LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 14

Search options

  1. Article ; Online: Best Practice Alerts in Electronic Medical Records to Improve Pneumococcal Vaccination in CKD.

    Kapoor, Sanjana / Sheth, Heena S / DeSilva, Ranil / Aggarwal, Rohit

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 81, Issue 2, Page(s) 245–246

    MeSH term(s) Humans ; Electronic Health Records ; Vaccination ; Renal Insufficiency, Chronic ; Pneumococcal Vaccines ; Pneumococcal Infections/prevention & control
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Letter
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 468: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: An integrated method for targeted Oxford Nanopore sequencing and automated bioinformatics for the simultaneous detection of bacteria, fungi, and ARG.

    Kuruwa, Sanjana / Zade, Amrutraj / Shah, Sanchi / Moidu, Rameez / Lad, Shailesh / Chande, Chhaya / Joshi, Ameeta / Hirani, Nilma / Nikam, Chaitali / Bhattacharya, Sanjay / Poojary, Aruna / Kapoor, Mahua / Kondabagil, Kiran / Chatterjee, Anirvan

    Journal of applied microbiology

    2024  Volume 135, Issue 2

    Abstract: Aims: The use of metagenomics for pathogen identification in clinical practice has been limited. Here we describe a workflow to encourage the clinical utility and potential of NGS for the screening of bacteria, fungi, and antimicrobial resistance genes ( ...

    Abstract Aims: The use of metagenomics for pathogen identification in clinical practice has been limited. Here we describe a workflow to encourage the clinical utility and potential of NGS for the screening of bacteria, fungi, and antimicrobial resistance genes (ARGs).
    Methods and results: The method includes target enrichment, long-read sequencing, and automated bioinformatics. Evaluation of several tools and databases was undertaken across standard organisms (n = 12), clinical isolates (n = 114), and blood samples from patients with suspected bloodstream infections (n = 33). The strategy used could offset the presence of host background DNA, error rates of long-read sequencing, and provide accurate and reproducible detection of pathogens. Eleven targets could be successfully tested in a single assay. Organisms could be confidently identified considering ≥60% of best hits of a BLAST-based threshold of e-value 0.001 and a percent identity of >80%. For ARGs, reads with percent identity of >90% and >60% overlap of the complete gene could be confidently annotated. A kappa of 0.83 was observed compared to standard diagnostic methods. Thus, a workflow for the direct-from-sample, on-site sequencing combined with automated genomics was demonstrated to be reproducible.
    Conclusion: NGS-based technologies overcome several limitations of current day diagnostics. Highly sensitive and comprehensive methods of pathogen screening are the need of the hour. We developed a framework for reliable, on-site, screening of pathogens.
    MeSH term(s) Humans ; Nanopore Sequencing ; Bacteria/genetics ; Fungi/genetics ; Computational Biology ; Genomics ; High-Throughput Nucleotide Sequencing/methods
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxae037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Implementing a self-reported immunosuppression adherence questionnaire to screen for non-adherence in routine care of kidney transplant recipients.

    Sharma, Akhil / Verma, Siddharth / Mirzai, Saeid / Viswanathan, Vignesh / Kapoor, Sanjana / Hariharan, Sundaram / Dew, Mary Amanda / Puttarajappa, Chethan M

    Clinical transplantation

    2023  Volume 38, Issue 1, Page(s) e15157

    Abstract: Introduction: Self-reported measures of immunosuppression adherence have been largely examined in research settings.: Methods: In this single center study of 610 kidney transplant recipients, we examined if a voluntary, non-anonymous self-report ... ...

    Abstract Introduction: Self-reported measures of immunosuppression adherence have been largely examined in research settings.
    Methods: In this single center study of 610 kidney transplant recipients, we examined if a voluntary, non-anonymous self-report measure could identify non-adherence in a routine clinic setting and how patients perceived such a measure. Non-adherence was measured using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) and patient perception was elicited using a customized questionnaire.
    Results: Non-responders to the survey (15%) were younger, more likely to be black, and less likely to have had a pre-emptive transplant. Among complete responders (n = 485), 38% reported non-adherence with non-adherent patients being younger (54 y vs. 60 y; p = .01), less likely to have been on dialysis pre-transplant (59% vs. 68%; p = .04), further out from transplant (37 vs. 22 months; p < .001) and had more rejections in the preceding year (8% vs. 3%; p = .02). Self-reported non-adherence was associated with higher calcineurin inhibitor intra-patient variability (27.4% vs. 24.5%; p = .02), but not with donor-specific antibody detection (27.8% vs. 21.2%, p = .15). Of patients providing feedback (n = 500), the majority of patients felt comfortable reporting adherence (92%), that the survey was relevant to their visit (71%), and that the survey did not interfere with their clinic visit (88%).
    Conclusion: In summary, a self-reported questionnaire during clinic visits identified immunosuppression non-adherence in a significant proportion of patients and was well received by patients. Integrating self-report measures into routine post-transplant care may enable early identification of non-adherence.
    MeSH term(s) Humans ; Self Report ; Kidney Transplantation ; Immunosuppressive Agents/therapeutic use ; Surveys and Questionnaires ; Immunosuppression Therapy ; Transplant Recipients ; Medication Adherence
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-10-04
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Medical Marijuana: Facts and Questions.

    Gupta, Sushilkumar S / Namana, Vinod / Ambesh, Paurush / Kapoor, Sanjana / Abbasi, Anna A / Kamholz, Stephan L

    American journal of therapeutics

    2018  Volume 26, Issue 4, Page(s) e502–e510

    MeSH term(s) Humans ; Medical Marijuana ; Policy ; United States
    Chemical Substances Medical Marijuana
    Language English
    Publishing date 2018-01-03
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 1280786-2
    ISSN 1536-3686 ; 1075-2765
    ISSN (online) 1536-3686
    ISSN 1075-2765
    DOI 10.1097/MJT.0000000000000716
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Carbohydrate Modifications of Neoandrographolide for Improved Reactive Oxygen Species-Mediated Apoptosis through Mitochondrial Pathway in Colon Cancer.

    Sharma, Venu / Qayum, Arem / Kaul, Sanjana / Singh, Ajeet / Kapoor, Kamal K / Mukherjee, Debaraj / Singh, Shashank K / Dhar, Manoj K

    ACS omega

    2019  Volume 4, Issue 24, Page(s) 20435–20442

    Abstract: Modifications at the carbohydrate moiety of neoandrographolide, isolated from the medicinal ... ...

    Abstract Modifications at the carbohydrate moiety of neoandrographolide, isolated from the medicinal plant
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b01249
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Carbohydrate Modifications of Neoandrographolide for Improved Reactive Oxygen Species-Mediated Apoptosis through Mitochondrial Pathway in Colon Cancer

    Venu Sharma / Arem Qayum / Sanjana Kaul / Ajeet Singh / Kamal K. Kapoor / Debaraj Mukherjee / Shashank K. Singh / Manoj K. Dhar

    ACS Omega, Vol 4, Iss 24, Pp 20435-

    2019  Volume 20442

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Camphor sulphonic acid mediated quantitative 1,3-diol protection of major Labdane diterpenes isolated from Andrographis paniculata.

    Sharma, Venu / Kapoor, Kamal K / Mukherjee, Debaraj / Gupta, Vivek K / Dhar, Manoj K / Kaul, Sanjana

    Natural product research

    2018  Volume 32, Issue 15, Page(s) 1751–1759

    Abstract: Phytochemical survey of the methanol extract of the dried aerial parts of Andrographis paniculata led to the isolation of major labdane diterpenes, namely 14-deoxy-11,12-didehydroandrographolide, andrographolide and neoandrographolide. Andrographolide ... ...

    Abstract Phytochemical survey of the methanol extract of the dried aerial parts of Andrographis paniculata led to the isolation of major labdane diterpenes, namely 14-deoxy-11,12-didehydroandrographolide, andrographolide and neoandrographolide. Andrographolide was found to be the major phytoconstituent of the plant which was biologically active. For better physiochemical characteristics and bioefficacy, andrographolide is subjected to semi-synthetic modifications. However, presence of several free hydroxyl groups associated with this molecule make it quite polar and poorly soluble in many organic solvents and hence unsuitable for synthetic modifications. One way of resolving its solubility issue is to protect 1,3-diol quantitatively under mild reaction condition without effecting other functional groups. Reaction conditions were optimised using different solvent systems and catalysts towards this direction. X-ray structure of 3,19-isopropylidene-14-deoxy-11,12-didehydroandrographolide is being reported here for the first time. Isolated compounds and derivatives were confirmed by spectral analysis or X-ray data analysis.
    MeSH term(s) Andrographis/chemistry ; Crystallography, X-Ray ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Glucosides/isolation & purification ; Medicine, Ayurvedic ; Plant Components, Aerial/chemistry ; Plant Extracts/chemistry ; Plants, Medicinal/chemistry ; Sulfonic Acids/chemistry ; Tetrahydronaphthalenes/isolation & purification
    Chemical Substances Diterpenes ; Glucosides ; Plant Extracts ; Sulfonic Acids ; Tetrahydronaphthalenes ; andrographolide (410105JHGR) ; neoandrographolide (XBY0Z806J2)
    Language English
    Publishing date 2018-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1402313
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: A Bronchogenic Cyst Presenting as Dysphagia.

    Kapoor, Sanjana / Abed, Jean / Dalapathi, Vijay / Prajapati, Shyam / Bhora, Faiz Y / Mankal, Pavan Kumar / Kotler, Donald P

    ACG case reports journal

    2015  Volume 2, Issue 4, Page(s) 194–195

    Language English
    Publishing date 2015-07-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.2015.53
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.

    Bhatia, Shilpa / Nguyen, Diemmy / Darragh, Laurel B / Van Court, Benjamin / Sharma, Jaspreet / Knitz, Michael W / Piper, Miles / Bukkapatnam, Sanjana / Gadwa, Jacob / Bickett, Thomas E / Bhuvane, Shiv / Corbo, Sophia / Wu, Brian / Lee, Yichien / Fujita, Mayumi / Joshi, Molishree / Heasley, Lynn E / Ferris, Robert L / Rodriguez, Olga /
    Albanese, Christopher / Kapoor, Mohit / Pasquale, Elena B / Karam, Sana D

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3535

    Abstract: Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its ... ...

    Abstract Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its microenvironment using genetically engineered mice, recombinant constructs, pharmacologic agonists and antagonists. We observe that manipulating the EphB4 intracellular domain on cancer cells accelerates tumor growth and angiogenesis. EphB4 cancer cell loss also triggers compensatory upregulation of EphA4 and T regulatory cells (Tregs) influx and their targeting results in reversal of accelerated tumor growth mediated by EphB4 knockdown. EphrinB2 knockout on cancer cells and vasculature, on the other hand, results in maximal tumor reduction and vascular normalization. We report that EphB4 agonism provides no additional anti-tumoral benefit in the absence of ephrinB2. These results identify ephrinB2 as a tumor promoter and its receptor, EphB4, as a tumor suppressor in HNSCC, presenting opportunities for rational drug design.
    MeSH term(s) Animals ; Ephrin-B2/genetics ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Mice ; Receptor, EphB4/genetics ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Tumor Microenvironment
    Chemical Substances EFNB2 protein, mouse ; Ephrin-B2 ; Ephb4 protein, mouse (EC 2.7.10.1) ; Receptor, EphB4 (EC 2.7.10.1)
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31124-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment

    Shilpa Bhatia / Diemmy Nguyen / Laurel B. Darragh / Benjamin Van Court / Jaspreet Sharma / Michael W. Knitz / Miles Piper / Sanjana Bukkapatnam / Jacob Gadwa / Thomas E. Bickett / Shiv Bhuvane / Sophia Corbo / Brian Wu / Yichien Lee / Mayumi Fujita / Molishree Joshi / Lynn E. Heasley / Robert L. Ferris / Olga Rodriguez /
    Christopher Albanese / Mohit Kapoor / Elena B. Pasquale / Sana D. Karam

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 21

    Abstract: EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell and ... ...

    Abstract EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell and endothelial compartments suggests that ephrinB2 acts as a tumor promoter and EphB4 as a tumor suppressor.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top