: Rapid and sensitive monitoring of pH and histamine is crucial for bridging biological and food systems and identifying corresponding abnormal situations. Herein, N-doped carbon dots (CDs) are fabricated by a hydrothermal method employing dipicolinic acid ...

Abstract	Rapid and sensitive monitoring of pH and histamine is crucial for bridging biological and food systems and identifying corresponding abnormal situations. Herein, N-doped carbon dots (CDs) are fabricated by a hydrothermal method employing dipicolinic acid and o-phenylenediamine as precursors. The CDs exhibit colorimetric and fluorescent dual-mode responses to track pH and histamine variations in living cells and food freshness, respectively. The aggregation-induced emission enhancement and intramolecular charge transfer result in a decrease in absorbance and an increase in fluorescence, which become readily apparent as the pH changes from acidic to neutral. This property enables precise differentiation between normal and cancerous cells. Furthermore, given the intrinsic basicity of histamine, pH-responsive CDs are advantageous for additional colorimetric and fluorescent monitoring of histamine in food freshness, achieving linearities of 25-1000 µM and 30-1000 µM, respectively, which are broader than those of alternative nanoprobes. Interestingly, the smartphone-integrated sensing platform can portably and visually evaluate pH and histamine changes due to sensitive color changes. Therefore, the sensor not only establishes a dynamic connection between pH and histamine for the purposes of biological and food monitoring, but also presents a novel approach for developing a multifunctional biosensor that can accomplish environmental monitoring and biosensing simultaneously.
MeSH term(s)	Histamine/analysis ; Carbon/chemistry ; Colorimetry/methods ; Hydrogen-Ion Concentration ; Quantum Dots/chemistry ; Humans ; Biosensing Techniques/methods ; Spectrometry, Fluorescence ; Smartphone ; Food Analysis/methods ; Nitrogen/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry
Chemical Substances	Histamine (820484N8I3) ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Fluorescent Dyes
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134271
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