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  1. Article ; Online: A Brief Review of Lung Ultrasonography in COVID-19: Is It Useful?

    Fiala, Matthew J

    Annals of emergency medicine

    2020  Volume 75, Issue 6, Page(s) 784–785

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Ultrasonography
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2020.03.033
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  4. Article ; Online: A Brief Review of Lung Ultrasonography in COVID-19

    Fiala, Matthew J.

    Annals of Emergency Medicine

    Is It Useful?

    2020  Volume 75, Issue 6, Page(s) 784–785

    Keywords Emergency Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2020.03.033
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Statin use in myelodysplastic syndromes is associated with a better survival and decreased progression to leukemia.

    Afzal, Amber / Fiala, Mark A / Jacoby, Meagan A / Walter, Matthew J

    Blood advances

    2023  Volume 7, Issue 15, Page(s) 3838–3841

    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Myelodysplastic Syndromes/drug therapy ; Leukemia
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023009818
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    Zs.A 7153: Show issues Location:
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  6. Article ; Online: Dynamic frailty risk assessment among older adults with multiple myeloma: A population-based cohort study.

    Mian, Hira / Wildes, Tanya M / Vij, Ravi / Pianko, Matthew J / Major, Ajay / Fiala, Mark A

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 76

    Abstract: Multiple myeloma (MM) is a cancer of older adults and those who are more frail are at high risk of poor outcomes. Current tools for identifying and categorizing frail patients are often static and measured only at the time of diagnosis. The concept of ... ...

    Abstract Multiple myeloma (MM) is a cancer of older adults and those who are more frail are at high risk of poor outcomes. Current tools for identifying and categorizing frail patients are often static and measured only at the time of diagnosis. The concept of dynamic frailty (i.e. frailty changing over time) is largely unexplored in MM. In our study, adults with newly-diagnosed MM who received novel drugs between the years 2007-2014 were identified in the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked databases. Using a previously published cumulative deficit approach, a frailty index score was calculated at diagnosis and each landmark interval (1-yr, 2-yr, 3-yr post diagnosis). The association of frailty with overall survival (OS) both at baseline and at each landmark interval as well as factors associated with worsening frailty status over time were evaluated. Overall, 4617 patients were included. At baseline, 39% of the patients were categorized as moderately frail or severely frail. Among those who had 3 years of follow-up, frailty categorization changed post diagnosis in 93% of the cohort (78% improved and 72% deteriorated at least at one time point during the follow up period). In a landmark analysis, the predictive ability of frailty at the time of diagnosis decreased over time for OS (Harrell's C Statistic 0.65 at diagnosis, 0.63 at 1-yr, 0.62 at 2-yr, and 0.60 at 3-yr) and was inferior compared to current frailty status at each landmark interval. Our study is one of the first to demonstrate the dynamic nature of frailty among older adults with MM. Frailty may improve or deteriorate over time. Current frailty status is a better predictor of outcomes than frailty status at time of diagnosis, indicating the need for re-measurement in this high-risk patient population.
    MeSH term(s) Humans ; Aged ; United States/epidemiology ; Frailty/diagnosis ; Frailty/epidemiology ; Multiple Myeloma/diagnosis ; Multiple Myeloma/epidemiology ; Cohort Studies ; Frail Elderly ; Geriatric Assessment/methods ; Medicare ; Risk Assessment
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00843-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phase I-II Trial of Early Azacitidine after Matched Unrelated Donor Hematopoietic Cell Transplantation.

    Xu, Ziheng / Choi, Jaebok / Cooper, Matthew / King, Jeffrey / Fiala, Mark A / Liu, Jingxia / Pusic, Iskra / Romee, Rizwan / Cashen, Amanda / Jacoby, Meagan A / Stockerl-Goldstein, Keith / Abboud, Camille / Vij, Ravi / Uy, Geoffrey / Westervelt, Peter / Walter, Matthew J / DiPersio, John F / Schroeder, Mark A

    Transplantation and cellular therapy

    2023  Volume 29, Issue 11, Page(s) 699.e1–699.e9

    Abstract: Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). The hypomethylating agent azacitidine (AZA) has been shown to be effective in preclinical and clinical studies for the prevention of ... ...

    Abstract Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). The hypomethylating agent azacitidine (AZA) has been shown to be effective in preclinical and clinical studies for the prevention of acute GVHD (aGVHD). We sought to determine the maximum tolerated dose (MTD) of AZA when given on days 1 to 5 of a 28-day cycle for 4 cycles, starting on day +7 after allo-HCT, as well as its impact on aGVHD and chronic GVHD (cGVHD), relapse, and overall survival (OS) in patients undergoing matched unrelated donor allo-HCT. This study was a single-arm, single-center, open-label phase I-II study with a total of 15 and 38 patients enrolled in the phase I and II portions of the trial, respectively. A standard 3+3 study design was used in phase I, and all patients in phase II received AZA at the MTD determined in phase I. The MTD of AZA starting at day +7 post-transplantation was 45 mg/m
    MeSH term(s) Humans ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Recurrence ; Unrelated Donors
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.08.017
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    Zs.A 5082: Show issues Location:
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  8. Article ; Online: Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner.

    Papotto, Pedro H / Yilmaz, Bahtiyar / Pimenta, Gonçalo / Mensurado, Sofia / Cunha, Carolina / Fiala, Gina J / Gomes da Costa, Daniel / Gonçalves-Sousa, Natacha / Chan, Brian H K / Blankenhaus, Birte / Domingues, Rita G / Carvalho, Tânia / Hepworth, Matthew R / Macpherson, Andrew J / Allen, Judith E / Silva-Santos, Bruno

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112074

    Abstract: Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient ( ... ...

    Abstract Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ
    MeSH term(s) Animals ; Mice ; Immunity, Innate ; Lymphocytes ; Gastrointestinal Microbiome ; Inflammation ; Lung ; Mice, Inbred C57BL
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Treating phantom limb pain: cryoablation of the posterior tibial nerve.

    Fiala, Matthew / Azariah, Abana / Woo, Jean / Aal, Ahmed Kamel Abdel / Levey, Alexa

    Radiology case reports

    2022  Volume 17, Issue 9, Page(s) 3168–3171

    Abstract: Phantom limb pain (PLP) is a complex pathophysiologic process involving both the central and peripheral nervous system for which there is no definitive treatment. The number of individuals living with amputated limbs is predicted to increase to 3.5 ... ...

    Abstract Phantom limb pain (PLP) is a complex pathophysiologic process involving both the central and peripheral nervous system for which there is no definitive treatment. The number of individuals living with amputated limbs is predicted to increase to 3.5 million by 2050, and up to 80% of these patients will have PLP. In this case report, we will demonstrate successful reduction of PLP in a patient with bilateral phantom toe pain utilizing nerve blockade and subsequent cryoablation of the posterior tibial nerves.
    Language English
    Publishing date 2022-06-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.05.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heterotopic ossification: radiological and pathological review.

    Mujtaba, Bilal / Taher, Ahmed / Fiala, Matthew J / Nassar, Sameh / Madewell, John E / Hanafy, Abdelrahman K / Aslam, Rizwan

    Radiology and oncology

    2019  Volume 53, Issue 3, Page(s) 275–284

    Abstract: Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. The exact ... ...

    Abstract Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. The exact pathogenesis of this disease remains unclear; however, there is ongoing research in prophylactic and therapeutic treatments that is promising. Conclusions Due to HO potential to cause disability, it is so important to differentiate it from other causes in order to establish the best possible management.
    MeSH term(s) Calcinosis/diagnostic imaging ; Chondrocalcinosis/diagnostic imaging ; Diagnosis, Differential ; Fractures, Avulsion/diagnostic imaging ; Gout/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Myositis Ossificans/diagnostic imaging ; Ossification, Heterotopic/diagnostic imaging ; Ossification, Heterotopic/etiology ; Ossification, Heterotopic/therapy ; Osteosarcoma/diagnostic imaging ; Radiography ; Tendinopathy/diagnostic imaging ; Wounds and Injuries/complications
    Language English
    Publishing date 2019-09-24
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 1128829-2
    ISSN 1581-3207 ; 0485-893X ; 1318-2099
    ISSN (online) 1581-3207
    ISSN 0485-893X ; 1318-2099
    DOI 10.2478/raon-2019-0039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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